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PubMed:18929508 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-61 Sentence denotes TDP-43: an emerging new player in neurodegenerative diseases.
TextSentencer_T2 62-222 Sentence denotes Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing.
TextSentencer_T3 223-625 Sentence denotes Since 2006, when the protein was reported to be present in inclusions in the neurons and/or glial cells of a range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive, tau- and alpha-synuclein-negative inclusions (FTLD-U) and Alzheimer's disease (AD), many reports on the medical aspects of TDP-43 have been published.
TextSentencer_T4 626-751 Sentence denotes Here, we summarize the current literature on TDP-43, focusing on recent studies that provide clues to the function of TDP-43.
TextSentencer_T5 752-1039 Sentence denotes Using this information and database analysis, we also suggest a molecular and cellular model for possible events in normal and diseased neurons in relation to the emerging importance of the function and dysfunction of this protein as a target for basic as well as translational research.
T1 0-61 Sentence denotes TDP-43: an emerging new player in neurodegenerative diseases.
T2 62-222 Sentence denotes Until a couple of years ago, TAR-DNA-binding protein-43 (TDP-43) was a relatively unknown nuclear protein implicated in transcriptional repression and splicing.
T3 223-625 Sentence denotes Since 2006, when the protein was reported to be present in inclusions in the neurons and/or glial cells of a range of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin-positive, tau- and alpha-synuclein-negative inclusions (FTLD-U) and Alzheimer's disease (AD), many reports on the medical aspects of TDP-43 have been published.
T4 626-751 Sentence denotes Here, we summarize the current literature on TDP-43, focusing on recent studies that provide clues to the function of TDP-43.
T5 752-1039 Sentence denotes Using this information and database analysis, we also suggest a molecular and cellular model for possible events in normal and diseased neurons in relation to the emerging importance of the function and dysfunction of this protein as a target for basic as well as translational research.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-6 gene:23435 denotes TDP-43
T1 34-60 disease:C0524851 denotes neurodegenerative diseases
R1 T0 T1 associated_with TDP-43,neurodegenerative diseases

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18929508-0#0#6#gene23435 0-6 gene23435 denotes TDP-43
18929508-0#34#60#diseaseC0524851 34-60 diseaseC0524851 denotes neurodegenerative diseases
18929508-2#375#381#gene23435 598-604 gene23435 denotes TDP-43
18929508-2#375#381#gene23435 598-604 gene23435 denotes TDP-43
18929508-2#193#226#diseaseC0751072 416-449 diseaseC0751072 denotes frontotemporal lobar degeneration
18929508-2#193#226#diseaseC3811918 416-449 diseaseC3811918 denotes frontotemporal lobar degeneration
18929508-2#156#185#diseaseC0002736 379-408 diseaseC0002736 denotes amyotrophic lateral sclerosis
18929508-2#187#190#diseaseC0002736 410-413 diseaseC0002736 denotes ALS
18929508-2#310#329#diseaseC0002395 533-552 diseaseC0002395 denotes Alzheimer's disease
18929508-2#331#333#diseaseC0002395 554-556 diseaseC0002395 denotes AD
0#6#gene2343534#60#diseaseC0524851 18929508-0#0#6#gene23435 18929508-0#34#60#diseaseC0524851 associated_with TDP-43,neurodegenerative diseases
375#381#gene23435193#226#diseaseC0751072 18929508-2#375#381#gene23435 18929508-2#193#226#diseaseC0751072 associated_with TDP-43,frontotemporal lobar degeneration
375#381#gene23435193#226#diseaseC3811918 18929508-2#375#381#gene23435 18929508-2#193#226#diseaseC3811918 associated_with TDP-43,frontotemporal lobar degeneration
375#381#gene23435156#185#diseaseC0002736 18929508-2#375#381#gene23435 18929508-2#156#185#diseaseC0002736 associated_with TDP-43,amyotrophic lateral sclerosis
375#381#gene23435187#190#diseaseC0002736 18929508-2#375#381#gene23435 18929508-2#187#190#diseaseC0002736 associated_with TDP-43,ALS
375#381#gene23435310#329#diseaseC0002395 18929508-2#375#381#gene23435 18929508-2#310#329#diseaseC0002395 associated_with TDP-43,Alzheimer's disease
375#381#gene23435331#333#diseaseC0002395 18929508-2#375#381#gene23435 18929508-2#331#333#diseaseC0002395 associated_with TDP-43,AD
375#381#gene23435193#226#diseaseC0751072 18929508-2#375#381#gene23435 18929508-2#193#226#diseaseC0751072 associated_with TDP-43,frontotemporal lobar degeneration
375#381#gene23435193#226#diseaseC3811918 18929508-2#375#381#gene23435 18929508-2#193#226#diseaseC3811918 associated_with TDP-43,frontotemporal lobar degeneration
375#381#gene23435156#185#diseaseC0002736 18929508-2#375#381#gene23435 18929508-2#156#185#diseaseC0002736 associated_with TDP-43,amyotrophic lateral sclerosis
375#381#gene23435187#190#diseaseC0002736 18929508-2#375#381#gene23435 18929508-2#187#190#diseaseC0002736 associated_with TDP-43,ALS
375#381#gene23435310#329#diseaseC0002395 18929508-2#375#381#gene23435 18929508-2#310#329#diseaseC0002395 associated_with TDP-43,Alzheimer's disease
375#381#gene23435331#333#diseaseC0002395 18929508-2#375#381#gene23435 18929508-2#331#333#diseaseC0002395 associated_with TDP-43,AD

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T42 598-604 gene:23435 denotes TDP-43
T43 416-449 disease:C0751072 denotes frontotemporal lobar degeneration
R1 T42 T43 associated_with TDP-43,frontotemporal lobar degeneration
R2 T42 T43 associated_with TDP-43,frontotemporal lobar degeneration

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 300-307 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T2 888-895 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons