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PubMed:1907460 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 36-46 protein denotes NF-kappa B
T2 94-112 DNA denotes HIV-1 proviral DNA
T3 126-139 DNA denotes binding sites
T4 148-168 protein denotes transcription factor
T5 169-179 protein denotes NF-kappa B
T6 252-280 protein denotes tumour necrosis factor alpha
T7 282-291 protein denotes TNF alpha
T8 430-440 protein denotes NF-kappa B
T9 632-638 cell_line denotes Molt-4
T10 643-653 cell_line denotes U937 cells
T11 781-791 protein denotes NF-kappa B
T12 860-894 protein denotes chloramphenicol acetyl-transferase
T13 896-899 protein denotes CAT
T14 934-944 protein denotes NF-kappa B
T15 945-958 DNA denotes binding sites
T16 962-978 cell_type denotes uninfected cells
T17 1085-1111 DNA denotes NF-kappa B-dependent genes

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-93 Sentence denotes Inhibition of HIV-1 replication and NF-kappa B activity by cysteine and cysteine derivatives.
S2 94-180 Sentence denotes HIV-1 proviral DNA contains two binding sites for the transcription factor NF-kappa B.
S3 181-335 Sentence denotes HIV-1-infected individuals have, on average, abnormally high levels of tumour necrosis factor alpha (TNF alpha) and abnormally low plasma cysteine levels.
S4 336-452 Sentence denotes We therefore investigated the effects of cysteine and related thiols on HIV-1 replication and NF-kappa B expression.
S5 453-654 Sentence denotes The experiments in this report show that cysteine or N-acetylcysteine (NAC) raise the intracellular glutathione (GSH) level and inhibit HIV-1 replication in persistently infected Molt-4 and U937 cells.
S6 655-750 Sentence denotes However, inhibition of HIV-1 replication appears not to be directly correlated with GSH levels.
S7 751-979 Sentence denotes Cysteine and NAC also inhibit NF-kappa B activity as determined by electrophoretic mobility shift assays and chloramphenicol acetyl-transferase (CAT) gene expression under control of NF-kappa B binding sites in uninfected cells.
S8 980-1142 Sentence denotes This suggests that the cysteine deficiency in HIV-1-infected individuals may cause an over-expression of NF-kappa B-dependent genes and enhance HIV-1 replication.
S9 1143-1213 Sentence denotes NAC may be considered for the treatment of HIV-1-infected individuals.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 14-31 NP denotes HIV-1 replication
C3 36-46 NP denotes NF-kappa B
C2 36-55 NP denotes NF-kappa B activity
C4 59-67 NP denotes cysteine
C5 144-179 NP denotes the transcription factor NF-kappa B
C6 181-207 NP denotes HIV-1-infected individuals
C7 377-385 NP denotes cysteine
C8 408-425 NP denotes HIV-1 replication
C9 494-502 NP denotes cysteine
C10 506-528 NP denotes N-acetylcysteine (NAC)
C11 535-576 NP denotes the intracellular glutathione (GSH) level
C12 589-606 NP denotes HIV-1 replication
C13 678-695 NP denotes HIV-1 replication
C14 739-749 NP denotes GSH levels
C15 751-759 NP denotes Cysteine
C16 764-767 NP denotes NAC
C18 781-791 NP denotes NF-kappa B
C17 781-800 NP denotes NF-kappa B activity
C19 1026-1052 NP denotes HIV-1-infected individuals
C20 1124-1141 NP denotes HIV-1 replication
C21 1143-1146 NP denotes NAC
C22 1186-1212 NP denotes HIV-1-infected individuals
R1 C5 C3 coref-ident the transcription factor NF-kappa B,NF-kappa B
R2 C7 C4 coref-ident cysteine,cysteine
R3 C8 C1 coref-ident HIV-1 replication,HIV-1 replication
R4 C9 C7 coref-ident cysteine,cysteine
R5 C12 C8 coref-ident HIV-1 replication,HIV-1 replication
R6 C13 C12 coref-ident HIV-1 replication,HIV-1 replication
R7 C14 C11 coref-ident GSH levels,the intracellular glutathione (GSH) level
R8 C15 C9 coref-ident Cysteine,cysteine
R9 C16 C10 coref-ident NAC,N-acetylcysteine (NAC)
R10 C18 C5 coref-ident NF-kappa B,the transcription factor NF-kappa B
R11 C17 C2 coref-ident NF-kappa B activity,NF-kappa B activity
R12 C19 C6 coref-ident HIV-1-infected individuals,HIV-1-infected individuals
R13 C20 C13 coref-ident HIV-1 replication,HIV-1 replication
R14 C21 C16 coref-ident NAC,NAC
R15 C22 C19 coref-ident HIV-1-infected individuals,HIV-1-infected individuals

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 14-19 virus denotes HIV-1
T2 20-31 other_name denotes replication
T3 36-46 protein_molecule denotes NF-kappa B
T4 59-67 amino_acid_monomer denotes cysteine
T5 72-80 amino_acid_monomer denotes cysteine
T6 94-99 virus denotes HIV-1
T7 126-139 DNA_domain_or_region denotes binding sites
T8 148-168 protein_family_or_group denotes transcription factor
T9 169-179 protein_molecule denotes NF-kappa B
T10 181-186 virus denotes HIV-1
T11 252-280 protein_molecule denotes tumour necrosis factor alpha
T12 282-291 protein_molecule denotes TNF alpha
T13 312-318 other_name denotes plasma
T14 319-327 amino_acid_monomer denotes cysteine
T15 377-385 amino_acid_monomer denotes cysteine
T16 398-404 other_organic_compound denotes thiols
T17 408-413 virus denotes HIV-1
T18 430-440 protein_molecule denotes NF-kappa B
T19 494-502 amino_acid_monomer denotes cysteine
T20 506-522 amino_acid_monomer denotes N-acetylcysteine
T21 524-527 amino_acid_monomer denotes NAC
T22 539-552 other_name denotes intracellular
T23 553-564 peptide denotes glutathione
T24 566-569 peptide denotes GSH
T25 589-594 virus denotes HIV-1
T26 632-638 cell_line denotes Molt-4
T27 643-653 cell_line denotes U937 cells
T28 678-683 virus denotes HIV-1
T29 739-742 peptide denotes GSH
T30 751-759 amino_acid_monomer denotes Cysteine
T31 764-767 amino_acid_monomer denotes NAC
T32 781-791 protein_molecule denotes NF-kappa B
T33 818-855 other_name denotes electrophoretic mobility shift assays
T34 860-894 protein_molecule denotes chloramphenicol acetyl-transferase
T35 896-899 protein_molecule denotes CAT
T36 934-944 protein_molecule denotes NF-kappa B
T37 945-958 DNA_domain_or_region denotes binding sites
T38 962-978 cell_type denotes uninfected cells
T39 1003-1011 amino_acid_monomer denotes cysteine
T40 1026-1031 virus denotes HIV-1
T41 1085-1095 protein_molecule denotes NF-kappa B
T42 1124-1129 virus denotes HIV-1
T43 1143-1146 amino_acid_monomer denotes NAC
T44 1186-1191 virus denotes HIV-1