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PubMed:18974200 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 12-15 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 12-15 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 83-86 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 83-86 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 508-511 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 508-511 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 712-715 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 712-715 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 869-872 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 869-872 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1003-1006 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1003-1006 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1161-1164 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1161-1164 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1202-1205 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1202-1205 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1263-1266 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1263-1266 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1398-1401 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 1398-1401 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 83-86 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 508-511 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 712-715 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 869-872 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T11 1003-1006 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T13 1161-1164 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T15 1202-1205 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T17 1263-1266 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T19 1398-1401 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1353-1357 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-100 Sentence denotes Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.
TextSentencer_T2 101-188 Sentence denotes Angiogenesis is associated with growth, invasion, and metastasis of human solid tumors.
TextSentencer_T3 189-488 Sentence denotes Aberrant activation of endothelial cells and induction of microvascular permeability by a vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) signaling pathway is observed in pathological angiogenesis including tumor, wound healing, arthritis, psoriasis, diabetic retinopathy, and others.
TextSentencer_T4 489-698 Sentence denotes Here, we show that GM3 regulated the activity of various downstream signaling pathways and biological events through the inhibition of VEGF-stimulated VEGFR-2 activation in vascular endothelial cells in vitro.
TextSentencer_T5 699-853 Sentence denotes Furthermore, GM3 strongly blocked VEGF-induced neovascularization in vivo, in models including the chick chorioallantoic membrane and Matrigel plug assay.
TextSentencer_T6 854-1088 Sentence denotes Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF.
TextSentencer_T7 1089-1165 Sentence denotes Primary tumor growth in mice was inhibited by subcutaneous injection of GM3.
TextSentencer_T8 1166-1262 Sentence denotes Immunohistochemical analyses showed GM3 inhibition of angiogenesis and tumor cell proliferation.
TextSentencer_T9 1263-1370 Sentence denotes GM3 also resulted in the suppression of VEGF-stimulated microvessel permeability in mouse skin capillaries.
TextSentencer_T10 1371-1541 Sentence denotes These results suggest that GM3 inhibits VEGFR-2-mediated changes in vascular endothelial cell function and angiogenesis, and might be of value in anti-angiogenic therapy.
T1 0-100 Sentence denotes Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.
T2 101-188 Sentence denotes Angiogenesis is associated with growth, invasion, and metastasis of human solid tumors.
T3 189-488 Sentence denotes Aberrant activation of endothelial cells and induction of microvascular permeability by a vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) signaling pathway is observed in pathological angiogenesis including tumor, wound healing, arthritis, psoriasis, diabetic retinopathy, and others.
T4 489-698 Sentence denotes Here, we show that GM3 regulated the activity of various downstream signaling pathways and biological events through the inhibition of VEGF-stimulated VEGFR-2 activation in vascular endothelial cells in vitro.
T5 699-853 Sentence denotes Furthermore, GM3 strongly blocked VEGF-induced neovascularization in vivo, in models including the chick chorioallantoic membrane and Matrigel plug assay.
T6 854-1088 Sentence denotes Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF.
T7 1089-1165 Sentence denotes Primary tumor growth in mice was inhibited by subcutaneous injection of GM3.
T8 1166-1262 Sentence denotes Immunohistochemical analyses showed GM3 inhibition of angiogenesis and tumor cell proliferation.
T9 1263-1370 Sentence denotes GM3 also resulted in the suppression of VEGF-stimulated microvessel permeability in mouse skin capillaries.
T10 1371-1541 Sentence denotes These results suggest that GM3 inhibits VEGFR-2-mediated changes in vascular endothelial cell function and angiogenesis, and might be of value in anti-angiogenic therapy.
T1 0-100 Sentence denotes Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.
T2 101-188 Sentence denotes Angiogenesis is associated with growth, invasion, and metastasis of human solid tumors.
T3 189-488 Sentence denotes Aberrant activation of endothelial cells and induction of microvascular permeability by a vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) signaling pathway is observed in pathological angiogenesis including tumor, wound healing, arthritis, psoriasis, diabetic retinopathy, and others.
T4 489-698 Sentence denotes Here, we show that GM3 regulated the activity of various downstream signaling pathways and biological events through the inhibition of VEGF-stimulated VEGFR-2 activation in vascular endothelial cells in vitro.
T5 699-853 Sentence denotes Furthermore, GM3 strongly blocked VEGF-induced neovascularization in vivo, in models including the chick chorioallantoic membrane and Matrigel plug assay.
T6 854-1088 Sentence denotes Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF.
T7 1089-1165 Sentence denotes Primary tumor growth in mice was inhibited by subcutaneous injection of GM3.
T8 1166-1262 Sentence denotes Immunohistochemical analyses showed GM3 inhibition of angiogenesis and tumor cell proliferation.
T9 1263-1370 Sentence denotes GM3 also resulted in the suppression of VEGF-stimulated microvessel permeability in mouse skin capillaries.
T10 1371-1541 Sentence denotes These results suggest that GM3 inhibits VEGFR-2-mediated changes in vascular endothelial cell function and angiogenesis, and might be of value in anti-angiogenic therapy.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-15 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 12-15 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 83-86 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 83-86 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 508-511 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 508-511 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 712-715 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 712-715 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 869-872 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 869-872 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 1003-1006 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 1003-1006 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 1161-1164 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 1161-1164 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 1202-1205 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 1202-1205 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1263-1266 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1263-1266 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1398-1401 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 1398-1401 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 83-86 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 508-511 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 712-715 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 869-872 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 1003-1006 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 1161-1164 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 1202-1205 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T9 1263-1266 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1398-1401 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

ICD10

Id Subject Object Predicate Lexical cue
T1 433-442 http://purl.bioontology.org/ontology/ICD10/M13.9 denotes arthritis
T2 444-453 http://purl.bioontology.org/ontology/ICD10/L40.9 denotes psoriasis
T3 444-453 http://purl.bioontology.org/ontology/ICD10/L40 denotes psoriasis
T4 455-475 http://purl.bioontology.org/ontology/ICD10/H36.0 denotes diabetic retinopathy

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-11 FMAID:196811 denotes Ganglioside
_T2 0-11 FMAID:82816 denotes Ganglioside
_T3 175-180 FMAID:85813 denotes solid
_T4 212-223 FMAID:63916 denotes endothelial
_T5 212-223 FMAID:162384 denotes endothelial
_T6 212-229 FMAID:69075 denotes endothelial cells
_T7 212-229 FMAID:164926 denotes endothelial cells
_T8 212-229 FMAID:66772 denotes endothelial cells
_T9 212-229 FMAID:169653 denotes endothelial cells
_T10 224-229 FMAID:169002 denotes cells
_T11 224-229 FMAID:68646 denotes cells
_T12 288-299 FMAID:63916 denotes endothelial
_T13 288-299 FMAID:162384 denotes endothelial
_T14 671-682 FMAID:162384 denotes endothelial
_T15 671-682 FMAID:63916 denotes endothelial
_T16 671-688 FMAID:169653 denotes endothelial cells
_T17 671-688 FMAID:66772 denotes endothelial cells
_T18 671-688 FMAID:69075 denotes endothelial cells
_T19 671-688 FMAID:164926 denotes endothelial cells
_T20 671-691 FMAID:166395 denotes endothelial cells in
_T21 671-691 FMAID:62104 denotes endothelial cells in
_T22 683-688 FMAID:169002 denotes cells
_T23 683-688 FMAID:68646 denotes cells
_T24 1353-1357 FMAID:93597 denotes skin
_T25 1353-1357 FMAID:7163 denotes skin
_T26 1358-1369 FMAID:167591 denotes capillaries
_T27 1358-1369 FMAID:63194 denotes capillaries
_T28 1448-1459 FMAID:63916 denotes endothelial
_T29 1448-1459 FMAID:162384 denotes endothelial
_T30 1460-1473 FMAID:67394 denotes cell function
_T31 1460-1473 FMAID:165114 denotes cell function

uniprot-human

Id Subject Object Predicate Lexical cue
T1 25-29 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T2 315-319 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T3 624-628 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T4 733-737 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T5 884-888 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T6 977-981 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T7 1083-1087 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T8 1303-1307 http://www.uniprot.org/uniprot/Q96NW5 denotes VEGF
T9 30-37 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T10 92-99 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T11 333-340 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T12 640-647 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T13 897-904 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T14 985-992 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T15 1061-1068 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T16 1411-1418 http://www.uniprot.org/uniprot/P35968 denotes VEGFR-2
T17 646-658 http://www.uniprot.org/uniprot/P05549 denotes 2 activation
T18 903-915 http://www.uniprot.org/uniprot/P05549 denotes 2 activation

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 30-37 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T2 92-99 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T3 333-340 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T4 640-647 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T5 897-904 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T6 985-992 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T7 1061-1068 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T8 1411-1418 http://www.uniprot.org/uniprot/P35918 denotes VEGFR-2
T9 646-658 http://www.uniprot.org/uniprot/Q91VX0 denotes 2 activation
T10 903-915 http://www.uniprot.org/uniprot/Q91VX0 denotes 2 activation

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 189-197 http://purl.bioontology.org/ontology/NCBITAXON/317910 denotes Aberrant
T2 224-229 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 591-597 http://purl.bioontology.org/ontology/STY/T051 denotes events
T4 683-688 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 1358-1369 http://purl.bioontology.org/ontology/NCBITAXON/119095 denotes capillaries
T6 1358-1369 http://purl.bioontology.org/ontology/NCBITAXON/241203 denotes capillaries
T7 1460-1473 http://purl.bioontology.org/ontology/STY/T043 denotes cell function

GO-BP

Id Subject Object Predicate Lexical cue
T1 47-59 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T2 388-400 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T3 1220-1232 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T4 101-113 http://purl.obolibrary.org/obo/GO_0001525 denotes Angiogenesis
T5 133-139 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T6 300-306 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T7 1103-1109 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T8 133-149 http://purl.obolibrary.org/obo/GO_0036267 denotes growth, invasion
T9 133-149 http://purl.obolibrary.org/obo/GO_0044409 denotes growth, invasion
T10 133-149 http://purl.obolibrary.org/obo/GO_0051828 denotes growth, invasion
T11 198-229 http://purl.obolibrary.org/obo/GO_0042118 denotes activation of endothelial cells
T12 198-229 http://purl.obolibrary.org/obo/GO_0045603 denotes activation of endothelial cells
T13 198-229 http://purl.obolibrary.org/obo/GO_1901552 denotes activation of endothelial cells
T14 198-229 http://purl.obolibrary.org/obo/GO_0001938 denotes activation of endothelial cells
T15 333-359 http://purl.obolibrary.org/obo/GO_0036324 denotes VEGFR-2) signaling pathway
T16 342-351 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T17 557-566 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18 342-359 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T19 557-575 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T20 418-431 http://purl.obolibrary.org/obo/GO_0042060 denotes wound healing
T21 512-521 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T22 1206-1232 http://purl.obolibrary.org/obo/GO_0016525 denotes inhibition of angiogenesis
T23 1243-1261 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation

GO-MF

Id Subject Object Predicate Lexical cue
T1 315-331 http://purl.obolibrary.org/obo/GO_0043184 denotes VEGF) receptor-2
T2 966-973 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 966-973 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T4 966-973 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T5 966-973 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6 966-981 http://purl.obolibrary.org/obo/GO_0038085 denotes binding of VEGF
T7 966-992 http://purl.obolibrary.org/obo/GO_0043184 denotes binding of VEGF to VEGFR-2

GO-CC

Id Subject Object Predicate Lexical cue
T1 224-229 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 683-688 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 1243-1247 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 1460-1464 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 820-828 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T6 1037-1050 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 804-828 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane
T2 1358-1369 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1353-1357 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 804-828 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane
PD-UBERON-AE-B_T2 1358-1369 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 12-15 Glycan denotes GM3
T2 83-86 Glycan denotes GM3
T3 508-511 Glycan denotes GM3
T4 712-715 Glycan denotes GM3
T5 869-872 Glycan denotes GM3
T6 1003-1006 Glycan denotes GM3
T7 1161-1164 Glycan denotes GM3
T8 1202-1205 Glycan denotes GM3
T9 1263-1266 Glycan denotes GM3
T10 1398-1401 Glycan denotes GM3

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 181-187 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T2 411-416 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 418-423 Disease denotes wound http://purl.obolibrary.org/obo/MONDO_0021178
T4 433-442 Disease denotes arthritis http://purl.obolibrary.org/obo/MONDO_0005578
T5 444-453 Disease denotes psoriasis http://purl.obolibrary.org/obo/MONDO_0005083
T6 455-475 Disease denotes diabetic retinopathy http://purl.obolibrary.org/obo/MONDO_0005266
T7 1001-1006 Disease denotes a GM3 http://purl.obolibrary.org/obo/MONDO_0013288
T8 1097-1102 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 1237-1242 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 411-416 Phenotype denotes tumor HP:0002664
T2 433-442 Phenotype denotes arthritis HP:0001369
T3 444-453 Phenotype denotes psoriasis HP:0003765
T4 464-475 Phenotype denotes retinopathy HP:0000488
T5 1097-1102 Phenotype denotes tumor HP:0002664
T6 1237-1242 Phenotype denotes tumor HP:0002664

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 169-174 OrganismTaxon denotes human 9606
T2 1113-1117 OrganismTaxon denotes mice 10088
T3 1347-1352 OrganismTaxon denotes mouse 10088|10090

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 212-229 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T2 662-688 Cell denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T3 1237-1247 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T4 1439-1464 Cell denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL:0002139
T5 1448-1464 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 212-229 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 662-688 Body_part denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T3 804-828 Body_part denotes chorioallantoic membrane http://purl.obolibrary.org/obo/UBERON_0005335
T4 1037-1050 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 1319-1330 Body_part denotes microvessel http://purl.obolibrary.org/obo/UBERON_8410081
T6 1353-1357 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014|http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0002097|http://purl.obolibrary.org/obo/UBERON_0002199
T10 1439-1464 Body_part denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL_0002139

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.
T2 101-188 Sentence denotes Angiogenesis is associated with growth, invasion, and metastasis of human solid tumors.
T3 189-488 Sentence denotes Aberrant activation of endothelial cells and induction of microvascular permeability by a vascular endothelial growth factor (VEGF) receptor-2 (VEGFR-2) signaling pathway is observed in pathological angiogenesis including tumor, wound healing, arthritis, psoriasis, diabetic retinopathy, and others.
T4 489-698 Sentence denotes Here, we show that GM3 regulated the activity of various downstream signaling pathways and biological events through the inhibition of VEGF-stimulated VEGFR-2 activation in vascular endothelial cells in vitro.
T5 699-853 Sentence denotes Furthermore, GM3 strongly blocked VEGF-induced neovascularization in vivo, in models including the chick chorioallantoic membrane and Matrigel plug assay.
T6 854-1088 Sentence denotes Interestingly, GM3 suppressed VEGF-induced VEGFR-2 activation by blocking its dimerization and also blocked the binding of VEGF to VEGFR-2 through a GM3-specific interaction with the extracellular domain of VEGFR-2, but not with VEGF.
T7 1089-1165 Sentence denotes Primary tumor growth in mice was inhibited by subcutaneous injection of GM3.
T8 1166-1262 Sentence denotes Immunohistochemical analyses showed GM3 inhibition of angiogenesis and tumor cell proliferation.
T9 1263-1370 Sentence denotes GM3 also resulted in the suppression of VEGF-stimulated microvessel permeability in mouse skin capillaries.
T10 1371-1541 Sentence denotes These results suggest that GM3 inhibits VEGFR-2-mediated changes in vascular endothelial cell function and angiogenesis, and might be of value in anti-angiogenic therapy.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 411-416 Disease denotes tumor MONDO:0005070
T2 433-442 Disease denotes arthritis MONDO:0005578
T3 444-453 Disease denotes psoriasis MONDO:0005083
T4 455-475 Disease denotes diabetic retinopathy MONDO:0005266
T5 1097-1102 Disease denotes tumor MONDO:0005070
T6 1237-1242 Disease denotes tumor MONDO:0005070

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 212-229 Body_part denotes endothelial cells FMA:66772
T2 671-688 Body_part denotes endothelial cells FMA:66772
T3 1353-1357 Body_part denotes skin FMA:7163
T4 1358-1369 Body_part denotes capillaries FMA:63194
T5 1448-1464 Body_part denotes endothelial cell FMA:66772

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1353-1357 Body_part denotes skin http://purl.obolibrary.org/obo/MAT_0000284

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 169-174 OrganismTaxon denotes human 9606
T2 1113-1117 OrganismTaxon denotes mice 10088
T3 1347-1352 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 212-229 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 662-688 Body_part denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL_0002139
T3 804-828 Body_part denotes chorioallantoic membrane http://purl.obolibrary.org/obo/UBERON_0005335
T4 1037-1050 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 1319-1330 Body_part denotes microvessel http://purl.obolibrary.org/obo/UBERON_8410081
T6 1353-1357 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014|http://purl.obolibrary.org/obo/UBERON_0001003|http://purl.obolibrary.org/obo/UBERON_0002097|http://purl.obolibrary.org/obo/UBERON_0002199
T10 1439-1464 Body_part denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL_0002139

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1353-1357 Body_part denotes skin http://purl.obolibrary.org/obo/MAT_0000284

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 411-416 Phenotype denotes tumor HP:0002664
T2 433-442 Phenotype denotes arthritis HP:0001369
T3 444-453 Phenotype denotes psoriasis HP:0003765
T4 464-475 Phenotype denotes retinopathy HP:0000488
T5 1097-1102 Phenotype denotes tumor HP:0002664
T6 1237-1242 Phenotype denotes tumor HP:0002664

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 212-229 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T2 662-688 Cell denotes vascular endothelial cells http://purl.obolibrary.org/obo/CL:0002139
T3 1237-1247 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T4 1439-1464 Cell denotes vascular endothelial cell http://purl.obolibrary.org/obo/CL:0002139
T5 1448-1464 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115