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PubMed:1906877 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-70 Sentence denotes Molecular characterization of a unique von Willebrand disease variant.
TextSentencer_T2 71-144 Sentence denotes A novel mutation affecting von Willebrand factor/factor VIII interaction.
TextSentencer_T3 145-361 Sentence denotes von Willebrand factor (vWF) plays a central role in blood coagulation, mediating the adhesion of the initial platelet plug to the subendothelium, and serving as the carrier for factor VIII (FVIII) in the circulation.
TextSentencer_T4 362-625 Sentence denotes In previous studies, we have mapped the epitope for an anti-vWF monoclonal antibody which inhibits the interaction between FVIII and vWF to a region spanning Thr78 to Thr96 of the mature protein (Bahou, W.F., Ginsburg, D., Sikkink, R., Litwiller, R., and Fass, D.
TextSentencer_T5 626-638 Sentence denotes N. (1989) J.
TextSentencer_T6 639-644 Sentence denotes Clin.
TextSentencer_T7 645-652 Sentence denotes Invest.
TextSentencer_T8 653-664 Sentence denotes 84, 56-61).
TextSentencer_T9 665-778 Sentence denotes We now report the identification of a mutation within this region of vWF that results in decreased FVIII binding.
TextSentencer_T10 779-1038 Sentence denotes Sequence analysis of polymerase chain reaction amplified platelet vWF mRNA from a von Willebrand disease (vWD) patient with a disproportionately low FVIII level identified a single nucleotide substitution (G----A), resulting in the conversion of Arg91----Gln.
TextSentencer_T11 1039-1221 Sentence denotes Recombinant vWF carrying this substitution showed decreased binding to FVIII compared with wild-type vWF or vWF carrying a polymorphic substitution in the same region (Arg89----Gln).
TextSentencer_T12 1222-1413 Sentence denotes These observations suggest a critical role for Arg91 in the interaction of vWF with FVIII and identify the molecular mechanism for a variant of vWD associated with unusually low FVIII levels.
T1 0-70 Sentence denotes Molecular characterization of a unique von Willebrand disease variant.
T2 71-144 Sentence denotes A novel mutation affecting von Willebrand factor/factor VIII interaction.
T3 145-361 Sentence denotes von Willebrand factor (vWF) plays a central role in blood coagulation, mediating the adhesion of the initial platelet plug to the subendothelium, and serving as the carrier for factor VIII (FVIII) in the circulation.
T4 362-625 Sentence denotes In previous studies, we have mapped the epitope for an anti-vWF monoclonal antibody which inhibits the interaction between FVIII and vWF to a region spanning Thr78 to Thr96 of the mature protein (Bahou, W.F., Ginsburg, D., Sikkink, R., Litwiller, R., and Fass, D.
T5 626-638 Sentence denotes N. (1989) J.
T6 639-644 Sentence denotes Clin.
T7 645-652 Sentence denotes Invest.
T8 653-664 Sentence denotes 84, 56-61).
T9 665-778 Sentence denotes We now report the identification of a mutation within this region of vWF that results in decreased FVIII binding.
T10 779-1038 Sentence denotes Sequence analysis of polymerase chain reaction amplified platelet vWF mRNA from a von Willebrand disease (vWD) patient with a disproportionately low FVIII level identified a single nucleotide substitution (G----A), resulting in the conversion of Arg91----Gln.
T11 1039-1221 Sentence denotes Recombinant vWF carrying this substitution showed decreased binding to FVIII compared with wild-type vWF or vWF carrying a polymorphic substitution in the same region (Arg89----Gln).
T12 1222-1413 Sentence denotes These observations suggest a critical role for Arg91 in the interaction of vWF with FVIII and identify the molecular mechanism for a variant of vWD associated with unusually low FVIII levels.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 197-202 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 197-202 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1297-1300 gene:7450 denotes vWF
T1 1366-1369 disease:C0042974 denotes vWD
R1 T0 T1 associated_with vWF,vWD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
1906877-6#75#78#gene7450 1297-1300 gene7450 denotes vWF
1906877-6#144#147#diseaseC0042974 1366-1369 diseaseC0042974 denotes vWD
75#78#gene7450144#147#diseaseC0042974 1906877-6#75#78#gene7450 1906877-6#144#147#diseaseC0042974 associated_with vWF,vWD

PubCasesORDO

Id Subject Object Predicate Lexical cue
TI1 39-61 ORDO:903 denotes von Willebrand disease
AB1 617-621 ORDO:1915 denotes Fass
AB2 861-883 ORDO:903 denotes von Willebrand disease

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 181-188 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 197-202 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 181-188 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
PD-UBERON-AE-B_T2 197-202 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 39-61 Disease denotes von Willebrand disease http://purl.obolibrary.org/obo/MONDO_0019565|http://purl.obolibrary.org/obo/MONDO_0024574
T3 861-883 Disease denotes von Willebrand disease http://purl.obolibrary.org/obo/MONDO_0019565|http://purl.obolibrary.org/obo/MONDO_0024574
T5 885-888 Disease denotes vWD http://purl.obolibrary.org/obo/MONDO_0019565
T6 1366-1369 Disease denotes vWD http://purl.obolibrary.org/obo/MONDO_0019565

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 197-202 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 890-897 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 197-202 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 254-262 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T3 836-844 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 254-262 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T2 836-844 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233