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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity.
T2 89-222 Sentence denotes Often, chemotherapy by doxorubicin (Adriamycin) is limited due to life threatening cardiotoxicity in patients during and posttherapy.
T3 223-341 Sentence denotes Recently, we have shown that moderate diet restriction remarkably protects against doxorubicin-induced cardiotoxicity.
T4 342-528 Sentence denotes This cardioprotection is accompanied by decreased cardiac oxidative stress and triglycerides and increased cardiac fatty-acid oxidation, ATP synthesis, and upregulated JAK/STAT3 pathway.
T5 529-752 Sentence denotes In the current study, we investigated whether a physiological intervention by feeding 40% high fat diet (HFD), which induces obesity in male Sprague-Dawley rats (250-275 g), sensitizes to doxorubicin-induced cardiotoxicity.
T6 753-1015 Sentence denotes A LD(10) dose (8 mg doxorubicin/kg, ip) administered on day 43 of the HFD feeding regimen led to higher cardiotoxicity, cardiac dysfunction, lipid peroxidation, and 80% mortality in the obese (OB) rats in the absence of any significant renal or hepatic toxicity.
T7 1016-1180 Sentence denotes Doxorubicin toxicokinetics studies revealed no change in accumulation of doxorubicin and doxorubicinol (toxic metabolite) in the normal diet-fed (ND) and OB hearts.
T8 1181-1744 Sentence denotes Mechanistic studies revealed that OB rats are sensitized due to: (1) higher oxyradical stress leading to upregulation of uncoupling proteins 2 and 3, (2) downregulation of cardiac peroxisome proliferators activated receptor-alpha, (3) decreased plasma adiponectin levels, (4) decreased cardiac fatty-acid oxidation (666.9+/-14.0 nmol/min/g heart in ND versus 400.2+/-11.8 nmol/min/g heart in OB), (5) decreased mitochondrial AMP-alpha2 protein kinase, and (6) 86% drop in cardiac ATP levels accompanied by decreased ATP/ADP ratio after doxorubicin administration.
T9 1745-1859 Sentence denotes Decreased cardiac erythropoietin and increased SOCS3 further downregulated the cardioprotective JAK/STAT3 pathway.
T10 1860-2097 Sentence denotes In conclusion, HFD-induced obese rats are highly sensitized to doxorubicin-induced cardiotoxicity by substantially downregulating cardiac mitochondrial ATP generation, increasing oxidative stress and downregulating the JAK/STAT3 pathway.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 24-28 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T4 685-689 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T7 950-954 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T10 1218-1222 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114
T13 1893-1897 OrganismTaxon denotes rats NCBItxid:10118|NCBItxid:10116|NCBItxid:10114

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
5381 5-8 ChemicalEntity denotes fat MESH:D004041
5382 18-23 DiseaseOrPhenotypicFeature denotes obese MESH:D009765
5383 24-28 OrganismTaxon denotes rats NCBITaxon:10116
5384 53-64 ChemicalEntity denotes doxorubicin MESH:D004317
5385 73-87 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5386 112-123 ChemicalEntity denotes doxorubicin MESH:D004317
5387 125-135 ChemicalEntity denotes Adriamycin MESH:D004317
5388 172-186 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5389 306-317 ChemicalEntity denotes doxorubicin MESH:D004317
5390 326-340 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5391 421-434 ChemicalEntity denotes triglycerides MESH:D014280
5392 457-467 ChemicalEntity denotes fatty-acid MESH:D005227
5393 479-482 ChemicalEntity denotes ATP MESH:D000255
5394 510-513 GeneOrGeneProduct denotes JAK NCBIGene:84598
5395 514-519 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
5396 624-627 ChemicalEntity denotes fat MESH:D004041
5397 654-661 DiseaseOrPhenotypicFeature denotes obesity MESH:D009765
5398 685-689 OrganismTaxon denotes rats NCBITaxon:10116
5399 717-728 ChemicalEntity denotes doxorubicin MESH:D004317
5400 737-751 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5401 773-784 ChemicalEntity denotes doxorubicin MESH:D004317
5402 857-871 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5403 873-892 DiseaseOrPhenotypicFeature denotes cardiac dysfunction MESH:D006331
5404 894-899 ChemicalEntity denotes lipid MESH:D008055
5405 939-944 DiseaseOrPhenotypicFeature denotes obese MESH:D009765
5406 946-948 DiseaseOrPhenotypicFeature denotes OB MESH:D009765
5407 950-954 OrganismTaxon denotes rats NCBITaxon:10116
5408 989-1014 DiseaseOrPhenotypicFeature denotes renal or hepatic toxicity MESH:D007674|MESH:D056486
5409 1016-1027 ChemicalEntity denotes Doxorubicin MESH:D004317
5410 1089-1100 ChemicalEntity denotes doxorubicin MESH:D004317
5411 1105-1118 ChemicalEntity denotes doxorubicinol MESH:C010013
5412 1170-1172 DiseaseOrPhenotypicFeature denotes OB MESH:D009765
5413 1215-1217 DiseaseOrPhenotypicFeature denotes OB MESH:D009765
5414 1218-1222 OrganismTaxon denotes rats NCBITaxon:10116
5415 1302-1329 GeneOrGeneProduct denotes uncoupling proteins 2 and 3 NCBIGene:25708|NCBIGene:54315
5416 1361-1410 GeneOrGeneProduct denotes peroxisome proliferators activated receptor-alpha NCBIGene:25747
5417 1433-1444 GeneOrGeneProduct denotes adiponectin NCBIGene:246253
5418 1475-1485 ChemicalEntity denotes fatty-acid MESH:D005227
5419 1573-1575 DiseaseOrPhenotypicFeature denotes OB MESH:D009765
5420 1606-1631 GeneOrGeneProduct denotes AMP-alpha2 protein kinase NCBIGene:65248
5421 1661-1664 ChemicalEntity denotes ATP MESH:D000255
5422 1697-1700 ChemicalEntity denotes ATP MESH:D000255
5423 1701-1704 ChemicalEntity denotes ADP MESH:D000244
5424 1717-1728 ChemicalEntity denotes doxorubicin MESH:D004317
5425 1763-1777 GeneOrGeneProduct denotes erythropoietin NCBIGene:24335
5426 1792-1797 GeneOrGeneProduct denotes SOCS3 NCBIGene:89829
5427 1841-1844 GeneOrGeneProduct denotes JAK NCBIGene:84598
5428 1845-1850 GeneOrGeneProduct denotes STAT3 NCBIGene:25125
5429 1887-1892 DiseaseOrPhenotypicFeature denotes obese MESH:D009765
5430 1893-1897 OrganismTaxon denotes rats NCBITaxon:10116
5431 1923-1934 ChemicalEntity denotes doxorubicin MESH:D004317
5432 1943-1957 DiseaseOrPhenotypicFeature denotes cardiotoxicity MESH:D066126
5433 2012-2015 ChemicalEntity denotes ATP MESH:D000255
5434 2079-2082 GeneOrGeneProduct denotes JAK NCBIGene:84598
5435 2083-2088 GeneOrGeneProduct denotes STAT3 NCBIGene:25125

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 998-1005 DiseaseOrPhenotypicFeature denotes hepatic 0002251

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 18-23 GeneOrGeneProduct denotes obese
T2 140-147 GeneOrGeneProduct denotes limited
T3 421-434 GeneOrGeneProduct denotes triglycerides
T4 463-467 GeneOrGeneProduct denotes acid
T5 514-519 GeneOrGeneProduct denotes STAT3
T6 619-623 GeneOrGeneProduct denotes high
T7 695-698 GeneOrGeneProduct denotes 275
T8 939-944 GeneOrGeneProduct denotes obese
T9 946-948 GeneOrGeneProduct denotes OB
T10 1170-1172 GeneOrGeneProduct denotes OB
T11 1215-1217 GeneOrGeneProduct denotes OB
T12 1302-1323 GeneOrGeneProduct denotes uncoupling proteins 2
T13 1396-1404 GeneOrGeneProduct denotes receptor
T14 1405-1410 GeneOrGeneProduct denotes alpha
T15 1433-1444 GeneOrGeneProduct denotes adiponectin
T16 1481-1485 GeneOrGeneProduct denotes acid
T17 1515-1520 GeneOrGeneProduct denotes min/g
T18 1521-1526 GeneOrGeneProduct denotes heart
T19 1558-1563 GeneOrGeneProduct denotes min/g
T20 1564-1569 GeneOrGeneProduct denotes heart
T21 1573-1575 GeneOrGeneProduct denotes OB
T22 1592-1605 GeneOrGeneProduct denotes mitochondrial
T23 1610-1616 GeneOrGeneProduct denotes alpha2
T24 1617-1631 GeneOrGeneProduct denotes protein kinase
T25 1645-1649 GeneOrGeneProduct denotes drop
T26 1763-1777 GeneOrGeneProduct denotes erythropoietin
T27 1792-1797 GeneOrGeneProduct denotes SOCS3
T28 1845-1850 GeneOrGeneProduct denotes STAT3
T29 1887-1892 GeneOrGeneProduct denotes obese
T30 1998-2011 GeneOrGeneProduct denotes mitochondrial
T31 2083-2088 GeneOrGeneProduct denotes STAT3

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-4 GeneOrGeneProduct denotes High
T2 18-23 GeneOrGeneProduct denotes obese
T3 33-39 GeneOrGeneProduct denotes highly
T4 65-72 GeneOrGeneProduct denotes induced
T5 140-147 GeneOrGeneProduct denotes limited
T6 318-325 GeneOrGeneProduct denotes induced
T7 421-434 GeneOrGeneProduct denotes triglycerides
T8 457-462 GeneOrGeneProduct denotes fatty
T9 463-467 GeneOrGeneProduct denotes acid
T10 479-482 GeneOrGeneProduct denotes ATP
T11 514-519 GeneOrGeneProduct denotes STAT3
T12 619-623 GeneOrGeneProduct denotes high
T13 646-653 GeneOrGeneProduct denotes induces
T14 654-661 GeneOrGeneProduct denotes obesity
T15 665-669 GeneOrGeneProduct denotes male
T16 695-698 GeneOrGeneProduct denotes 275
T17 729-736 GeneOrGeneProduct denotes induced
T18 770-772 GeneOrGeneProduct denotes mg
T19 900-912 GeneOrGeneProduct denotes peroxidation
T20 939-944 GeneOrGeneProduct denotes obese
T21 946-948 GeneOrGeneProduct denotes OB
T22 1170-1172 GeneOrGeneProduct denotes OB
T23 1173-1179 GeneOrGeneProduct denotes hearts
T24 1215-1217 GeneOrGeneProduct denotes OB
T25 1242-1249 GeneOrGeneProduct denotes to: (1)
T26 1302-1323 GeneOrGeneProduct denotes uncoupling proteins 2
T27 1396-1404 GeneOrGeneProduct denotes receptor
T28 1405-1410 GeneOrGeneProduct denotes alpha
T29 1433-1444 GeneOrGeneProduct denotes adiponectin
T30 1475-1480 GeneOrGeneProduct denotes fatty
T31 1481-1485 GeneOrGeneProduct denotes acid
T32 1515-1520 GeneOrGeneProduct denotes min/g
T33 1521-1526 GeneOrGeneProduct denotes heart
T34 1558-1563 GeneOrGeneProduct denotes min/g
T35 1564-1569 GeneOrGeneProduct denotes heart
T36 1573-1575 GeneOrGeneProduct denotes OB
T37 1592-1605 GeneOrGeneProduct denotes mitochondrial
T38 1606-1609 GeneOrGeneProduct denotes AMP
T39 1610-1616 GeneOrGeneProduct denotes alpha2
T40 1617-1631 GeneOrGeneProduct denotes protein kinase
T41 1645-1649 GeneOrGeneProduct denotes drop
T42 1661-1664 GeneOrGeneProduct denotes ATP
T43 1697-1700 GeneOrGeneProduct denotes ATP
T44 1701-1704 GeneOrGeneProduct denotes ADP
T45 1763-1777 GeneOrGeneProduct denotes erythropoietin
T46 1792-1797 GeneOrGeneProduct denotes SOCS3
T47 1845-1850 GeneOrGeneProduct denotes STAT3
T48 1879-1886 GeneOrGeneProduct denotes induced
T49 1887-1892 GeneOrGeneProduct denotes obese
T50 1902-1908 GeneOrGeneProduct denotes highly
T51 1935-1942 GeneOrGeneProduct denotes induced
T52 1998-2011 GeneOrGeneProduct denotes mitochondrial
T53 2012-2015 GeneOrGeneProduct denotes ATP
T54 2083-2088 GeneOrGeneProduct denotes STAT3

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 18-23 DiseaseOrPhenotypicFeature denotes obese DISEASE
T2 73-87 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T3 172-186 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 326-340 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T5 654-661 DiseaseOrPhenotypicFeature denotes obesity D009765
T6 737-751 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T7 857-871 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T8 873-892 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T9 939-944 DiseaseOrPhenotypicFeature denotes obese DISEASE
T10 946-948 DiseaseOrPhenotypicFeature denotes OB DISEASE
T11 1006-1014 DiseaseOrPhenotypicFeature denotes toxicity DISEASE
T12 1170-1172 DiseaseOrPhenotypicFeature denotes OB DISEASE
T13 1215-1217 DiseaseOrPhenotypicFeature denotes OB DISEASE
T14 1573-1575 DiseaseOrPhenotypicFeature denotes OB DISEASE
T15 1887-1892 DiseaseOrPhenotypicFeature denotes obese DISEASE
T16 1943-1957 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 514-519 GeneOrGeneProduct denotes STAT3
T2 695-698 GeneOrGeneProduct denotes 275
T3 1302-1323 GeneOrGeneProduct denotes uncoupling proteins 2
T4 1361-1404 GeneOrGeneProduct denotes peroxisome proliferators activated receptor
T5 1405-1410 GeneOrGeneProduct denotes alpha
T6 1433-1444 GeneOrGeneProduct denotes adiponectin
T7 1610-1616 GeneOrGeneProduct denotes alpha2
T8 1645-1649 GeneOrGeneProduct denotes drop
T9 1763-1777 GeneOrGeneProduct denotes erythropoietin
T10 1792-1797 GeneOrGeneProduct denotes SOCS3
T11 1845-1850 GeneOrGeneProduct denotes STAT3
T12 2083-2088 GeneOrGeneProduct denotes STAT3

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 14-17 DiseaseOrPhenotypicFeature denotes fed 0007620
T2 40-49 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T3 654-661 DiseaseOrPhenotypicFeature denotes obesity 0011122
T4 1157-1160 DiseaseOrPhenotypicFeature denotes fed 0007620
T5 1162-1164 DiseaseOrPhenotypicFeature denotes ND 0010691
T6 1530-1532 DiseaseOrPhenotypicFeature denotes ND 0010691

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 18-23 DiseaseOrPhenotypicFeature denotes obese DISEASE
T2 73-87 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T3 172-186 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 326-340 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T5 654-661 DiseaseOrPhenotypicFeature denotes obesity D009765
T6 737-751 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T7 857-871 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T8 873-892 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T9 939-944 DiseaseOrPhenotypicFeature denotes obese DISEASE
T10 946-948 DiseaseOrPhenotypicFeature denotes OB DISEASE
T11 989-1014 DiseaseOrPhenotypicFeature denotes renal or hepatic toxicity DISEASE
T12 1170-1172 DiseaseOrPhenotypicFeature denotes OB DISEASE
T13 1215-1217 DiseaseOrPhenotypicFeature denotes OB DISEASE
T14 1573-1575 DiseaseOrPhenotypicFeature denotes OB DISEASE
T15 1887-1892 DiseaseOrPhenotypicFeature denotes obese DISEASE
T16 1943-1957 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 18-23 DiseaseOrPhenotypicFeature denotes obese DISEASE
T2 73-87 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T3 172-186 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4 326-340 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T5 654-661 DiseaseOrPhenotypicFeature denotes obesity D009765
T6 737-751 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T7 857-871 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T8 873-892 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T9 939-944 DiseaseOrPhenotypicFeature denotes obese DISEASE
T10 946-948 DiseaseOrPhenotypicFeature denotes OB DISEASE
T11 989-1014 DiseaseOrPhenotypicFeature denotes renal or hepatic toxicity DISEASE
T12 1170-1172 DiseaseOrPhenotypicFeature denotes OB DISEASE
T13 1215-1217 DiseaseOrPhenotypicFeature denotes OB DISEASE
T14 1573-1575 DiseaseOrPhenotypicFeature denotes OB DISEASE
T15 1887-1892 DiseaseOrPhenotypicFeature denotes obese DISEASE
T16 1943-1957 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 53-64 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T4 112-123 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T7 125-135 ChemicalEntity denotes Adriamycin http://purl.obolibrary.org/obo/CHEBI_28748
T8 306-317 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T11 421-434 ChemicalEntity denotes triglycerides D014280|http://purl.obolibrary.org/obo/CHEBI_17855
T13 479-482 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_30616|http://purl.obolibrary.org/obo/CHEBI_15422
T15 717-728 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T18 773-784 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T21 1016-1027 ChemicalEntity denotes Doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748
T22 1089-1100 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T25 1105-1118 ChemicalEntity denotes doxorubicinol C010013|http://purl.obolibrary.org/obo/CHEBI_133817
T27 1433-1444 ChemicalEntity denotes adiponectin http://purl.obolibrary.org/obo/CHEBI_81572
T28 1606-1609 ChemicalEntity denotes AMP http://purl.obolibrary.org/obo/CHEBI_456215|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_16027
T31 1661-1664 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_30616|http://purl.obolibrary.org/obo/CHEBI_15422
T33 1697-1700 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_30616|http://purl.obolibrary.org/obo/CHEBI_15422
T35 1701-1704 ChemicalEntity denotes ADP http://purl.obolibrary.org/obo/CHEBI_73342|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_16761
T38 1717-1728 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T41 1763-1777 ChemicalEntity denotes erythropoietin http://purl.obolibrary.org/obo/CHEBI_81579
T42 1923-1934 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T45 2012-2015 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_30616|http://purl.obolibrary.org/obo/CHEBI_15422

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 24-28 OrganismTaxon denotes rats
T2 190-198 OrganismTaxon denotes patients
T3 685-689 OrganismTaxon denotes rats
T4 950-954 OrganismTaxon denotes rats
T5 1218-1222 OrganismTaxon denotes rats
T6 1893-1897 OrganismTaxon denotes rats

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T45 2012-2015 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T42 1923-1934 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T41 1763-1777 ChemicalEntity denotes erythropoietin http://purl.obolibrary.org/obo/CHEBI_81579
T38 1717-1728 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T35 1701-1704 ChemicalEntity denotes ADP http://purl.obolibrary.org/obo/CHEBI_16761|http://purl.obolibrary.org/obo/CHEBI_456216|http://purl.obolibrary.org/obo/CHEBI_73342
T33 1697-1700 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T31 1661-1664 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T28 1606-1609 ChemicalEntity denotes AMP http://purl.obolibrary.org/obo/CHEBI_16027|http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_456215
T27 1433-1444 ChemicalEntity denotes adiponectin http://purl.obolibrary.org/obo/CHEBI_81572
T25 1105-1118 ChemicalEntity denotes doxorubicinol http://purl.obolibrary.org/obo/CHEBI_133817|C010013
T22 1089-1100 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T21 1016-1027 ChemicalEntity denotes Doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748
T18 773-784 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T15 717-728 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T13 479-482 ChemicalEntity denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T11 421-434 ChemicalEntity denotes triglycerides http://purl.obolibrary.org/obo/CHEBI_17855|D014280
T8 306-317 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T7 125-135 ChemicalEntity denotes Adriamycin http://purl.obolibrary.org/obo/CHEBI_28748
T4 112-123 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T1 53-64 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T12 2083-2088 GeneOrGeneProduct denotes STAT3
T17064 1845-1850 GeneOrGeneProduct denotes STAT3
T10 1792-1797 GeneOrGeneProduct denotes SOCS3
T9 1763-1777 GeneOrGeneProduct denotes erythropoietin
T70269 1645-1649 GeneOrGeneProduct denotes drop
T37019 1610-1616 GeneOrGeneProduct denotes alpha2
T6 1433-1444 GeneOrGeneProduct denotes adiponectin
T5 1405-1410 GeneOrGeneProduct denotes alpha
T35860 1361-1404 GeneOrGeneProduct denotes peroxisome proliferators activated receptor
T3 1302-1323 GeneOrGeneProduct denotes uncoupling proteins 2
T2 695-698 GeneOrGeneProduct denotes 275
T7633 514-519 GeneOrGeneProduct denotes STAT3
T16 1943-1957 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T28629 1887-1892 DiseaseOrPhenotypicFeature denotes obese DISEASE
T14 1573-1575 DiseaseOrPhenotypicFeature denotes OB DISEASE
T43014 1215-1217 DiseaseOrPhenotypicFeature denotes OB DISEASE
T90986 1170-1172 DiseaseOrPhenotypicFeature denotes OB DISEASE
T86539 989-1014 DiseaseOrPhenotypicFeature denotes renal or hepatic toxicity DISEASE
T91619 946-948 DiseaseOrPhenotypicFeature denotes OB DISEASE
T65804 939-944 DiseaseOrPhenotypicFeature denotes obese DISEASE
T20828 873-892 DiseaseOrPhenotypicFeature denotes cardiac dysfunction DISEASE
T90021 857-871 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T77711 737-751 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T15965 654-661 DiseaseOrPhenotypicFeature denotes obesity D009765
T93175 326-340 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T4968 172-186 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T50358 73-87 DiseaseOrPhenotypicFeature denotes cardiotoxicity D066126
T92405 18-23 DiseaseOrPhenotypicFeature denotes obese DISEASE
T20518 1893-1897 OrganismTaxon denotes rats
T41232 1218-1222 OrganismTaxon denotes rats
T36993 950-954 OrganismTaxon denotes rats
T72859 685-689 OrganismTaxon denotes rats
T88270 190-198 OrganismTaxon denotes patients
T37219 24-28 OrganismTaxon denotes rats

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 5-8 Chemical denotes fat
T2 18-23 Disease denotes obese
T3 53-64 Chemical denotes doxorubicin
T4 73-87 Disease denotes cardiotoxicity
T5 112-123 Chemical denotes doxorubicin
T6 125-135 Chemical denotes Adriamycin
T7 172-186 Disease denotes cardiotoxicity
T8 306-317 Chemical denotes doxorubicin
T9 326-340 Disease denotes cardiotoxicity
T10 421-434 Chemical denotes triglycerides
T11 479-482 Chemical denotes ATP
T12 624-627 Chemical denotes fat
T13 654-661 Disease denotes obesity
T14 717-728 Chemical denotes doxorubicin
T15 737-751 Disease denotes cardiotoxicity
T16 773-784 Chemical denotes doxorubicin
T17 857-871 Disease denotes cardiotoxicity
T18 873-892 Disease denotes cardiac dysfunction
T19 939-944 Disease denotes obese
T20 946-948 Disease denotes OB
T21 989-994 Disease denotes renal
T22 989-1014 Disease denotes renal or hepatic toxicity
T23 998-1014 Disease denotes hepatic toxicity
T24 1006-1014 Disease denotes toxicity
T25 1016-1027 Chemical denotes Doxorubicin
T26 1089-1100 Chemical denotes doxorubicin
T27 1105-1118 Chemical denotes doxorubicinol
T28 1170-1172 Disease denotes OB
T29 1215-1217 Disease denotes OB
T30 1573-1575 Disease denotes OB
T31 1606-1609 Chemical denotes AMP
T32 1661-1664 Chemical denotes ATP
T33 1697-1700 Chemical denotes ATP
T34 1701-1704 Chemical denotes ADP
T35 1717-1728 Chemical denotes doxorubicin
T36 1887-1892 Disease denotes obese
T37 1923-1934 Chemical denotes doxorubicin
T38 1943-1957 Disease denotes cardiotoxicity
T39 2012-2015 Chemical denotes ATP