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PubMed:18982394 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
TextSentencer_T2 139-354 Sentence denotes The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN).
TextSentencer_T3 355-641 Sentence denotes Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness.
TextSentencer_T4 642-694 Sentence denotes SLNs were examined by serial-section histopathology.
TextSentencer_T5 695-815 Sentence denotes A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T.
TextSentencer_T6 816-929 Sentence denotes In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis.
TextSentencer_T7 930-1013 Sentence denotes Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences.
TextSentencer_T8 1014-1066 Sentence denotes A total of 370 lymph nodes were analyzed by qRT-PCR.
TextSentencer_T9 1067-1167 Sentence denotes No association was found between quantitative expression level of any marker and disease recurrence.
TextSentencer_T10 1168-1349 Sentence denotes Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes.
TextSentencer_T11 1350-1458 Sentence denotes No associations with recurrence were found regardless of the transcripts amplified by different primer sets.
TextSentencer_T12 1459-1587 Sentence denotes PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis.
TextSentencer_T13 1588-1719 Sentence denotes We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence.
TextSentencer_T14 1720-1851 Sentence denotes Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.
T1 0-138 Sentence denotes Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR.
T2 139-354 Sentence denotes The aim of this study was to evaluate the prognostic potential of quantitative reverse-transcription, polymerase chain reaction (qRT-PCR) in melanoma patients with pathologically negative sentinel lymph nodes (SLN).
T3 355-641 Sentence denotes Our study included 195 node-negative melanoma patients with a Breslow thickness greater than 0.76 mm (n = 158), or less than 0.76 mm but who had Clark level IV-V, microscopic ulceration, or pathological signs of regression (n = 32), and five patients with melanoma of unknown thickness.
T4 642-694 Sentence denotes SLNs were examined by serial-section histopathology.
T5 695-815 Sentence denotes A portion of each SLN was frozen for qRT-PCR analysis using markers Tyrosinase, MART1, SSX2, MAGEA3, PAX3, and GalNAc-T.
T6 816-929 Sentence denotes In addition, two other markers (PLAB and L1CAM) were evaluated for melanoma specificity but not for SLN analysis.
T7 930-1013 Sentence denotes Median follow-up was 64 months, during which time there were 15 (7.7%) recurrences.
T8 1014-1066 Sentence denotes A total of 370 lymph nodes were analyzed by qRT-PCR.
T9 1067-1167 Sentence denotes No association was found between quantitative expression level of any marker and disease recurrence.
T10 1168-1349 Sentence denotes Previously published primer designs were tested for PAX3 and GalNAc-T and revealed that alternative PAX3 transcripts are differentially expressed in melanoma and benign lymph nodes.
T11 1350-1458 Sentence denotes No associations with recurrence were found regardless of the transcripts amplified by different primer sets.
T12 1459-1587 Sentence denotes PLAB and L1CAM did not appear to differentiate between malignant melanoma and benign melanocytes or lymph nodes in our analysis.
T13 1588-1719 Sentence denotes We conclude that, in this large cohort of patients, multimarker qRT-PCR analysis of SLNs did not correlate with disease recurrence.
T14 1720-1851 Sentence denotes Our data support specific PAX3 splice variants but not GalNAc-T, PLAB or L1CAM as possible markers for melanoma metastasis to SLNs.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 848-852 gene:9518 denotes PLAB
T1 883-891 disease:C0025202 denotes melanoma
T2 857-862 gene:7412 denotes L1CAM
T3 883-891 disease:C0025202 denotes melanoma
T4 857-862 gene:3897 denotes L1CAM
T5 883-891 disease:C0025202 denotes melanoma
T6 1220-1224 gene:5077 denotes PAX3
T7 1317-1325 disease:C0025202 denotes melanoma
T8 1229-1237 gene:2583 denotes GalNAc-T
T9 1317-1325 disease:C0025202 denotes melanoma
T10 1268-1272 gene:5077 denotes PAX3
T11 1317-1325 disease:C0025202 denotes melanoma
R1 T0 T1 associated_with PLAB,melanoma
R2 T2 T3 associated_with L1CAM,melanoma
R3 T4 T5 associated_with L1CAM,melanoma
R4 T6 T7 associated_with PAX3,melanoma
R5 T8 T9 associated_with GalNAc-T,melanoma
R6 T10 T11 associated_with PAX3,melanoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18982394-13#73#78#gene3897 1793-1798 gene3897 denotes L1CAM
18982394-13#26#30#gene5077 1746-1750 gene5077 denotes PAX3
18982394-13#65#69#gene9518 1785-1789 gene9518 denotes PLAB
18982394-13#73#78#gene3897 1793-1798 gene3897 denotes L1CAM
18982394-13#112#122#diseaseC0027627 1832-1842 diseaseC0027627 denotes metastasis
18982394-13#103#111#diseaseC0025202 1823-1831 diseaseC0025202 denotes melanoma
18982394-9#61#69#gene2583 1229-1237 gene2583 denotes GalNAc-T
18982394-9#149#157#diseaseC0025202 1317-1325 diseaseC0025202 denotes melanoma
73#78#gene3897112#122#diseaseC0027627 18982394-13#73#78#gene3897 18982394-13#112#122#diseaseC0027627 associated_with L1CAM,metastasis
73#78#gene3897103#111#diseaseC0025202 18982394-13#73#78#gene3897 18982394-13#103#111#diseaseC0025202 associated_with L1CAM,melanoma
26#30#gene5077112#122#diseaseC0027627 18982394-13#26#30#gene5077 18982394-13#112#122#diseaseC0027627 associated_with PAX3,metastasis
26#30#gene5077103#111#diseaseC0025202 18982394-13#26#30#gene5077 18982394-13#103#111#diseaseC0025202 associated_with PAX3,melanoma
65#69#gene9518112#122#diseaseC0027627 18982394-13#65#69#gene9518 18982394-13#112#122#diseaseC0027627 associated_with PLAB,metastasis
65#69#gene9518103#111#diseaseC0025202 18982394-13#65#69#gene9518 18982394-13#103#111#diseaseC0025202 associated_with PLAB,melanoma
73#78#gene3897112#122#diseaseC0027627 18982394-13#73#78#gene3897 18982394-13#112#122#diseaseC0027627 associated_with L1CAM,metastasis
73#78#gene3897103#111#diseaseC0025202 18982394-13#73#78#gene3897 18982394-13#103#111#diseaseC0025202 associated_with L1CAM,melanoma
61#69#gene2583149#157#diseaseC0025202 18982394-9#61#69#gene2583 18982394-9#149#157#diseaseC0025202 associated_with GalNAc-T,melanoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2725 1793-1798 gene:3897 denotes L1CAM
T2726 1832-1842 disease:C0027627 denotes metastasis
R1 T2725 T2726 associated_with L1CAM,metastasis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 54-59 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T2 336-341 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T3 1029-1034 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T4 1337-1342 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T5 1559-1564 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T6 54-65 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T7 336-347 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T8 1029-1040 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T9 1337-1348 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T10 1559-1570 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 54-59 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T2 336-341 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T3 1029-1034 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T4 1337-1342 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T5 1559-1564 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
PD-UBERON-AE-B_T6 54-65 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T7 336-347 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T8 1029-1040 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T9 1337-1348 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes
PD-UBERON-AE-B_T10 1559-1570 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes