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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.
T2 108-211 Sentence denotes There is currently no known genetic disease linked to prolactin (Prl) or its receptor (PrlR) in humans.
T3 212-422 Sentence denotes Given the essential role of this hormonal system in breast physiology, we reasoned that genetic anomalies of Prl/PrlR genes may be related to the occurrence of breast diseases with high proliferative potential.
T4 423-609 Sentence denotes Multiple fibroadenomas (MFA) are benign breast tumors which appear most frequently in young women, including at puberty, when Prl has well-recognized proliferative actions on the breast.
T5 610-862 Sentence denotes In a prospective study involving 74 MFA patients and 170 control subjects, we identified four patients harboring a heterozygous single nucleotide polymorphism in exon 6 of the PrlR gene, encoding Ile(146)-->Leu substitution in its extracellular domain.
T6 863-1323 Sentence denotes This sole substitution was sufficient to confer constitutive activity to the receptor variant (PrlR(I146L)), as assessed in three reconstituted cell models (Ba/F3, HEK293 and MCF-7 cells) by Prl-independent (i) PrlR tyrosine phosphorylation, (ii) activation of signal transducer and activator of transcription 5 (STAT5) signaling, (iii) transcriptional activity toward a Prl-responsive reporter gene, and (iv) cell proliferation and protection from cell death.
T7 1324-1440 Sentence denotes Constitutive activity of PrlR(I146L) in the breast sample from a patient was supported by increased STAT5 signaling.
T8 1441-1539 Sentence denotes This is a unique description of a functional mutation of the PrlR associated with a human disease.
T9 1540-1753 Sentence denotes Hallmarks of constitutive activity were all reversed by a specific PrlR antagonist, which opens potential therapeutic approaches for MFA, or any other disease that could be associated with this mutation in future.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 204-210 OrganismTaxon denotes humans NCBItxid:9605
T2 1038-1041 OrganismTaxon denotes MCF NCBItxid:11785
T3 1525-1530 OrganismTaxon denotes human NCBItxid:9606

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5455 53-71 GeneOrGeneProduct denotes prolactin receptor NCBIGene:5618
5456 75-80 OrganismTaxon denotes women NCBITaxon:9606
5457 86-106 DiseaseOrPhenotypicFeature denotes benign breast tumors MESH:D001943
5458 136-151 DiseaseOrPhenotypicFeature denotes genetic disease MESH:D030342
5459 162-171 GeneOrGeneProduct denotes prolactin NCBIGene:5617
5460 173-176 GeneOrGeneProduct denotes Prl NCBIGene:5617
5461 195-199 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5462 204-210 OrganismTaxon denotes humans NCBITaxon:9606
5463 321-324 GeneOrGeneProduct denotes Prl NCBIGene:5617
5464 325-329 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5465 372-387 DiseaseOrPhenotypicFeature denotes breast diseases MESH:D001941
5466 423-445 DiseaseOrPhenotypicFeature denotes Multiple fibroadenomas MESH:D018226
5467 447-450 DiseaseOrPhenotypicFeature denotes MFA MESH:D018226
5468 456-476 DiseaseOrPhenotypicFeature denotes benign breast tumors MESH:D001943
5469 515-520 OrganismTaxon denotes women NCBITaxon:9606
5470 549-552 GeneOrGeneProduct denotes Prl NCBIGene:5617
5471 646-649 DiseaseOrPhenotypicFeature denotes MFA MESH:D018226
5472 650-658 OrganismTaxon denotes patients NCBITaxon:9606
5473 704-712 OrganismTaxon denotes patients NCBITaxon:9606
5474 786-790 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5475 806-820 SequenceVariant denotes Ile(146)-->Leu DBSNP:rs72478580
5476 958-962 GeneOrGeneProduct denotes PrlR NCBIGene:19116
5477 963-968 SequenceVariant denotes I146L DBSNP:rs72478580
5478 1020-1025 CellLine denotes Ba/F3 NCBITaxon:10090
5479 1027-1033 CellLine denotes HEK293 NCBITaxon:9606
5480 1038-1043 CellLine denotes MCF-7 NCBITaxon:9606
5481 1054-1057 GeneOrGeneProduct denotes Prl NCBIGene:5617
5482 1074-1078 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5483 1124-1174 GeneOrGeneProduct denotes signal transducer and activator of transcription 5 NCBIGene:6776
5484 1176-1181 GeneOrGeneProduct denotes STAT5 NCBIGene:6776
5485 1234-1237 GeneOrGeneProduct denotes Prl NCBIGene:5617
5486 1349-1353 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5487 1354-1359 SequenceVariant denotes I146L DBSNP:rs72478580
5488 1389-1396 OrganismTaxon denotes patient NCBITaxon:9606
5489 1424-1429 GeneOrGeneProduct denotes STAT5 NCBIGene:6776
5490 1502-1506 GeneOrGeneProduct denotes PrlR NCBIGene:5618
5491 1525-1530 OrganismTaxon denotes human NCBITaxon:9606
5492 1607-1622 ChemicalEntity denotes PrlR antagonist
5493 1673-1676 DiseaseOrPhenotypicFeature denotes MFA MESH:D018226

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 372-387 DiseaseOrPhenotypicFeature denotes breast diseases 0002657

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 963-968 SequenceVariant denotes I146L
T2 1354-1359 SequenceVariant denotes I146L

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 86-106 DiseaseOrPhenotypicFeature denotes benign breast tumors 0000620
T2 136-151 DiseaseOrPhenotypicFeature denotes genetic disease 0003847
T3 372-387 DiseaseOrPhenotypicFeature denotes breast diseases 0002657
T4 456-476 DiseaseOrPhenotypicFeature denotes benign breast tumors 0000620

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 37-45 GeneOrGeneProduct denotes mutation
T2 53-71 GeneOrGeneProduct denotes prolactin receptor
T3 100-106 GeneOrGeneProduct denotes tumors
T4 152-158 GeneOrGeneProduct denotes linked
T5 162-171 GeneOrGeneProduct denotes prolactin
T6 173-176 GeneOrGeneProduct denotes Prl
T7 185-193 GeneOrGeneProduct denotes receptor
T8 195-199 GeneOrGeneProduct denotes PrlR
T9 245-253 GeneOrGeneProduct denotes hormonal
T10 321-324 GeneOrGeneProduct denotes Prl
T11 325-329 GeneOrGeneProduct denotes PrlR
T12 393-397 GeneOrGeneProduct denotes high
T13 423-431 GeneOrGeneProduct denotes Multiple
T14 470-476 GeneOrGeneProduct denotes tumors
T15 509-514 GeneOrGeneProduct denotes young
T16 549-552 GeneOrGeneProduct denotes Prl
T17 786-790 GeneOrGeneProduct denotes PrlR
T18 806-809 GeneOrGeneProduct denotes Ile
T19 841-854 GeneOrGeneProduct denotes extracellular
T20 940-948 GeneOrGeneProduct denotes receptor
T21 958-962 GeneOrGeneProduct denotes PrlR
T22 1007-1011 GeneOrGeneProduct denotes cell
T23 1044-1049 GeneOrGeneProduct denotes cells
T24 1054-1057 GeneOrGeneProduct denotes Prl
T25 1074-1078 GeneOrGeneProduct denotes PrlR
T26 1079-1087 GeneOrGeneProduct denotes tyrosine
T27 1106-1108 GeneOrGeneProduct denotes ii
T28 1110-1120 GeneOrGeneProduct denotes activation
T29 1124-1172 GeneOrGeneProduct denotes signal transducer and activator of transcription
T30 1176-1181 GeneOrGeneProduct denotes STAT5
T31 1195-1198 GeneOrGeneProduct denotes iii
T32 1200-1215 GeneOrGeneProduct denotes transcriptional
T33 1216-1224 GeneOrGeneProduct denotes activity
T34 1234-1237 GeneOrGeneProduct denotes Prl
T35 1258-1272 GeneOrGeneProduct denotes gene, and (iv)
T36 1273-1277 GeneOrGeneProduct denotes cell
T37 1312-1316 GeneOrGeneProduct denotes cell
T38 1337-1345 GeneOrGeneProduct denotes activity
T39 1349-1353 GeneOrGeneProduct denotes PrlR
T40 1424-1429 GeneOrGeneProduct denotes STAT5
T41 1486-1494 GeneOrGeneProduct denotes mutation
T42 1502-1506 GeneOrGeneProduct denotes PrlR
T43 1566-1574 GeneOrGeneProduct denotes activity
T44 1580-1583 GeneOrGeneProduct denotes all
T45 1607-1611 GeneOrGeneProduct denotes PrlR
T46 1612-1622 GeneOrGeneProduct denotes antagonist
T47 1630-1635 GeneOrGeneProduct denotes opens
T48 1685-1690 GeneOrGeneProduct denotes other
T49 1734-1742 GeneOrGeneProduct denotes mutation

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 53-71 GeneOrGeneProduct denotes prolactin receptor
T2 162-171 GeneOrGeneProduct denotes prolactin
T3 173-176 GeneOrGeneProduct denotes Prl
T4 185-193 GeneOrGeneProduct denotes receptor
T5 321-324 GeneOrGeneProduct denotes Prl
T6 393-397 GeneOrGeneProduct denotes high
T7 423-431 GeneOrGeneProduct denotes Multiple
T8 509-514 GeneOrGeneProduct denotes young
T9 549-552 GeneOrGeneProduct denotes Prl
T10 841-854 GeneOrGeneProduct denotes extracellular
T11 940-948 GeneOrGeneProduct denotes receptor
T12 1007-1011 GeneOrGeneProduct denotes cell
T13 1054-1057 GeneOrGeneProduct denotes Prl
T14 1079-1087 GeneOrGeneProduct denotes tyrosine
T15 1124-1172 GeneOrGeneProduct denotes signal transducer and activator of transcription
T16 1176-1181 GeneOrGeneProduct denotes STAT5
T17 1200-1215 GeneOrGeneProduct denotes transcriptional
T18 1234-1237 GeneOrGeneProduct denotes Prl
T19 1273-1277 GeneOrGeneProduct denotes cell
T20 1312-1316 GeneOrGeneProduct denotes cell
T21 1424-1429 GeneOrGeneProduct denotes STAT5
T22 1685-1690 GeneOrGeneProduct denotes other

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 75-80 OrganismTaxon denotes women
T2 204-210 OrganismTaxon denotes humans
T3 515-520 OrganismTaxon denotes women
T4 650-658 OrganismTaxon denotes patients
T5 704-712 OrganismTaxon denotes patients
T6 868-872 OrganismTaxon denotes sole
T7 1038-1041 OrganismTaxon denotes MCF
T8 1389-1396 OrganismTaxon denotes patient
T9 1525-1530 OrganismTaxon denotes human

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 93-106 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T2 136-151 DiseaseOrPhenotypicFeature denotes genetic disease D030342
T3 372-387 DiseaseOrPhenotypicFeature denotes breast diseases D001941
T4 432-445 DiseaseOrPhenotypicFeature denotes fibroadenomas D018226
T5 463-476 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T6 1317-1322 DiseaseOrPhenotypicFeature denotes death D003643
T7 1531-1538 DiseaseOrPhenotypicFeature denotes disease D004194
T8 1691-1698 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 53-71 GeneOrGeneProduct denotes prolactin receptor
T2 162-171 GeneOrGeneProduct denotes prolactin
T3 173-176 GeneOrGeneProduct denotes Prl
T4 321-324 GeneOrGeneProduct denotes Prl
T5 549-552 GeneOrGeneProduct denotes Prl
T6 911-948 GeneOrGeneProduct denotes constitutive activity to the receptor
T7 1054-1057 GeneOrGeneProduct denotes Prl
T8 1124-1172 GeneOrGeneProduct denotes signal transducer and activator of transcription
T9 1176-1181 GeneOrGeneProduct denotes STAT5
T10 1200-1224 GeneOrGeneProduct denotes transcriptional activity
T11 1234-1237 GeneOrGeneProduct denotes Prl
T12 1424-1429 GeneOrGeneProduct denotes STAT5

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 86-106 DiseaseOrPhenotypicFeature denotes benign breast tumors 0000620
T2 136-151 DiseaseOrPhenotypicFeature denotes genetic disease 0003847
T3 372-387 DiseaseOrPhenotypicFeature denotes breast diseases 0002657
T4 456-476 DiseaseOrPhenotypicFeature denotes benign breast tumors 0000620

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 93-106 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T2 136-151 DiseaseOrPhenotypicFeature denotes genetic disease D030342
T3 372-387 DiseaseOrPhenotypicFeature denotes breast diseases D001941
T4 432-445 DiseaseOrPhenotypicFeature denotes fibroadenomas D018226
T5 447-450 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T6 463-476 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T7 646-649 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T8 1317-1322 DiseaseOrPhenotypicFeature denotes death D003643
T9 1531-1538 DiseaseOrPhenotypicFeature denotes disease D004194
T10 1673-1676 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T11 1691-1698 DiseaseOrPhenotypicFeature denotes disease D004194

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 1020-1025 CellLine denotes Ba/F3 CVCL_0161
T2 1027-1033 CellLine denotes HEK293 CVCL_0045
T3 1038-1043 CellLine denotes MCF-7 CVCL_0031

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 93-106 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T2 136-151 DiseaseOrPhenotypicFeature denotes genetic disease D030342
T3 372-387 DiseaseOrPhenotypicFeature denotes breast diseases D001941
T4 432-445 DiseaseOrPhenotypicFeature denotes fibroadenomas D018226
T5 447-450 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T6 463-476 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T7 646-649 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T8 1673-1676 DiseaseOrPhenotypicFeature denotes MFA DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 53-62 ChemicalEntity denotes prolactin http://purl.obolibrary.org/obo/CHEBI_81580
T2 162-171 ChemicalEntity denotes prolactin http://purl.obolibrary.org/obo/CHEBI_81580
T3 173-176 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T4 321-324 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T5 549-552 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T6 806-809 ChemicalEntity denotes Ile http://purl.obolibrary.org/obo/CHEBI_30009|http://purl.obolibrary.org/obo/CHEBI_17191
T8 817-820 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_30006|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_15603
T11 1054-1057 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T12 1079-1087 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T13 1234-1237 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T14 1607-1622 ChemicalEntity denotes PrlR antagonist ChemicalEntity

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T3 1038-1043 CellLine denotes MCF-7 CVCL_0031
T2 1027-1033 CellLine denotes HEK293 CVCL_0045
T1 1020-1025 CellLine denotes Ba/F3 CVCL_0161
T14 1607-1622 ChemicalEntity denotes PrlR antagonist ChemicalEntity
T13 1234-1237 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T12 1079-1087 ChemicalEntity denotes tyrosine http://purl.obolibrary.org/obo/CHEBI_18186
T11 1054-1057 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T8 817-820 ChemicalEntity denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T6 806-809 ChemicalEntity denotes Ile http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T5 549-552 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T4 321-324 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T6129 173-176 ChemicalEntity denotes Prl http://purl.obolibrary.org/obo/CHEBI_81580
T3459 162-171 ChemicalEntity denotes prolactin http://purl.obolibrary.org/obo/CHEBI_81580
T97534 53-62 ChemicalEntity denotes prolactin http://purl.obolibrary.org/obo/CHEBI_81580
T72538 1424-1429 GeneOrGeneProduct denotes STAT5
T50772 1234-1237 GeneOrGeneProduct denotes Prl
T10 1200-1224 GeneOrGeneProduct denotes transcriptional activity
T9 1176-1181 GeneOrGeneProduct denotes STAT5
T75079 1124-1172 GeneOrGeneProduct denotes signal transducer and activator of transcription
T7 1054-1057 GeneOrGeneProduct denotes Prl
T41115 911-948 GeneOrGeneProduct denotes constitutive activity to the receptor
T26523 549-552 GeneOrGeneProduct denotes Prl
T36435 321-324 GeneOrGeneProduct denotes Prl
T39008 173-176 GeneOrGeneProduct denotes Prl
T93667 162-171 GeneOrGeneProduct denotes prolactin
T33186 53-71 GeneOrGeneProduct denotes prolactin receptor
T64263 1673-1676 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T45518 646-649 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T20458 463-476 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T86886 447-450 DiseaseOrPhenotypicFeature denotes MFA DISEASE
T98689 432-445 DiseaseOrPhenotypicFeature denotes fibroadenomas D018226
T76528 372-387 DiseaseOrPhenotypicFeature denotes breast diseases D001941
T88361 136-151 DiseaseOrPhenotypicFeature denotes genetic disease D030342
T20916 93-106 DiseaseOrPhenotypicFeature denotes breast tumors D001943
T17999 1525-1530 OrganismTaxon denotes human
T71866 1389-1396 OrganismTaxon denotes patient
T99306 1038-1041 OrganismTaxon denotes MCF
T94933 868-872 OrganismTaxon denotes sole
T50806 704-712 OrganismTaxon denotes patients
T80969 650-658 OrganismTaxon denotes patients
T24385 515-520 OrganismTaxon denotes women
T64960 204-210 OrganismTaxon denotes humans
T63002 75-80 OrganismTaxon denotes women
T9434 1354-1359 SequenceVariant denotes I146L
T73427 963-968 SequenceVariant denotes I146L

DisGeNET

Id Subject Object Predicate Lexical cue
T0 53-71 gene:5618 denotes prolactin receptor
T1 86-106 disease:C0346156 denotes benign breast tumors
T2 162-171 gene:5617 denotes prolactin
T3 136-151 disease:C0019247 denotes genetic disease
T4 173-176 gene:5617 denotes Prl
T5 136-151 disease:C0019247 denotes genetic disease
T6 325-329 gene:5618 denotes PrlR
T7 372-387 disease:C0006145 denotes breast diseases
T8 321-324 gene:5617 denotes Prl
T9 372-387 disease:C0006145 denotes breast diseases
T10 549-552 gene:5617 denotes Prl
T11 456-476 disease:C0346156 denotes benign breast tumors
R1 T0 T1 associated_with prolactin receptor,benign breast tumors
R2 T2 T3 associated_with prolactin,genetic disease
R3 T4 T5 associated_with Prl,genetic disease
R4 T6 T7 associated_with PrlR,breast diseases
R5 T8 T9 associated_with Prl,breast diseases
R6 T10 T11 associated_with Prl,benign breast tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18779591-0#53#71#gene5618 53-71 gene5618 denotes prolactin receptor
18779591-0#86#106#diseaseC0346156 86-106 diseaseC0346156 denotes benign breast tumors
18779591-2#109#112#gene5617 321-324 gene5617 denotes Prl
18779591-2#113#117#gene5618 325-329 gene5618 denotes PrlR
18779591-2#160#175#diseaseC0006145 372-387 diseaseC0006145 denotes breast diseases
18779591-3#126#129#gene5617 549-552 gene5617 denotes Prl
18779591-3#33#53#diseaseC0346156 456-476 diseaseC0346156 denotes benign breast tumors
53#71#gene561886#106#diseaseC0346156 18779591-0#53#71#gene5618 18779591-0#86#106#diseaseC0346156 associated_with prolactin receptor,benign breast tumors
109#112#gene5617160#175#diseaseC0006145 18779591-2#109#112#gene5617 18779591-2#160#175#diseaseC0006145 associated_with Prl,breast diseases
113#117#gene5618160#175#diseaseC0006145 18779591-2#113#117#gene5618 18779591-2#160#175#diseaseC0006145 associated_with PrlR,breast diseases
126#129#gene561733#53#diseaseC0346156 18779591-3#126#129#gene5617 18779591-3#33#53#diseaseC0346156 associated_with Prl,benign breast tumors

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 806-820 ProteinMutation:p|SUB|I|146|L denotes Ile(146)-->Leu
T2 963-968 ProteinMutation:p|SUB|I|146|L denotes I146L
T3 1354-1359 ProteinMutation:p|SUB|I|146|L denotes I146L