PubMed:18974200 / 854-1088 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T9","span":{"begin":15,"end":18},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T10","span":{"begin":15,"end":18},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T11","span":{"begin":149,"end":152},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T12","span":{"begin":149,"end":152},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T9","span":{"begin":15,"end":18},"obj":"Glycan_Motif"},{"id":"T11","span":{"begin":149,"end":152},"obj":"Glycan_Motif"}],"attributes":[{"id":"A9","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A10","pred":"image","subj":"T9","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"},{"id":"A11","pred":"image","subj":"T11","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A12","pred":"image","subj":"T11","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T6","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":234},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T9","span":{"begin":15,"end":18},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T10","span":{"begin":15,"end":18},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T11","span":{"begin":149,"end":152},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T12","span":{"begin":149,"end":152},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T5","span":{"begin":15,"end":18},"obj":"Glycan"},{"id":"T6","span":{"begin":149,"end":152},"obj":"Glycan"}],"attributes":[{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A15","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A16","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"uniprot-human","denotations":[{"id":"T5","span":{"begin":30,"end":34},"obj":"http://www.uniprot.org/uniprot/Q96NW5"},{"id":"T6","span":{"begin":123,"end":127},"obj":"http://www.uniprot.org/uniprot/Q96NW5"},{"id":"T7","span":{"begin":229,"end":233},"obj":"http://www.uniprot.org/uniprot/Q96NW5"},{"id":"T13","span":{"begin":43,"end":50},"obj":"http://www.uniprot.org/uniprot/P35968"},{"id":"T14","span":{"begin":131,"end":138},"obj":"http://www.uniprot.org/uniprot/P35968"},{"id":"T15","span":{"begin":207,"end":214},"obj":"http://www.uniprot.org/uniprot/P35968"},{"id":"T18","span":{"begin":49,"end":61},"obj":"http://www.uniprot.org/uniprot/P05549"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"uniprot-mouse","denotations":[{"id":"T5","span":{"begin":43,"end":50},"obj":"http://www.uniprot.org/uniprot/P35918"},{"id":"T6","span":{"begin":131,"end":138},"obj":"http://www.uniprot.org/uniprot/P35918"},{"id":"T7","span":{"begin":207,"end":214},"obj":"http://www.uniprot.org/uniprot/P35918"},{"id":"T10","span":{"begin":49,"end":61},"obj":"http://www.uniprot.org/uniprot/Q91VX0"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GO-MF","denotations":[{"id":"T2","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0070026"},{"id":"T3","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0003680"},{"id":"T4","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0017091"},{"id":"T5","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T6","span":{"begin":112,"end":127},"obj":"http://purl.obolibrary.org/obo/GO_0038085"},{"id":"T7","span":{"begin":112,"end":138},"obj":"http://purl.obolibrary.org/obo/GO_0043184"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GO-CC","denotations":[{"id":"T6","span":{"begin":183,"end":196},"obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"mondo_disease","denotations":[{"id":"T7","span":{"begin":147,"end":152},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0013288"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T7","span":{"begin":147,"end":152},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0013288"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T4","span":{"begin":183,"end":196},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T6","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":234},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T6","span":{"begin":0,"end":234},"obj":"Sentence"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T5","span":{"begin":15,"end":18},"obj":"Glycan"},{"id":"T6","span":{"begin":149,"end":152},"obj":"Glycan"}],"attributes":[{"id":"A5","pred":"glycosmos_id","subj":"T5","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A15","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A6","pred":"glycosmos_id","subj":"T6","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A16","pred":"image","subj":"T6","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T4","span":{"begin":183,"end":196},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF."}