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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-47 Sentence denotes Leptin signaling in breast cancer: an overview.
TextSentencer_T2 48-200 Sentence denotes The adipocyte-derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa-f) have been identified up to now.
TextSentencer_T3 201-352 Sentence denotes Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 signaling pathways.
TextSentencer_T4 353-583 Sentence denotes Since the circulating levels of leptin are elevated in obese individuals, and excess body weight has been shown to increase breast cancer risk in postmenopausal women, several studies addressed the role of leptin in breast cancer.
TextSentencer_T5 584-720 Sentence denotes Expression of leptin and its receptors has been demonstrated to occur in breast cancer cell lines and in human primary breast carcinoma.
TextSentencer_T6 721-948 Sentence denotes Leptin is able to induce the growth of breast cancer cells through activation of the Jak/STAT3, ERK1/2, and/or PI3K pathways, and can mediate angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF).
TextSentencer_T7 949-1199 Sentence denotes In addition, leptin induces transactivation of ErbB-2, and interacts in triple negative breast cancer cells with insulin like growth factor-1 (IGF-1) to transactivate the epidermal growth factor receptor (EGFR), thus promoting invasion and migration.
TextSentencer_T8 1200-1453 Sentence denotes Leptin can also affect the growth of estrogen receptor (ER)-positive breast cancer cells, by stimulating aromatase expression and thereby increasing estrogen levels through the aromatization of androgens, and by inducing MAPK-dependent activation of ER.
TextSentencer_T9 1454-1681 Sentence denotes Taken together, these findings suggest that the leptin system might play an important role in breast cancer pathogenesis and progression, and that it might represent a novel target for therapeutic intervention in breast cancer.
T1 0-47 Sentence denotes Leptin signaling in breast cancer: an overview.
T2 48-200 Sentence denotes The adipocyte-derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa-f) have been identified up to now.
T3 201-352 Sentence denotes Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 signaling pathways.
T4 353-583 Sentence denotes Since the circulating levels of leptin are elevated in obese individuals, and excess body weight has been shown to increase breast cancer risk in postmenopausal women, several studies addressed the role of leptin in breast cancer.
T5 584-720 Sentence denotes Expression of leptin and its receptors has been demonstrated to occur in breast cancer cell lines and in human primary breast carcinoma.
T6 721-948 Sentence denotes Leptin is able to induce the growth of breast cancer cells through activation of the Jak/STAT3, ERK1/2, and/or PI3K pathways, and can mediate angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF).
T7 949-1199 Sentence denotes In addition, leptin induces transactivation of ErbB-2, and interacts in triple negative breast cancer cells with insulin like growth factor-1 (IGF-1) to transactivate the epidermal growth factor receptor (EGFR), thus promoting invasion and migration.
T8 1200-1453 Sentence denotes Leptin can also affect the growth of estrogen receptor (ER)-positive breast cancer cells, by stimulating aromatase expression and thereby increasing estrogen levels through the aromatization of androgens, and by inducing MAPK-dependent activation of ER.
T9 1454-1681 Sentence denotes Taken together, these findings suggest that the leptin system might play an important role in breast cancer pathogenesis and progression, and that it might represent a novel target for therapeutic intervention in breast cancer.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 559-565 gene:3952 denotes leptin
T1 569-582 disease:C0678222 denotes breast cancer
T2 559-565 gene:3952 denotes leptin
T3 569-582 disease:C0006142 denotes breast cancer
T4 559-565 gene:3952 denotes leptin
T5 477-490 disease:C0678222 denotes breast cancer
T6 559-565 gene:3952 denotes leptin
T7 477-490 disease:C0006142 denotes breast cancer
T8 559-565 gene:3952 denotes leptin
T9 408-413 disease:C0028754 denotes obese
T10 385-391 gene:3952 denotes leptin
T11 569-582 disease:C0678222 denotes breast cancer
T12 385-391 gene:3952 denotes leptin
T13 408-413 disease:C0028754 denotes obese
T14 385-391 gene:3952 denotes leptin
T15 477-490 disease:C0678222 denotes breast cancer
T16 385-391 gene:3952 denotes leptin
T17 477-490 disease:C0006142 denotes breast cancer
T18 385-391 gene:3952 denotes leptin
T19 569-582 disease:C0006142 denotes breast cancer
T20 598-604 gene:3952 denotes leptin
T21 703-719 disease:C0678222 denotes breast carcinoma
T22 598-604 gene:3952 denotes leptin
T23 703-719 disease:C0006142 denotes breast carcinoma
T24 598-604 gene:3952 denotes leptin
T25 657-670 disease:C0006142 denotes breast cancer
T26 598-604 gene:3952 denotes leptin
T27 657-670 disease:C0678222 denotes breast cancer
T28 721-727 gene:3952 denotes Leptin
T29 760-773 disease:C0678222 denotes breast cancer
T30 721-727 gene:3952 denotes Leptin
T31 760-773 disease:C0006142 denotes breast cancer
T32 1154-1158 gene:1956 denotes EGFR
T33 1021-1050 disease:C3539878 denotes triple negative breast cancer
T34 1062-1069 gene:723961 denotes insulin
T35 1021-1050 disease:C3539878 denotes triple negative breast cancer
T36 1062-1069 gene:3630 denotes insulin
T37 1021-1050 disease:C3539878 denotes triple negative breast cancer
T38 1092-1097 gene:3479 denotes IGF-1
T39 1021-1050 disease:C3539878 denotes triple negative breast cancer
T40 1256-1258 gene:2099 denotes ER
T41 1269-1282 disease:C0006142 denotes breast cancer
T42 1256-1258 gene:2099 denotes ER
T43 1269-1282 disease:C0678222 denotes breast cancer
T44 1502-1508 gene:3952 denotes leptin
T45 1667-1680 disease:C0678222 denotes breast cancer
T46 1502-1508 gene:3952 denotes leptin
T47 1667-1680 disease:C0006142 denotes breast cancer
T48 1502-1508 gene:3952 denotes leptin
T49 1548-1561 disease:C0678222 denotes breast cancer
T50 1502-1508 gene:3952 denotes leptin
T51 1548-1561 disease:C0006142 denotes breast cancer
R1 T0 T1 associated_with leptin,breast cancer
R2 T2 T3 associated_with leptin,breast cancer
R3 T4 T5 associated_with leptin,breast cancer
R4 T6 T7 associated_with leptin,breast cancer
R5 T8 T9 associated_with leptin,obese
R6 T10 T11 associated_with leptin,breast cancer
R7 T12 T13 associated_with leptin,obese
R8 T14 T15 associated_with leptin,breast cancer
R9 T16 T17 associated_with leptin,breast cancer
R10 T18 T19 associated_with leptin,breast cancer
R11 T20 T21 associated_with leptin,breast carcinoma
R12 T22 T23 associated_with leptin,breast carcinoma
R13 T24 T25 associated_with leptin,breast cancer
R14 T26 T27 associated_with leptin,breast cancer
R15 T28 T29 associated_with Leptin,breast cancer
R16 T30 T31 associated_with Leptin,breast cancer
R17 T32 T33 associated_with EGFR,triple negative breast cancer
R18 T34 T35 associated_with insulin,triple negative breast cancer
R19 T36 T37 associated_with insulin,triple negative breast cancer
R20 T38 T39 associated_with IGF-1,triple negative breast cancer
R21 T40 T41 associated_with ER,breast cancer
R22 T42 T43 associated_with ER,breast cancer
R23 T44 T45 associated_with leptin,breast cancer
R24 T46 T47 associated_with leptin,breast cancer
R25 T48 T49 associated_with leptin,breast cancer
R26 T50 T51 associated_with leptin,breast cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18821585-3#32#38#gene3952 385-391 gene3952 denotes leptin
18821585-3#206#212#gene3952 559-565 gene3952 denotes leptin
18821585-3#55#60#diseaseC0028754 408-413 diseaseC0028754 denotes obese
18821585-6#143#148#gene3479 1092-1097 gene3479 denotes IGF-1
18821585-6#72#101#diseaseC3539878 1021-1050 diseaseC3539878 denotes triple negative breast cancer
18821585-7#37#54#gene2099 1237-1254 gene2099 denotes estrogen receptor
18821585-7#56#58#gene2099 1256-1258 gene2099 denotes ER
18821585-7#69#82#diseaseC0006142 1269-1282 diseaseC0006142 denotes breast cancer
18821585-7#69#82#diseaseC0678222 1269-1282 diseaseC0678222 denotes breast cancer
18821585-7#69#82#diseaseC0006142 1269-1282 diseaseC0006142 denotes breast cancer
18821585-7#69#82#diseaseC0678222 1269-1282 diseaseC0678222 denotes breast cancer
18821585-8#48#54#gene3952 1502-1508 gene3952 denotes leptin
18821585-8#94#107#diseaseC0006142 1548-1561 diseaseC0006142 denotes breast cancer
18821585-8#94#107#diseaseC0678222 1548-1561 diseaseC0678222 denotes breast cancer
18821585-8#213#226#diseaseC0006142 1667-1680 diseaseC0006142 denotes breast cancer
18821585-8#213#226#diseaseC0678222 1667-1680 diseaseC0678222 denotes breast cancer
32#38#gene395255#60#diseaseC0028754 18821585-3#32#38#gene3952 18821585-3#55#60#diseaseC0028754 associated_with leptin,obese
206#212#gene395255#60#diseaseC0028754 18821585-3#206#212#gene3952 18821585-3#55#60#diseaseC0028754 associated_with leptin,obese
143#148#gene347972#101#diseaseC3539878 18821585-6#143#148#gene3479 18821585-6#72#101#diseaseC3539878 associated_with IGF-1,triple negative breast cancer
37#54#gene209969#82#diseaseC0006142 18821585-7#37#54#gene2099 18821585-7#69#82#diseaseC0006142 associated_with estrogen receptor,breast cancer
37#54#gene209969#82#diseaseC0678222 18821585-7#37#54#gene2099 18821585-7#69#82#diseaseC0678222 associated_with estrogen receptor,breast cancer
37#54#gene209969#82#diseaseC0006142 18821585-7#37#54#gene2099 18821585-7#69#82#diseaseC0006142 associated_with estrogen receptor,breast cancer
37#54#gene209969#82#diseaseC0678222 18821585-7#37#54#gene2099 18821585-7#69#82#diseaseC0678222 associated_with estrogen receptor,breast cancer
56#58#gene209969#82#diseaseC0006142 18821585-7#56#58#gene2099 18821585-7#69#82#diseaseC0006142 associated_with ER,breast cancer
56#58#gene209969#82#diseaseC0678222 18821585-7#56#58#gene2099 18821585-7#69#82#diseaseC0678222 associated_with ER,breast cancer
56#58#gene209969#82#diseaseC0006142 18821585-7#56#58#gene2099 18821585-7#69#82#diseaseC0006142 associated_with ER,breast cancer
56#58#gene209969#82#diseaseC0678222 18821585-7#56#58#gene2099 18821585-7#69#82#diseaseC0678222 associated_with ER,breast cancer
48#54#gene395294#107#diseaseC0006142 18821585-8#48#54#gene3952 18821585-8#94#107#diseaseC0006142 associated_with leptin,breast cancer
48#54#gene395294#107#diseaseC0678222 18821585-8#48#54#gene3952 18821585-8#94#107#diseaseC0678222 associated_with leptin,breast cancer
48#54#gene3952213#226#diseaseC0006142 18821585-8#48#54#gene3952 18821585-8#213#226#diseaseC0006142 associated_with leptin,breast cancer
48#54#gene3952213#226#diseaseC0678222 18821585-8#48#54#gene3952 18821585-8#213#226#diseaseC0678222 associated_with leptin,breast cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2386 1237-1254 gene:2099 denotes estrogen receptor
T2387 1269-1282 disease:C0006142 denotes breast cancer
T2388 1256-1258 gene:2099 denotes ER
R1 T2386 T2387 associated_with estrogen receptor,breast cancer
R2 T2386 T2387 associated_with estrogen receptor,breast cancer
R3 T2388 T2387 associated_with ER,breast cancer
R4 T2388 T2387 associated_with ER,breast cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 20-26 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 477-483 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 569-575 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 657-663 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 703-709 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 760-766 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1037-1043 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1269-1275 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1548-1554 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 1667-1673 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 20-26 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 477-483 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T3 569-575 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T4 657-663 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T5 703-709 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T6 760-766 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T7 1037-1043 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T8 1269-1275 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T9 1548-1554 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T10 1667-1673 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast