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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells.
T2 101-298 Sentence denotes Mast cell activation is a central event in allergic diseases, and investigating the signalling pathways triggered during mast cell activation may lead to the discovery of novel therapeutic targets.
T3 299-524 Sentence denotes Mast cells can be activated by a multitude of stimuli including antibodies/antigen, cytokines/chemokines and neuropeptides, resulting in a variety of responses including the immediate release of potent inflammatory mediators.
T4 525-688 Sentence denotes Moreover, recent data suggest that mast cell-mediated responses are also influenced by the differential sphingolipids/sphingosine to sphingosine-1-phosphate ratio.
T5 689-1066 Sentence denotes The importance of sphingolipids as potent biological mediators of both intracellular and extracellular responses is being increasingly recognized and accepted; it is now appreciated that activation of mast cells, via the high-affinity IgE-receptor (FcepsilonRI) leads to the activation of sphingosine kinases (SphK), resulting in increased formation of sphingosine-1-phosphate.
T6 1067-1231 Sentence denotes Furthermore, FcepsilonRI activates SphK-dependent calcium mobilization in mast cells, leading to degranulation, cytokine, and eicosanoid production, and chemotaxis.
T7 1232-1321 Sentence denotes In the past two years a critical role for SphK in allergic responses in vivo has emerged.
T8 1322-1604 Sentence denotes In this review, I focus on the current understanding of the role of sphingosine kinases during mast cell signalling in vitro and their role during hypersensitivity responses in vivo, and discuss the potential of these enzymes as novel therapeutic targets to treat allergic diseases.
T1 0-100 Sentence denotes Allergy therapy: the therapeutic potential of targeting sphingosine kinase signalling in mast cells.
T2 101-298 Sentence denotes Mast cell activation is a central event in allergic diseases, and investigating the signalling pathways triggered during mast cell activation may lead to the discovery of novel therapeutic targets.
T3 299-524 Sentence denotes Mast cells can be activated by a multitude of stimuli including antibodies/antigen, cytokines/chemokines and neuropeptides, resulting in a variety of responses including the immediate release of potent inflammatory mediators.
T4 525-688 Sentence denotes Moreover, recent data suggest that mast cell-mediated responses are also influenced by the differential sphingolipids/sphingosine to sphingosine-1-phosphate ratio.
T5 689-1066 Sentence denotes The importance of sphingolipids as potent biological mediators of both intracellular and extracellular responses is being increasingly recognized and accepted; it is now appreciated that activation of mast cells, via the high-affinity IgE-receptor (FcepsilonRI) leads to the activation of sphingosine kinases (SphK), resulting in increased formation of sphingosine-1-phosphate.
T6 1067-1231 Sentence denotes Furthermore, FcepsilonRI activates SphK-dependent calcium mobilization in mast cells, leading to degranulation, cytokine, and eicosanoid production, and chemotaxis.
T7 1232-1321 Sentence denotes In the past two years a critical role for SphK in allergic responses in vivo has emerged.
T8 1322-1604 Sentence denotes In this review, I focus on the current understanding of the role of sphingosine kinases during mast cell signalling in vitro and their role during hypersensitivity responses in vivo, and discuss the potential of these enzymes as novel therapeutic targets to treat allergic diseases.