PubMed:1907283
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-173 | Sentence | denotes | Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. |
| T2 | 174-403 | Sentence | denotes | A panel of monoclonal antibodies prepared to the chondroitin sulfate proteoglycans of rat brain was used for their immunocytochemical localization and isolation of individual proteoglycan species by immunoaffinity chromatography. |
| T3 | 404-633 | Sentence | denotes | One of these proteoglycans (designated 1D1) consists of a major component with an average molecular size of 300 kDa in 7-day brain, containing a 245-kDa core glycoprotein and an average of three 22-kDa chondroitin sulfate chains. |
| T4 | 634-852 | Sentence | denotes | A 1D1 proteoglycan of approximately 180 kDa with a 150-kDa core glycoprotein is also present at 7 days, and by 2-3 weeks postnatal this becomes the major species, containing a single 32-kDa chondroitin 4-sulfate chain. |
| T5 | 853-1029 | Sentence | denotes | The concentration of 1D1 decreases during development, from 20% of the total chondroitin sulfate proteoglycan protein (0.1 mg/g brain) at 7 days postnatal to 6% in adult brain. |
| T6 | 1030-1233 | Sentence | denotes | A 45-kDa protein which is recognized by the 8A4 monoclonal antibody to rat chondrosarcoma link protein copurifies with the 1D1 proteoglycan, which aggregates to a significant extent with hyaluronic acid. |
| T7 | 1234-1417 | Sentence | denotes | A chondroitin/keratan sulfate proteoglycan (designated 3H1) with a size of approximately 500 kDa was isolated from rat brain using monoclonal antibodies to the keratan sulfate chains. |
| T8 | 1418-1636 | Sentence | denotes | The core glycoprotein obtained after treatment of the 3H1 proteoglycan with chondroitinase ABC and endo-beta-galactosidase decreases in size from approximately 360 kDa at 7 days to approximately 280 kDa in adult brain. |
| T9 | 1637-1938 | Sentence | denotes | In 7-day brain, the proteoglycan contains three to five 25-kDa chondroitin 4-sulfate chains and three to six 8.4-kDa keratan sulfate chains, whereas the adult brain proteoglycan contains two to four chondroitin 4-sulfate chains and eight to nine keratan sulfate chains, with an average size of 10 kDa. |
| T10 | 1939-2178 | Sentence | denotes | The concentration of 3H1 increases during development from 3% of the total soluble proteoglycan protein at 7 days to 11% in adult brain, and there is a developmental decrease in the branching and/or sulfation of the keratan sulfate chains. |
| T11 | 2179-2386 | Sentence | denotes | A third monoclonal antibody (3F8) was used to isolate a approximately 500-kDa chondroitin sulfate proteoglycan comprising a 400-kDa core glycoprotein and an average of four 28-kDa chondroitin sulfate chains. |
| T12 | 2387-2662 | Sentence | denotes | In the 1D1 and 3F8 proteoglycans of 7-day brain, 20 and 33%, respectively, of the chondroitin sulfate is 6-sulfated, whereas chondroitin 4-sulfate accounts for greater than 96% of the glycosaminoglycan chains in the adult brain proteoglycans.(ABSTRACT TRUNCATED AT 400 WORDS) |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 60-71 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T2 | 84-95 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T3 | 96-111 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T4 | 223-234 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T5 | 606-617 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T6 | 824-845 | Glycan_Motif | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19059PI |
| T7 | 824-835 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T8 | 930-941 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T9 | 1236-1247 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T10 | 1248-1263 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T11 | 1394-1409 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T12 | 1700-1721 | Glycan_Motif | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19059PI |
| T13 | 1700-1711 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T14 | 1754-1769 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T15 | 1836-1857 | Glycan_Motif | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19059PI |
| T16 | 1836-1847 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T17 | 1883-1898 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T18 | 2155-2170 | Glycan_Motif | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82109MW |
| T19 | 2257-2268 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T20 | 2359-2370 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T21 | 2469-2480 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
| T22 | 2512-2533 | Glycan_Motif | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19059PI |
| T23 | 2512-2523 | Glycan_Motif | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 60-71 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T2 | 84-95 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T3 | 96-111 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T4 | 223-234 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T5 | 606-617 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T6 | 824-845 | https://glytoucan.org/Structures/Glycans/G19059PI | denotes | chondroitin 4-sulfate |
| T7 | 824-835 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T8 | 930-941 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T9 | 1236-1247 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T10 | 1248-1263 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T11 | 1394-1409 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T12 | 1700-1721 | https://glytoucan.org/Structures/Glycans/G19059PI | denotes | chondroitin 4-sulfate |
| T13 | 1700-1711 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T14 | 1754-1769 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T15 | 1836-1857 | https://glytoucan.org/Structures/Glycans/G19059PI | denotes | chondroitin 4-sulfate |
| T16 | 1836-1847 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T17 | 1883-1898 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T18 | 2155-2170 | https://glytoucan.org/Structures/Glycans/G82109MW | denotes | keratan sulfate |
| T19 | 2257-2268 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T20 | 2359-2370 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T21 | 2469-2480 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
| T22 | 2512-2533 | https://glytoucan.org/Structures/Glycans/G19059PI | denotes | chondroitin 4-sulfate |
| T23 | 2512-2523 | https://glytoucan.org/Structures/Glycans/G43702JT | denotes | chondroitin |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 60-71 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T2 | 84-95 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T3 | 96-111 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T4 | 223-234 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T5 | 606-617 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T6 | 824-845 | http://www.glycoepitope.jp/epitopes/EP0082 | denotes | chondroitin 4-sulfate |
| T7 | 824-835 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T8 | 930-941 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T9 | 1236-1247 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T10 | 1248-1263 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T11 | 1289-1292 | http://www.glycoepitope.jp/epitopes/AN0222 | denotes | 3H1 |
| T12 | 1394-1409 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T13 | 1472-1475 | http://www.glycoepitope.jp/epitopes/AN0222 | denotes | 3H1 |
| T14 | 1700-1721 | http://www.glycoepitope.jp/epitopes/EP0082 | denotes | chondroitin 4-sulfate |
| T15 | 1700-1711 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T16 | 1754-1769 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T17 | 1836-1857 | http://www.glycoepitope.jp/epitopes/EP0082 | denotes | chondroitin 4-sulfate |
| T18 | 1836-1847 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T19 | 1883-1898 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T20 | 1960-1963 | http://www.glycoepitope.jp/epitopes/AN0222 | denotes | 3H1 |
| T21 | 2155-2170 | http://www.glycoepitope.jp/epitopes/EP0085 | denotes | keratan sulfate |
| T22 | 2208-2211 | http://www.glycoepitope.jp/epitopes/AN0409 | denotes | 3F8 |
| T23 | 2257-2268 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T24 | 2359-2370 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T25 | 2402-2405 | http://www.glycoepitope.jp/epitopes/AN0409 | denotes | 3F8 |
| T26 | 2469-2480 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
| T27 | 2512-2533 | http://www.glycoepitope.jp/epitopes/EP0082 | denotes | chondroitin 4-sulfate |
| T28 | 2512-2523 | http://www.glycoepitope.jp/epitopes/EP0081 | denotes | chondroitin |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 129-134 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T2 | 264-269 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T3 | 529-534 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T4 | 981-986 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T5 | 1023-1028 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T6 | 1353-1358 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T7 | 1630-1635 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T8 | 1646-1651 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T9 | 1796-1801 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T10 | 2069-2074 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T11 | 2429-2434 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
| T12 | 2609-2614 | http://purl.obolibrary.org/obo/MAT_0000098 | denotes | brain |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1105-1119 | Disease | denotes | chondrosarcoma | http://purl.obolibrary.org/obo/MONDO_0008977 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1105-1119 | Phenotype | denotes | chondrosarcoma | HP:0006765 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 60-71 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 84-95 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 96-111 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T4 | 223-234 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 606-617 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 824-845 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T7 | 930-941 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 1236-1247 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T9 | 1248-1263 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T10 | 1394-1409 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T11 | 1700-1721 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T12 | 1754-1769 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T13 | 1836-1857 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T14 | 1883-1898 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T15 | 2155-2170 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T16 | 2257-2268 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T17 | 2359-2370 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T18 | 2469-2480 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T19 | 2512-2533 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 60-71 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 84-95 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 96-111 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T4 | 223-234 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 606-617 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 824-845 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T7 | 930-941 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 1236-1247 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1248-1263 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T10 | 1289-1292 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T11 | 1394-1409 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T12 | 1472-1475 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T13 | 1700-1721 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T14 | 1754-1769 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T15 | 1836-1857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T16 | 1883-1898 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T17 | 1960-1963 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T18 | 2155-2170 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T19 | 2208-2211 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3F8 | http://www.glycoepitope.jp/epitopes/AN0409 |
| T20 | 2257-2268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T21 | 2359-2370 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T22 | 2402-2405 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3F8 | http://www.glycoepitope.jp/epitopes/AN0409 |
| T23 | 2469-2480 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T24 | 2512-2533 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 1105-1119 | Phenotype | denotes | chondrosarcoma | HP:0006765 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 1105-1119 | Disease | denotes | chondrosarcoma | MONDO:0008977 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 260-263 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 1101-1104 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 1349-1352 | OrganismTaxon | denotes | rat | 10114|10116 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 129-134 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 264-269 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 529-534 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 981-986 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T9 | 1023-1028 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T11 | 1353-1358 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T13 | 1630-1635 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T15 | 1646-1651 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T17 | 1796-1801 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T19 | 2069-2074 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T21 | 2429-2434 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T23 | 2609-2614 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-173 | Sentence | denotes | Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. |
| T2 | 174-403 | Sentence | denotes | A panel of monoclonal antibodies prepared to the chondroitin sulfate proteoglycans of rat brain was used for their immunocytochemical localization and isolation of individual proteoglycan species by immunoaffinity chromatography. |
| T3 | 404-633 | Sentence | denotes | One of these proteoglycans (designated 1D1) consists of a major component with an average molecular size of 300 kDa in 7-day brain, containing a 245-kDa core glycoprotein and an average of three 22-kDa chondroitin sulfate chains. |
| T4 | 634-852 | Sentence | denotes | A 1D1 proteoglycan of approximately 180 kDa with a 150-kDa core glycoprotein is also present at 7 days, and by 2-3 weeks postnatal this becomes the major species, containing a single 32-kDa chondroitin 4-sulfate chain. |
| T5 | 853-1029 | Sentence | denotes | The concentration of 1D1 decreases during development, from 20% of the total chondroitin sulfate proteoglycan protein (0.1 mg/g brain) at 7 days postnatal to 6% in adult brain. |
| T6 | 1030-1233 | Sentence | denotes | A 45-kDa protein which is recognized by the 8A4 monoclonal antibody to rat chondrosarcoma link protein copurifies with the 1D1 proteoglycan, which aggregates to a significant extent with hyaluronic acid. |
| T7 | 1234-1417 | Sentence | denotes | A chondroitin/keratan sulfate proteoglycan (designated 3H1) with a size of approximately 500 kDa was isolated from rat brain using monoclonal antibodies to the keratan sulfate chains. |
| T8 | 1418-1636 | Sentence | denotes | The core glycoprotein obtained after treatment of the 3H1 proteoglycan with chondroitinase ABC and endo-beta-galactosidase decreases in size from approximately 360 kDa at 7 days to approximately 280 kDa in adult brain. |
| T9 | 1637-1938 | Sentence | denotes | In 7-day brain, the proteoglycan contains three to five 25-kDa chondroitin 4-sulfate chains and three to six 8.4-kDa keratan sulfate chains, whereas the adult brain proteoglycan contains two to four chondroitin 4-sulfate chains and eight to nine keratan sulfate chains, with an average size of 10 kDa. |
| T10 | 1939-2178 | Sentence | denotes | The concentration of 3H1 increases during development from 3% of the total soluble proteoglycan protein at 7 days to 11% in adult brain, and there is a developmental decrease in the branching and/or sulfation of the keratan sulfate chains. |
| T11 | 2179-2386 | Sentence | denotes | A third monoclonal antibody (3F8) was used to isolate a approximately 500-kDa chondroitin sulfate proteoglycan comprising a 400-kDa core glycoprotein and an average of four 28-kDa chondroitin sulfate chains. |
| T12 | 2387-2662 | Sentence | denotes | In the 1D1 and 3F8 proteoglycans of 7-day brain, 20 and 33%, respectively, of the chondroitin sulfate is 6-sulfated, whereas chondroitin 4-sulfate accounts for greater than 96% of the glycosaminoglycan chains in the adult brain proteoglycans.(ABSTRACT TRUNCATED AT 400 WORDS) |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-173 | Sentence | denotes | Isolation and characterization of developmentally regulated chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of brain identified with monoclonal antibodies. |
| T2 | 174-403 | Sentence | denotes | A panel of monoclonal antibodies prepared to the chondroitin sulfate proteoglycans of rat brain was used for their immunocytochemical localization and isolation of individual proteoglycan species by immunoaffinity chromatography. |
| T3 | 404-633 | Sentence | denotes | One of these proteoglycans (designated 1D1) consists of a major component with an average molecular size of 300 kDa in 7-day brain, containing a 245-kDa core glycoprotein and an average of three 22-kDa chondroitin sulfate chains. |
| T4 | 634-852 | Sentence | denotes | A 1D1 proteoglycan of approximately 180 kDa with a 150-kDa core glycoprotein is also present at 7 days, and by 2-3 weeks postnatal this becomes the major species, containing a single 32-kDa chondroitin 4-sulfate chain. |
| T5 | 853-1029 | Sentence | denotes | The concentration of 1D1 decreases during development, from 20% of the total chondroitin sulfate proteoglycan protein (0.1 mg/g brain) at 7 days postnatal to 6% in adult brain. |
| T6 | 1030-1233 | Sentence | denotes | A 45-kDa protein which is recognized by the 8A4 monoclonal antibody to rat chondrosarcoma link protein copurifies with the 1D1 proteoglycan, which aggregates to a significant extent with hyaluronic acid. |
| T7 | 1234-1417 | Sentence | denotes | A chondroitin/keratan sulfate proteoglycan (designated 3H1) with a size of approximately 500 kDa was isolated from rat brain using monoclonal antibodies to the keratan sulfate chains. |
| T8 | 1418-1636 | Sentence | denotes | The core glycoprotein obtained after treatment of the 3H1 proteoglycan with chondroitinase ABC and endo-beta-galactosidase decreases in size from approximately 360 kDa at 7 days to approximately 280 kDa in adult brain. |
| T9 | 1637-1938 | Sentence | denotes | In 7-day brain, the proteoglycan contains three to five 25-kDa chondroitin 4-sulfate chains and three to six 8.4-kDa keratan sulfate chains, whereas the adult brain proteoglycan contains two to four chondroitin 4-sulfate chains and eight to nine keratan sulfate chains, with an average size of 10 kDa. |
| T10 | 1939-2178 | Sentence | denotes | The concentration of 3H1 increases during development from 3% of the total soluble proteoglycan protein at 7 days to 11% in adult brain, and there is a developmental decrease in the branching and/or sulfation of the keratan sulfate chains. |
| T11 | 2179-2386 | Sentence | denotes | A third monoclonal antibody (3F8) was used to isolate a approximately 500-kDa chondroitin sulfate proteoglycan comprising a 400-kDa core glycoprotein and an average of four 28-kDa chondroitin sulfate chains. |
| T12 | 2387-2662 | Sentence | denotes | In the 1D1 and 3F8 proteoglycans of 7-day brain, 20 and 33%, respectively, of the chondroitin sulfate is 6-sulfated, whereas chondroitin 4-sulfate accounts for greater than 96% of the glycosaminoglycan chains in the adult brain proteoglycans.(ABSTRACT TRUNCATED AT 400 WORDS) |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 60-71 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T2 | 84-95 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T3 | 96-111 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T4 | 223-234 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T5 | 606-617 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T6 | 824-845 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T7 | 930-941 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T8 | 1236-1247 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T9 | 1248-1263 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T10 | 1289-1292 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T11 | 1394-1409 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T12 | 1472-1475 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T13 | 1700-1721 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T14 | 1754-1769 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T15 | 1836-1857 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
| T16 | 1883-1898 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T17 | 1960-1963 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3H1 | http://www.glycoepitope.jp/epitopes/AN0222 |
| T18 | 2155-2170 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | keratan sulfate | http://www.glycoepitope.jp/epitopes/EP0085 |
| T19 | 2208-2211 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3F8 | http://www.glycoepitope.jp/epitopes/AN0409 |
| T20 | 2257-2268 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T21 | 2359-2370 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T22 | 2402-2405 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | 3F8 | http://www.glycoepitope.jp/epitopes/AN0409 |
| T23 | 2469-2480 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin | http://www.glycoepitope.jp/epitopes/EP0081 |
| T24 | 2512-2533 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | chondroitin 4-sulfate | http://www.glycoepitope.jp/epitopes/EP0082 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 260-263 | OrganismTaxon | denotes | rat | 10114|10116 |
| T3 | 1101-1104 | OrganismTaxon | denotes | rat | 10114|10116 |
| T5 | 1349-1352 | OrganismTaxon | denotes | rat | 10114|10116 |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 60-71 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T2 | 84-95 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T3 | 96-111 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T4 | 223-234 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T5 | 606-617 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T6 | 824-845 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T7 | 930-941 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T8 | 1236-1247 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T9 | 1248-1263 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T10 | 1394-1409 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T11 | 1700-1721 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T12 | 1754-1769 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T13 | 1836-1857 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
| T14 | 1883-1898 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T15 | 2155-2170 | Glycan | denotes | keratan sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G82109MW |
| T16 | 2257-2268 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T17 | 2359-2370 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T18 | 2469-2480 | Glycan | denotes | chondroitin | https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT |
| T19 | 2512-2533 | Glycan | denotes | chondroitin 4-sulfate | https://api.glycosmos.org/wurcs2image/latest/png/binary/G19059PI |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 129-134 | Body_part | denotes | brain | FMA:50801 |
| T2 | 264-269 | Body_part | denotes | brain | FMA:50801 |
| T3 | 529-534 | Body_part | denotes | brain | FMA:50801 |
| T4 | 981-986 | Body_part | denotes | brain | FMA:50801 |
| T5 | 1023-1028 | Body_part | denotes | brain | FMA:50801 |
| T6 | 1353-1358 | Body_part | denotes | brain | FMA:50801 |
| T7 | 1630-1635 | Body_part | denotes | brain | FMA:50801 |
| T8 | 1646-1651 | Body_part | denotes | brain | FMA:50801 |
| T9 | 1796-1801 | Body_part | denotes | brain | FMA:50801 |
| T10 | 2069-2074 | Body_part | denotes | brain | FMA:50801 |
| T11 | 2429-2434 | Body_part | denotes | brain | FMA:50801 |
| T12 | 2609-2614 | Body_part | denotes | brain | FMA:50801 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 129-134 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 264-269 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 529-534 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 981-986 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T5 | 1023-1028 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T6 | 1353-1358 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 1630-1635 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 1646-1651 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T9 | 1796-1801 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T10 | 2069-2074 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T11 | 2429-2434 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T12 | 2609-2614 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 129-134 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T2 | 264-269 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T3 | 529-534 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T4 | 981-986 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T5 | 1023-1028 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T6 | 1353-1358 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T7 | 1630-1635 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T8 | 1646-1651 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T9 | 1796-1801 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T10 | 2069-2074 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T11 | 2429-2434 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
| T12 | 2609-2614 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/MAT_0000098 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 129-134 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T3 | 264-269 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T5 | 529-534 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T7 | 981-986 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T9 | 1023-1028 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T11 | 1353-1358 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T13 | 1630-1635 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T15 | 1646-1651 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T17 | 1796-1801 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T19 | 2069-2074 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T21 | 2429-2434 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |
| T23 | 2609-2614 | Body_part | denotes | brain | http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636 |