PubMed:18621992 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T1","span":{"begin":47,"end":54},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T2","span":{"begin":151,"end":158},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T3","span":{"begin":224,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T4","span":{"begin":410,"end":417},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T5","span":{"begin":594,"end":601},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos600-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":47,"end":54},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T2","span":{"begin":151,"end":158},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T3","span":{"begin":224,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T4","span":{"begin":410,"end":417},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T5","span":{"begin":594,"end":601},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos600-CLO","denotations":[{"id":"T1","span":{"begin":568,"end":577},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T2","span":{"begin":666,"end":674},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T3","span":{"begin":717,"end":725},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T4","span":{"begin":870,"end":874},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":47,"end":54},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":151,"end":158},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":224,"end":231},"obj":"Glycan_Motif"},{"id":"T4","span":{"begin":410,"end":417},"obj":"Glycan_Motif"},{"id":"T5","span":{"begin":594,"end":601},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A4","pred":"image","subj":"T4","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"},{"id":"A5","pred":"image","subj":"T5","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":181,"end":183},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":762,"end":764},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0016063"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0016063"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":78,"end":427},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":428,"end":675},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":676,"end":883},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":884,"end":1083},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":1084,"end":1255},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T2","span":{"begin":78,"end":427},"obj":"Sentence"},{"id":"T3","span":{"begin":428,"end":675},"obj":"Sentence"},{"id":"T4","span":{"begin":676,"end":883},"obj":"Sentence"},{"id":"T5","span":{"begin":884,"end":1083},"obj":"Sentence"},{"id":"T6","span":{"begin":1084,"end":1255},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":47,"end":54},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T2","span":{"begin":151,"end":158},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T3","span":{"begin":224,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T4","span":{"begin":410,"end":417},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"},{"id":"T5","span":{"begin":594,"end":601},"obj":"https://glytoucan.org/Structures/Glycans/G70323CJ"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"ICD10","denotations":[{"id":"T1","span":{"begin":503,"end":511},"obj":"http://purl.bioontology.org/ontology/ICD10/O80-O84.9"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":181,"end":187},"obj":"http://www.uniprot.org/uniprot/P20645"},{"id":"T2","span":{"begin":762,"end":768},"obj":"http://www.uniprot.org/uniprot/P20645"},{"id":"T3","span":{"begin":184,"end":200},"obj":"http://www.uniprot.org/uniprot/P11717"},{"id":"T4","span":{"begin":254,"end":260},"obj":"http://www.uniprot.org/uniprot/P11717"},{"id":"T5","span":{"begin":742,"end":748},"obj":"http://www.uniprot.org/uniprot/P11717"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":181,"end":187},"obj":"http://www.uniprot.org/uniprot/P24668"},{"id":"T2","span":{"begin":762,"end":768},"obj":"http://www.uniprot.org/uniprot/P24668"},{"id":"T3","span":{"begin":184,"end":200},"obj":"http://www.uniprot.org/uniprot/Q07113"},{"id":"T4","span":{"begin":254,"end":260},"obj":"http://www.uniprot.org/uniprot/Q07113"},{"id":"T5","span":{"begin":742,"end":748},"obj":"http://www.uniprot.org/uniprot/Q07113"},{"id":"T6","span":{"begin":888,"end":892},"obj":"http://www.uniprot.org/uniprot/Q6A009"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":67,"end":76},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T2","span":{"begin":254,"end":256},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/245896"},{"id":"T3","span":{"begin":742,"end":744},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/245896"},{"id":"T4","span":{"begin":1052,"end":1055},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/604139"},{"id":"T5","span":{"begin":1156,"end":1165},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T6","span":{"begin":1170,"end":1177},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/353209"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":395,"end":409},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GO-MF","denotations":[{"id":"T1","span":{"begin":910,"end":917},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T2","span":{"begin":1075,"end":1082},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":568,"end":577},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T2","span":{"begin":666,"end":674},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T3","span":{"begin":717,"end":725},"obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"T4","span":{"begin":695,"end":708},"obj":"http://purl.obolibrary.org/obo/GO_0005622"},{"id":"T5","span":{"begin":870,"end":874},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T6","span":{"begin":870,"end":882},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T7","span":{"begin":896,"end":909},"obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos600-FMA","denotations":[{"id":"T1","span":{"begin":15,"end":27},"obj":"Body_part"},{"id":"T2","span":{"begin":47,"end":54},"obj":"Body_part"},{"id":"T3","span":{"begin":151,"end":158},"obj":"Body_part"},{"id":"T4","span":{"begin":224,"end":231},"obj":"Body_part"},{"id":"T5","span":{"begin":410,"end":417},"obj":"Body_part"},{"id":"T6","span":{"begin":568,"end":577},"obj":"Body_part"},{"id":"T7","span":{"begin":594,"end":601},"obj":"Body_part"},{"id":"T8","span":{"begin":642,"end":658},"obj":"Body_part"},{"id":"T9","span":{"begin":666,"end":674},"obj":"Body_part"},{"id":"T10","span":{"begin":717,"end":725},"obj":"Body_part"},{"id":"T11","span":{"begin":870,"end":882},"obj":"Body_part"},{"id":"T12","span":{"begin":870,"end":874},"obj":"Body_part"},{"id":"T13","span":{"begin":1024,"end":1032},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma82737"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma82801"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma82742"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma63836"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"glycosmos-test-glycan-structure","denotations":[{"id":"PD-GlycanStructures-B_T1","span":{"begin":47,"end":54},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T2","span":{"begin":151,"end":158},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T3","span":{"begin":224,"end":231},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T4","span":{"begin":410,"end":417},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T5","span":{"begin":594,"end":601},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"glycosmos-test-structure-v1","denotations":[{"id":"PD-GlycanStructures-B_T1","span":{"begin":47,"end":54},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T2","span":{"begin":151,"end":158},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T3","span":{"begin":224,"end":231},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T4","span":{"begin":410,"end":417},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"},{"id":"PD-GlycanStructures-B_T5","span":{"begin":594,"end":601},"obj":"http://rdf.glyconavi.org/CarTNa/CarTNa218/trivialname"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyCosmos600-GlycoProteins","denotations":[{"id":"PD-GlycoProteins-B_T1","span":{"begin":134,"end":179},"obj":"https://acgg.asia/db/gpdb/id/GPDB0003510"},{"id":"PD-GlycoProteins-B_T2","span":{"begin":205,"end":252},"obj":"https://acgg.asia/db/gpdb/id/GPDB0003923"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"pubmed-enju-pas","denotations":[{"id":"EnjuParser_T0","span":{"begin":0,"end":10},"obj":"NNS"},{"id":"EnjuParser_T1","span":{"begin":11,"end":14},"obj":"IN"},{"id":"EnjuParser_T2","span":{"begin":15,"end":27},"obj":"NN"},{"id":"EnjuParser_T3","span":{"begin":28,"end":39},"obj":"NN"},{"id":"EnjuParser_T4","span":{"begin":40,"end":42},"obj":"IN"},{"id":"EnjuParser_T5","span":{"begin":43,"end":46},"obj":"DT"},{"id":"EnjuParser_T6","span":{"begin":47,"end":54},"obj":"NN"},{"id":"EnjuParser_T7","span":{"begin":55,"end":66},"obj":"NN"},{"id":"EnjuParser_T8","span":{"begin":67,"end":76},"obj":"NNS"},{"id":"EnjuParser_T9","span":{"begin":78,"end":81},"obj":"DT"},{"id":"EnjuParser_T10","span":{"begin":82,"end":85},"obj":"CD"},{"id":"EnjuParser_T11","span":{"begin":86,"end":93},"obj":"NNS"},{"id":"EnjuParser_T12","span":{"begin":94,"end":96},"obj":"IN"},{"id":"EnjuParser_T13","span":{"begin":97,"end":100},"obj":"DT"},{"id":"EnjuParser_T14","span":{"begin":101,"end":107},"obj":"JJ"},{"id":"EnjuParser_T15","span":{"begin":108,"end":114},"obj":"NN"},{"id":"EnjuParser_T16","span":{"begin":115,"end":121},"obj":"NN"},{"id":"EnjuParser_T17","span":{"begin":121,"end":122},"obj":"-COMMA-"},{"id":"EnjuParser_T18","span":{"begin":123,"end":126},"obj":"DT"},{"id":"EnjuParser_T19","span":{"begin":127,"end":129},"obj":"CD"},{"id":"EnjuParser_T20","span":{"begin":130,"end":133},"obj":"NN"},{"id":"EnjuParser_T21","span":{"begin":134,"end":150},"obj":"JJ"},{"id":"EnjuParser_T22","span":{"begin":151,"end":158},"obj":"NN"},{"id":"EnjuParser_T23","span":{"begin":159,"end":170},"obj":"NN"},{"id":"EnjuParser_T24","span":{"begin":171,"end":179},"obj":"NN"},{"id":"EnjuParser_T25","span":{"begin":180,"end":181},"obj":"-LRB-"},{"id":"EnjuParser_T26","span":{"begin":181,"end":187},"obj":"NN"},{"id":"EnjuParser_T27","span":{"begin":187,"end":188},"obj":"-RRB-"},{"id":"EnjuParser_T28","span":{"begin":189,"end":192},"obj":"CC"},{"id":"EnjuParser_T29","span":{"begin":193,"end":196},"obj":"DT"},{"id":"EnjuParser_T30","span":{"begin":197,"end":200},"obj":"CD"},{"id":"EnjuParser_T31","span":{"begin":201,"end":204},"obj":"NN"},{"id":"EnjuParser_T32","span":{"begin":205,"end":223},"obj":"JJ"},{"id":"EnjuParser_T33","span":{"begin":224,"end":231},"obj":"NN"},{"id":"EnjuParser_T34","span":{"begin":232,"end":243},"obj":"NN"},{"id":"EnjuParser_T35","span":{"begin":244,"end":252},"obj":"NN"},{"id":"EnjuParser_T36","span":{"begin":253,"end":254},"obj":"-LRB-"},{"id":"EnjuParser_T37","span":{"begin":254,"end":260},"obj":"NN"},{"id":"EnjuParser_T38","span":{"begin":260,"end":261},"obj":"-RRB-"},{"id":"EnjuParser_T39","span":{"begin":261,"end":262},"obj":"-COMMA-"},{"id":"EnjuParser_T40","span":{"begin":263,"end":266},"obj":"VBP"},{"id":"EnjuParser_T41","span":{"begin":267,"end":279},"obj":"RB"},{"id":"EnjuParser_T42","span":{"begin":280,"end":289},"obj":"VBN"},{"id":"EnjuParser_T43","span":{"begin":290,"end":300},"obj":"IN"},{"id":"EnjuParser_T44","span":{"begin":301,"end":304},"obj":"DT"},{"id":"EnjuParser_T45","span":{"begin":305,"end":311},"obj":"NN"},{"id":"EnjuParser_T46","span":{"begin":312,"end":319},"obj":"NN"},{"id":"EnjuParser_T47","span":{"begin":320,"end":323},"obj":"CC"},{"id":"EnjuParser_T48","span":{"begin":324,"end":327},"obj":"VBP"},{"id":"EnjuParser_T49","span":{"begin":328,"end":341},"obj":"VBN"},{"id":"EnjuParser_T50","span":{"begin":342,"end":346},"obj":"IN"},{"id":"EnjuParser_T51","span":{"begin":347,"end":350},"obj":"DT"},{"id":"EnjuParser_T52","span":{"begin":351,"end":356},"obj":"JJ"},{"id":"EnjuParser_T53","span":{"begin":357,"end":364},"obj":"NNS"},{"id":"EnjuParser_T54","span":{"begin":365,"end":367},"obj":"IN"},{"id":"EnjuParser_T55","span":{"begin":368,"end":373},"obj":"PRP-DOLLAR-"},{"id":"EnjuParser_T56","span":{"begin":374,"end":381},"obj":"NN"},{"id":"EnjuParser_T57","span":{"begin":382,"end":384},"obj":"TO"},{"id":"EnjuParser_T58","span":{"begin":385,"end":394},"obj":"VB"},{"id":"EnjuParser_T59","span":{"begin":395,"end":409},"obj":"VBN"},{"id":"EnjuParser_T60","span":{"begin":410,"end":417},"obj":"NN"},{"id":"EnjuParser_T61","span":{"begin":418,"end":426},"obj":"NNS"},{"id":"EnjuParser_T62","span":{"begin":428,"end":431},"obj":"DT"},{"id":"EnjuParser_T63","span":{"begin":432,"end":450},"obj":"JJ"},{"id":"EnjuParser_T64","span":{"begin":451,"end":459},"obj":"NN"},{"id":"EnjuParser_T65","span":{"begin":460,"end":462},"obj":"IN"},{"id":"EnjuParser_T66","span":{"begin":463,"end":466},"obj":"DT"},{"id":"EnjuParser_T67","span":{"begin":467,"end":471},"obj":"NNS"},{"id":"EnjuParser_T68","span":{"begin":472,"end":474},"obj":"VBZ"},{"id":"EnjuParser_T69","span":{"begin":475,"end":480},"obj":"PRP-DOLLAR-"},{"id":"EnjuParser_T70","span":{"begin":481,"end":488},"obj":"NN"},{"id":"EnjuParser_T71","span":{"begin":489,"end":491},"obj":"TO"},{"id":"EnjuParser_T72","span":{"begin":492,"end":498},"obj":"VB"},{"id":"EnjuParser_T73","span":{"begin":499,"end":502},"obj":"DT"},{"id":"EnjuParser_T74","span":{"begin":503,"end":511},"obj":"NN"},{"id":"EnjuParser_T75","span":{"begin":512,"end":514},"obj":"IN"},{"id":"EnjuParser_T76","span":{"begin":515,"end":528},"obj":"RB"},{"id":"EnjuParser_T77","span":{"begin":529,"end":531},"obj":"CD"},{"id":"EnjuParser_T78","span":{"begin":532,"end":541},"obj":"JJ"},{"id":"EnjuParser_T79","span":{"begin":542,"end":547},"obj":"RB"},{"id":"EnjuParser_T80","span":{"begin":548,"end":559},"obj":"VBN"},{"id":"EnjuParser_T81","span":{"begin":560,"end":567},"obj":"JJ"},{"id":"EnjuParser_T82","span":{"begin":568,"end":577},"obj":"JJ"},{"id":"EnjuParser_T83","span":{"begin":578,"end":585},"obj":"NNS"},{"id":"EnjuParser_T84","span":{"begin":586,"end":593},"obj":"VBG"},{"id":"EnjuParser_T85","span":{"begin":594,"end":601},"obj":"NN"},{"id":"EnjuParser_T86","span":{"begin":602,"end":613},"obj":"NN"},{"id":"EnjuParser_T87","span":{"begin":614,"end":615},"obj":"-LRB-"},{"id":"EnjuParser_T88","span":{"begin":615,"end":622},"obj":"NN"},{"id":"EnjuParser_T89","span":{"begin":622,"end":623},"obj":"-RRB-"},{"id":"EnjuParser_T90","span":{"begin":624,"end":626},"obj":"IN"},{"id":"EnjuParser_T91","span":{"begin":627,"end":632},"obj":"PRP-DOLLAR-"},{"id":"EnjuParser_T92","span":{"begin":633,"end":641},"obj":"VBN"},{"id":"EnjuParser_T93","span":{"begin":642,"end":658},"obj":"NNS"},{"id":"EnjuParser_T94","span":{"begin":659,"end":661},"obj":"TO"},{"id":"EnjuParser_T95","span":{"begin":662,"end":665},"obj":"DT"},{"id":"EnjuParser_T96","span":{"begin":666,"end":674},"obj":"NN"},{"id":"EnjuParser_T97","span":{"begin":676,"end":678},"obj":"IN"},{"id":"EnjuParser_T98","span":{"begin":679,"end":687},"obj":"NN"},{"id":"EnjuParser_T99","span":{"begin":688,"end":690},"obj":"TO"},{"id":"EnjuParser_T100","span":{"begin":691,"end":694},"obj":"PRP-DOLLAR-"},{"id":"EnjuParser_T101","span":{"begin":695,"end":708},"obj":"JJ"},{"id":"EnjuParser_T102","span":{"begin":709,"end":713},"obj":"NN"},{"id":"EnjuParser_T103","span":{"begin":714,"end":716},"obj":"IN"},{"id":"EnjuParser_T104","span":{"begin":717,"end":725},"obj":"NN"},{"id":"EnjuParser_T105","span":{"begin":726,"end":736},"obj":"NN"},{"id":"EnjuParser_T106","span":{"begin":736,"end":737},"obj":"-COMMA-"},{"id":"EnjuParser_T107","span":{"begin":738,"end":741},"obj":"DT"},{"id":"EnjuParser_T108","span":{"begin":742,"end":748},"obj":"NN"},{"id":"EnjuParser_T109","span":{"begin":748,"end":749},"obj":"-COMMA-"},{"id":"EnjuParser_T110","span":{"begin":750,"end":753},"obj":"CC"},{"id":"EnjuParser_T111","span":{"begin":754,"end":757},"obj":"RB"},{"id":"EnjuParser_T112","span":{"begin":758,"end":761},"obj":"DT"},{"id":"EnjuParser_T113","span":{"begin":762,"end":768},"obj":"NN"},{"id":"EnjuParser_T114","span":{"begin":768,"end":769},"obj":"-COMMA-"},{"id":"EnjuParser_T115","span":{"begin":770,"end":782},"obj":"VBZ"},{"id":"EnjuParser_T116","span":{"begin":783,"end":785},"obj":"IN"},{"id":"EnjuParser_T117","span":{"begin":786,"end":787},"obj":"DT"},{"id":"EnjuParser_T118","span":{"begin":788,"end":794},"obj":"NN"},{"id":"EnjuParser_T119","span":{"begin":795,"end":797},"obj":"IN"},{"id":"EnjuParser_T120","span":{"begin":798,"end":803},"obj":"JJ"},{"id":"EnjuParser_T121","span":{"begin":804,"end":814},"obj":"JJ"},{"id":"EnjuParser_T122","span":{"begin":815,"end":824},"obj":"NNS"},{"id":"EnjuParser_T123","span":{"begin":825,"end":827},"obj":"IN"},{"id":"EnjuParser_T124","span":{"begin":828,"end":839},"obj":"VBG"},{"id":"EnjuParser_T125","span":{"begin":840,"end":844},"obj":"IN"},{"id":"EnjuParser_T126","span":{"begin":845,"end":852},"obj":"JJ"},{"id":"EnjuParser_T127","span":{"begin":853,"end":862},"obj":"NNS"},{"id":"EnjuParser_T128","span":{"begin":863,"end":865},"obj":"IN"},{"id":"EnjuParser_T129","span":{"begin":866,"end":869},"obj":"DT"},{"id":"EnjuParser_T130","span":{"begin":870,"end":874},"obj":"NN"},{"id":"EnjuParser_T131","span":{"begin":875,"end":882},"obj":"NN"},{"id":"EnjuParser_T132","span":{"begin":884,"end":887},"obj":"DT"},{"id":"EnjuParser_T133","span":{"begin":888,"end":892},"obj":"NN"},{"id":"EnjuParser_T134","span":{"begin":893,"end":895},"obj":"IN"},{"id":"EnjuParser_T135","span":{"begin":896,"end":909},"obj":"JJ"},{"id":"EnjuParser_T136","span":{"begin":910,"end":917},"obj":"NNS"},{"id":"EnjuParser_T137","span":{"begin":918,"end":928},"obj":"VBN"},{"id":"EnjuParser_T138","span":{"begin":929,"end":931},"obj":"IN"},{"id":"EnjuParser_T139","span":{"begin":932,"end":936},"obj":"DT"},{"id":"EnjuParser_T140","span":{"begin":937,"end":952},"obj":"JJ"},{"id":"EnjuParser_T141","span":{"begin":953,"end":961},"obj":"NN"},{"id":"EnjuParser_T142","span":{"begin":962,"end":965},"obj":"VBZ"},{"id":"EnjuParser_T143","span":{"begin":966,"end":971},"obj":"VBN"},{"id":"EnjuParser_T144","span":{"begin":972,"end":974},"obj":"TO"},{"id":"EnjuParser_T145","span":{"begin":975,"end":982},"obj":"VB"},{"id":"EnjuParser_T146","span":{"begin":983,"end":984},"obj":"DT"},{"id":"EnjuParser_T147","span":{"begin":985,"end":992},"obj":"JJ"},{"id":"EnjuParser_T148","span":{"begin":993,"end":1001},"obj":"NN"},{"id":"EnjuParser_T149","span":{"begin":1002,"end":1004},"obj":"IN"},{"id":"EnjuParser_T150","span":{"begin":1005,"end":1023},"obj":"JJ"},{"id":"EnjuParser_T151","span":{"begin":1024,"end":1032},"obj":"NNS"},{"id":"EnjuParser_T152","span":{"begin":1033,"end":1035},"obj":"RB"},{"id":"EnjuParser_T153","span":{"begin":1036,"end":1040},"obj":"RB"},{"id":"EnjuParser_T154","span":{"begin":1041,"end":1043},"obj":"IN"},{"id":"EnjuParser_T155","span":{"begin":1044,"end":1051},"obj":"JJ"},{"id":"EnjuParser_T156","span":{"begin":1052,"end":1074},"obj":"JJ"},{"id":"EnjuParser_T157","span":{"begin":1075,"end":1082},"obj":"NNS"},{"id":"EnjuParser_T158","span":{"begin":1084,"end":1090},"obj":"JJ"},{"id":"EnjuParser_T159","span":{"begin":1091,"end":1101},"obj":"JJ"},{"id":"EnjuParser_T160","span":{"begin":1102,"end":1109},"obj":"NNS"},{"id":"EnjuParser_T161","span":{"begin":1110,"end":1114},"obj":"VBP"},{"id":"EnjuParser_T162","span":{"begin":1115,"end":1120},"obj":"VBN"},{"id":"EnjuParser_T163","span":{"begin":1121,"end":1123},"obj":"PRP"},{"id":"EnjuParser_T164","span":{"begin":1124,"end":1125},"obj":"DT"},{"id":"EnjuParser_T165","span":{"begin":1126,"end":1133},"obj":"JJR"},{"id":"EnjuParser_T166","span":{"begin":1134,"end":1138},"obj":"NN"},{"id":"EnjuParser_T167","span":{"begin":1139,"end":1141},"obj":"IN"},{"id":"EnjuParser_T168","span":{"begin":1142,"end":1145},"obj":"WRB"},{"id":"EnjuParser_T169","span":{"begin":1146,"end":1151},"obj":"DT"},{"id":"EnjuParser_T170","span":{"begin":1152,"end":1155},"obj":"CD"},{"id":"EnjuParser_T171","span":{"begin":1156,"end":1165},"obj":"NNS"},{"id":"EnjuParser_T172","span":{"begin":1166,"end":1169},"obj":"VBP"},{"id":"EnjuParser_T173","span":{"begin":1170,"end":1177},"obj":"VBN"},{"id":"EnjuParser_T174","span":{"begin":1177,"end":1178},"obj":"-COMMA-"},{"id":"EnjuParser_T175","span":{"begin":1179,"end":1182},"obj":"CC"},{"id":"EnjuParser_T176","span":{"begin":1183,"end":1186},"obj":"RB"},{"id":"EnjuParser_T177","span":{"begin":1187,"end":1195},"obj":"JJ"},{"id":"EnjuParser_T178","span":{"begin":1195,"end":1196},"obj":"-COMMA-"},{"id":"EnjuParser_T179","span":{"begin":1197,"end":1207},"obj":"NNS"},{"id":"EnjuParser_T180","span":{"begin":1208,"end":1210},"obj":"IN"},{"id":"EnjuParser_T181","span":{"begin":1211,"end":1214},"obj":"DT"},{"id":"EnjuParser_T182","span":{"begin":1215,"end":1226},"obj":"NN"},{"id":"EnjuParser_T183","span":{"begin":1227,"end":1229},"obj":"IN"},{"id":"EnjuParser_T184","span":{"begin":1230,"end":1245},"obj":"NN"},{"id":"EnjuParser_T185","span":{"begin":1246,"end":1254},"obj":"NNS"}],"relations":[{"id":"EnjuParser_R0","pred":"arg1Of","subj":"EnjuParser_T0","obj":"EnjuParser_T1"},{"id":"EnjuParser_R1","pred":"arg2Of","subj":"EnjuParser_T3","obj":"EnjuParser_T1"},{"id":"EnjuParser_R2","pred":"arg1Of","subj":"EnjuParser_T3","obj":"EnjuParser_T2"},{"id":"EnjuParser_R3","pred":"arg1Of","subj":"EnjuParser_T0","obj":"EnjuParser_T4"},{"id":"EnjuParser_R4","pred":"arg2Of","subj":"EnjuParser_T8","obj":"EnjuParser_T4"},{"id":"EnjuParser_R5","pred":"arg1Of","subj":"EnjuParser_T8","obj":"EnjuParser_T5"},{"id":"EnjuParser_R6","pred":"arg1Of","subj":"EnjuParser_T8","obj":"EnjuParser_T6"},{"id":"EnjuParser_R7","pred":"arg1Of","subj":"EnjuParser_T8","obj":"EnjuParser_T7"},{"id":"EnjuParser_R8","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T9"},{"id":"EnjuParser_R9","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T10"},{"id":"EnjuParser_R10","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T12"},{"id":"EnjuParser_R11","pred":"arg2Of","subj":"EnjuParser_T16","obj":"EnjuParser_T12"},{"id":"EnjuParser_R12","pred":"arg1Of","subj":"EnjuParser_T16","obj":"EnjuParser_T13"},{"id":"EnjuParser_R13","pred":"arg1Of","subj":"EnjuParser_T16","obj":"EnjuParser_T14"},{"id":"EnjuParser_R14","pred":"arg1Of","subj":"EnjuParser_T16","obj":"EnjuParser_T15"},{"id":"EnjuParser_R15","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T17"},{"id":"EnjuParser_R16","pred":"arg2Of","subj":"EnjuParser_T28","obj":"EnjuParser_T17"},{"id":"EnjuParser_R17","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T18"},{"id":"EnjuParser_R18","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T19"},{"id":"EnjuParser_R19","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T20"},{"id":"EnjuParser_R20","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T21"},{"id":"EnjuParser_R21","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T22"},{"id":"EnjuParser_R22","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T23"},{"id":"EnjuParser_R23","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T25"},{"id":"EnjuParser_R24","pred":"arg2Of","subj":"EnjuParser_T26","obj":"EnjuParser_T25"},{"id":"EnjuParser_R25","pred":"arg3Of","subj":"EnjuParser_T27","obj":"EnjuParser_T25"},{"id":"EnjuParser_R26","pred":"arg1Of","subj":"EnjuParser_T24","obj":"EnjuParser_T28"},{"id":"EnjuParser_R27","pred":"arg2Of","subj":"EnjuParser_T35","obj":"EnjuParser_T28"},{"id":"EnjuParser_R28","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T29"},{"id":"EnjuParser_R29","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T30"},{"id":"EnjuParser_R30","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T31"},{"id":"EnjuParser_R31","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T32"},{"id":"EnjuParser_R32","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T33"},{"id":"EnjuParser_R33","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T34"},{"id":"EnjuParser_R34","pred":"arg1Of","subj":"EnjuParser_T35","obj":"EnjuParser_T36"},{"id":"EnjuParser_R35","pred":"arg2Of","subj":"EnjuParser_T37","obj":"EnjuParser_T36"},{"id":"EnjuParser_R36","pred":"arg3Of","subj":"EnjuParser_T38","obj":"EnjuParser_T36"},{"id":"EnjuParser_R37","pred":"arg1Of","subj":"EnjuParser_T47","obj":"EnjuParser_T39"},{"id":"EnjuParser_R38","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T40"},{"id":"EnjuParser_R39","pred":"arg2Of","subj":"EnjuParser_T42","obj":"EnjuParser_T40"},{"id":"EnjuParser_R40","pred":"arg1Of","subj":"EnjuParser_T42","obj":"EnjuParser_T41"},{"id":"EnjuParser_R41","pred":"arg2Of","subj":"EnjuParser_T11","obj":"EnjuParser_T42"},{"id":"EnjuParser_R42","pred":"arg1Of","subj":"EnjuParser_T42","obj":"EnjuParser_T43"},{"id":"EnjuParser_R43","pred":"arg2Of","subj":"EnjuParser_T46","obj":"EnjuParser_T43"},{"id":"EnjuParser_R44","pred":"arg1Of","subj":"EnjuParser_T46","obj":"EnjuParser_T44"},{"id":"EnjuParser_R45","pred":"arg1Of","subj":"EnjuParser_T46","obj":"EnjuParser_T45"},{"id":"EnjuParser_R46","pred":"arg1Of","subj":"EnjuParser_T42","obj":"EnjuParser_T47"},{"id":"EnjuParser_R47","pred":"arg2Of","subj":"EnjuParser_T49","obj":"EnjuParser_T47"},{"id":"EnjuParser_R48","pred":"arg1Of","subj":"EnjuParser_T11","obj":"EnjuParser_T48"},{"id":"EnjuParser_R49","pred":"arg2Of","subj":"EnjuParser_T49","obj":"EnjuParser_T48"},{"id":"EnjuParser_R50","pred":"arg2Of","subj":"EnjuParser_T11","obj":"EnjuParser_T49"},{"id":"EnjuParser_R51","pred":"arg1Of","subj":"EnjuParser_T49","obj":"EnjuParser_T50"},{"id":"EnjuParser_R52","pred":"arg2Of","subj":"EnjuParser_T53","obj":"EnjuParser_T50"},{"id":"EnjuParser_R53","pred":"arg1Of","subj":"EnjuParser_T53","obj":"EnjuParser_T51"},{"id":"EnjuParser_R54","pred":"arg1Of","subj":"EnjuParser_T53","obj":"EnjuParser_T52"},{"id":"EnjuParser_R55","pred":"arg1Of","subj":"EnjuParser_T49","obj":"EnjuParser_T54"},{"id":"EnjuParser_R56","pred":"arg2Of","subj":"EnjuParser_T56","obj":"EnjuParser_T54"},{"id":"EnjuParser_R57","pred":"arg1Of","subj":"EnjuParser_T56","obj":"EnjuParser_T55"},{"id":"EnjuParser_R58","pred":"arg1Of","subj":"EnjuParser_T58","obj":"EnjuParser_T57"},{"id":"EnjuParser_R59","pred":"modOf","subj":"EnjuParser_T56","obj":"EnjuParser_T57"},{"id":"EnjuParser_R60","pred":"arg2Of","subj":"EnjuParser_T61","obj":"EnjuParser_T58"},{"id":"EnjuParser_R61","pred":"arg2Of","subj":"EnjuParser_T61","obj":"EnjuParser_T59"},{"id":"EnjuParser_R62","pred":"arg1Of","subj":"EnjuParser_T61","obj":"EnjuParser_T60"},{"id":"EnjuParser_R63","pred":"arg1Of","subj":"EnjuParser_T64","obj":"EnjuParser_T62"},{"id":"EnjuParser_R64","pred":"arg1Of","subj":"EnjuParser_T64","obj":"EnjuParser_T63"},{"id":"EnjuParser_R65","pred":"arg1Of","subj":"EnjuParser_T64","obj":"EnjuParser_T65"},{"id":"EnjuParser_R66","pred":"arg2Of","subj":"EnjuParser_T67","obj":"EnjuParser_T65"},{"id":"EnjuParser_R67","pred":"arg1Of","subj":"EnjuParser_T67","obj":"EnjuParser_T66"},{"id":"EnjuParser_R68","pred":"arg1Of","subj":"EnjuParser_T64","obj":"EnjuParser_T68"},{"id":"EnjuParser_R69","pred":"arg2Of","subj":"EnjuParser_T70","obj":"EnjuParser_T68"},{"id":"EnjuParser_R70","pred":"arg1Of","subj":"EnjuParser_T70","obj":"EnjuParser_T69"},{"id":"EnjuParser_R71","pred":"arg1Of","subj":"EnjuParser_T72","obj":"EnjuParser_T71"},{"id":"EnjuParser_R72","pred":"modOf","subj":"EnjuParser_T70","obj":"EnjuParser_T71"},{"id":"EnjuParser_R73","pred":"arg2Of","subj":"EnjuParser_T74","obj":"EnjuParser_T72"},{"id":"EnjuParser_R74","pred":"arg1Of","subj":"EnjuParser_T74","obj":"EnjuParser_T73"},{"id":"EnjuParser_R75","pred":"arg1Of","subj":"EnjuParser_T74","obj":"EnjuParser_T75"},{"id":"EnjuParser_R76","pred":"arg2Of","subj":"EnjuParser_T83","obj":"EnjuParser_T75"},{"id":"EnjuParser_R77","pred":"arg1Of","subj":"EnjuParser_T77","obj":"EnjuParser_T76"},{"id":"EnjuParser_R78","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T77"},{"id":"EnjuParser_R79","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T78"},{"id":"EnjuParser_R80","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T79"},{"id":"EnjuParser_R81","pred":"arg2Of","subj":"EnjuParser_T83","obj":"EnjuParser_T80"},{"id":"EnjuParser_R82","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T81"},{"id":"EnjuParser_R83","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T82"},{"id":"EnjuParser_R84","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T84"},{"id":"EnjuParser_R85","pred":"arg2Of","subj":"EnjuParser_T86","obj":"EnjuParser_T84"},{"id":"EnjuParser_R86","pred":"arg1Of","subj":"EnjuParser_T86","obj":"EnjuParser_T85"},{"id":"EnjuParser_R87","pred":"arg1Of","subj":"EnjuParser_T86","obj":"EnjuParser_T87"},{"id":"EnjuParser_R88","pred":"arg2Of","subj":"EnjuParser_T88","obj":"EnjuParser_T87"},{"id":"EnjuParser_R89","pred":"arg3Of","subj":"EnjuParser_T89","obj":"EnjuParser_T87"},{"id":"EnjuParser_R90","pred":"arg1Of","subj":"EnjuParser_T84","obj":"EnjuParser_T90"},{"id":"EnjuParser_R91","pred":"arg2Of","subj":"EnjuParser_T93","obj":"EnjuParser_T90"},{"id":"EnjuParser_R92","pred":"arg1Of","subj":"EnjuParser_T93","obj":"EnjuParser_T91"},{"id":"EnjuParser_R93","pred":"arg2Of","subj":"EnjuParser_T93","obj":"EnjuParser_T92"},{"id":"EnjuParser_R94","pred":"arg1Of","subj":"EnjuParser_T83","obj":"EnjuParser_T94"},{"id":"EnjuParser_R95","pred":"arg2Of","subj":"EnjuParser_T96","obj":"EnjuParser_T94"},{"id":"EnjuParser_R96","pred":"arg1Of","subj":"EnjuParser_T96","obj":"EnjuParser_T95"},{"id":"EnjuParser_R97","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T97"},{"id":"EnjuParser_R98","pred":"arg2Of","subj":"EnjuParser_T98","obj":"EnjuParser_T97"},{"id":"EnjuParser_R99","pred":"arg3Of","subj":"EnjuParser_T102","obj":"EnjuParser_T97"},{"id":"EnjuParser_R100","pred":"arg1Of","subj":"EnjuParser_T97","obj":"EnjuParser_T99"},{"id":"EnjuParser_R101","pred":"arg1Of","subj":"EnjuParser_T102","obj":"EnjuParser_T100"},{"id":"EnjuParser_R102","pred":"arg1Of","subj":"EnjuParser_T102","obj":"EnjuParser_T101"},{"id":"EnjuParser_R103","pred":"arg1Of","subj":"EnjuParser_T102","obj":"EnjuParser_T103"},{"id":"EnjuParser_R104","pred":"arg2Of","subj":"EnjuParser_T105","obj":"EnjuParser_T103"},{"id":"EnjuParser_R105","pred":"arg1Of","subj":"EnjuParser_T105","obj":"EnjuParser_T104"},{"id":"EnjuParser_R106","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T106"},{"id":"EnjuParser_R107","pred":"arg1Of","subj":"EnjuParser_T108","obj":"EnjuParser_T107"},{"id":"EnjuParser_R108","pred":"arg1Of","subj":"EnjuParser_T110","obj":"EnjuParser_T109"},{"id":"EnjuParser_R109","pred":"arg1Of","subj":"EnjuParser_T108","obj":"EnjuParser_T110"},{"id":"EnjuParser_R110","pred":"arg2Of","subj":"EnjuParser_T113","obj":"EnjuParser_T110"},{"id":"EnjuParser_R111","pred":"arg1Of","subj":"EnjuParser_T110","obj":"EnjuParser_T111"},{"id":"EnjuParser_R112","pred":"arg1Of","subj":"EnjuParser_T113","obj":"EnjuParser_T112"},{"id":"EnjuParser_R113","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T114"},{"id":"EnjuParser_R114","pred":"arg1Of","subj":"EnjuParser_T110","obj":"EnjuParser_T115"},{"id":"EnjuParser_R115","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T116"},{"id":"EnjuParser_R116","pred":"arg2Of","subj":"EnjuParser_T118","obj":"EnjuParser_T116"},{"id":"EnjuParser_R117","pred":"arg1Of","subj":"EnjuParser_T118","obj":"EnjuParser_T117"},{"id":"EnjuParser_R118","pred":"arg1Of","subj":"EnjuParser_T118","obj":"EnjuParser_T119"},{"id":"EnjuParser_R119","pred":"arg2Of","subj":"EnjuParser_T122","obj":"EnjuParser_T119"},{"id":"EnjuParser_R120","pred":"arg1Of","subj":"EnjuParser_T122","obj":"EnjuParser_T120"},{"id":"EnjuParser_R121","pred":"arg1Of","subj":"EnjuParser_T122","obj":"EnjuParser_T121"},{"id":"EnjuParser_R122","pred":"arg1Of","subj":"EnjuParser_T115","obj":"EnjuParser_T123"},{"id":"EnjuParser_R123","pred":"arg2Of","subj":"EnjuParser_T124","obj":"EnjuParser_T123"},{"id":"EnjuParser_R124","pred":"arg1Of","subj":"EnjuParser_T110","obj":"EnjuParser_T124"},{"id":"EnjuParser_R125","pred":"arg1Of","subj":"EnjuParser_T124","obj":"EnjuParser_T125"},{"id":"EnjuParser_R126","pred":"arg2Of","subj":"EnjuParser_T127","obj":"EnjuParser_T125"},{"id":"EnjuParser_R127","pred":"arg1Of","subj":"EnjuParser_T127","obj":"EnjuParser_T126"},{"id":"EnjuParser_R128","pred":"arg1Of","subj":"EnjuParser_T124","obj":"EnjuParser_T128"},{"id":"EnjuParser_R129","pred":"arg2Of","subj":"EnjuParser_T131","obj":"EnjuParser_T128"},{"id":"EnjuParser_R130","pred":"arg1Of","subj":"EnjuParser_T131","obj":"EnjuParser_T129"},{"id":"EnjuParser_R131","pred":"arg1Of","subj":"EnjuParser_T131","obj":"EnjuParser_T130"},{"id":"EnjuParser_R132","pred":"arg1Of","subj":"EnjuParser_T133","obj":"EnjuParser_T132"},{"id":"EnjuParser_R133","pred":"arg1Of","subj":"EnjuParser_T133","obj":"EnjuParser_T134"},{"id":"EnjuParser_R134","pred":"arg2Of","subj":"EnjuParser_T136","obj":"EnjuParser_T134"},{"id":"EnjuParser_R135","pred":"arg1Of","subj":"EnjuParser_T136","obj":"EnjuParser_T135"},{"id":"EnjuParser_R136","pred":"arg1Of","subj":"EnjuParser_T141","obj":"EnjuParser_T137"},{"id":"EnjuParser_R137","pred":"arg2Of","subj":"EnjuParser_T136","obj":"EnjuParser_T137"},{"id":"EnjuParser_R138","pred":"arg2Of","subj":"EnjuParser_T141","obj":"EnjuParser_T138"},{"id":"EnjuParser_R139","pred":"arg1Of","subj":"EnjuParser_T141","obj":"EnjuParser_T139"},{"id":"EnjuParser_R140","pred":"arg1Of","subj":"EnjuParser_T141","obj":"EnjuParser_T140"},{"id":"EnjuParser_R141","pred":"arg1Of","subj":"EnjuParser_T133","obj":"EnjuParser_T142"},{"id":"EnjuParser_R142","pred":"arg2Of","subj":"EnjuParser_T143","obj":"EnjuParser_T142"},{"id":"EnjuParser_R143","pred":"arg1Of","subj":"EnjuParser_T133","obj":"EnjuParser_T143"},{"id":"EnjuParser_R144","pred":"arg2Of","subj":"EnjuParser_T145","obj":"EnjuParser_T143"},{"id":"EnjuParser_R145","pred":"arg1Of","subj":"EnjuParser_T145","obj":"EnjuParser_T144"},{"id":"EnjuParser_R146","pred":"arg1Of","subj":"EnjuParser_T133","obj":"EnjuParser_T145"},{"id":"EnjuParser_R147","pred":"arg2Of","subj":"EnjuParser_T148","obj":"EnjuParser_T145"},{"id":"EnjuParser_R148","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T146"},{"id":"EnjuParser_R149","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T147"},{"id":"EnjuParser_R150","pred":"arg1Of","subj":"EnjuParser_T148","obj":"EnjuParser_T149"},{"id":"EnjuParser_R151","pred":"arg2Of","subj":"EnjuParser_T154","obj":"EnjuParser_T149"},{"id":"EnjuParser_R152","pred":"arg1Of","subj":"EnjuParser_T151","obj":"EnjuParser_T150"},{"id":"EnjuParser_R153","pred":"arg1Of","subj":"EnjuParser_T154","obj":"EnjuParser_T152"},{"id":"EnjuParser_R154","pred":"arg1Of","subj":"EnjuParser_T154","obj":"EnjuParser_T153"},{"id":"EnjuParser_R155","pred":"arg1Of","subj":"EnjuParser_T151","obj":"EnjuParser_T154"},{"id":"EnjuParser_R156","pred":"arg2Of","subj":"EnjuParser_T157","obj":"EnjuParser_T154"},{"id":"EnjuParser_R157","pred":"arg1Of","subj":"EnjuParser_T157","obj":"EnjuParser_T155"},{"id":"EnjuParser_R158","pred":"arg1Of","subj":"EnjuParser_T157","obj":"EnjuParser_T156"},{"id":"EnjuParser_R159","pred":"arg1Of","subj":"EnjuParser_T160","obj":"EnjuParser_T158"},{"id":"EnjuParser_R160","pred":"arg1Of","subj":"EnjuParser_T160","obj":"EnjuParser_T159"},{"id":"EnjuParser_R161","pred":"arg1Of","subj":"EnjuParser_T160","obj":"EnjuParser_T161"},{"id":"EnjuParser_R162","pred":"arg2Of","subj":"EnjuParser_T162","obj":"EnjuParser_T161"},{"id":"EnjuParser_R163","pred":"arg1Of","subj":"EnjuParser_T160","obj":"EnjuParser_T162"},{"id":"EnjuParser_R164","pred":"arg2Of","subj":"EnjuParser_T163","obj":"EnjuParser_T162"},{"id":"EnjuParser_R165","pred":"arg3Of","subj":"EnjuParser_T166","obj":"EnjuParser_T162"},{"id":"EnjuParser_R166","pred":"arg1Of","subj":"EnjuParser_T166","obj":"EnjuParser_T164"},{"id":"EnjuParser_R167","pred":"arg1Of","subj":"EnjuParser_T166","obj":"EnjuParser_T165"},{"id":"EnjuParser_R168","pred":"arg1Of","subj":"EnjuParser_T166","obj":"EnjuParser_T167"},{"id":"EnjuParser_R169","pred":"arg2Of","subj":"EnjuParser_T168","obj":"EnjuParser_T167"},{"id":"EnjuParser_R170","pred":"arg1Of","subj":"EnjuParser_T172","obj":"EnjuParser_T168"},{"id":"EnjuParser_R171","pred":"arg1Of","subj":"EnjuParser_T171","obj":"EnjuParser_T169"},{"id":"EnjuParser_R172","pred":"arg1Of","subj":"EnjuParser_T171","obj":"EnjuParser_T170"},{"id":"EnjuParser_R173","pred":"arg1Of","subj":"EnjuParser_T171","obj":"EnjuParser_T172"},{"id":"EnjuParser_R174","pred":"arg2Of","subj":"EnjuParser_T179","obj":"EnjuParser_T172"},{"id":"EnjuParser_R175","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T173"},{"id":"EnjuParser_R176","pred":"arg1Of","subj":"EnjuParser_T175","obj":"EnjuParser_T174"},{"id":"EnjuParser_R177","pred":"arg1Of","subj":"EnjuParser_T173","obj":"EnjuParser_T175"},{"id":"EnjuParser_R178","pred":"arg2Of","subj":"EnjuParser_T177","obj":"EnjuParser_T175"},{"id":"EnjuParser_R179","pred":"arg1Of","subj":"EnjuParser_T177","obj":"EnjuParser_T176"},{"id":"EnjuParser_R180","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T177"},{"id":"EnjuParser_R181","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T178"},{"id":"EnjuParser_R182","pred":"arg1Of","subj":"EnjuParser_T179","obj":"EnjuParser_T180"},{"id":"EnjuParser_R183","pred":"arg2Of","subj":"EnjuParser_T182","obj":"EnjuParser_T180"},{"id":"EnjuParser_R184","pred":"arg1Of","subj":"EnjuParser_T182","obj":"EnjuParser_T181"},{"id":"EnjuParser_R185","pred":"arg1Of","subj":"EnjuParser_T182","obj":"EnjuParser_T183"},{"id":"EnjuParser_R186","pred":"arg2Of","subj":"EnjuParser_T185","obj":"EnjuParser_T183"},{"id":"EnjuParser_R187","pred":"arg1Of","subj":"EnjuParser_T185","obj":"EnjuParser_T184"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"Lectin","denotations":[{"id":"Lectin_T1","span":{"begin":615,"end":618},"obj":"https://acgg.asia/db/lfdb/LfDB0217"},{"id":"Lectin_T2","span":{"begin":1005,"end":1008},"obj":"https://acgg.asia/db/lfdb/LfDB0217"},{"id":"Lectin_T3","span":{"begin":1056,"end":1059},"obj":"https://acgg.asia/db/lfdb/LfDB0217"},{"id":"Lectin_T4","span":{"begin":181,"end":187},"obj":"https://acgg.asia/db/lfdb/LfDB0096"},{"id":"Lectin_T5","span":{"begin":762,"end":768},"obj":"https://acgg.asia/db/lfdb/LfDB0096"},{"id":"Lectin_T6","span":{"begin":254,"end":260},"obj":"https://acgg.asia/db/lfdb/LfDB0097"},{"id":"Lectin_T7","span":{"begin":742,"end":748},"obj":"https://acgg.asia/db/lfdb/LfDB0097"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G41652MJ\""},{"id":"GlycanIUPAC_T2","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G20761YC\""},{"id":"GlycanIUPAC_T3","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G19807HM\""},{"id":"GlycanIUPAC_T4","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G20351TE\""},{"id":"GlycanIUPAC_T5","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G71957MR\""},{"id":"GlycanIUPAC_T6","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G59040AE\""},{"id":"GlycanIUPAC_T7","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G14987PW\""},{"id":"GlycanIUPAC_T8","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G95064PC\""},{"id":"GlycanIUPAC_T9","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G39143AQ\""},{"id":"GlycanIUPAC_T10","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G65149OO\""},{"id":"GlycanIUPAC_T11","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G02766SY\""},{"id":"GlycanIUPAC_T12","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G26019KJ\""},{"id":"GlycanIUPAC_T13","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G36429CZ\""},{"id":"GlycanIUPAC_T14","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G89633TP\""},{"id":"GlycanIUPAC_T15","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G28494FO\""},{"id":"GlycanIUPAC_T16","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G06219CP\""},{"id":"GlycanIUPAC_T17","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G44237SM\""},{"id":"GlycanIUPAC_T18","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G57948RL\""},{"id":"GlycanIUPAC_T19","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G64016DN\""},{"id":"GlycanIUPAC_T20","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G14536PC\""},{"id":"GlycanIUPAC_T21","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G14356FW\""},{"id":"GlycanIUPAC_T22","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G34565UO\""},{"id":"GlycanIUPAC_T23","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G67124MW\""},{"id":"GlycanIUPAC_T24","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G71457ZU\""},{"id":"GlycanIUPAC_T25","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G55228VZ\""},{"id":"GlycanIUPAC_T26","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G31034MJ\""},{"id":"GlycanIUPAC_T27","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G25776IP\""},{"id":"GlycanIUPAC_T28","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G64442BV\""},{"id":"GlycanIUPAC_T29","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G57018LE\""},{"id":"GlycanIUPAC_T30","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G61761GX\""},{"id":"GlycanIUPAC_T31","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G76318UX\""},{"id":"GlycanIUPAC_T32","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G61906ER\""},{"id":"GlycanIUPAC_T33","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G68723GR\""},{"id":"GlycanIUPAC_T34","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G19540LE\""},{"id":"GlycanIUPAC_T35","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G74944PO\""},{"id":"GlycanIUPAC_T36","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G89489ZJ\""},{"id":"GlycanIUPAC_T37","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G04434YU\""},{"id":"GlycanIUPAC_T38","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G21450PB\""},{"id":"GlycanIUPAC_T39","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G93629QY\""},{"id":"GlycanIUPAC_T40","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G02603TR\""},{"id":"GlycanIUPAC_T41","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G40280JP\""},{"id":"GlycanIUPAC_T42","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G95259IC\""},{"id":"GlycanIUPAC_T43","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G26900FE\""},{"id":"GlycanIUPAC_T44","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G21346KK\""},{"id":"GlycanIUPAC_T45","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G62509FF\""},{"id":"GlycanIUPAC_T46","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G83932AK\""},{"id":"GlycanIUPAC_T47","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G96978IB\""},{"id":"GlycanIUPAC_T48","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G34275DN\""},{"id":"GlycanIUPAC_T49","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G07071JF\""},{"id":"GlycanIUPAC_T50","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G80639QD\""},{"id":"GlycanIUPAC_T51","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G99460PJ\""},{"id":"GlycanIUPAC_T52","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G22024BZ\""},{"id":"GlycanIUPAC_T53","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G74097ZY\""},{"id":"GlycanIUPAC_T54","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G84439YP\""},{"id":"GlycanIUPAC_T55","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G52207WQ\""},{"id":"GlycanIUPAC_T56","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G90695MS\""},{"id":"GlycanIUPAC_T57","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G50398QX\""},{"id":"GlycanIUPAC_T58","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G12166ZT\""},{"id":"GlycanIUPAC_T59","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G48368BR\""},{"id":"GlycanIUPAC_T60","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G57407RW\""},{"id":"GlycanIUPAC_T61","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G00386TY\""},{"id":"GlycanIUPAC_T62","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G18723JK\""},{"id":"GlycanIUPAC_T63","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G93757OR\""},{"id":"GlycanIUPAC_T64","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G29006SI\""},{"id":"GlycanIUPAC_T65","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G03099OQ\""},{"id":"GlycanIUPAC_T66","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G53739OW\""},{"id":"GlycanIUPAC_T67","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G70440ZO\""},{"id":"GlycanIUPAC_T68","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G29951RR\""},{"id":"GlycanIUPAC_T69","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G58402TI\""},{"id":"GlycanIUPAC_T70","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G39875TP\""},{"id":"GlycanIUPAC_T71","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G83439QV\""},{"id":"GlycanIUPAC_T72","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G41762RC\""},{"id":"GlycanIUPAC_T73","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G91604UI\""},{"id":"GlycanIUPAC_T74","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G88447WE\""},{"id":"GlycanIUPAC_T75","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G93634BS\""},{"id":"GlycanIUPAC_T76","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G02587BH\""},{"id":"GlycanIUPAC_T77","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G43511MX\""},{"id":"GlycanIUPAC_T78","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G64958DH\""},{"id":"GlycanIUPAC_T79","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G30384TR\""},{"id":"GlycanIUPAC_T80","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G15624EX\""},{"id":"GlycanIUPAC_T81","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G22706ST\""},{"id":"GlycanIUPAC_T82","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G57408PI\""},{"id":"GlycanIUPAC_T83","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G86403XX\""},{"id":"GlycanIUPAC_T84","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G78043YB\""},{"id":"GlycanIUPAC_T85","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G18952JK\""},{"id":"GlycanIUPAC_T86","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G49020ND\""},{"id":"GlycanIUPAC_T87","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G63590YW\""},{"id":"GlycanIUPAC_T88","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G22793KS\""},{"id":"GlycanIUPAC_T89","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G64134SS\""},{"id":"GlycanIUPAC_T90","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G17338HY\""},{"id":"GlycanIUPAC_T91","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G99745XF\""},{"id":"GlycanIUPAC_T92","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G27782HN\""},{"id":"GlycanIUPAC_T93","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G57496DC\""},{"id":"GlycanIUPAC_T94","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G93169WB\""},{"id":"GlycanIUPAC_T95","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G05518TD\""},{"id":"GlycanIUPAC_T96","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G62603DN\""},{"id":"GlycanIUPAC_T97","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G59574FS\""},{"id":"GlycanIUPAC_T98","span":{"begin":347,"end":350},"obj":"\"http://rdf.glycoinfo.org/glycan/G47567WC\""},{"id":"GlycanIUPAC_T99","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G19151BJ\""},{"id":"GlycanIUPAC_T100","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G19151BJ\""},{"id":"GlycanIUPAC_T101","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G19151BJ\""},{"id":"GlycanIUPAC_T102","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G63727IH\""},{"id":"GlycanIUPAC_T103","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G63727IH\""},{"id":"GlycanIUPAC_T104","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G63727IH\""},{"id":"GlycanIUPAC_T105","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G05795KA\""},{"id":"GlycanIUPAC_T106","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G05795KA\""},{"id":"GlycanIUPAC_T107","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G05795KA\""},{"id":"GlycanIUPAC_T108","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G90812SJ\""},{"id":"GlycanIUPAC_T109","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G90812SJ\""},{"id":"GlycanIUPAC_T110","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G90812SJ\""},{"id":"GlycanIUPAC_T111","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G07124DB\""},{"id":"GlycanIUPAC_T112","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G07124DB\""},{"id":"GlycanIUPAC_T113","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G07124DB\""},{"id":"GlycanIUPAC_T114","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G20567HS\""},{"id":"GlycanIUPAC_T115","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G20567HS\""},{"id":"GlycanIUPAC_T116","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G20567HS\""},{"id":"GlycanIUPAC_T117","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G76159WX\""},{"id":"GlycanIUPAC_T118","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G76159WX\""},{"id":"GlycanIUPAC_T119","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G76159WX\""},{"id":"GlycanIUPAC_T120","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G40623UW\""},{"id":"GlycanIUPAC_T121","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G40623UW\""},{"id":"GlycanIUPAC_T122","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G40623UW\""},{"id":"GlycanIUPAC_T123","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G06447MP\""},{"id":"GlycanIUPAC_T124","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G06447MP\""},{"id":"GlycanIUPAC_T125","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G06447MP\""},{"id":"GlycanIUPAC_T126","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G62764VZ\""},{"id":"GlycanIUPAC_T127","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G62764VZ\""},{"id":"GlycanIUPAC_T128","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G62764VZ\""},{"id":"GlycanIUPAC_T129","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G21434YY\""},{"id":"GlycanIUPAC_T130","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G21434YY\""},{"id":"GlycanIUPAC_T131","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G21434YY\""},{"id":"GlycanIUPAC_T132","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G34267PK\""},{"id":"GlycanIUPAC_T133","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G34267PK\""},{"id":"GlycanIUPAC_T134","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G34267PK\""},{"id":"GlycanIUPAC_T135","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G30235PC\""},{"id":"GlycanIUPAC_T136","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G30235PC\""},{"id":"GlycanIUPAC_T137","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G30235PC\""},{"id":"GlycanIUPAC_T138","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G34820UC\""},{"id":"GlycanIUPAC_T139","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G34820UC\""},{"id":"GlycanIUPAC_T140","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G34820UC\""},{"id":"GlycanIUPAC_T141","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G95531HX\""},{"id":"GlycanIUPAC_T142","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G95531HX\""},{"id":"GlycanIUPAC_T143","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G95531HX\""},{"id":"GlycanIUPAC_T144","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G74672YG\""},{"id":"GlycanIUPAC_T145","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G74672YG\""},{"id":"GlycanIUPAC_T146","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G74672YG\""},{"id":"GlycanIUPAC_T147","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G54440FW\""},{"id":"GlycanIUPAC_T148","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G54440FW\""},{"id":"GlycanIUPAC_T149","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G54440FW\""},{"id":"GlycanIUPAC_T150","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G69182II\""},{"id":"GlycanIUPAC_T151","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G69182II\""},{"id":"GlycanIUPAC_T152","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G69182II\""},{"id":"GlycanIUPAC_T153","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G68961XX\""},{"id":"GlycanIUPAC_T154","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G68961XX\""},{"id":"GlycanIUPAC_T155","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G68961XX\""},{"id":"GlycanIUPAC_T156","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G11710CQ\""},{"id":"GlycanIUPAC_T157","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G11710CQ\""},{"id":"GlycanIUPAC_T158","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G11710CQ\""},{"id":"GlycanIUPAC_T159","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G70765DS\""},{"id":"GlycanIUPAC_T160","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G70765DS\""},{"id":"GlycanIUPAC_T161","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G70765DS\""},{"id":"GlycanIUPAC_T162","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G51661YR\""},{"id":"GlycanIUPAC_T163","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G51661YR\""},{"id":"GlycanIUPAC_T164","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G51661YR\""},{"id":"GlycanIUPAC_T165","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G18477VG\""},{"id":"GlycanIUPAC_T166","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G18477VG\""},{"id":"GlycanIUPAC_T167","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G18477VG\""},{"id":"GlycanIUPAC_T168","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G12337MH\""},{"id":"GlycanIUPAC_T169","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G12337MH\""},{"id":"GlycanIUPAC_T170","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G12337MH\""},{"id":"GlycanIUPAC_T171","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G40783MY\""},{"id":"GlycanIUPAC_T172","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G40783MY\""},{"id":"GlycanIUPAC_T173","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G40783MY\""},{"id":"GlycanIUPAC_T174","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G72867LN\""},{"id":"GlycanIUPAC_T175","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G72867LN\""},{"id":"GlycanIUPAC_T176","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G72867LN\""},{"id":"GlycanIUPAC_T177","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G79061OT\""},{"id":"GlycanIUPAC_T178","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G79061OT\""},{"id":"GlycanIUPAC_T179","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G79061OT\""},{"id":"GlycanIUPAC_T180","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G45970UX\""},{"id":"GlycanIUPAC_T181","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G45970UX\""},{"id":"GlycanIUPAC_T182","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G45970UX\""},{"id":"GlycanIUPAC_T183","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G93661NW\""},{"id":"GlycanIUPAC_T184","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G93661NW\""},{"id":"GlycanIUPAC_T185","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G93661NW\""},{"id":"GlycanIUPAC_T186","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G04988XL\""},{"id":"GlycanIUPAC_T187","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G04988XL\""},{"id":"GlycanIUPAC_T188","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G04988XL\""},{"id":"GlycanIUPAC_T189","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G85800UH\""},{"id":"GlycanIUPAC_T190","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G85800UH\""},{"id":"GlycanIUPAC_T191","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G85800UH\""},{"id":"GlycanIUPAC_T192","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G96338GZ\""},{"id":"GlycanIUPAC_T193","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G96338GZ\""},{"id":"GlycanIUPAC_T194","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G96338GZ\""},{"id":"GlycanIUPAC_T195","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G96296PU\""},{"id":"GlycanIUPAC_T196","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G96296PU\""},{"id":"GlycanIUPAC_T197","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G96296PU\""},{"id":"GlycanIUPAC_T198","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G59124WZ\""},{"id":"GlycanIUPAC_T199","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G59124WZ\""},{"id":"GlycanIUPAC_T200","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G59124WZ\""},{"id":"GlycanIUPAC_T201","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G57275GR\""},{"id":"GlycanIUPAC_T202","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G57275GR\""},{"id":"GlycanIUPAC_T203","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G57275GR\""},{"id":"GlycanIUPAC_T204","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G46105MZ\""},{"id":"GlycanIUPAC_T205","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G46105MZ\""},{"id":"GlycanIUPAC_T206","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G46105MZ\""},{"id":"GlycanIUPAC_T207","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G76001GO\""},{"id":"GlycanIUPAC_T208","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G76001GO\""},{"id":"GlycanIUPAC_T209","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G76001GO\""},{"id":"GlycanIUPAC_T210","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G89599ML\""},{"id":"GlycanIUPAC_T211","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G89599ML\""},{"id":"GlycanIUPAC_T212","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G89599ML\""},{"id":"GlycanIUPAC_T213","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G85872BD\""},{"id":"GlycanIUPAC_T214","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G85872BD\""},{"id":"GlycanIUPAC_T215","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G85872BD\""},{"id":"GlycanIUPAC_T216","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G69460YK\""},{"id":"GlycanIUPAC_T217","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G69460YK\""},{"id":"GlycanIUPAC_T218","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G69460YK\""},{"id":"GlycanIUPAC_T219","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G25240JV\""},{"id":"GlycanIUPAC_T220","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G25240JV\""},{"id":"GlycanIUPAC_T221","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G25240JV\""},{"id":"GlycanIUPAC_T222","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G80489OS\""},{"id":"GlycanIUPAC_T223","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G80489OS\""},{"id":"GlycanIUPAC_T224","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G80489OS\""},{"id":"GlycanIUPAC_T225","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G35726XK\""},{"id":"GlycanIUPAC_T226","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G35726XK\""},{"id":"GlycanIUPAC_T227","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G35726XK\""},{"id":"GlycanIUPAC_T228","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G11002JA\""},{"id":"GlycanIUPAC_T229","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G11002JA\""},{"id":"GlycanIUPAC_T230","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G11002JA\""},{"id":"GlycanIUPAC_T231","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G85388FO\""},{"id":"GlycanIUPAC_T232","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G85388FO\""},{"id":"GlycanIUPAC_T233","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G85388FO\""},{"id":"GlycanIUPAC_T234","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G20221JL\""},{"id":"GlycanIUPAC_T235","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G20221JL\""},{"id":"GlycanIUPAC_T236","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G20221JL\""},{"id":"GlycanIUPAC_T237","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G39026SP\""},{"id":"GlycanIUPAC_T238","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G39026SP\""},{"id":"GlycanIUPAC_T239","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G39026SP\""},{"id":"GlycanIUPAC_T240","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G66979UZ\""},{"id":"GlycanIUPAC_T241","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G66979UZ\""},{"id":"GlycanIUPAC_T242","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G66979UZ\""},{"id":"GlycanIUPAC_T243","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G68566EA\""},{"id":"GlycanIUPAC_T244","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G68566EA\""},{"id":"GlycanIUPAC_T245","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G68566EA\""},{"id":"GlycanIUPAC_T246","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G20255ZD\""},{"id":"GlycanIUPAC_T247","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G20255ZD\""},{"id":"GlycanIUPAC_T248","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G20255ZD\""},{"id":"GlycanIUPAC_T249","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G68860MF\""},{"id":"GlycanIUPAC_T250","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G68860MF\""},{"id":"GlycanIUPAC_T251","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G68860MF\""},{"id":"GlycanIUPAC_T252","span":{"begin":615,"end":618},"obj":"\"http://rdf.glycoinfo.org/glycan/G50413KD\""},{"id":"GlycanIUPAC_T253","span":{"begin":1005,"end":1008},"obj":"\"http://rdf.glycoinfo.org/glycan/G50413KD\""},{"id":"GlycanIUPAC_T254","span":{"begin":1056,"end":1059},"obj":"\"http://rdf.glycoinfo.org/glycan/G50413KD\""},{"id":"GlycanIUPAC_T255","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G02780QX\""},{"id":"GlycanIUPAC_T256","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G18425DX\""},{"id":"GlycanIUPAC_T257","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G18630JE\""},{"id":"GlycanIUPAC_T258","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G01004IT\""},{"id":"GlycanIUPAC_T259","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G87301QZ\""},{"id":"GlycanIUPAC_T260","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G39790GW\""},{"id":"GlycanIUPAC_T261","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G42928BB\""},{"id":"GlycanIUPAC_T262","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G51134HC\""},{"id":"GlycanIUPAC_T263","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G68183GR\""},{"id":"GlycanIUPAC_T264","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G46883FA\""},{"id":"GlycanIUPAC_T265","span":{"begin":1052,"end":1055},"obj":"\"http://rdf.glycoinfo.org/glycan/G54702VY\""}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"Lectin-Jamboree-Sentence","blocks":[{"id":"T1","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T2","span":{"begin":78,"end":427},"obj":"Sentence"},{"id":"T3","span":{"begin":428,"end":675},"obj":"Sentence"},{"id":"T4","span":{"begin":676,"end":883},"obj":"Sentence"},{"id":"T5","span":{"begin":884,"end":1083},"obj":"Sentence"},{"id":"T6","span":{"begin":1084,"end":1255},"obj":"Sentence"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":666,"end":674},"obj":"Body_part"},{"id":"T2","span":{"begin":695,"end":708},"obj":"Body_part"},{"id":"T3","span":{"begin":717,"end":725},"obj":"Body_part"},{"id":"T4","span":{"begin":896,"end":909},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/GO_0005622"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/GO_0005764"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0005576"}],"text":"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors.\nThe two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues."}