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PubMed:18844453 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-121 Sentence denotes Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer.
TextSentencer_T2 122-216 Sentence denotes Apoptosis is a tightly regulated process that plays a critical role in many biological events.
TextSentencer_T3 217-404 Sentence denotes Members of the BCL2 (Bcl-2) family of apoptosis-related genes have been found to be differentially expressed in various malignancies and have been proposed as prognostic tumor biomarkers.
TextSentencer_T4 405-518 Sentence denotes We have recently discovered and cloned a new member of the BCL2 gene family, BCL2L12, expressed in colon tissues.
TextSentencer_T5 519-634 Sentence denotes Here we have investigated expression of the BCL2L12 gene in colon cancer tissues and assessed its prognostic value.
TextSentencer_T6 635-702 Sentence denotes Total RNA was isolated from 96 specimens of malignant colon tissue.
TextSentencer_T7 703-777 Sentence denotes After testing the RNA quality, cDNA was prepared by reverse transcription.
TextSentencer_T8 778-891 Sentence denotes A highly sensitive real-time PCR method for BCL2L12 mRNA quantification was developed using SYBR Green chemistry.
TextSentencer_T9 892-928 Sentence denotes GAPDH served as a housekeeping gene.
TextSentencer_T10 929-1029 Sentence denotes Relative quantification analysis was performed using the comparative C(T) method (2(-DeltaDeltaCT)).
TextSentencer_T11 1030-1190 Sentence denotes High BCL2L12 expression levels were found in smaller (< or =5 cm, p=0.027) and well-differentiated tumors (p=0.034), as well as in early-stage tumors (p=0.039).
TextSentencer_T12 1191-1376 Sentence denotes Survival analysis demonstrated that patients with BCL2L12-positive colon tumors have significantly longer disease-free survival and overall survival (p=0.015 and p=0.027, respectively).
TextSentencer_T13 1377-1483 Sentence denotes Our results suggest that BCL2L12 gene expression may represent a potential new biomarker for colon cancer.
T1 0-121 Sentence denotes Quantitative expression analysis and prognostic significance of the novel apoptosis-related gene BCL2L12 in colon cancer.
T2 122-216 Sentence denotes Apoptosis is a tightly regulated process that plays a critical role in many biological events.
T3 217-404 Sentence denotes Members of the BCL2 (Bcl-2) family of apoptosis-related genes have been found to be differentially expressed in various malignancies and have been proposed as prognostic tumor biomarkers.
T4 405-518 Sentence denotes We have recently discovered and cloned a new member of the BCL2 gene family, BCL2L12, expressed in colon tissues.
T5 519-634 Sentence denotes Here we have investigated expression of the BCL2L12 gene in colon cancer tissues and assessed its prognostic value.
T6 635-702 Sentence denotes Total RNA was isolated from 96 specimens of malignant colon tissue.
T7 703-777 Sentence denotes After testing the RNA quality, cDNA was prepared by reverse transcription.
T8 778-891 Sentence denotes A highly sensitive real-time PCR method for BCL2L12 mRNA quantification was developed using SYBR Green chemistry.
T9 892-928 Sentence denotes GAPDH served as a housekeeping gene.
T10 929-1029 Sentence denotes Relative quantification analysis was performed using the comparative C(T) method (2(-DeltaDeltaCT)).
T11 1030-1190 Sentence denotes High BCL2L12 expression levels were found in smaller (< or =5 cm, p=0.027) and well-differentiated tumors (p=0.034), as well as in early-stage tumors (p=0.039).
T12 1191-1376 Sentence denotes Survival analysis demonstrated that patients with BCL2L12-positive colon tumors have significantly longer disease-free survival and overall survival (p=0.015 and p=0.027, respectively).
T13 1377-1483 Sentence denotes Our results suggest that BCL2L12 gene expression may represent a potential new biomarker for colon cancer.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1241-1248 gene:83596 denotes BCL2L12
T1 1258-1270 disease:C0009375 denotes colon tumors
R1 T0 T1 associated_with BCL2L12,colon tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18844453-0#97#104#gene83596 97-104 gene83596 denotes BCL2L12
18844453-0#108#120#diseaseC0007102 108-120 diseaseC0007102 denotes colon cancer
18844453-0#108#120#diseaseC0699790 108-120 diseaseC0699790 denotes colon cancer
18844453-10#50#57#gene83596 1241-1248 gene83596 denotes BCL2L12
18844453-10#67#79#diseaseC0009375 1258-1270 diseaseC0009375 denotes colon tumors
97#104#gene83596108#120#diseaseC0007102 18844453-0#97#104#gene83596 18844453-0#108#120#diseaseC0007102 associated_with BCL2L12,colon cancer
97#104#gene83596108#120#diseaseC0699790 18844453-0#97#104#gene83596 18844453-0#108#120#diseaseC0699790 associated_with BCL2L12,colon cancer
50#57#gene8359667#79#diseaseC0009375 18844453-10#50#57#gene83596 18844453-10#67#79#diseaseC0009375 associated_with BCL2L12,colon tumors

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 510-517 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 592-599 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 695-701 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T4 108-113 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 504-509 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 579-584 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T7 689-694 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T8 1258-1263 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T9 1470-1475 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T217 97-104 gene:83596 denotes BCL2L12
T218 108-120 disease:C0007102 denotes colon cancer
R1 T217 T218 associated_with BCL2L12,colon cancer
R2 T217 T218 associated_with BCL2L12,colon cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 108-113 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T2 504-509 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 579-584 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 689-694 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 1258-1263 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 1470-1475 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T7 510-517 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T8 592-599 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T9 695-701 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue