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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 D006801 denotes Human
T2 6-10 PR:Q9ZRV4 denotes MLH1
T3 6-10 PR:P38920 denotes MLH1
T4 6-10 PR:Q54KD8 denotes MLH1
T6 6-10 PR:Q9JK91 denotes MLH1
T7 6-10 PR:P97679 denotes MLH1
T8 6-10 PR:Q9P7W6 denotes MLH1
T9 6-10 PR:000010442 denotes MLH1
T10 6-10 PR:P40692 denotes MLH1
T5 6-10 CVCL_G669 denotes MLH1
T11 6-18 D000070957 denotes MLH1 protein
T16 11-18 SO:0000104 denotes protein
T15 11-18 PR:000000001 denotes protein
T12 11-18 GO:0003675 denotes protein
T17 61-70 GO:0023052 denotes signaling
T20 86-89 SO:0000352 denotes DNA
T19 86-89 CHEBI:16991 denotes DNA
T21 86-89 D004247 denotes DNA
T18 86-89 GO:0005574 denotes DNA
T23 120-123 CHEBI:16768 denotes MSH
T27 120-123 D009074 denotes MSH
T28 120-123 D009074 denotes MSH
T29 120-124 PR:000010666 denotes MSH2
T30 120-124 PR:P25847 denotes MSH2
T31 120-124 PR:P43246 denotes MSH2
T32 120-124 P22711 denotes MSH2
T33 120-124 PR:P22711 denotes MSH2
T34 120-124 PR:P54275 denotes MSH2
T35 120-124 PR:O74773 denotes MSH2
T36 120-124 PR:P43247 denotes MSH2
T37 120-124 PR:Q553L4 denotes MSH2
T38 120-124 PR:O24617 denotes MSH2
T41 138-141 SO:0000352 denotes DNA
T40 138-141 CHEBI:16991 denotes DNA
T42 138-141 D004247 denotes DNA
T39 138-141 GO:0005574 denotes DNA
T43 138-148 GO:0006281 denotes DNA repair
T46 258-261 Q9C124 denotes ICL
T47 258-261 A8NR45 denotes ICL
T48 258-261 P28240 denotes ICL
T49 258-261 Q8RQN6 denotes ICL
T50 258-261 P28297 denotes ICL
T51 258-261 Q43097 denotes ICL
T52 258-261 PR:000022036 denotes ICL
T53 258-261 P9WKK7 denotes ICL
T54 258-261 P25248 denotes ICL
T55 258-261 P0A9G6 denotes ICL
T56 258-261 Q9I0K4 denotes ICL
T57 258-261 O07717 denotes ICL
T58 258-261 O94198 denotes ICL
T59 258-261 P49296 denotes ICL
T60 258-261 PR:P0A9G6 denotes ICL
T61 258-261 Q6T267 denotes ICL
T62 258-261 O13439 denotes ICL
T63 258-261 Q9K9H0 denotes ICL
T64 258-261 Q6Z6M4 denotes ICL
T65 258-261 P28299 denotes ICL
T66 258-261 Q86ZF1 denotes ICL
T67 258-261 P46831 denotes ICL
T68 258-261 P28467 denotes ICL
T69 258-261 Q96TP5 denotes ICL
T70 258-261 P17069 denotes ICL
T71 258-261 P20014 denotes ICL
T72 258-261 D4GTL3 denotes ICL
T73 258-261 L7HUY5 denotes ICL
T74 258-261 P42449 denotes ICL
T75 258-261 P0CT06 denotes ICL
T76 258-261 Q9P8Q7 denotes ICL
T77 258-261 Q8NJ72 denotes ICL
T78 258-261 P0A9G7 denotes ICL
T79 258-261 P49297 denotes ICL
T80 258-261 P41555 denotes ICL
T81 258-261 Q9HFN2 denotes ICL
T82 258-261 Q4HYR2 denotes ICL
T83 258-261 O50078 denotes ICL
T84 258-261 Q6FPK7 denotes ICL
T85 258-261 Q9SE26 denotes ICL
T86 258-261 P15479 denotes ICL
T87 258-261 O07718 denotes ICL
T88 258-261 P51066 denotes ICL
T89 258-261 Q96WZ5 denotes ICL
T90 258-261 P41554 denotes ICL
T91 258-261 PR:P28297 denotes ICL
T92 258-261 Q6BRY4 denotes ICL
T93 258-261 P20699 denotes ICL
T94 258-261 P93110 denotes ICL
T95 258-261 P28298 denotes ICL
T45 258-261 D018344 denotes ICL
T97 325-334 2555 denotes cisplatin
T96 325-334 CHEBI:27899 denotes cisplatin
T98 325-334 D002945 denotes cisplatin
T99 325-334 D002945 denotes cisplatin
T100 339-347 7456 denotes nitrogen
T103 339-356 CHEBI:37598 denotes nitrogen mustards
T104 348-356 D009149 denotes mustards
T105 390-398 D005363 denotes psoralen
T106 390-398 CHEBI:27616 denotes psoralen
T107 390-398 D005363 denotes psoralen
T108 438-447 D011565 denotes psoriasis
T109 438-447 D011565 denotes psoriasis
T110 492-497 D006801 denotes human
T111 498-504 SO:0001026 denotes genome
T113 561-564 CHEBI:16768 denotes MSH
T117 561-564 D009074 denotes MSH
T118 561-564 D009074 denotes MSH
T119 561-565 PR:000010666 denotes MSH2
T120 561-565 PR:P25847 denotes MSH2
T121 561-565 PR:P43246 denotes MSH2
T122 561-565 P22711 denotes MSH2
T123 561-565 PR:P22711 denotes MSH2
T124 561-565 PR:P54275 denotes MSH2
T125 561-565 PR:O74773 denotes MSH2
T126 561-565 PR:P43247 denotes MSH2
T127 561-565 PR:Q553L4 denotes MSH2
T128 561-565 PR:O24617 denotes MSH2
T129 593-598 D006801 denotes human
T130 695-703 D005363 denotes psoralen
T131 695-703 CHEBI:27616 denotes psoralen
T132 695-703 D005363 denotes psoralen
T133 731-735 PR:Q9ZRV4 denotes MLH1
T134 731-735 PR:P38920 denotes MLH1
T135 731-735 PR:Q54KD8 denotes MLH1
T137 731-735 PR:Q9JK91 denotes MLH1
T138 731-735 PR:P97679 denotes MLH1
T139 731-735 PR:Q9P7W6 denotes MLH1
T140 731-735 PR:000010442 denotes MLH1
T141 731-735 PR:P40692 denotes MLH1
T136 731-735 CVCL_G669 denotes MLH1
T142 759-764 D006801 denotes human
T143 765-769 PR:000023324 denotes MutL
T144 765-769 PR:Q93T05 denotes MutL
T145 765-769 PR:P23367 denotes MutL
T146 826-834 D005363 denotes psoralen
T147 826-834 CHEBI:27616 denotes psoralen
T148 826-834 D005363 denotes psoralen
T149 877-881 PR:Q9ZRV4 denotes MLH1
T150 877-881 PR:P38920 denotes MLH1
T151 877-881 PR:Q54KD8 denotes MLH1
T153 877-881 PR:Q9JK91 denotes MLH1
T154 877-881 PR:P97679 denotes MLH1
T155 877-881 PR:Q9P7W6 denotes MLH1
T156 877-881 PR:000010442 denotes MLH1
T157 877-881 PR:P40692 denotes MLH1
T152 877-881 CVCL_G669 denotes MLH1
T158 892-897 D006801 denotes human
T159 926-934 D005363 denotes psoralen
T160 926-934 CHEBI:27616 denotes psoralen
T161 926-934 D005363 denotes psoralen
T163 1002-1005 CHEBI:16768 denotes MSH
T167 1002-1005 D009074 denotes MSH
T168 1002-1005 D009074 denotes MSH
T169 1002-1006 PR:000010666 denotes MSH2
T170 1002-1006 PR:P25847 denotes MSH2
T171 1002-1006 PR:P43246 denotes MSH2
T172 1002-1006 P22711 denotes MSH2
T173 1002-1006 PR:P22711 denotes MSH2
T174 1002-1006 PR:P54275 denotes MSH2
T175 1002-1006 PR:O74773 denotes MSH2
T176 1002-1006 PR:P43247 denotes MSH2
T177 1002-1006 PR:Q553L4 denotes MSH2
T178 1002-1006 PR:O24617 denotes MSH2
T179 1068-1076 D005363 denotes psoralen
T180 1068-1076 CHEBI:27616 denotes psoralen
T181 1068-1076 D005363 denotes psoralen
T182 1085-1089 PR:Q9ZRV4 denotes MLH1
T183 1085-1089 PR:P38920 denotes MLH1
T184 1085-1089 PR:Q54KD8 denotes MLH1
T186 1085-1089 PR:Q9JK91 denotes MLH1
T187 1085-1089 PR:P97679 denotes MLH1
T188 1085-1089 PR:Q9P7W6 denotes MLH1
T189 1085-1089 PR:000010442 denotes MLH1
T190 1085-1089 PR:P40692 denotes MLH1
T185 1085-1089 CVCL_G669 denotes MLH1
T191 1112-1116 PR:Q9ZRV4 denotes MLH1
T192 1112-1116 PR:P38920 denotes MLH1
T193 1112-1116 PR:Q54KD8 denotes MLH1
T195 1112-1116 PR:Q9JK91 denotes MLH1
T196 1112-1116 PR:P97679 denotes MLH1
T197 1112-1116 PR:Q9P7W6 denotes MLH1
T198 1112-1116 PR:000010442 denotes MLH1
T199 1112-1116 PR:P40692 denotes MLH1
T194 1112-1116 CVCL_G669 denotes MLH1
T202 1151-1160 P55866 denotes caspase-3
T203 1151-1160 Q8MJC3 denotes caspase-3
T204 1151-1160 Q2PFV2 denotes caspase-3
T205 1151-1160 Q08DY9 denotes caspase-3
T206 1151-1160 Q5IS54 denotes caspase-3
T207 1151-1160 Q8MKI5 denotes caspase-3
T208 1151-1160 PR:000002312 denotes caspase-3
T209 1151-1160 Q8MJU1 denotes caspase-3
T210 1151-1160 Q60431 denotes caspase-3
T211 1151-1160 P42574 denotes caspase-3
T212 1151-1160 Q5IS99 denotes caspase-3
T213 1151-1160 Q95ND5 denotes caspase-3
T214 1151-1160 P70677 denotes caspase-3
T215 1151-1160 P55213 denotes caspase-3
T201 1151-1160 D053148 denotes caspase-3
T216 1176-1183 SO:0100018 denotes binding
T217 1176-1183 SO:0001091 denotes binding
T218 1176-1183 GO:0005488 denotes binding
T220 1187-1196 P17153 denotes annexin V
T221 1187-1196 Q5R1W0 denotes annexin V
T222 1187-1196 P81287 denotes annexin V
T223 1187-1196 P14668 denotes annexin V
T224 1187-1196 P70075 denotes annexin V
T225 1187-1196 Q4R4H7 denotes annexin V
T226 1187-1196 PR:000004078 denotes annexin V
T227 1187-1196 P48036 denotes annexin V
T228 1187-1196 P08758 denotes annexin V
T229 1187-1196 D017304 denotes annexin V
T235 1210-1214 PR:O96017 denotes CHK2
T236 1210-1214 PR:000005418 denotes CHK2
T237 1210-1214 PR:Q9Z265 denotes CHK2
T238 1210-1214 PR:Q9U1Y5 denotes CHK2
T239 1215-1230 GO:0016310 denotes phosphorylation
T240 1251-1255 PR:Q9ZRV4 denotes MLH1
T241 1251-1255 PR:P38920 denotes MLH1
T242 1251-1255 PR:Q54KD8 denotes MLH1
T244 1251-1255 PR:Q9JK91 denotes MLH1
T245 1251-1255 PR:P97679 denotes MLH1
T246 1251-1255 PR:Q9P7W6 denotes MLH1
T247 1251-1255 PR:000010442 denotes MLH1
T248 1251-1255 PR:P40692 denotes MLH1
T243 1251-1255 CVCL_G669 denotes MLH1
T249 1277-1292 GO:0016310 denotes phosphorylation
T255 1296-1300 PR:O35280 denotes CHK1
T256 1296-1300 PR:000005417 denotes CHK1
T257 1296-1300 PR:Q8AYC9 denotes CHK1
T258 1296-1300 PR:P38147 denotes CHK1
T259 1296-1300 PR:Q9N3Z3 denotes CHK1
T260 1296-1300 PR:P34208 denotes CHK1
T261 1296-1300 PR:Q5AHA0 denotes CHK1
T262 1296-1300 PR:O14757 denotes CHK1
T263 1296-1300 PR:Q91ZN7 denotes CHK1
T264 1351-1355 PR:Q9ZRV4 denotes MLH1
T265 1351-1355 PR:P38920 denotes MLH1
T266 1351-1355 PR:Q54KD8 denotes MLH1
T268 1351-1355 PR:Q9JK91 denotes MLH1
T269 1351-1355 PR:P97679 denotes MLH1
T270 1351-1355 PR:Q9P7W6 denotes MLH1
T271 1351-1355 PR:000010442 denotes MLH1
T272 1351-1355 PR:P40692 denotes MLH1
T267 1351-1355 CVCL_G669 denotes MLH1
T273 1371-1380 GO:0023052 denotes signaling
T274 1381-1389 D005363 denotes psoralen
T275 1381-1389 CHEBI:27616 denotes psoralen
T276 1381-1389 D005363 denotes psoralen
T278 1390-1393 Q9C124 denotes ICL
T279 1390-1393 A8NR45 denotes ICL
T280 1390-1393 P28240 denotes ICL
T281 1390-1393 Q8RQN6 denotes ICL
T282 1390-1393 P28297 denotes ICL
T283 1390-1393 Q43097 denotes ICL
T284 1390-1393 PR:000022036 denotes ICL
T285 1390-1393 P9WKK7 denotes ICL
T286 1390-1393 P25248 denotes ICL
T287 1390-1393 P0A9G6 denotes ICL
T288 1390-1393 Q9I0K4 denotes ICL
T289 1390-1393 O07717 denotes ICL
T290 1390-1393 O94198 denotes ICL
T291 1390-1393 P49296 denotes ICL
T292 1390-1393 PR:P0A9G6 denotes ICL
T293 1390-1393 Q6T267 denotes ICL
T294 1390-1393 O13439 denotes ICL
T295 1390-1393 Q9K9H0 denotes ICL
T296 1390-1393 Q6Z6M4 denotes ICL
T297 1390-1393 P28299 denotes ICL
T298 1390-1393 Q86ZF1 denotes ICL
T299 1390-1393 P46831 denotes ICL
T300 1390-1393 P28467 denotes ICL
T301 1390-1393 Q96TP5 denotes ICL
T302 1390-1393 P17069 denotes ICL
T303 1390-1393 P20014 denotes ICL
T304 1390-1393 D4GTL3 denotes ICL
T305 1390-1393 L7HUY5 denotes ICL
T306 1390-1393 P42449 denotes ICL
T307 1390-1393 P0CT06 denotes ICL
T308 1390-1393 Q9P8Q7 denotes ICL
T309 1390-1393 Q8NJ72 denotes ICL
T310 1390-1393 P0A9G7 denotes ICL
T311 1390-1393 P49297 denotes ICL
T312 1390-1393 P41555 denotes ICL
T313 1390-1393 Q9HFN2 denotes ICL
T314 1390-1393 Q4HYR2 denotes ICL
T315 1390-1393 O50078 denotes ICL
T316 1390-1393 Q6FPK7 denotes ICL
T317 1390-1393 Q9SE26 denotes ICL
T318 1390-1393 P15479 denotes ICL
T319 1390-1393 O07718 denotes ICL
T320 1390-1393 P51066 denotes ICL
T321 1390-1393 Q96WZ5 denotes ICL
T322 1390-1393 P41554 denotes ICL
T323 1390-1393 PR:P28297 denotes ICL
T324 1390-1393 Q6BRY4 denotes ICL
T325 1390-1393 P20699 denotes ICL
T326 1390-1393 P93110 denotes ICL
T327 1390-1393 P28298 denotes ICL
T277 1390-1393 D018344 denotes ICL
T328 1425-1433 D005363 denotes Psoralen
T329 1425-1433 CHEBI:27616 denotes Psoralen
T330 1425-1433 D005363 denotes Psoralen
T331 1500-1504 PR:Q9ZRV4 denotes MLH1
T332 1500-1504 PR:P38920 denotes MLH1
T333 1500-1504 PR:Q54KD8 denotes MLH1
T335 1500-1504 PR:Q9JK91 denotes MLH1
T336 1500-1504 PR:P97679 denotes MLH1
T337 1500-1504 PR:Q9P7W6 denotes MLH1
T338 1500-1504 PR:000010442 denotes MLH1
T339 1500-1504 PR:P40692 denotes MLH1
T334 1500-1504 CVCL_G669 denotes MLH1
T340 1585-1594 GO:0023052 denotes signaling
T341 1642-1659 D042822 denotes genomic stability
T342 1642-1659 D042822 denotes genomic stability
T344 1682-1685 Q9C124 denotes ICL
T345 1682-1685 A8NR45 denotes ICL
T346 1682-1685 P28240 denotes ICL
T347 1682-1685 Q8RQN6 denotes ICL
T348 1682-1685 P28297 denotes ICL
T349 1682-1685 Q43097 denotes ICL
T350 1682-1685 PR:000022036 denotes ICL
T351 1682-1685 P9WKK7 denotes ICL
T352 1682-1685 P25248 denotes ICL
T353 1682-1685 P0A9G6 denotes ICL
T354 1682-1685 Q9I0K4 denotes ICL
T355 1682-1685 O07717 denotes ICL
T356 1682-1685 O94198 denotes ICL
T357 1682-1685 P49296 denotes ICL
T358 1682-1685 PR:P0A9G6 denotes ICL
T359 1682-1685 Q6T267 denotes ICL
T360 1682-1685 O13439 denotes ICL
T361 1682-1685 Q9K9H0 denotes ICL
T362 1682-1685 Q6Z6M4 denotes ICL
T363 1682-1685 P28299 denotes ICL
T364 1682-1685 Q86ZF1 denotes ICL
T365 1682-1685 P46831 denotes ICL
T366 1682-1685 P28467 denotes ICL
T367 1682-1685 Q96TP5 denotes ICL
T368 1682-1685 P17069 denotes ICL
T369 1682-1685 P20014 denotes ICL
T370 1682-1685 D4GTL3 denotes ICL
T371 1682-1685 L7HUY5 denotes ICL
T372 1682-1685 P42449 denotes ICL
T373 1682-1685 P0CT06 denotes ICL
T374 1682-1685 Q9P8Q7 denotes ICL
T375 1682-1685 Q8NJ72 denotes ICL
T376 1682-1685 P0A9G7 denotes ICL
T377 1682-1685 P49297 denotes ICL
T378 1682-1685 P41555 denotes ICL
T379 1682-1685 Q9HFN2 denotes ICL
T380 1682-1685 Q4HYR2 denotes ICL
T381 1682-1685 O50078 denotes ICL
T382 1682-1685 Q6FPK7 denotes ICL
T383 1682-1685 Q9SE26 denotes ICL
T384 1682-1685 P15479 denotes ICL
T385 1682-1685 O07718 denotes ICL
T386 1682-1685 P51066 denotes ICL
T387 1682-1685 Q96WZ5 denotes ICL
T388 1682-1685 P41554 denotes ICL
T389 1682-1685 PR:P28297 denotes ICL
T390 1682-1685 Q6BRY4 denotes ICL
T391 1682-1685 P20699 denotes ICL
T392 1682-1685 P93110 denotes ICL
T393 1682-1685 P28298 denotes ICL
T343 1682-1685 D018344 denotes ICL
T394 1694-1697 GO:0005574 denotes DNA
T396 1694-1697 SO:0000352 denotes DNA
T395 1694-1697 CHEBI:16991 denotes DNA
T397 1694-1697 D004247 denotes DNA
T400 1743-1746 P22897 denotes MMR
T401 1743-1746 PR:000002972 denotes MMR
T402 1743-1746 Q61830 denotes MMR
T399 1743-1746 CVCL_E779 denotes MMR
T398 1743-1746 GO:0006298 denotes MMR
T403 1757-1763 D009369 denotes tumors
T404 1757-1763 D009369 denotes tumors
T406 1767-1770 CHEBI:16768 denotes MSH
T410 1767-1770 D009074 denotes MSH
T411 1767-1770 D009074 denotes MSH
T412 1767-1771 PR:000010666 denotes MSH2
T413 1767-1771 PR:P25847 denotes MSH2
T414 1767-1771 PR:P43246 denotes MSH2
T415 1767-1771 P22711 denotes MSH2
T416 1767-1771 PR:P22711 denotes MSH2
T417 1767-1771 PR:P54275 denotes MSH2
T418 1767-1771 PR:O74773 denotes MSH2
T419 1767-1771 PR:P43247 denotes MSH2
T420 1767-1771 PR:Q553L4 denotes MSH2
T421 1767-1771 PR:O24617 denotes MSH2
T422 1785-1789 PR:Q9ZRV4 denotes MLH1
T423 1785-1789 PR:P38920 denotes MLH1
T424 1785-1789 PR:Q54KD8 denotes MLH1
T426 1785-1789 PR:Q9JK91 denotes MLH1
T427 1785-1789 PR:P97679 denotes MLH1
T428 1785-1789 PR:Q9P7W6 denotes MLH1
T429 1785-1789 PR:000010442 denotes MLH1
T430 1785-1789 PR:P40692 denotes MLH1
T425 1785-1789 CVCL_G669 denotes MLH1
T431 1875-1883 D005363 denotes psoralen
T432 1875-1883 CHEBI:27616 denotes psoralen
T433 1875-1883 D005363 denotes psoralen
T435 1907-1910 Q9C124 denotes ICL
T436 1907-1910 A8NR45 denotes ICL
T437 1907-1910 P28240 denotes ICL
T438 1907-1910 Q8RQN6 denotes ICL
T439 1907-1910 P28297 denotes ICL
T440 1907-1910 Q43097 denotes ICL
T441 1907-1910 PR:000022036 denotes ICL
T442 1907-1910 P9WKK7 denotes ICL
T443 1907-1910 P25248 denotes ICL
T444 1907-1910 P0A9G6 denotes ICL
T445 1907-1910 Q9I0K4 denotes ICL
T446 1907-1910 O07717 denotes ICL
T447 1907-1910 O94198 denotes ICL
T448 1907-1910 P49296 denotes ICL
T449 1907-1910 PR:P0A9G6 denotes ICL
T450 1907-1910 Q6T267 denotes ICL
T451 1907-1910 O13439 denotes ICL
T452 1907-1910 Q9K9H0 denotes ICL
T453 1907-1910 Q6Z6M4 denotes ICL
T454 1907-1910 P28299 denotes ICL
T455 1907-1910 Q86ZF1 denotes ICL
T456 1907-1910 P46831 denotes ICL
T457 1907-1910 P28467 denotes ICL
T458 1907-1910 Q96TP5 denotes ICL
T459 1907-1910 P17069 denotes ICL
T460 1907-1910 P20014 denotes ICL
T461 1907-1910 D4GTL3 denotes ICL
T462 1907-1910 L7HUY5 denotes ICL
T463 1907-1910 P42449 denotes ICL
T464 1907-1910 P0CT06 denotes ICL
T465 1907-1910 Q9P8Q7 denotes ICL
T466 1907-1910 Q8NJ72 denotes ICL
T467 1907-1910 P0A9G7 denotes ICL
T468 1907-1910 P49297 denotes ICL
T469 1907-1910 P41555 denotes ICL
T470 1907-1910 Q9HFN2 denotes ICL
T471 1907-1910 Q4HYR2 denotes ICL
T472 1907-1910 O50078 denotes ICL
T473 1907-1910 Q6FPK7 denotes ICL
T474 1907-1910 Q9SE26 denotes ICL
T475 1907-1910 P15479 denotes ICL
T476 1907-1910 O07718 denotes ICL
T477 1907-1910 P51066 denotes ICL
T478 1907-1910 Q96WZ5 denotes ICL
T479 1907-1910 P41554 denotes ICL
T480 1907-1910 PR:P28297 denotes ICL
T481 1907-1910 Q6BRY4 denotes ICL
T482 1907-1910 P20699 denotes ICL
T483 1907-1910 P93110 denotes ICL
T484 1907-1910 P28298 denotes ICL
T434 1907-1910 D018344 denotes ICL

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 258-261 DiseaseOrPhenotypicFeature denotes ICL 0014226
T2 438-447 DiseaseOrPhenotypicFeature denotes psoriasis 0005083
T3 960-971 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T4 1390-1393 DiseaseOrPhenotypicFeature denotes ICL 0014226
T5 1439-1442 DiseaseOrPhenotypicFeature denotes can 0012833
T6 1682-1685 DiseaseOrPhenotypicFeature denotes ICL 0014226
T7 1907-1910 DiseaseOrPhenotypicFeature denotes ICL 0014226

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-149 DRI_Approach denotes Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.
T2 150-235 DRI_Approach denotes DNA interstrand crosslinks (ICLs) are among the most toxic types of damage to a cell.
T3 236-311 DRI_Approach denotes For this reason, many ICL-inducing agents are effective therapeutic agents.
T4 312-448 DRI_Background denotes For example, cisplatin and nitrogen mustards are used for treating cancer and psoralen plus UVA (PUVA) is useful for treating psoriasis.
T5 449-529 DRI_Background denotes However, repair mechanisms for ICLs in the human genome are not clearly defined.
T6 530-709 DRI_Outcome denotes Previously, we have shown that MSH2, the common subunit of the human MutSalpha and MutSbeta mismatch recognition complexes, plays a role in the error-free repair of psoralen ICLs.
T7 710-840 DRI_Background denotes We hypothesized that MLH1, the common subunit of human MutL complexes, is also involved in the cellular response to psoralen ICLs.
T8 841-1023 DRI_Outcome denotes Surprisingly, we instead found that MLH1-deficient human cells are more resistant to psoralen ICLs, in contrast to the sensitivity to these lesions displayed by MSH2-deficient cells.
T9 1024-1424 DRI_Background denotes Apoptosis was not as efficiently induced by psoralen ICLs in MLH1-deficient cells as in MLH1-proficient cells as determined by caspase-3/7 activity and binding of annexin V. Strikingly, CHK2 phosphorylation was undetectable in MLH1-deficient cells, and phosphorylation of CHK1 was reduced after PUVA treatment, indicating that MLH1 is involved in signaling psoralen ICL-induced checkpoint activation.
T10 1425-1705 DRI_Background denotes Psoralen ICLs can result in mutations near the crosslinked sites; however, MLH1 function was not required for the mutagenic repair of these lesions, and so its signaling function appears to have a role in maintaining genomic stability following exposure to ICL-induced DNA damage.
T11 1706-1927 DRI_Challenge denotes Distinguishing the genetic status of MMR-deficient tumors as MSH2-deficient or MLH1-deficient is thus potentially important in predicting the efficacy of treatment with psoralen and perhaps with other ICL-inducing agents.