PubMed:18701576 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":56,"end":74},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":245,"end":263},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":265,"end":267},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":614,"end":616},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T7","span":{"begin":706,"end":708},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T9","span":{"begin":818,"end":820},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T11","span":{"begin":893,"end":895},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T13","span":{"begin":975,"end":977},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T15","span":{"begin":1188,"end":1190},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T17","span":{"begin":1400,"end":1402},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005301"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0005301"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0006861"},{"id":"A4","pred":"mondo_id","subj":"T3","obj":"0005301"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0006861"},{"id":"A6","pred":"mondo_id","subj":"T5","obj":"0005301"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"0006861"},{"id":"A8","pred":"mondo_id","subj":"T7","obj":"0005301"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"0006861"},{"id":"A10","pred":"mondo_id","subj":"T9","obj":"0005301"},{"id":"A11","pred":"mondo_id","subj":"T11","obj":"0006861"},{"id":"A12","pred":"mondo_id","subj":"T11","obj":"0005301"},{"id":"A13","pred":"mondo_id","subj":"T13","obj":"0006861"},{"id":"A14","pred":"mondo_id","subj":"T13","obj":"0005301"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"0006861"},{"id":"A16","pred":"mondo_id","subj":"T15","obj":"0005301"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"0006861"},{"id":"A18","pred":"mondo_id","subj":"T17","obj":"0005301"}],"text":"Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis.\nBackgroundThe human endogenous retrovirus (HERV)-K18 Env is an Epstein-Barr virus (EBV)-associated superantigen. Given the evidence for a role of EBV in the etiology of multiple sclerosis (MS), HERV-K18 Env is a plausible candidate for association with MS.ObjectiveTo assess whether variation in HERV-K18 Env is a risk factor for MS.MethodsWe developed a single nucleotide polymorphism-based genotyping method to determine the distribution of the three alleles of HERV-K18 env. We then conducted a nested case-control study including 207 MS cases and 403 matched controls. Analyses were replicated in an independent series of 909 MS cases and 339 controls.ResultsOverall, there was a significant association between HERV-K18 env genotype and MS risk (chi2 P = 0.03). As compared with K18.2/K18.2 individuals, risk of MS was three fold higher among K18.3/K18.3 individuals (P = 0.03). An increase in MS risk among carriers of the K18.3 allele was also observed in the replication study, but did not reach statistical significance. In pooled analyses, K18.3/K18.3 individuals had a significantly increased risk of MS (relative risks [RR] comparing K18.3/K18.3 vs K18.2/K18.2 = 2.7; 95% confidence interval: 1.1-6.4).ConclusionVariation in EBV-associated superantigen HERV-K18 Env could influence the genetic susceptibility to MS."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":270,"end":278},"obj":"gene:100775105"},{"id":"T1","span":{"begin":245,"end":267},"obj":"disease:C0026769"},{"id":"T2","span":{"begin":372,"end":380},"obj":"gene:100775105"},{"id":"T3","span":{"begin":245,"end":267},"obj":"disease:C0026769"},{"id":"T4","span":{"begin":540,"end":548},"obj":"gene:100775105"},{"id":"T5","span":{"begin":245,"end":267},"obj":"disease:C0026769"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis.\nBackgroundThe human endogenous retrovirus (HERV)-K18 Env is an Epstein-Barr virus (EBV)-associated superantigen. Given the evidence for a role of EBV in the etiology of multiple sclerosis (MS), HERV-K18 Env is a plausible candidate for association with MS.ObjectiveTo assess whether variation in HERV-K18 Env is a risk factor for MS.MethodsWe developed a single nucleotide polymorphism-based genotyping method to determine the distribution of the three alleles of HERV-K18 env. We then conducted a nested case-control study including 207 MS cases and 403 matched controls. Analyses were replicated in an independent series of 909 MS cases and 339 controls.ResultsOverall, there was a significant association between HERV-K18 env genotype and MS risk (chi2 P = 0.03). As compared with K18.2/K18.2 individuals, risk of MS was three fold higher among K18.3/K18.3 individuals (P = 0.03). An increase in MS risk among carriers of the K18.3 allele was also observed in the replication study, but did not reach statistical significance. In pooled analyses, K18.3/K18.3 individuals had a significantly increased risk of MS (relative risks [RR] comparing K18.3/K18.3 vs K18.2/K18.2 = 2.7; 95% confidence interval: 1.1-6.4).ConclusionVariation in EBV-associated superantigen HERV-K18 Env could influence the genetic susceptibility to MS."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"18701576-7#235#243#gene100775105","span":{"begin":1341,"end":1349},"obj":"gene100775105"},{"id":"18701576-7#82#84#diseaseC0026769","span":{"begin":1188,"end":1190},"obj":"diseaseC0026769"},{"id":"18701576-7#294#296#diseaseC0026769","span":{"begin":1400,"end":1402},"obj":"diseaseC0026769"}],"relations":[{"id":"235#243#gene10077510582#84#diseaseC0026769","pred":"associated_with","subj":"18701576-7#235#243#gene100775105","obj":"18701576-7#82#84#diseaseC0026769"},{"id":"235#243#gene100775105294#296#diseaseC0026769","pred":"associated_with","subj":"18701576-7#235#243#gene100775105","obj":"18701576-7#294#296#diseaseC0026769"}],"text":"Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis.\nBackgroundThe human endogenous retrovirus (HERV)-K18 Env is an Epstein-Barr virus (EBV)-associated superantigen. Given the evidence for a role of EBV in the etiology of multiple sclerosis (MS), HERV-K18 Env is a plausible candidate for association with MS.ObjectiveTo assess whether variation in HERV-K18 Env is a risk factor for MS.MethodsWe developed a single nucleotide polymorphism-based genotyping method to determine the distribution of the three alleles of HERV-K18 env. We then conducted a nested case-control study including 207 MS cases and 403 matched controls. Analyses were replicated in an independent series of 909 MS cases and 339 controls.ResultsOverall, there was a significant association between HERV-K18 env genotype and MS risk (chi2 P = 0.03). As compared with K18.2/K18.2 individuals, risk of MS was three fold higher among K18.3/K18.3 individuals (P = 0.03). An increase in MS risk among carriers of the K18.3 allele was also observed in the replication study, but did not reach statistical significance. In pooled analyses, K18.3/K18.3 individuals had a significantly increased risk of MS (relative risks [RR] comparing K18.3/K18.3 vs K18.2/K18.2 = 2.7; 95% confidence interval: 1.1-6.4).ConclusionVariation in EBV-associated superantigen HERV-K18 Env could influence the genetic susceptibility to MS."}