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c_corpus

Id Subject Object Predicate Lexical cue
T3 7-31 D002285 denotes ductal carcinoma in situ
T4 7-31 D002285 denotes ductal carcinoma in situ
T9 56-77 GO:0012501 denotes programmed cell death
T12 86-90 CVCL_5552 denotes DCIS
T11 86-90 D002285 denotes DCIS
T13 86-90 D002285 denotes DCIS
T14 130-136 UBERON:0000310 denotes breast
T15 137-146 D009369 denotes neoplasia
T16 137-146 D009369 denotes neoplasia
T17 182-202 GO:0006915 denotes apoptotic cell death
T20 250-254 CVCL_5552 denotes DCIS
T19 250-254 D002285 denotes DCIS
T21 250-254 D002285 denotes DCIS
T22 299-308 GO:0097194 denotes apoptosis
T23 299-308 GO:0006915 denotes apoptosis
T25 319-323 CVCL_5552 denotes DCIS
T24 319-323 D002285 denotes DCIS
T26 319-323 D002285 denotes DCIS
T28 361-365 CVCL_5552 denotes DCIS
T27 361-365 D002285 denotes DCIS
T29 361-365 D002285 denotes DCIS
T31 402-406 CVCL_5552 denotes DCIS
T30 402-406 D002285 denotes DCIS
T32 402-406 D002285 denotes DCIS
T35 425-438 CVCL_5552 denotes MCF10DCIS.com
T36 430-434 D002285 denotes DCIS
T38 430-434 D002285 denotes DCIS
T40 435-438 CHEBI:17905 denotes com
T41 439-444 D006801 denotes human
T42 445-451 UBERON:0000310 denotes breast
T43 445-458 D001943 denotes breast cancer
T44 445-458 D001943 denotes breast cancer
T46 506-510 CVCL_5552 denotes DCIS
T45 506-510 D002285 denotes DCIS
T47 506-510 D002285 denotes DCIS
T48 536-543 D010634 denotes luminal
T49 536-543 D010634 denotes luminal
T50 536-543 CHEBI:8069 denotes luminal
T51 619-623 PR:P35875 denotes PARP
T52 619-623 P08469 denotes PARP
T53 619-623 P35875 denotes PARP
T54 619-623 Q11208 denotes PARP
T55 619-623 P14043 denotes PARP
T57 619-623 P55057 denotes PARP
T56 619-623 CHEBI:62913 denotes PARP
T58 624-632 GO:0019815 denotes antibody
T59 624-632 GO:0042571 denotes antibody
T60 624-632 GO:0019814 denotes antibody
T61 624-632 GO:0003823 denotes antibody
T62 637-647 GO:0008219 denotes cell death
T65 722-735 CVCL_5552 denotes MCF10DCIS.com
T66 727-731 D002285 denotes DCIS
T68 727-731 D002285 denotes DCIS
T70 732-735 CHEBI:17905 denotes com
T71 762-771 GO:0097194 denotes apoptosis
T72 762-771 GO:0006915 denotes apoptosis
T73 862-884 GO:0031966 denotes mitochondrial membrane
T74 876-884 UBERON:0000094 denotes membrane
T76 876-884 UBERON:0000158 denotes membrane
T78 911-914 PR:000035019 denotes Bax
T79 911-914 PR:Q07813 denotes Bax
T80 911-914 PR:P27297 denotes Bax
T81 911-914 PR:Q07812 denotes Bax
T82 911-914 PR:Q63690 denotes Bax
T83 911-914 PR:000002193 denotes Bax
T77 911-914 CVCL_N585 denotes Bax
T85 915-920 PR:P49950 denotes Bcl-2
T86 915-920 PR:000002307 denotes Bcl-2
T87 915-920 PR:P10417 denotes Bcl-2
T88 915-920 PR:Q00709 denotes Bcl-2
T89 915-920 PR:P10415 denotes Bcl-2
T84 915-920 GO:0015283 denotes Bcl-2
T92 942-951 D053453 denotes caspase-9
T91 942-951 PR:000002318 denotes caspase-9
T93 942-951 Q8C3Q9 denotes caspase-9
T94 942-951 P55211 denotes caspase-9
T95 962-965 PR:P04637 denotes p53
T96 962-965 PR:000003035 denotes p53
T97 962-965 PR:P02340 denotes p53
T98 962-965 PR:Q42578 denotes p53
T99 962-965 PR:P10361 denotes p53
T100 978-985 CHEBI:34922 denotes pathway
T101 1006-1015 GO:0097194 denotes apoptosis
T102 1006-1015 GO:0006915 denotes apoptosis
T103 1084-1093 GO:0097194 denotes apoptosis
T104 1084-1093 GO:0006915 denotes apoptosis
T105 1123-1127 PR:P35875 denotes PARP
T106 1123-1127 P08469 denotes PARP
T107 1123-1127 P35875 denotes PARP
T108 1123-1127 Q11208 denotes PARP
T109 1123-1127 P14043 denotes PARP
T111 1123-1127 P55057 denotes PARP
T110 1123-1127 CHEBI:62913 denotes PARP
T112 1128-1136 GO:0019815 denotes antibody
T113 1128-1136 GO:0042571 denotes antibody
T114 1128-1136 GO:0019814 denotes antibody
T115 1128-1136 GO:0003823 denotes antibody
T116 1163-1172 GO:0097194 denotes apoptosis
T117 1163-1172 GO:0006915 denotes apoptosis
T119 1214-1218 CVCL_5552 denotes DCIS
T118 1214-1218 D002285 denotes DCIS
T120 1214-1218 D002285 denotes DCIS
T122 1243-1247 CVCL_5552 denotes DCIS
T121 1243-1247 D002285 denotes DCIS
T123 1243-1247 D002285 denotes DCIS
T126 1260-1273 CVCL_5552 denotes MCF10DCIS.com
T127 1265-1269 D002285 denotes DCIS
T129 1265-1269 D002285 denotes DCIS
T131 1270-1273 CHEBI:17905 denotes com
T132 1304-1307 CHEBI:340824 denotes MMP
T135 1304-1307 CHEBI:59761 denotes MMP
T136 1304-1309 PR:P08253 denotes MMP-2
T137 1304-1309 Q9GLE5 denotes MMP-2
T138 1304-1309 P08253 denotes MMP-2
T139 1304-1309 Q90611 denotes MMP-2
T141 1304-1309 PR:Q8MPP3 denotes MMP-2
T142 1304-1309 P33436 denotes MMP-2
T143 1304-1309 PR:Q90611 denotes MMP-2
T144 1304-1309 PR:P33436 denotes MMP-2
T145 1304-1309 PR:000010479 denotes MMP-2
T146 1304-1309 PR:P33434 denotes MMP-2
T147 1304-1309 P33434 denotes MMP-2
T148 1304-1309 P50757 denotes MMP-2
T140 1304-1309 GO:0004228 denotes MMP-2
T149 1308-1314 PR:O04529 denotes 2, MMP
T150 1311-1314 CHEBI:340824 denotes MMP
T153 1311-1314 CHEBI:59761 denotes MMP
T154 1311-1316 P28863 denotes MMP-3
T155 1311-1316 P08254 denotes MMP-3
T156 1311-1316 Q28397 denotes MMP-3
T157 1311-1316 PR:P08254 denotes MMP-3
T158 1311-1316 PR:P03957 denotes MMP-3
T159 1311-1316 Q6Y4Q5 denotes MMP-3
T160 1311-1316 P28862 denotes MMP-3
T162 1311-1316 PR:000010488 denotes MMP-3
T163 1311-1316 PR:P28862 denotes MMP-3
T164 1311-1316 P03957 denotes MMP-3
T161 1311-1316 GO:0004248 denotes MMP-3
T165 1315-1321 PR:Q5XF51 denotes 3, MMP
T166 1318-1321 CHEBI:340824 denotes MMP
T169 1318-1321 CHEBI:59761 denotes MMP
T170 1318-1323 PR:P50282 denotes MMP-9
T171 1318-1323 PR:P14780 denotes MMP-9
T172 1318-1323 P14780 denotes MMP-9
T173 1318-1323 PR:P41245 denotes MMP-9
T174 1318-1323 P41246 denotes MMP-9
T175 1318-1323 P41245 denotes MMP-9
T176 1318-1323 PR:P52176 denotes MMP-9
T177 1318-1323 P50282 denotes MMP-9
T179 1318-1323 PR:000010491 denotes MMP-9
T180 1318-1323 P52176 denotes MMP-9
T181 1318-1323 O18733 denotes MMP-9
T178 1318-1323 GO:0004229 denotes MMP-9
T182 1328-1331 CHEBI:340824 denotes MMP
T185 1328-1331 CHEBI:59761 denotes MMP
T186 1328-1334 Q499S5 denotes MMP-11
T187 1328-1334 Q11005 denotes MMP-11
T188 1328-1334 PR:P24347 denotes MMP-11
T189 1328-1334 P24347 denotes MMP-11
T190 1328-1334 PR:Q499S5 denotes MMP-11
T191 1328-1334 PR:000010471 denotes MMP-11
T192 1328-1334 PR:Q02853 denotes MMP-11
T194 1328-1334 Q02853 denotes MMP-11
T193 1328-1334 GO:0004249 denotes MMP-11
T195 1355-1361 UBERON:0003891 denotes stroma
T197 1385-1389 CVCL_5552 denotes DCIS
T196 1385-1389 D002285 denotes DCIS
T198 1385-1389 D002285 denotes DCIS
T200 1428-1432 CVCL_5552 denotes DCIS
T199 1428-1432 D002285 denotes DCIS
T201 1428-1432 D002285 denotes DCIS
T204 1449-1462 CVCL_5552 denotes MCF10DCIS.com
T205 1454-1458 D002285 denotes DCIS
T207 1454-1458 D002285 denotes DCIS
T209 1459-1462 CHEBI:17905 denotes com
T210 1472-1479 4716 denotes Gelatin
T211 1472-1479 D005780 denotes Gelatin
T212 1472-1479 CHEBI:5291 denotes Gelatin
T213 1505-1508 CHEBI:340824 denotes MMP
T216 1505-1508 CHEBI:59761 denotes MMP
T217 1505-1510 PR:P08253 denotes MMP-2
T218 1505-1510 Q9GLE5 denotes MMP-2
T219 1505-1510 P08253 denotes MMP-2
T220 1505-1510 Q90611 denotes MMP-2
T222 1505-1510 PR:Q8MPP3 denotes MMP-2
T223 1505-1510 P33436 denotes MMP-2
T224 1505-1510 PR:Q90611 denotes MMP-2
T225 1505-1510 PR:P33436 denotes MMP-2
T226 1505-1510 PR:000010479 denotes MMP-2
T227 1505-1510 PR:P33434 denotes MMP-2
T228 1505-1510 P33434 denotes MMP-2
T229 1505-1510 P50757 denotes MMP-2
T221 1505-1510 GO:0004228 denotes MMP-2
T230 1533-1550 D017077 denotes conditioned media
T232 1554-1563 CVCL_5552 denotes MCF10DCIS
T233 1559-1563 D002285 denotes DCIS
T235 1559-1563 D002285 denotes DCIS
T236 1565-1568 CHEBI:17905 denotes com
T237 1586-1595 GO:0097194 denotes apoptosis
T238 1586-1595 GO:0006915 denotes apoptosis
T239 1679-1685 SO:0001073 denotes inside
T240 1724-1728 UBERON:0000025 denotes duct
T241 1724-1728 UBERON:0000058 denotes duct
T242 1755-1764 GO:0097194 denotes apoptosis
T243 1755-1764 GO:0006915 denotes apoptosis
T244 1786-1793 D010634 denotes luminal
T245 1786-1793 D010634 denotes luminal
T246 1786-1793 CHEBI:8069 denotes luminal
T247 1847-1856 GO:0097194 denotes apoptosis
T248 1847-1856 GO:0006915 denotes apoptosis
T250 1904-1908 CVCL_5552 denotes DCIS
T249 1904-1908 D002285 denotes DCIS
T251 1904-1908 D002285 denotes DCIS
T252 1942-1951 GO:0097194 denotes apoptosis
T253 1942-1951 GO:0006915 denotes apoptosis
T254 2090-2099 GO:0097194 denotes apoptosis
T255 2090-2099 GO:0006915 denotes apoptosis

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 7-31 DiseaseOrPhenotypicFeature denotes ductal carcinoma in situ 0005023
T2 86-90 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T3 137-146 DiseaseOrPhenotypicFeature denotes neoplasia 0005070
T4 250-254 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T5 319-323 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T6 361-365 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T7 402-406 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T8 445-458 DiseaseOrPhenotypicFeature denotes breast cancer 0004989|0007254
T10 506-510 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T11 1214-1218 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T12 1243-1247 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T13 1385-1389 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T14 1428-1432 DiseaseOrPhenotypicFeature denotes DCIS 0005023
T15 1904-1908 DiseaseOrPhenotypicFeature denotes DCIS 0005023

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-78 DRI_Background denotes Comedo-ductal carcinoma in situ: A paradoxical role for programmed cell death.
T2 79-264 DRI_Challenge denotes Comedo-DCIS is a histologic subtype of preinvasive breast neoplasia that is characterized by prominent apoptotic cell death and has greater malignant potential than other DCIS subtypes.
T3 265-385 DRI_Challenge denotes We investigated the mechanisms of apoptosis in comedo-DCIS and its role in conversion of comedo-DCIS to invasive cancer.
T4 386-525 DRI_Background denotes Clinical comedo-DCIS excisions and the MCF10DCIS.com human breast cancer model which produces lesions resembling comedo-DCIS were analyzed.
T5 526-721 DRI_Background denotes Apoptotic luminal and myoepithelial cells were identified by TUNEL and reactivity to cleaved PARP antibody and cell death assessed by Western blotting, Mitocapture and immunohistochemical assays.
T6 722-941 DRI_Background denotes MCF10DCIS.com cells undergo spontaneous apoptosis in vitro, both in monolayers and multicellular spheroids; it is associated with increased mitochondrial membrane permeability, increase in Bax/Bcl-2 ratio and occurs via
T7 942-977 Token_Label.OUTSIDE denotes caspase-9-dependent p53-independent
T8 978-986 DRI_Background denotes pathway.
T9 987-1094 DRI_Background denotes This suggests that apoptosis is stromal-independent and that the cells are programmed to undergo apoptosis.
T10 1095-1282 DRI_Outcome denotes Immunostaining with cleaved PARP antibody showed that myoepithelial apoptosis occurs before lesions progress to comedo-DCIS in both clinical comedo-DCIS and in vivo MCF10DCIS.com lesions.
T11 1283-1471 DRI_Background denotes Intense staining for MMP-2, MMP-3, MMP-9 and MMP-11 was observed in the stroma and epithelia of solid DCIS lesions prior to conversion to comedo-DCIS in clinical and MCF10DCIS.com lesions.
T12 1472-1564 DRI_Unspecified denotes Gelatin zymography showed higher MMP-2 levels in lysates and conditioned media of MCF10DCIS.
T13 1565-1596 DRI_Unspecified denotes com cells undergoing apoptosis.
T14 1597-1811 DRI_Outcome denotes These data suggest that signals arising from the outside (microenvironmental) and inside (internal genetic alterations) of the duct act in concert to trigger apoptosis of myoepithelial and luminal epithelial cells.
T15 1812-1909 DRI_Outcome denotes Our findings implicate spontaneous apoptosis in both the etiology and progression of comedo-DCIS.
T16 1910-2100 DRI_Challenge denotes It is possible that spontaneous apoptosis facilitates elimination of cells thus permitting expansion and malignant transformation of cancer cells that are resistant to spontaneous apoptosis.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 79-264 DRI_Challenge denotes Comedo-DCIS is a histologic subtype of preinvasive breast neoplasia that is characterized by prominent apoptotic cell death and has greater malignant potential than other DCIS subtypes.
T2 265-385 DRI_Challenge denotes We investigated the mechanisms of apoptosis in comedo-DCIS and its role in conversion of comedo-DCIS to invasive cancer.
T3 386-525 DRI_Background denotes Clinical comedo-DCIS excisions and the MCF10DCIS.com human breast cancer model which produces lesions resembling comedo-DCIS were analyzed.
T4 526-721 DRI_Background denotes Apoptotic luminal and myoepithelial cells were identified by TUNEL and reactivity to cleaved PARP antibody and cell death assessed by Western blotting, Mitocapture and immunohistochemical assays.
T5 722-941 DRI_Background denotes MCF10DCIS.com cells undergo spontaneous apoptosis in vitro, both in monolayers and multicellular spheroids; it is associated with increased mitochondrial membrane permeability, increase in Bax/Bcl-2 ratio and occurs via
T6 978-986 DRI_Background denotes pathway.
T7 987-1094 DRI_Background denotes This suggests that apoptosis is stromal-independent and that the cells are programmed to undergo apoptosis.
T8 1095-1282 DRI_Outcome denotes Immunostaining with cleaved PARP antibody showed that myoepithelial apoptosis occurs before lesions progress to comedo-DCIS in both clinical comedo-DCIS and in vivo MCF10DCIS.com lesions.
T9 1283-1471 DRI_Background denotes Intense staining for MMP-2, MMP-3, MMP-9 and MMP-11 was observed in the stroma and epithelia of solid DCIS lesions prior to conversion to comedo-DCIS in clinical and MCF10DCIS.com lesions.
T10 1597-1811 DRI_Outcome denotes These data suggest that signals arising from the outside (microenvironmental) and inside (internal genetic alterations) of the duct act in concert to trigger apoptosis of myoepithelial and luminal epithelial cells.
T11 1812-1909 DRI_Outcome denotes Our findings implicate spontaneous apoptosis in both the etiology and progression of comedo-DCIS.
T12 1910-2100 DRI_Challenge denotes It is possible that spontaneous apoptosis facilitates elimination of cells thus permitting expansion and malignant transformation of cancer cells that are resistant to spontaneous apoptosis.