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PubMed:18814027 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 186-188 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T3 492-494 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T5 874-876 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T7 907-909 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T9 1096-1098 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO
T11 1253-1255 Glycan_Motif denotes Ln https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G04616ST|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 186-188 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln
T2 492-494 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln
T3 874-876 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln
T4 907-909 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln
T5 1096-1098 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln
T6 1253-1255 https://glytoucan.org/Structures/Glycans/G04616ST denotes Ln

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-117 Sentence denotes Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway.
TextSentencer_T2 118-287 Sentence denotes One of the possible mechanisms of the angiogenic effect of laminin (Ln) involves modulation of the biological activity of VEGF by regulating poly ADP ribosylation (PAR).
TextSentencer_T3 288-406 Sentence denotes PAR modification of VEGF was found to be related with the changes in NAD(+) associated with a shift in LDH isoenzymes.
TextSentencer_T4 407-566 Sentence denotes Further investigations on LDH gene expression in HUVECs suggested that the effect of Ln was mediated through alpha(6)beta(4) integrin-FAK-src-p38 MAPK pathway.
TextSentencer_T5 567-961 Sentence denotes This was evidenced by (a) co-immunoprecipitation of beta(4) integrin with alpha(6) subunit, (b) activation by tyrosine phosphorylation of beta(4) integrin and FAK, (c) co-immunoprecipitation of FAK with beta(4) and with adapter protein, src, (d) increased phosphorylation of p38 MAPK in cells maintained on Ln and (e) blocking of effect of Ln on LDH-B gene expression by inhibition of p38 MAPK.
TextSentencer_T6 962-1149 Sentence denotes Increase in serine phosphorylation of c-fos and c-jun and higher levels of heterodimers of AP-1 in the nucleus in cells maintained on Ln suggested activation of AP-1 transcription factor.
TextSentencer_T7 1150-1289 Sentence denotes These results provide evidence for modulation of endothelial cell function relevant to angiogenesis by Ln through alpha(6)beta(4) integrin.
T1 0-117 Sentence denotes Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway.
T2 118-287 Sentence denotes One of the possible mechanisms of the angiogenic effect of laminin (Ln) involves modulation of the biological activity of VEGF by regulating poly ADP ribosylation (PAR).
T3 288-406 Sentence denotes PAR modification of VEGF was found to be related with the changes in NAD(+) associated with a shift in LDH isoenzymes.
T4 407-566 Sentence denotes Further investigations on LDH gene expression in HUVECs suggested that the effect of Ln was mediated through alpha(6)beta(4) integrin-FAK-src-p38 MAPK pathway.
T5 567-961 Sentence denotes This was evidenced by (a) co-immunoprecipitation of beta(4) integrin with alpha(6) subunit, (b) activation by tyrosine phosphorylation of beta(4) integrin and FAK, (c) co-immunoprecipitation of FAK with beta(4) and with adapter protein, src, (d) increased phosphorylation of p38 MAPK in cells maintained on Ln and (e) blocking of effect of Ln on LDH-B gene expression by inhibition of p38 MAPK.
T6 962-1149 Sentence denotes Increase in serine phosphorylation of c-fos and c-jun and higher levels of heterodimers of AP-1 in the nucleus in cells maintained on Ln suggested activation of AP-1 transcription factor.
T7 1150-1289 Sentence denotes These results provide evidence for modulation of endothelial cell function relevant to angiogenesis by Ln through alpha(6)beta(4) integrin.

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-16 Body_part denotes Endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 1065-1072 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T4 1199-1215 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-16 Cell denotes Endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 259-263 Cell denotes poly http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775
T4 1199-1215 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115