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PubMed:18818423 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 976-985 https://glytoucan.org/Structures/Glycans/G71832QJ denotes A antigen

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 976-985 Glycan_Motif denotes A antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71832QJ

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 42-46 DiseaseOrPhenotypicFeature denotes SARS 0005091
T2 129-162 DiseaseOrPhenotypicFeature denotes Severe acute respiratory syndrome 0005091
T3 176-180 DiseaseOrPhenotypicFeature denotes SARS 0005091
T4 255-258 DiseaseOrPhenotypicFeature denotes can 0012833
T5 324-328 DiseaseOrPhenotypicFeature denotes SARS 0005091
T6 552-561 DiseaseOrPhenotypicFeature denotes infection 0005550
T7 1476-1480 DiseaseOrPhenotypicFeature denotes SARS 0005091

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 976-985 https://glytoucan.org/Structures/Glycans/G71832QJ denotes A antigen

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies.
TextSentencer_T2 129-298 Sentence denotes Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic emergent virus which replicates in cells that can express ABH histo-blood group antigens.
TextSentencer_T3 299-428 Sentence denotes The heavily glycosylated SARS-CoV spike (S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor.
TextSentencer_T4 429-562 Sentence denotes Epidemiological analysis of a hospital outbreak in Hong Kong revealed that blood group O was associated with a low risk of infection.
TextSentencer_T5 563-749 Sentence denotes In this study, we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction.
TextSentencer_T6 750-1006 Sentence denotes To this aim, a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an alpha1,2-fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface.
TextSentencer_T7 1007-1373 Sentence denotes We observed that the S protein/angiotensin-converting enzyme 2-dependent adhesion of these cells to an angiotensin-converting enzyme 2 expressing cell line was specifically inhibited by either a monoclonal or human natural anti-A antibodies, indicating that these antibodies may block the interaction between the virus and its receptor, thereby providing protection.
TextSentencer_T8 1374-1619 Sentence denotes In order to more fully appreciate the potential effect of the ABO polymorphism on the epidemiology of SARS, we built a mathematical model of the virus transmission dynamics that takes into account the protective effect of ABO natural antibodies.
TextSentencer_T9 1620-1814 Sentence denotes The model indicated that the ABO polymorphism could contribute to substantially reduce the virus transmission, affecting both the number of infected individuals and the kinetics of the epidemic.
T1 0-128 Sentence denotes Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies.
T2 129-298 Sentence denotes Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic emergent virus which replicates in cells that can express ABH histo-blood group antigens.
T3 299-428 Sentence denotes The heavily glycosylated SARS-CoV spike (S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor.
T4 429-562 Sentence denotes Epidemiological analysis of a hospital outbreak in Hong Kong revealed that blood group O was associated with a low risk of infection.
T5 563-749 Sentence denotes In this study, we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction.
T6 750-1006 Sentence denotes To this aim, a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an alpha1,2-fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface.
T7 1007-1373 Sentence denotes We observed that the S protein/angiotensin-converting enzyme 2-dependent adhesion of these cells to an angiotensin-converting enzyme 2 expressing cell line was specifically inhibited by either a monoclonal or human natural anti-A antibodies, indicating that these antibodies may block the interaction between the virus and its receptor, thereby providing protection.
T8 1374-1619 Sentence denotes In order to more fully appreciate the potential effect of the ABO polymorphism on the epidemiology of SARS, we built a mathematical model of the virus transmission dynamics that takes into account the protective effect of ABO natural antibodies.
T9 1620-1814 Sentence denotes The model indicated that the ABO polymorphism could contribute to substantially reduce the virus transmission, affecting both the number of infected individuals and the kinetics of the epidemic.
T1 0-128 Sentence denotes Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies.
T2 129-298 Sentence denotes Severe acute respiratory syndrome coronavirus (SARS-CoV) is a highly pathogenic emergent virus which replicates in cells that can express ABH histo-blood group antigens.
T3 299-428 Sentence denotes The heavily glycosylated SARS-CoV spike (S) protein binds to angiotensin-converting enzyme 2 which serves as a cellular receptor.
T4 429-562 Sentence denotes Epidemiological analysis of a hospital outbreak in Hong Kong revealed that blood group O was associated with a low risk of infection.
T5 563-749 Sentence denotes In this study, we used a cellular model of adhesion to investigate whether natural antibodies of the ABO system could block the S protein and angiotensin-converting enzyme 2 interaction.
T6 750-1006 Sentence denotes To this aim, a C-terminally EGFP-tagged S protein was expressed in chinese hamster ovary cells cotransfected with an alpha1,2-fucosyltransferase and an A-transferase in order to coexpress the S glycoprotein ectodomain and the A antigen at the cell surface.
T7 1007-1373 Sentence denotes We observed that the S protein/angiotensin-converting enzyme 2-dependent adhesion of these cells to an angiotensin-converting enzyme 2 expressing cell line was specifically inhibited by either a monoclonal or human natural anti-A antibodies, indicating that these antibodies may block the interaction between the virus and its receptor, thereby providing protection.
T8 1374-1619 Sentence denotes In order to more fully appreciate the potential effect of the ABO polymorphism on the epidemiology of SARS, we built a mathematical model of the virus transmission dynamics that takes into account the protective effect of ABO natural antibodies.
T9 1620-1814 Sentence denotes The model indicated that the ABO polymorphism could contribute to substantially reduce the virus transmission, affecting both the number of infected individuals and the kinetics of the epidemic.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 105-110 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 105-110 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 277-282 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T4 277-282 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T5 504-509 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T6 504-509 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T32 1237-1247 FMAID:167180 denotes antibodies
_T1 57-64 FMAID:165447 denotes protein
_T2 57-64 FMAID:67257 denotes protein
_T3 105-110 FMAID:256053 denotes blood
_T4 117-127 FMAID:167180 denotes antibodies
_T5 241-249 FMAID:199054 denotes in cells
_T6 241-249 FMAID:84785 denotes in cells
_T7 244-249 FMAID:68646 denotes cells
_T8 244-249 FMAID:169002 denotes cells
_T9 277-282 FMAID:256053 denotes blood
_T10 343-350 FMAID:165447 denotes protein
_T11 343-350 FMAID:67257 denotes protein
_T12 504-509 FMAID:256053 denotes blood
_T13 646-656 FMAID:167180 denotes antibodies
_T14 693-700 FMAID:165447 denotes protein
_T15 693-700 FMAID:67257 denotes protein
_T16 792-799 FMAID:67257 denotes protein
_T17 792-799 FMAID:165447 denotes protein
_T18 833-838 FMAID:7209 denotes ovary
_T19 833-838 FMAID:93687 denotes ovary
_T20 839-844 FMAID:169002 denotes cells
_T21 839-844 FMAID:68646 denotes cells
_T22 944-956 FMAID:167256 denotes glycoprotein
_T23 944-956 FMAID:62925 denotes glycoprotein
_T24 993-1005 FMAID:200942 denotes cell surface
_T25 993-1005 FMAID:212684 denotes cell surface
_T26 998-1005 FMAID:146300 denotes surface
_T27 998-1005 FMAID:50594 denotes surface
_T28 1030-1037 FMAID:67257 denotes protein
_T29 1030-1037 FMAID:165447 denotes protein
_T30 1098-1103 FMAID:68646 denotes cells
_T31 1098-1103 FMAID:169002 denotes cells
_T33 1271-1281 FMAID:167180 denotes antibodies
_T34 1608-1618 FMAID:167180 denotes antibodies
_T35 1686-1699 FMAID:188924 denotes substantially

uniprot-human

Id Subject Object Predicate Lexical cue
T1 42-46 http://www.uniprot.org/uniprot/P49591 denotes SARS
T2 176-180 http://www.uniprot.org/uniprot/P49591 denotes SARS
T3 324-328 http://www.uniprot.org/uniprot/P49591 denotes SARS
T4 1476-1480 http://www.uniprot.org/uniprot/P49591 denotes SARS
T5 267-270 http://www.uniprot.org/uniprot/Q13686 denotes ABH
T6 277-297 http://www.uniprot.org/uniprot/Q96PL6 denotes blood group antigens
T7 277-297 http://www.uniprot.org/uniprot/B2RUZ4 denotes blood group antigens
T8 277-297 http://www.uniprot.org/uniprot/O75326 denotes blood group antigens
T9 277-297 http://www.uniprot.org/uniprot/P35613 denotes blood group antigens
T10 340-350 http://www.uniprot.org/uniprot/P04004 denotes S) protein
T11 360-389 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme
T12 705-734 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme
T13 360-391 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme 2
T14 705-736 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme 2
T15 1038-1069 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme 2
T16 1110-1141 http://www.uniprot.org/uniprot/Q9BYF1 denotes angiotensin-converting enzyme 2
T17 360-389 http://www.uniprot.org/uniprot/P12821 denotes angiotensin-converting enzyme
T18 705-734 http://www.uniprot.org/uniprot/P12821 denotes angiotensin-converting enzyme
T19 1038-1067 http://www.uniprot.org/uniprot/P12821 denotes angiotensin-converting enzyme
T20 1110-1139 http://www.uniprot.org/uniprot/P12821 denotes angiotensin-converting enzyme
T21 664-667 http://www.uniprot.org/uniprot/Q99484 denotes ABO
T22 1436-1439 http://www.uniprot.org/uniprot/Q99484 denotes ABO
T23 1596-1599 http://www.uniprot.org/uniprot/Q99484 denotes ABO
T24 904-915 http://www.uniprot.org/uniprot/Q99484 denotes transferase

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 340-350 http://www.uniprot.org/uniprot/P29788 denotes S) protein
T2 360-389 http://www.uniprot.org/uniprot/P09470 denotes angiotensin-converting enzyme
T3 705-734 http://www.uniprot.org/uniprot/P09470 denotes angiotensin-converting enzyme
T4 1038-1067 http://www.uniprot.org/uniprot/P09470 denotes angiotensin-converting enzyme
T5 1110-1139 http://www.uniprot.org/uniprot/P09470 denotes angiotensin-converting enzyme
T6 360-391 http://www.uniprot.org/uniprot/Q8R0I0 denotes angiotensin-converting enzyme 2
T7 705-736 http://www.uniprot.org/uniprot/Q8R0I0 denotes angiotensin-converting enzyme 2
T8 1038-1069 http://www.uniprot.org/uniprot/Q8R0I0 denotes angiotensin-converting enzyme 2
T9 1110-1141 http://www.uniprot.org/uniprot/Q8R0I0 denotes angiotensin-converting enzyme 2
T10 904-915 http://www.uniprot.org/uniprot/P38649 denotes transferase

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 111-116 http://purl.bioontology.org/ontology/STY/T096 denotes group
T2 129-174 http://purl.bioontology.org/ontology/NCBITAXON/694009 denotes Severe acute respiratory syndrome coronavirus
T3 218-223 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T4 244-249 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T5 283-288 http://purl.bioontology.org/ontology/STY/T096 denotes group
T6 510-515 http://purl.bioontology.org/ontology/STY/T096 denotes group
T7 839-844 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T8 1098-1103 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T9 1202-1212 http://purl.bioontology.org/ontology/NCBITAXON/608684 denotes monoclonal
T10 1320-1325 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T11 1440-1452 http://purl.bioontology.org/ontology/NCBITAXON/60540 denotes polymorphism
T12 1440-1452 http://purl.bioontology.org/ontology/NCBITAXON/991903 denotes polymorphism
T13 1519-1524 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus
T14 1653-1665 http://purl.bioontology.org/ontology/NCBITAXON/991903 denotes polymorphism
T15 1653-1665 http://purl.bioontology.org/ontology/NCBITAXON/60540 denotes polymorphism
T16 1711-1716 http://purl.bioontology.org/ontology/NCBITAXON/184751 denotes virus

GO-BP

Id Subject Object Predicate Lexical cue
T1 73-81 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T2 410-418 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3 588-596 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T4 311-323 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylated
T5 1080-1103 http://purl.obolibrary.org/obo/GO_0007155 denotes adhesion of these cells
T6 1519-1537 http://purl.obolibrary.org/obo/GO_0019089 denotes virus transmission
T7 1711-1729 http://purl.obolibrary.org/obo/GO_0019089 denotes virus transmission

GO-MF

Id Subject Object Predicate Lexical cue
T1 117-127 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T2 646-656 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3 1237-1247 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4 1271-1281 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T5 1608-1618 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6 343-356 http://purl.obolibrary.org/obo/GO_0005515 denotes protein binds
T7 351-356 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T8 351-356 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T9 351-356 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T10 351-356 http://purl.obolibrary.org/obo/GO_0005488 denotes binds

GO-CC

Id Subject Object Predicate Lexical cue
T1 244-249 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2 839-844 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3 993-997 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 1153-1157 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5 993-1005 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 105-110 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T2 277-282 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T3 504-509 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 105-110 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T2 105-110 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 277-282 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 277-282 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T5 504-509 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T6 504-509 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 105-116 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group
T2 277-288 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group
T3 504-515 http://rdf.glycoinfo.org/glycan/G00066MO denotes blood group

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 105-110 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 277-282 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T3 504-509 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 105-110 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 277-282 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T5 504-509 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 42-50 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 129-162 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T3 176-184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 324-332 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 552-561 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T6 1476-1480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 42-50 OrganismTaxon denotes SARS-CoV 694009
T2 129-162 OrganismTaxon denotes Severe acute respiratory syndrome 694009
T3 176-184 OrganismTaxon denotes SARS-CoV 694009
T4 324-332 OrganismTaxon denotes SARS-CoV 694009
T5 817-832 OrganismTaxon denotes chinese hamster 10029
T6 1216-1221 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 105-110 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 277-282 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T3 504-509 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T4 833-838 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992