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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Isoproterenol induces primary loss of dystrophin in rat hearts: correlation with myocardial injury.
T2 100-347 Sentence denotes The mechanism of isoproterenol-induced myocardial damage is unknown, but a mismatch of oxygen supply vs. demand following coronary hypotension and myocardial hyperactivity is the best explanation for the complex morphological alterations observed.
T3 348-484 Sentence denotes Severe alterations in the structural integrity of the sarcolemma of cardiomyocytes have been demonstrated to be caused by isoproterenol.
T4 485-817 Sentence denotes Taking into account that the sarcolemmal integrity is stabilized by the dystrophin-glycoprotein complex (DGC) that connects actin and laminin in contractile machinery and extracellular matrix and by integrins, this study tests the hypothesis that isoproterenol affects sarcolemmal stability through changes in the DGC and integrins.
T5 818-918 Sentence denotes We found different sensitivity of the DGC and integrin to isoproterenol subcutaneous administration.
T6 919-1098 Sentence denotes Immunofluorescent staining revealed that dystrophin is the most sensitive among the structures connecting the actin in the cardiomyocyte cytoskeleton and the extracellular matrix.
T7 1099-1183 Sentence denotes The sarcomeric actin dissolution occurred after the reduction or loss of dystrophin.
T8 1184-1399 Sentence denotes Subsequently, after lysis of myofilaments, gamma-sarcoglycan, beta-dystroglycan, beta1-integrin, and laminin alpha-2 expressions were reduced followed by their breakdown, as epiphenomena of the myocytolytic process.
T9 1400-1638 Sentence denotes In conclusion, administration of isoproterenol to rats results in primary loss of dystrophin, the most sensitive among the structural proteins that form the DGC that connects the extracellular matrix and the cytoskeleton in cardiomyocyte.
T10 1639-1844 Sentence denotes These changes, related to ischaemic injury, explain the severe alterations in the structural integrity of the sarcolemma of cardiomyocytes and hence severe and irreversible injury induced by isoproterenol.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 52-55 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T3 1450-1454 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5494 0-13 ChemicalEntity denotes Isoproterenol MESH:D007545
5495 38-48 GeneOrGeneProduct denotes dystrophin NCBIGene:24907
5496 52-55 OrganismTaxon denotes rat NCBITaxon:10116
5497 81-98 DiseaseOrPhenotypicFeature denotes myocardial injury MESH:D009202
5498 117-130 ChemicalEntity denotes isoproterenol MESH:D007545
5499 139-156 DiseaseOrPhenotypicFeature denotes myocardial damage MESH:D009202
5500 187-193 ChemicalEntity denotes oxygen MESH:D010100
5501 231-242 DiseaseOrPhenotypicFeature denotes hypotension MESH:D007022
5502 247-271 DiseaseOrPhenotypicFeature denotes myocardial hyperactivity MESH:D009202
5503 470-483 ChemicalEntity denotes isoproterenol MESH:D007545
5504 557-567 GeneOrGeneProduct denotes dystrophin NCBIGene:24907
5505 568-580 GeneOrGeneProduct denotes glycoprotein NCBIGene:11820
5506 609-614 GeneOrGeneProduct denotes actin NCBIGene:60
5507 619-626 GeneOrGeneProduct denotes laminin NCBIGene:309368
5508 732-745 ChemicalEntity denotes isoproterenol MESH:D007545
5509 876-889 ChemicalEntity denotes isoproterenol MESH:D007545
5510 960-970 GeneOrGeneProduct denotes dystrophin NCBIGene:24907
5511 1029-1034 GeneOrGeneProduct denotes actin NCBIGene:60
5512 1114-1119 GeneOrGeneProduct denotes actin NCBIGene:60
5513 1172-1182 GeneOrGeneProduct denotes dystrophin NCBIGene:24907
5514 1227-1244 GeneOrGeneProduct denotes gamma-sarcoglycan NCBIGene:305941
5515 1246-1263 GeneOrGeneProduct denotes beta-dystroglycan NCBIGene:114489
5516 1265-1279 GeneOrGeneProduct denotes beta1-integrin NCBIGene:24511
5517 1285-1300 GeneOrGeneProduct denotes laminin alpha-2 NCBIGene:309368
5518 1433-1446 ChemicalEntity denotes isoproterenol MESH:D007545
5519 1450-1454 OrganismTaxon denotes rats NCBITaxon:10116
5520 1482-1492 GeneOrGeneProduct denotes dystrophin NCBIGene:24907
5521 1665-1681 DiseaseOrPhenotypicFeature denotes ischaemic injury MESH:D007511
5522 1830-1843 ChemicalEntity denotes isoproterenol MESH:D007545

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 92-98 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 231-242 DiseaseOrPhenotypicFeature denotes hypotension 0005468
T3 837-848 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T4 983-992 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T5 1503-1512 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T6 1675-1681 DiseaseOrPhenotypicFeature denotes injury 0021178
T7 1812-1818 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 92-98 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 1675-1681 DiseaseOrPhenotypicFeature denotes injury 0021178
T3 1812-1818 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 38-48 GeneOrGeneProduct denotes dystrophin
T2 160-167 GeneOrGeneProduct denotes unknown
T3 279-283 GeneOrGeneProduct denotes best
T4 557-567 GeneOrGeneProduct denotes dystrophin
T5 568-580 GeneOrGeneProduct denotes glycoprotein
T6 609-614 GeneOrGeneProduct denotes actin
T7 619-626 GeneOrGeneProduct denotes laminin
T8 656-669 GeneOrGeneProduct denotes extracellular
T9 670-676 GeneOrGeneProduct denotes matrix
T10 864-872 GeneOrGeneProduct denotes integrin
T11 960-970 GeneOrGeneProduct denotes dystrophin
T12 1029-1034 GeneOrGeneProduct denotes actin
T13 1077-1090 GeneOrGeneProduct denotes extracellular
T14 1091-1097 GeneOrGeneProduct denotes matrix
T15 1103-1119 GeneOrGeneProduct denotes sarcomeric actin
T16 1172-1182 GeneOrGeneProduct denotes dystrophin
T17 1204-1209 GeneOrGeneProduct denotes lysis
T18 1227-1244 GeneOrGeneProduct denotes gamma-sarcoglycan
T19 1246-1263 GeneOrGeneProduct denotes beta-dystroglycan
T20 1265-1279 GeneOrGeneProduct denotes beta1-integrin
T21 1285-1298 GeneOrGeneProduct denotes laminin alpha
T22 1318-1325 GeneOrGeneProduct denotes reduced
T23 1482-1492 GeneOrGeneProduct denotes dystrophin
T24 1523-1542 GeneOrGeneProduct denotes structural proteins
T25 1579-1592 GeneOrGeneProduct denotes extracellular
T26 1593-1599 GeneOrGeneProduct denotes matrix

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 14-21 GeneOrGeneProduct denotes induces
T2 38-48 GeneOrGeneProduct denotes dystrophin
T3 56-62 GeneOrGeneProduct denotes hearts
T4 131-138 GeneOrGeneProduct denotes induced
T5 150-156 GeneOrGeneProduct denotes damage
T6 160-167 GeneOrGeneProduct denotes unknown
T7 279-283 GeneOrGeneProduct denotes best
T8 557-567 GeneOrGeneProduct denotes dystrophin
T9 568-580 GeneOrGeneProduct denotes glycoprotein
T10 609-614 GeneOrGeneProduct denotes actin
T11 619-626 GeneOrGeneProduct denotes laminin
T12 656-669 GeneOrGeneProduct denotes extracellular
T13 670-676 GeneOrGeneProduct denotes matrix
T14 684-693 GeneOrGeneProduct denotes integrins
T15 706-711 GeneOrGeneProduct denotes tests
T16 807-816 GeneOrGeneProduct denotes integrins
T17 864-872 GeneOrGeneProduct denotes integrin
T18 960-970 GeneOrGeneProduct denotes dystrophin
T19 1029-1034 GeneOrGeneProduct denotes actin
T20 1077-1090 GeneOrGeneProduct denotes extracellular
T21 1091-1097 GeneOrGeneProduct denotes matrix
T22 1103-1119 GeneOrGeneProduct denotes sarcomeric actin
T23 1172-1182 GeneOrGeneProduct denotes dystrophin
T24 1204-1209 GeneOrGeneProduct denotes lysis
T25 1227-1244 GeneOrGeneProduct denotes gamma-sarcoglycan
T26 1246-1263 GeneOrGeneProduct denotes beta-dystroglycan
T27 1265-1279 GeneOrGeneProduct denotes beta1-integrin
T28 1285-1298 GeneOrGeneProduct denotes laminin alpha
T29 1318-1325 GeneOrGeneProduct denotes reduced
T30 1391-1398 GeneOrGeneProduct denotes process
T31 1482-1492 GeneOrGeneProduct denotes dystrophin
T32 1523-1542 GeneOrGeneProduct denotes structural proteins
T33 1579-1592 GeneOrGeneProduct denotes extracellular
T34 1593-1599 GeneOrGeneProduct denotes matrix
T35 1819-1826 GeneOrGeneProduct denotes induced

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 92-98 DiseaseOrPhenotypicFeature denotes injury D014947
T2 139-156 DiseaseOrPhenotypicFeature denotes myocardial damage DISEASE
T3 231-242 DiseaseOrPhenotypicFeature denotes hypotension D007022
T4 258-271 DiseaseOrPhenotypicFeature denotes hyperactivity DISEASE
T5 1675-1681 DiseaseOrPhenotypicFeature denotes injury D014947
T6 1812-1818 DiseaseOrPhenotypicFeature denotes injury D014947

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 38-48 GeneOrGeneProduct denotes dystrophin
T2 557-567 GeneOrGeneProduct denotes dystrophin
T3 568-580 GeneOrGeneProduct denotes glycoprotein
T4 609-614 GeneOrGeneProduct denotes actin
T5 619-626 GeneOrGeneProduct denotes laminin
T6 960-970 GeneOrGeneProduct denotes dystrophin
T7 1029-1034 GeneOrGeneProduct denotes actin
T8 1103-1119 GeneOrGeneProduct denotes sarcomeric actin
T9 1172-1182 GeneOrGeneProduct denotes dystrophin
T10 1204-1209 GeneOrGeneProduct denotes lysis
T11 1227-1244 GeneOrGeneProduct denotes gamma-sarcoglycan
T12 1246-1263 GeneOrGeneProduct denotes beta-dystroglycan
T13 1265-1279 GeneOrGeneProduct denotes beta1-integrin
T14 1285-1298 GeneOrGeneProduct denotes laminin alpha
T15 1482-1492 GeneOrGeneProduct denotes dystrophin
T16 1523-1542 GeneOrGeneProduct denotes structural proteins

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 92-98 DiseaseOrPhenotypicFeature denotes injury 0021178
T2 231-242 DiseaseOrPhenotypicFeature denotes hypotension 0005468
T3 837-848 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T4 983-992 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T5 1503-1512 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T6 1675-1681 DiseaseOrPhenotypicFeature denotes injury 0021178
T7 1812-1818 DiseaseOrPhenotypicFeature denotes injury 0021178

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 92-98 DiseaseOrPhenotypicFeature denotes injury D014947
T2 139-156 DiseaseOrPhenotypicFeature denotes myocardial damage DISEASE
T3 231-242 DiseaseOrPhenotypicFeature denotes hypotension D007022
T4 247-271 DiseaseOrPhenotypicFeature denotes myocardial hyperactivity DISEASE
T5 1675-1681 DiseaseOrPhenotypicFeature denotes injury D014947
T6 1812-1818 DiseaseOrPhenotypicFeature denotes injury D014947

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 81-98 DiseaseOrPhenotypicFeature denotes myocardial injury EisukeAdded
T2 139-156 DiseaseOrPhenotypicFeature denotes myocardial damage DISEASE
T3 231-242 DiseaseOrPhenotypicFeature denotes hypotension D007022
T4 247-271 DiseaseOrPhenotypicFeature denotes myocardial hyperactivity DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 52-55 OrganismTaxon denotes rat
T2 1450-1454 OrganismTaxon denotes rats

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-13 ChemicalEntity denotes Isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T3 117-130 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T5 187-193 ChemicalEntity denotes oxygen D010100|http://purl.obolibrary.org/obo/CHEBI_25805
T7 470-483 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T9 732-745 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T11 876-889 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T13 1433-1446 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317
T15 1830-1843 ChemicalEntity denotes isoproterenol D007545|http://purl.obolibrary.org/obo/CHEBI_64317

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T15 1830-1843 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T13 1433-1446 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T11 876-889 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T9 732-745 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T7 470-483 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T5 187-193 ChemicalEntity denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805|D010100
T3 117-130 ChemicalEntity denotes isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T1 0-13 ChemicalEntity denotes Isoproterenol http://purl.obolibrary.org/obo/CHEBI_64317|D007545
T16 1523-1542 GeneOrGeneProduct denotes structural proteins
T82103 1482-1492 GeneOrGeneProduct denotes dystrophin
T14 1285-1298 GeneOrGeneProduct denotes laminin alpha
T22746 1265-1279 GeneOrGeneProduct denotes beta1-integrin
T12 1246-1263 GeneOrGeneProduct denotes beta-dystroglycan
T14042 1227-1244 GeneOrGeneProduct denotes gamma-sarcoglycan
T10 1204-1209 GeneOrGeneProduct denotes lysis
T44373 1172-1182 GeneOrGeneProduct denotes dystrophin
T8 1103-1119 GeneOrGeneProduct denotes sarcomeric actin
T81670 1029-1034 GeneOrGeneProduct denotes actin
T6 960-970 GeneOrGeneProduct denotes dystrophin
T70806 619-626 GeneOrGeneProduct denotes laminin
T4 609-614 GeneOrGeneProduct denotes actin
T94763 568-580 GeneOrGeneProduct denotes glycoprotein
T2 557-567 GeneOrGeneProduct denotes dystrophin
T64157 38-48 GeneOrGeneProduct denotes dystrophin
T65200 247-271 DiseaseOrPhenotypicFeature denotes myocardial hyperactivity DISEASE
T28028 231-242 DiseaseOrPhenotypicFeature denotes hypotension D007022
T9687 139-156 DiseaseOrPhenotypicFeature denotes myocardial damage DISEASE
T35514 81-98 DiseaseOrPhenotypicFeature denotes myocardial injury EisukeAdded
T75347 1450-1454 OrganismTaxon denotes rats
T40800 52-55 OrganismTaxon denotes rat