PubMed:186999 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/186999","sourcedb":"PubMed","sourceid":"186999","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/186999","text":"Immunoreactive ACTH, immunoreactive human chorionic somatomammotrophin (HCS) and 11-OH steroids plasma levels in normal and pathological pregnancies.\nPlasma immunoreactive ACTH (I.R.ACTH), immunoreactive human chorionic somatomammotrophin (I.R.HCS) and 11-OH steroids levels were measured during normal and pathological pregnancies. Plasma I.R.ACTH levels were found to be above normal during pregnancy, with a slight decrease near term. This observation correlates well with the recent description of human chorionic corticotrophin (HCC), i.e. a factor of placental origin possessing a high biological adrenocorticotrophic activity and presenting partial immunological cross-reaction with human ACTH. The 11-OH steroids levels, as measured by a fluorimetric method, increased regularly during pregnancy but, unlike ACTH, reached their highest value near term, I.R.HCS increased progressively until term when a slight decrease was observed. In pathological pregnancies, I.R.ACTH levels behaved like other placental hormones. On the contrary, 11-OH steroids levels remained generally unmodified. Treatment with high doses of prednisolone caused no inhibition of the plasma I.R.ACTH and of plasma 11-OH steroids levels. These data suggest placental autonomy of the secretion of HCC and low adrenal responsiveness to endogenous ACTH variations throughout pregnancy.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":557,"end":566},"obj":"http://purl.obolibrary.org/obo/UBERON_0001987"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":1005,"end":1014},"obj":"http://purl.obolibrary.org/obo/UBERON_0001987"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":1237,"end":1246},"obj":"http://purl.obolibrary.org/obo/UBERON_0001987"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":42,"end":51},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":210,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":508,"end":517},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T4","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T5","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T6","pred":"source","obj":"performance-test"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":149},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":150,"end":332},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":333,"end":437},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":438,"end":701},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":702,"end":940},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":941,"end":1024},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1025,"end":1094},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1095,"end":1217},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1218,"end":1362},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":149},"obj":"Sentence"},{"id":"T2","span":{"begin":150,"end":332},"obj":"Sentence"},{"id":"T3","span":{"begin":333,"end":437},"obj":"Sentence"},{"id":"T4","span":{"begin":438,"end":701},"obj":"Sentence"},{"id":"T5","span":{"begin":702,"end":940},"obj":"Sentence"},{"id":"T6","span":{"begin":941,"end":1024},"obj":"Sentence"},{"id":"T7","span":{"begin":1025,"end":1094},"obj":"Sentence"},{"id":"T8","span":{"begin":1095,"end":1217},"obj":"Sentence"},{"id":"T9","span":{"begin":1218,"end":1362},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T7","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T8","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T9","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"},{"subj":"T7","pred":"source","obj":"sentences"},{"subj":"T8","pred":"source","obj":"sentences"},{"subj":"T9","pred":"source","obj":"sentences"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":42,"end":51},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":210,"end":219},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":508,"end":517},"obj":"http://purl.obolibrary.org/obo/UBERON_0003124"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"UBERON-AE"},{"subj":"PD-UBERON-AE-B_T3","pred":"source","obj":"UBERON-AE"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"performance-test","color":"#ecaa93","default":true},{"id":"sentences","color":"#9395ec"},{"id":"UBERON-AE","color":"#afec93"}]}]}}