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PubMed:18779591 JSONTXT

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LitCoin-sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-107	Sentence	denotes	Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
T2	108-211	Sentence	denotes	There is currently no known genetic disease linked to prolactin (Prl) or its receptor (PrlR) in humans.
T3	212-422	Sentence	denotes	Given the essential role of this hormonal system in breast physiology, we reasoned that genetic anomalies of Prl/PrlR genes may be related to the occurrence of breast diseases with high proliferative potential.
T4	423-609	Sentence	denotes	Multiple fibroadenomas (MFA) are benign breast tumors which appear most frequently in young women, including at puberty, when Prl has well-recognized proliferative actions on the breast.
T5	610-862	Sentence	denotes	In a prospective study involving 74 MFA patients and 170 control subjects, we identified four patients harboring a heterozygous single nucleotide polymorphism in exon 6 of the PrlR gene, encoding Ile(146)-->Leu substitution in its extracellular domain.
T6	863-1323	Sentence	denotes	This sole substitution was sufficient to confer constitutive activity to the receptor variant (PrlR(I146L)), as assessed in three reconstituted cell models (Ba/F3, HEK293 and MCF-7 cells) by Prl-independent (i) PrlR tyrosine phosphorylation, (ii) activation of signal transducer and activator of transcription 5 (STAT5) signaling, (iii) transcriptional activity toward a Prl-responsive reporter gene, and (iv) cell proliferation and protection from cell death.
T7	1324-1440	Sentence	denotes	Constitutive activity of PrlR(I146L) in the breast sample from a patient was supported by increased STAT5 signaling.
T8	1441-1539	Sentence	denotes	This is a unique description of a functional mutation of the PrlR associated with a human disease.
T9	1540-1753	Sentence	denotes	Hallmarks of constitutive activity were all reversed by a specific PrlR antagonist, which opens potential therapeutic approaches for MFA, or any other disease that could be associated with this mutation in future.

LitCoin-entities-OrganismTaxon-PD

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	204-210	OrganismTaxon	denotes	humans	NCBItxid:9605
T2	1038-1041	OrganismTaxon	denotes	MCF	NCBItxid:11785
T3	1525-1530	OrganismTaxon	denotes	human	NCBItxid:9606

LitCoin-entities

Id	Subject	Object	Predicate	Lexical cue	db_id
5455	53-71	GeneOrGeneProduct	denotes	prolactin receptor	NCBIGene:5618
5456	75-80	OrganismTaxon	denotes	women	NCBITaxon:9606
5457	86-106	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	MESH:D001943
5458	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	MESH:D030342
5459	162-171	GeneOrGeneProduct	denotes	prolactin	NCBIGene:5617
5460	173-176	GeneOrGeneProduct	denotes	Prl	NCBIGene:5617
5461	195-199	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5462	204-210	OrganismTaxon	denotes	humans	NCBITaxon:9606
5463	321-324	GeneOrGeneProduct	denotes	Prl	NCBIGene:5617
5464	325-329	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5465	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	MESH:D001941
5466	423-445	DiseaseOrPhenotypicFeature	denotes	Multiple fibroadenomas	MESH:D018226
5467	447-450	DiseaseOrPhenotypicFeature	denotes	MFA	MESH:D018226
5468	456-476	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	MESH:D001943
5469	515-520	OrganismTaxon	denotes	women	NCBITaxon:9606
5470	549-552	GeneOrGeneProduct	denotes	Prl	NCBIGene:5617
5471	646-649	DiseaseOrPhenotypicFeature	denotes	MFA	MESH:D018226
5472	650-658	OrganismTaxon	denotes	patients	NCBITaxon:9606
5473	704-712	OrganismTaxon	denotes	patients	NCBITaxon:9606
5474	786-790	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5475	806-820	SequenceVariant	denotes	Ile(146)-->Leu	DBSNP:rs72478580
5476	958-962	GeneOrGeneProduct	denotes	PrlR	NCBIGene:19116
5477	963-968	SequenceVariant	denotes	I146L	DBSNP:rs72478580
5478	1020-1025	CellLine	denotes	Ba/F3	NCBITaxon:10090
5479	1027-1033	CellLine	denotes	HEK293	NCBITaxon:9606
5480	1038-1043	CellLine	denotes	MCF-7	NCBITaxon:9606
5481	1054-1057	GeneOrGeneProduct	denotes	Prl	NCBIGene:5617
5482	1074-1078	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5483	1124-1174	GeneOrGeneProduct	denotes	signal transducer and activator of transcription 5	NCBIGene:6776
5484	1176-1181	GeneOrGeneProduct	denotes	STAT5	NCBIGene:6776
5485	1234-1237	GeneOrGeneProduct	denotes	Prl	NCBIGene:5617
5486	1349-1353	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5487	1354-1359	SequenceVariant	denotes	I146L	DBSNP:rs72478580
5488	1389-1396	OrganismTaxon	denotes	patient	NCBITaxon:9606
5489	1424-1429	GeneOrGeneProduct	denotes	STAT5	NCBIGene:6776
5490	1502-1506	GeneOrGeneProduct	denotes	PrlR	NCBIGene:5618
5491	1525-1530	OrganismTaxon	denotes	human	NCBITaxon:9606
5492	1607-1622	ChemicalEntity	denotes	PrlR antagonist
5493	1673-1676	DiseaseOrPhenotypicFeature	denotes	MFA	MESH:D018226

LitCoin_Mondo

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	0002657

LitCoin-SeqVar

Id	Subject	Object	Predicate	Lexical cue
T1	963-968	SequenceVariant	denotes	I146L
T2	1354-1359	SequenceVariant	denotes	I146L

PMID_GLOBAL

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	86-106	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	0000620
T2	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	0003847
T3	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	0002657
T4	456-476	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	0000620

LitCoin-GeneOrGeneProduct-v0

Id	Subject	Object	Predicate	Lexical cue
T1	37-45	GeneOrGeneProduct	denotes	mutation
T2	53-71	GeneOrGeneProduct	denotes	prolactin receptor
T3	100-106	GeneOrGeneProduct	denotes	tumors
T4	152-158	GeneOrGeneProduct	denotes	linked
T5	162-171	GeneOrGeneProduct	denotes	prolactin
T6	173-176	GeneOrGeneProduct	denotes	Prl
T7	185-193	GeneOrGeneProduct	denotes	receptor
T8	195-199	GeneOrGeneProduct	denotes	PrlR
T9	245-253	GeneOrGeneProduct	denotes	hormonal
T10	321-324	GeneOrGeneProduct	denotes	Prl
T11	325-329	GeneOrGeneProduct	denotes	PrlR
T12	393-397	GeneOrGeneProduct	denotes	high
T13	423-431	GeneOrGeneProduct	denotes	Multiple
T14	470-476	GeneOrGeneProduct	denotes	tumors
T15	509-514	GeneOrGeneProduct	denotes	young
T16	549-552	GeneOrGeneProduct	denotes	Prl
T17	786-790	GeneOrGeneProduct	denotes	PrlR
T18	806-809	GeneOrGeneProduct	denotes	Ile
T19	841-854	GeneOrGeneProduct	denotes	extracellular
T20	940-948	GeneOrGeneProduct	denotes	receptor
T21	958-962	GeneOrGeneProduct	denotes	PrlR
T22	1007-1011	GeneOrGeneProduct	denotes	cell
T23	1044-1049	GeneOrGeneProduct	denotes	cells
T24	1054-1057	GeneOrGeneProduct	denotes	Prl
T25	1074-1078	GeneOrGeneProduct	denotes	PrlR
T26	1079-1087	GeneOrGeneProduct	denotes	tyrosine
T27	1106-1108	GeneOrGeneProduct	denotes	ii
T28	1110-1120	GeneOrGeneProduct	denotes	activation
T29	1124-1172	GeneOrGeneProduct	denotes	signal transducer and activator of transcription
T30	1176-1181	GeneOrGeneProduct	denotes	STAT5
T31	1195-1198	GeneOrGeneProduct	denotes	iii
T32	1200-1215	GeneOrGeneProduct	denotes	transcriptional
T33	1216-1224	GeneOrGeneProduct	denotes	activity
T34	1234-1237	GeneOrGeneProduct	denotes	Prl
T35	1258-1272	GeneOrGeneProduct	denotes	gene, and (iv)
T36	1273-1277	GeneOrGeneProduct	denotes	cell
T37	1312-1316	GeneOrGeneProduct	denotes	cell
T38	1337-1345	GeneOrGeneProduct	denotes	activity
T39	1349-1353	GeneOrGeneProduct	denotes	PrlR
T40	1424-1429	GeneOrGeneProduct	denotes	STAT5
T41	1486-1494	GeneOrGeneProduct	denotes	mutation
T42	1502-1506	GeneOrGeneProduct	denotes	PrlR
T43	1566-1574	GeneOrGeneProduct	denotes	activity
T44	1580-1583	GeneOrGeneProduct	denotes	all
T45	1607-1611	GeneOrGeneProduct	denotes	PrlR
T46	1612-1622	GeneOrGeneProduct	denotes	antagonist
T47	1630-1635	GeneOrGeneProduct	denotes	opens
T48	1685-1690	GeneOrGeneProduct	denotes	other
T49	1734-1742	GeneOrGeneProduct	denotes	mutation

LitCoin-GeneOrGeneProduct-v2

Id	Subject	Object	Predicate	Lexical cue
T1	53-71	GeneOrGeneProduct	denotes	prolactin receptor
T2	162-171	GeneOrGeneProduct	denotes	prolactin
T3	173-176	GeneOrGeneProduct	denotes	Prl
T4	185-193	GeneOrGeneProduct	denotes	receptor
T5	321-324	GeneOrGeneProduct	denotes	Prl
T6	393-397	GeneOrGeneProduct	denotes	high
T7	423-431	GeneOrGeneProduct	denotes	Multiple
T8	509-514	GeneOrGeneProduct	denotes	young
T9	549-552	GeneOrGeneProduct	denotes	Prl
T10	841-854	GeneOrGeneProduct	denotes	extracellular
T11	940-948	GeneOrGeneProduct	denotes	receptor
T12	1007-1011	GeneOrGeneProduct	denotes	cell
T13	1054-1057	GeneOrGeneProduct	denotes	Prl
T14	1079-1087	GeneOrGeneProduct	denotes	tyrosine
T15	1124-1172	GeneOrGeneProduct	denotes	signal transducer and activator of transcription
T16	1176-1181	GeneOrGeneProduct	denotes	STAT5
T17	1200-1215	GeneOrGeneProduct	denotes	transcriptional
T18	1234-1237	GeneOrGeneProduct	denotes	Prl
T19	1273-1277	GeneOrGeneProduct	denotes	cell
T20	1312-1316	GeneOrGeneProduct	denotes	cell
T21	1424-1429	GeneOrGeneProduct	denotes	STAT5
T22	1685-1690	GeneOrGeneProduct	denotes	other

LitCoin-NCBITaxon-2

Id	Subject	Object	Predicate	Lexical cue
T1	75-80	OrganismTaxon	denotes	women
T2	204-210	OrganismTaxon	denotes	humans
T3	515-520	OrganismTaxon	denotes	women
T4	650-658	OrganismTaxon	denotes	patients
T5	704-712	OrganismTaxon	denotes	patients
T6	868-872	OrganismTaxon	denotes	sole
T7	1038-1041	OrganismTaxon	denotes	MCF
T8	1389-1396	OrganismTaxon	denotes	patient
T9	1525-1530	OrganismTaxon	denotes	human

LitCoin-Disease-MeSH

Id	Subject	Object	Predicate	Lexical cue	originalLabel
T1	93-106	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T2	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	D030342
T3	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	D001941
T4	432-445	DiseaseOrPhenotypicFeature	denotes	fibroadenomas	D018226
T5	463-476	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T6	1317-1322	DiseaseOrPhenotypicFeature	denotes	death	D003643
T7	1531-1538	DiseaseOrPhenotypicFeature	denotes	disease	D004194
T8	1691-1698	DiseaseOrPhenotypicFeature	denotes	disease	D004194

LitCoin-GeneOrGeneProduct-v3

Id	Subject	Object	Predicate	Lexical cue
T1	53-71	GeneOrGeneProduct	denotes	prolactin receptor
T2	162-171	GeneOrGeneProduct	denotes	prolactin
T3	173-176	GeneOrGeneProduct	denotes	Prl
T4	321-324	GeneOrGeneProduct	denotes	Prl
T5	549-552	GeneOrGeneProduct	denotes	Prl
T6	911-948	GeneOrGeneProduct	denotes	constitutive activity to the receptor
T7	1054-1057	GeneOrGeneProduct	denotes	Prl
T8	1124-1172	GeneOrGeneProduct	denotes	signal transducer and activator of transcription
T9	1176-1181	GeneOrGeneProduct	denotes	STAT5
T10	1200-1224	GeneOrGeneProduct	denotes	transcriptional activity
T11	1234-1237	GeneOrGeneProduct	denotes	Prl
T12	1424-1429	GeneOrGeneProduct	denotes	STAT5

LitCoin_Mondo_095

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	86-106	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	0000620
T2	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	0003847
T3	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	0002657
T4	456-476	DiseaseOrPhenotypicFeature	denotes	benign breast tumors	0000620

LitCoin-MeSH-Disease-2

Id	Subject	Object	Predicate	Lexical cue	ID:
T1	93-106	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T2	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	D030342
T3	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	D001941
T4	432-445	DiseaseOrPhenotypicFeature	denotes	fibroadenomas	D018226
T5	447-450	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T6	463-476	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T7	646-649	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T8	1317-1322	DiseaseOrPhenotypicFeature	denotes	death	D003643
T9	1531-1538	DiseaseOrPhenotypicFeature	denotes	disease	D004194
T10	1673-1676	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T11	1691-1698	DiseaseOrPhenotypicFeature	denotes	disease	D004194

LitCoin_CellLine

Id	Subject	Object	Predicate	Lexical cue	cellosaurus_accession_id
T1	1020-1025	CellLine	denotes	Ba/F3	CVCL_0161
T2	1027-1033	CellLine	denotes	HEK293	CVCL_0045
T3	1038-1043	CellLine	denotes	MCF-7	CVCL_0031

LitCoin-MONDO_bioort2019

Id	Subject	Object	Predicate	Lexical cue	#label
T1	93-106	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T2	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	D030342
T3	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	D001941
T4	432-445	DiseaseOrPhenotypicFeature	denotes	fibroadenomas	D018226
T5	447-450	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T6	463-476	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T7	646-649	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T8	1673-1676	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id	Subject	Object	Predicate	Lexical cue	ID:
T1	53-62	ChemicalEntity	denotes	prolactin	http://purl.obolibrary.org/obo/CHEBI_81580
T2	162-171	ChemicalEntity	denotes	prolactin	http://purl.obolibrary.org/obo/CHEBI_81580
T3	173-176	ChemicalEntity	denotes	Prl	http://purl.obolibrary.org/obo/CHEBI_81580
T4	321-324	ChemicalEntity	denotes	Prl	http://purl.obolibrary.org/obo/CHEBI_81580
T5	549-552	ChemicalEntity	denotes	Prl	http://purl.obolibrary.org/obo/CHEBI_81580
T6	806-809	ChemicalEntity	denotes	Ile	http://purl.obolibrary.org/obo/CHEBI_30009|http://purl.obolibrary.org/obo/CHEBI_17191
T8	817-820	ChemicalEntity	denotes	Leu	http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T11	1054-1057	ChemicalEntity	denotes	Prl	http://purl.obolibrary.org/obo/CHEBI_81580
T12	1079-1087	ChemicalEntity	denotes	tyrosine	http://purl.obolibrary.org/obo/CHEBI_18186
T13	1234-1237	ChemicalEntity	denotes	Prl	http://purl.obolibrary.org/obo/CHEBI_81580
T14	1607-1622	ChemicalEntity	denotes	PrlR antagonist	ChemicalEntity

LitCoin-training-merged

Id	Subject	Object	Predicate	Lexical cue	#label	ID:	cellosaurus_accession_id
T3	1038-1043	CellLine	denotes	MCF-7			CVCL_0031
T2	1027-1033	CellLine	denotes	HEK293			CVCL_0045
T1	1020-1025	CellLine	denotes	Ba/F3			CVCL_0161
T14	1607-1622	ChemicalEntity	denotes	PrlR antagonist		ChemicalEntity
T13	1234-1237	ChemicalEntity	denotes	Prl		http://purl.obolibrary.org/obo/CHEBI_81580
T12	1079-1087	ChemicalEntity	denotes	tyrosine		http://purl.obolibrary.org/obo/CHEBI_18186
T11	1054-1057	ChemicalEntity	denotes	Prl		http://purl.obolibrary.org/obo/CHEBI_81580
T8	817-820	ChemicalEntity	denotes	Leu		http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T6	806-809	ChemicalEntity	denotes	Ile		http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T5	549-552	ChemicalEntity	denotes	Prl		http://purl.obolibrary.org/obo/CHEBI_81580
T4	321-324	ChemicalEntity	denotes	Prl		http://purl.obolibrary.org/obo/CHEBI_81580
T6129	173-176	ChemicalEntity	denotes	Prl		http://purl.obolibrary.org/obo/CHEBI_81580
T3459	162-171	ChemicalEntity	denotes	prolactin		http://purl.obolibrary.org/obo/CHEBI_81580
T97534	53-62	ChemicalEntity	denotes	prolactin		http://purl.obolibrary.org/obo/CHEBI_81580
T72538	1424-1429	GeneOrGeneProduct	denotes	STAT5
T50772	1234-1237	GeneOrGeneProduct	denotes	Prl
T10	1200-1224	GeneOrGeneProduct	denotes	transcriptional activity
T9	1176-1181	GeneOrGeneProduct	denotes	STAT5
T75079	1124-1172	GeneOrGeneProduct	denotes	signal transducer and activator of transcription
T7	1054-1057	GeneOrGeneProduct	denotes	Prl
T41115	911-948	GeneOrGeneProduct	denotes	constitutive activity to the receptor
T26523	549-552	GeneOrGeneProduct	denotes	Prl
T36435	321-324	GeneOrGeneProduct	denotes	Prl
T39008	173-176	GeneOrGeneProduct	denotes	Prl
T93667	162-171	GeneOrGeneProduct	denotes	prolactin
T33186	53-71	GeneOrGeneProduct	denotes	prolactin receptor
T64263	1673-1676	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T45518	646-649	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T20458	463-476	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T86886	447-450	DiseaseOrPhenotypicFeature	denotes	MFA	DISEASE
T98689	432-445	DiseaseOrPhenotypicFeature	denotes	fibroadenomas	D018226
T76528	372-387	DiseaseOrPhenotypicFeature	denotes	breast diseases	D001941
T88361	136-151	DiseaseOrPhenotypicFeature	denotes	genetic disease	D030342
T20916	93-106	DiseaseOrPhenotypicFeature	denotes	breast tumors	D001943
T17999	1525-1530	OrganismTaxon	denotes	human
T71866	1389-1396	OrganismTaxon	denotes	patient
T99306	1038-1041	OrganismTaxon	denotes	MCF
T94933	868-872	OrganismTaxon	denotes	sole
T50806	704-712	OrganismTaxon	denotes	patients
T80969	650-658	OrganismTaxon	denotes	patients
T24385	515-520	OrganismTaxon	denotes	women
T64960	204-210	OrganismTaxon	denotes	humans
T63002	75-80	OrganismTaxon	denotes	women
T9434	1354-1359	SequenceVariant	denotes	I146L
T73427	963-968	SequenceVariant	denotes	I146L

DisGeNET

Id	Subject	Object	Predicate	Lexical cue
T0	53-71	gene:5618	denotes	prolactin receptor
T1	86-106	disease:C0346156	denotes	benign breast tumors
T2	162-171	gene:5617	denotes	prolactin
T3	136-151	disease:C0019247	denotes	genetic disease
T4	173-176	gene:5617	denotes	Prl
T5	136-151	disease:C0019247	denotes	genetic disease
T6	325-329	gene:5618	denotes	PrlR
T7	372-387	disease:C0006145	denotes	breast diseases
T8	321-324	gene:5617	denotes	Prl
T9	372-387	disease:C0006145	denotes	breast diseases
T10	549-552	gene:5617	denotes	Prl
T11	456-476	disease:C0346156	denotes	benign breast tumors
R1	T0	T1	associated_with	prolactin receptor,benign breast tumors
R2	T2	T3	associated_with	prolactin,genetic disease
R3	T4	T5	associated_with	Prl,genetic disease
R4	T6	T7	associated_with	PrlR,breast diseases
R5	T8	T9	associated_with	Prl,breast diseases
R6	T10	T11	associated_with	Prl,benign breast tumors

DisGeNET5_gene_disease

Id	Subject	Object	Predicate	Lexical cue
18779591-0#53#71#gene5618	53-71	gene5618	denotes	prolactin receptor
18779591-0#86#106#diseaseC0346156	86-106	diseaseC0346156	denotes	benign breast tumors
18779591-2#109#112#gene5617	321-324	gene5617	denotes	Prl
18779591-2#113#117#gene5618	325-329	gene5618	denotes	PrlR
18779591-2#160#175#diseaseC0006145	372-387	diseaseC0006145	denotes	breast diseases
18779591-3#126#129#gene5617	549-552	gene5617	denotes	Prl
18779591-3#33#53#diseaseC0346156	456-476	diseaseC0346156	denotes	benign breast tumors
53#71#gene561886#106#diseaseC0346156	18779591-0#53#71#gene5618	18779591-0#86#106#diseaseC0346156	associated_with	prolactin receptor,benign breast tumors
109#112#gene5617160#175#diseaseC0006145	18779591-2#109#112#gene5617	18779591-2#160#175#diseaseC0006145	associated_with	Prl,breast diseases
113#117#gene5618160#175#diseaseC0006145	18779591-2#113#117#gene5618	18779591-2#160#175#diseaseC0006145	associated_with	PrlR,breast diseases
126#129#gene561733#53#diseaseC0346156	18779591-3#126#129#gene5617	18779591-3#33#53#diseaseC0346156	associated_with	Prl,benign breast tumors

tmVarCorpus

Id	Subject	Object	Predicate	Lexical cue
T1	806-820	ProteinMutation:p|SUB|I|146|L	denotes	Ile(146)-->Leu
T2	963-968	ProteinMutation:p|SUB|I|146|L	denotes	I146L
T3	1354-1359	ProteinMutation:p|SUB|I|146|L	denotes	I146L