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PubMed:18757779 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T2 289-310 https://glytoucan.org/Structures/Glycans/G00059MO denotes globotriaosylceramide
T3 312-315 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T4 461-464 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T5 506-509 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T6 583-586 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T7 633-636 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T2 289-310 Glycan_Motif denotes globotriaosylceramide https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T3 312-315 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T4 461-464 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T5 506-509 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T6 583-586 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO
T7 633-636 Glycan_Motif denotes Gb3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00059MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 49-52 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T2 289-310 https://glytoucan.org/Structures/Glycans/G00059MO denotes globotriaosylceramide
T3 312-315 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T4 461-464 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T5 506-509 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T6 583-586 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3
T7 633-636 https://glytoucan.org/Structures/Glycans/G00059MO denotes Gb3

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1048-1056 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
TextSentencer_T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
TextSentencer_T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
TextSentencer_T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
TextSentencer_T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
TextSentencer_T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
TextSentencer_T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
TextSentencer_T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
TextSentencer_T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
TextSentencer_T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
TextSentencer_T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.
T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.
T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 49-52 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T2 312-315 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T3 461-464 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T4 506-509 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T5 583-586 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
T6 633-636 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1634-1638 gene:53947 denotes Gb3S
T1 1693-1696 disease:C0302810 denotes HUS
R1 T0 T1 associated_with Gb3S,HUS

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T5 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC295,LEC417 denotes Escherichia coli
_T1 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC002,LEC056,LEC062,LEC069,LEC081,LEC111,LEC133,LEC171,LEC177,LEC187,LEC211,LEC242,LEC252,LEC258,LEC259,LEC260,LEC262,LEC369,LEC377,LEC422,LEC442,LEC448,LEC450,LEC451,LEC454,LEC472,LEC492,LEC620 denotes Escherichia coli
_T2 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC636 denotes Escherichia coli
_T3 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC754 denotes Escherichia coli
_T4 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC243,LEC640 denotes Escherichia coli
_T6 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC244,LEC256,LEC354 denotes Escherichia coli
_T7 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC054,LEC058,LEC073,LEC082,LEC091,LEC103,LEC109,LEC110,LEC123,LEC158,LEC179,LEC198,LEC205,LEC222,LEC223,LEC224,LEC225,LEC232,LEC298,LEC357,LEC378,LEC383,LEC388,LEC389,LEC397,LEC401,LEC410,LEC452 denotes Escherichia coli
_T8 161-177 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC487 denotes Escherichia coli
_T9 161-182 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC267,LEC475 denotes Escherichia coli O157
_T10 161-182 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC157,LEC407 denotes Escherichia coli O157

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 67-71 FMAID:198663 denotes gene
_T2 241-252 FMAID:162384 denotes endothelial
_T3 241-252 FMAID:63916 denotes endothelial
_T4 241-257 FMAID:69075 denotes endothelial cell
_T5 241-257 FMAID:169653 denotes endothelial cell
_T6 241-257 FMAID:66772 denotes endothelial cell
_T7 241-257 FMAID:164926 denotes endothelial cell
_T8 651-655 FMAID:198663 denotes gene
_T9 708-712 FMAID:198663 denotes gene
_T10 1048-1056 FMAID:30326 denotes proximal
_T11 1048-1056 FMAID:171415 denotes proximal
_T12 1177-1182 FMAID:179279 denotes basal
_T13 1177-1182 FMAID:74542 denotes basal
_T14 1512-1517 FMAID:198663 denotes genes
_T15 1554-1563 FMAID:197972 denotes cytokines
_T16 1554-1563 FMAID:84050 denotes cytokines
_T17 1639-1643 FMAID:198663 denotes gene

uniprot-human

Id Subject Object Predicate Lexical cue
T1 53-66 http://www.uniprot.org/uniprot/Q9NPC4 denotes CD77 synthase
T2 637-650 http://www.uniprot.org/uniprot/Q9NPC4 denotes CD77 synthase
T3 1024-1026 http://www.uniprot.org/uniprot/Q6I9R6 denotes GC
T4 1139-1141 http://www.uniprot.org/uniprot/Q6I9R6 denotes GC
T5 1263-1265 http://www.uniprot.org/uniprot/Q6I9R6 denotes GC
T6 1346-1348 http://www.uniprot.org/uniprot/Q6I9R6 denotes GC
T7 1024-1026 http://www.uniprot.org/uniprot/P38435 denotes GC
T8 1139-1141 http://www.uniprot.org/uniprot/P38435 denotes GC
T9 1263-1265 http://www.uniprot.org/uniprot/P38435 denotes GC
T10 1346-1348 http://www.uniprot.org/uniprot/P38435 denotes GC
T11 1024-1026 http://www.uniprot.org/uniprot/P02774 denotes GC
T12 1139-1141 http://www.uniprot.org/uniprot/P02774 denotes GC
T13 1263-1265 http://www.uniprot.org/uniprot/P02774 denotes GC
T14 1346-1348 http://www.uniprot.org/uniprot/P02774 denotes GC

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 686-707 http://www.uniprot.org/uniprot/P23336 denotes galactosyltransferase
T2 1389-1392 http://www.uniprot.org/uniprot/Q76LW6 denotes Sp1
T3 1426-1429 http://www.uniprot.org/uniprot/Q76LW6 denotes Sp1
T4 1483-1486 http://www.uniprot.org/uniprot/Q76LW6 denotes Sp1
T5 1647-1650 http://www.uniprot.org/uniprot/Q76LW6 denotes Sp1
T6 1389-1392 http://www.uniprot.org/uniprot/O89090 denotes Sp1
T7 1426-1429 http://www.uniprot.org/uniprot/O89090 denotes Sp1
T8 1483-1486 http://www.uniprot.org/uniprot/O89090 denotes Sp1
T9 1647-1650 http://www.uniprot.org/uniprot/O89090 denotes Sp1

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 161-172 http://purl.bioontology.org/ontology/NCBITAXON/561 denotes Escherichia
T2 719-728 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism
T3 832-841 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanism

GO-BP

Id Subject Object Predicate Lexical cue
T1 263-268 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T2 601-616 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3 779-794 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T4 948-963 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T5 1183-1198 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T6 1292-1307 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T7 1600-1615 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T8 1278-1287 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T9 1465-1475 http://purl.obolibrary.org/obo/GO_0065007 denotes regulators
T10 1616-1626 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T11 1671-1682 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitivity

GO-MF

Id Subject Object Predicate Lexical cue
T1 1393-1400 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 1430-1437 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 1393-1400 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T4 1430-1437 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T5 1393-1400 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T6 1430-1437 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T7 1393-1400 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8 1430-1437 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 253-257 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18757779-10#157#161#gene53947 1634-1638 gene53947 denotes Gb3S
18757779-10#216#219#diseaseC0019061 1693-1696 diseaseC0019061 denotes HUS
157#161#gene53947216#219#diseaseC0019061 18757779-10#157#161#gene53947 18757779-10#216#219#diseaseC0019061 associated_with Gb3S,HUS

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1048-1056 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1416-1419 "http://rdf.glycoinfo.org/glycan/G41652MJ" denotes all
GlycanIUPAC_T2 1416-1419 "http://rdf.glycoinfo.org/glycan/G20761YC" denotes all
GlycanIUPAC_T3 1416-1419 "http://rdf.glycoinfo.org/glycan/G19807HM" denotes all
GlycanIUPAC_T4 1416-1419 "http://rdf.glycoinfo.org/glycan/G20351TE" denotes all
GlycanIUPAC_T5 1416-1419 "http://rdf.glycoinfo.org/glycan/G71957MR" denotes all
GlycanIUPAC_T6 1416-1419 "http://rdf.glycoinfo.org/glycan/G59040AE" denotes all
GlycanIUPAC_T7 1416-1419 "http://rdf.glycoinfo.org/glycan/G14987PW" denotes all
GlycanIUPAC_T8 1416-1419 "http://rdf.glycoinfo.org/glycan/G95064PC" denotes all
GlycanIUPAC_T9 1416-1419 "http://rdf.glycoinfo.org/glycan/G39143AQ" denotes all
GlycanIUPAC_T10 1416-1419 "http://rdf.glycoinfo.org/glycan/G65149OO" denotes all
GlycanIUPAC_T11 1416-1419 "http://rdf.glycoinfo.org/glycan/G02766SY" denotes all
GlycanIUPAC_T12 1416-1419 "http://rdf.glycoinfo.org/glycan/G26019KJ" denotes all
GlycanIUPAC_T13 1416-1419 "http://rdf.glycoinfo.org/glycan/G36429CZ" denotes all
GlycanIUPAC_T14 1416-1419 "http://rdf.glycoinfo.org/glycan/G89633TP" denotes all
GlycanIUPAC_T15 1416-1419 "http://rdf.glycoinfo.org/glycan/G28494FO" denotes all
GlycanIUPAC_T16 1416-1419 "http://rdf.glycoinfo.org/glycan/G06219CP" denotes all
GlycanIUPAC_T17 1416-1419 "http://rdf.glycoinfo.org/glycan/G44237SM" denotes all
GlycanIUPAC_T18 1416-1419 "http://rdf.glycoinfo.org/glycan/G57948RL" denotes all
GlycanIUPAC_T19 1416-1419 "http://rdf.glycoinfo.org/glycan/G64016DN" denotes all
GlycanIUPAC_T20 1416-1419 "http://rdf.glycoinfo.org/glycan/G14536PC" denotes all
GlycanIUPAC_T21 1416-1419 "http://rdf.glycoinfo.org/glycan/G14356FW" denotes all
GlycanIUPAC_T22 1416-1419 "http://rdf.glycoinfo.org/glycan/G34565UO" denotes all
GlycanIUPAC_T23 1416-1419 "http://rdf.glycoinfo.org/glycan/G67124MW" denotes all
GlycanIUPAC_T24 1416-1419 "http://rdf.glycoinfo.org/glycan/G71457ZU" denotes all
GlycanIUPAC_T25 1416-1419 "http://rdf.glycoinfo.org/glycan/G55228VZ" denotes all
GlycanIUPAC_T26 1416-1419 "http://rdf.glycoinfo.org/glycan/G31034MJ" denotes all
GlycanIUPAC_T27 1416-1419 "http://rdf.glycoinfo.org/glycan/G25776IP" denotes all
GlycanIUPAC_T28 1416-1419 "http://rdf.glycoinfo.org/glycan/G64442BV" denotes all
GlycanIUPAC_T29 1416-1419 "http://rdf.glycoinfo.org/glycan/G57018LE" denotes all
GlycanIUPAC_T30 1416-1419 "http://rdf.glycoinfo.org/glycan/G61761GX" denotes all
GlycanIUPAC_T31 1416-1419 "http://rdf.glycoinfo.org/glycan/G76318UX" denotes all
GlycanIUPAC_T32 1416-1419 "http://rdf.glycoinfo.org/glycan/G61906ER" denotes all
GlycanIUPAC_T33 1416-1419 "http://rdf.glycoinfo.org/glycan/G68723GR" denotes all
GlycanIUPAC_T34 1416-1419 "http://rdf.glycoinfo.org/glycan/G19540LE" denotes all
GlycanIUPAC_T35 1416-1419 "http://rdf.glycoinfo.org/glycan/G74944PO" denotes all
GlycanIUPAC_T36 1416-1419 "http://rdf.glycoinfo.org/glycan/G89489ZJ" denotes all
GlycanIUPAC_T37 1416-1419 "http://rdf.glycoinfo.org/glycan/G04434YU" denotes all
GlycanIUPAC_T38 1416-1419 "http://rdf.glycoinfo.org/glycan/G21450PB" denotes all
GlycanIUPAC_T39 1416-1419 "http://rdf.glycoinfo.org/glycan/G93629QY" denotes all
GlycanIUPAC_T40 1416-1419 "http://rdf.glycoinfo.org/glycan/G02603TR" denotes all
GlycanIUPAC_T41 1416-1419 "http://rdf.glycoinfo.org/glycan/G40280JP" denotes all
GlycanIUPAC_T42 1416-1419 "http://rdf.glycoinfo.org/glycan/G95259IC" denotes all
GlycanIUPAC_T43 1416-1419 "http://rdf.glycoinfo.org/glycan/G26900FE" denotes all
GlycanIUPAC_T44 1416-1419 "http://rdf.glycoinfo.org/glycan/G21346KK" denotes all
GlycanIUPAC_T45 1416-1419 "http://rdf.glycoinfo.org/glycan/G62509FF" denotes all
GlycanIUPAC_T46 1416-1419 "http://rdf.glycoinfo.org/glycan/G83932AK" denotes all
GlycanIUPAC_T47 1416-1419 "http://rdf.glycoinfo.org/glycan/G96978IB" denotes all
GlycanIUPAC_T48 1416-1419 "http://rdf.glycoinfo.org/glycan/G34275DN" denotes all
GlycanIUPAC_T49 1416-1419 "http://rdf.glycoinfo.org/glycan/G07071JF" denotes all
GlycanIUPAC_T50 1416-1419 "http://rdf.glycoinfo.org/glycan/G80639QD" denotes all
GlycanIUPAC_T51 1416-1419 "http://rdf.glycoinfo.org/glycan/G99460PJ" denotes all
GlycanIUPAC_T52 1416-1419 "http://rdf.glycoinfo.org/glycan/G22024BZ" denotes all
GlycanIUPAC_T53 1416-1419 "http://rdf.glycoinfo.org/glycan/G74097ZY" denotes all
GlycanIUPAC_T54 1416-1419 "http://rdf.glycoinfo.org/glycan/G84439YP" denotes all
GlycanIUPAC_T55 1416-1419 "http://rdf.glycoinfo.org/glycan/G52207WQ" denotes all
GlycanIUPAC_T56 1416-1419 "http://rdf.glycoinfo.org/glycan/G90695MS" denotes all
GlycanIUPAC_T57 1416-1419 "http://rdf.glycoinfo.org/glycan/G50398QX" denotes all
GlycanIUPAC_T58 1416-1419 "http://rdf.glycoinfo.org/glycan/G12166ZT" denotes all
GlycanIUPAC_T59 1416-1419 "http://rdf.glycoinfo.org/glycan/G48368BR" denotes all
GlycanIUPAC_T60 1416-1419 "http://rdf.glycoinfo.org/glycan/G57407RW" denotes all
GlycanIUPAC_T61 1416-1419 "http://rdf.glycoinfo.org/glycan/G00386TY" denotes all
GlycanIUPAC_T62 1416-1419 "http://rdf.glycoinfo.org/glycan/G18723JK" denotes all
GlycanIUPAC_T63 1416-1419 "http://rdf.glycoinfo.org/glycan/G93757OR" denotes all
GlycanIUPAC_T64 1416-1419 "http://rdf.glycoinfo.org/glycan/G29006SI" denotes all
GlycanIUPAC_T65 1416-1419 "http://rdf.glycoinfo.org/glycan/G03099OQ" denotes all
GlycanIUPAC_T66 1416-1419 "http://rdf.glycoinfo.org/glycan/G53739OW" denotes all
GlycanIUPAC_T67 1416-1419 "http://rdf.glycoinfo.org/glycan/G70440ZO" denotes all
GlycanIUPAC_T68 1416-1419 "http://rdf.glycoinfo.org/glycan/G29951RR" denotes all
GlycanIUPAC_T69 1416-1419 "http://rdf.glycoinfo.org/glycan/G58402TI" denotes all
GlycanIUPAC_T70 1416-1419 "http://rdf.glycoinfo.org/glycan/G39875TP" denotes all
GlycanIUPAC_T71 1416-1419 "http://rdf.glycoinfo.org/glycan/G83439QV" denotes all
GlycanIUPAC_T72 1416-1419 "http://rdf.glycoinfo.org/glycan/G41762RC" denotes all
GlycanIUPAC_T73 1416-1419 "http://rdf.glycoinfo.org/glycan/G91604UI" denotes all
GlycanIUPAC_T74 1416-1419 "http://rdf.glycoinfo.org/glycan/G88447WE" denotes all
GlycanIUPAC_T75 1416-1419 "http://rdf.glycoinfo.org/glycan/G93634BS" denotes all
GlycanIUPAC_T76 1416-1419 "http://rdf.glycoinfo.org/glycan/G02587BH" denotes all
GlycanIUPAC_T77 1416-1419 "http://rdf.glycoinfo.org/glycan/G43511MX" denotes all
GlycanIUPAC_T78 1416-1419 "http://rdf.glycoinfo.org/glycan/G64958DH" denotes all
GlycanIUPAC_T79 1416-1419 "http://rdf.glycoinfo.org/glycan/G30384TR" denotes all
GlycanIUPAC_T80 1416-1419 "http://rdf.glycoinfo.org/glycan/G15624EX" denotes all
GlycanIUPAC_T81 1416-1419 "http://rdf.glycoinfo.org/glycan/G22706ST" denotes all
GlycanIUPAC_T82 1416-1419 "http://rdf.glycoinfo.org/glycan/G57408PI" denotes all
GlycanIUPAC_T83 1416-1419 "http://rdf.glycoinfo.org/glycan/G86403XX" denotes all
GlycanIUPAC_T84 1416-1419 "http://rdf.glycoinfo.org/glycan/G78043YB" denotes all
GlycanIUPAC_T85 1416-1419 "http://rdf.glycoinfo.org/glycan/G18952JK" denotes all
GlycanIUPAC_T86 1416-1419 "http://rdf.glycoinfo.org/glycan/G49020ND" denotes all
GlycanIUPAC_T87 1416-1419 "http://rdf.glycoinfo.org/glycan/G63590YW" denotes all
GlycanIUPAC_T88 1416-1419 "http://rdf.glycoinfo.org/glycan/G22793KS" denotes all
GlycanIUPAC_T89 1416-1419 "http://rdf.glycoinfo.org/glycan/G64134SS" denotes all
GlycanIUPAC_T90 1416-1419 "http://rdf.glycoinfo.org/glycan/G17338HY" denotes all
GlycanIUPAC_T91 1416-1419 "http://rdf.glycoinfo.org/glycan/G99745XF" denotes all
GlycanIUPAC_T92 1416-1419 "http://rdf.glycoinfo.org/glycan/G27782HN" denotes all
GlycanIUPAC_T93 1416-1419 "http://rdf.glycoinfo.org/glycan/G57496DC" denotes all
GlycanIUPAC_T94 1416-1419 "http://rdf.glycoinfo.org/glycan/G93169WB" denotes all
GlycanIUPAC_T95 1416-1419 "http://rdf.glycoinfo.org/glycan/G05518TD" denotes all
GlycanIUPAC_T96 1416-1419 "http://rdf.glycoinfo.org/glycan/G62603DN" denotes all
GlycanIUPAC_T97 1416-1419 "http://rdf.glycoinfo.org/glycan/G59574FS" denotes all
GlycanIUPAC_T98 1416-1419 "http://rdf.glycoinfo.org/glycan/G47567WC" denotes all

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 49-52 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
PD-GlycoEpitope-B_T2 312-315 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
PD-GlycoEpitope-B_T3 461-464 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
PD-GlycoEpitope-B_T4 506-509 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
PD-GlycoEpitope-B_T5 583-586 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3
PD-GlycoEpitope-B_T6 633-636 http://www.glycoepitope.jp/epitopes/EP0071 denotes Gb3

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T2 312-315 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T3 461-464 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T4 506-509 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T5 583-586 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T6 633-636 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1048-1056 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 82-107 Phenotype denotes Hemolytic uremic syndrome HP:0005575
T2 109-112 Phenotype denotes HUS HP:0005575
T3 550-553 Phenotype denotes HUS HP:0005575
T4 845-848 Phenotype denotes HUS HP:0005575
T5 1693-1696 Phenotype denotes HUS HP:0005575

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 82-107 Disease denotes Hemolytic uremic syndrome http://purl.obolibrary.org/obo/MONDO_0001549
T2 109-112 Disease denotes HUS http://purl.obolibrary.org/obo/MONDO_0001549
T3 417-426 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T4 550-553 Disease denotes HUS http://purl.obolibrary.org/obo/MONDO_0001549
T5 845-848 Disease denotes HUS http://purl.obolibrary.org/obo/MONDO_0001549
T6 1693-1696 Disease denotes HUS http://purl.obolibrary.org/obo/MONDO_0001549

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 49-52 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T2 312-315 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T3 461-464 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T4 506-509 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T5 583-586 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO
T6 633-636 Glycan denotes Gb3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G00059MO

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 82-107 Phenotype denotes Hemolytic uremic syndrome HP:0005575
T2 109-112 Phenotype denotes HUS HP:0005575
T3 550-553 Phenotype denotes HUS HP:0005575
T4 845-848 Phenotype denotes HUS HP:0005575
T5 1693-1696 Phenotype denotes HUS HP:0005575

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 241-257 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 259-261 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T3 468-470 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T4 1177-1182 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T5 1567-1569 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T6 1686-1688 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 241-257 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 259-261 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T3 468-470 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T4 1567-1569 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T5 1686-1688 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 43-48 Organism denotes human 9606
T2 161-177 Organism denotes Escherichia coli 562
T3 404-411 Organism denotes E. coli 562
T4 882-887 Organism denotes human 9606

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 49-52 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T2 312-315 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T3 461-464 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T4 506-509 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T5 583-586 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T6 633-636 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-81 Sentence denotes Identification and characterization of the human Gb3/CD77 synthase gene promoter.
T2 82-190 Sentence denotes Hemolytic uremic syndrome (HUS) is triggered by verotoxin (VT) produced by the Escherichia coli O157 strain.
T3 191-346 Sentence denotes Several studies have demonstrated that VT induces endothelial cell (EC) death via the VT receptor globotriaosylceramide (Gb3/CD77) leading to this symptom.
T4 347-471 Sentence denotes Inflammatory mediators which are produced as a result of E. coli O157 infection, increase the expression level of Gb3 in EC.
T5 472-554 Sentence denotes Therefore increased expression of Gb3 is considered as a progression step for HUS.
T6 555-760 Sentence denotes The increased expression of Gb3 is due to the transcriptional upregulation of Gb3/CD77 synthase gene (Gb3S, also known as alpha1,4-galactosyltransferase gene), the mechanism of which still remains unknown.
T7 761-902 Sentence denotes To understand the transcriptional machinery and to elucidate the onset mechanism of HUS, we cloned and characterized the human Gb3S promoter.
T8 903-1064 Sentence denotes A modified 5'-RACE was used to determine the transcriptional initiation site, which revealed the presence of a TATA-less GC-rich sequence in the proximal region.
T9 1065-1314 Sentence denotes Promoter activity measured using a luciferase assay demonstrated that the GC-rich sequence is necessary for the basal transcriptional activity, and two silencer elements located 5'-upstream of this GC-rich region regulated the transcriptional level.
T10 1315-1476 Sentence denotes Furthermore, we found that the GC-rich sequence contained three potential Sp1 binding sites and that all three Sp1 binding elements acted as positive regulators.
T11 1477-1709 Sentence denotes Since Sp1 is an inducer of several genes in the presence of the inflammatory cytokines in EC, our results suggest that the transcriptional regulation of the Gb3S gene by Sp1 might affect the VT sensitivity of EC and HUS progression.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 82-107 Disease denotes Hemolytic uremic syndrome MONDO:0001549
T2 109-112 Disease denotes HUS MONDO:0001549
T3 417-426 Disease denotes infection MONDO:0005550
T4 550-553 Disease denotes HUS MONDO:0001549
T5 845-848 Disease denotes HUS MONDO:0001549
T6 1693-1696 Disease denotes HUS MONDO:0001549

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 241-257 Body_part denotes endothelial cell FMA:66772
T2 259-261 Body_part denotes EC FMA:66772
T3 468-470 Body_part denotes EC FMA:66772
T4 1567-1569 Body_part denotes EC FMA:66772
T5 1686-1688 Body_part denotes EC FMA:66772

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1048-1056 Body_part denotes proximal http://purl.obolibrary.org/obo/MAT_0000491

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 43-48 OrganismTaxon denotes human 9606
T2 161-177 OrganismTaxon denotes Escherichia coli 562
T3 404-411 OrganismTaxon denotes E. coli 562
T4 882-887 OrganismTaxon denotes human 9606

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 49-52 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T2 312-315 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T3 461-464 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T4 506-509 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T5 583-586 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071
T6 633-636 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Gb3 http://www.glycoepitope.jp/epitopes/EP0071

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 241-257 Body_part denotes endothelial cell http://purl.obolibrary.org/obo/CL_0000115
T2 259-261 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T3 468-470 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T4 1567-1569 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115
T5 1686-1688 Body_part denotes EC http://purl.obolibrary.org/obo/CL_0000115

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 241-257 Cell denotes endothelial cell http://purl.obolibrary.org/obo/CL:0000115
T2 259-261 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T3 468-470 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T4 1177-1182 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T5 1567-1569 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115
T6 1686-1688 Cell denotes EC http://purl.obolibrary.org/obo/CL:0000115