> top > docs > PubMed:18611854 > annotations

PubMed:18611854 JSONTXT

Annnotations TAB JSON ListView MergeView

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 556-567 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 556-567 GlycoEpitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 556-567 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 87-93 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342
T3 733-739 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342
T5 813-819 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342
T7 1304-1310 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342
T9 1469-1489 DiseaseOrPhenotypicFeature denotes primary brain tumors 0001657|0021632
T11 1593-1599 DiseaseOrPhenotypicFeature denotes glioma 0021042|0100342

sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
T2 109-233 Sentence denotes The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier to cell and neurite motility.
T3 234-377 Sentence denotes Nonneural tumors that metastasize to the central nervous system almost never infiltrate it and instead displace the neural tissue as they grow.
T4 378-479 Sentence denotes In contrast, invasive gliomas disrupt the extracellular matrix and disperse within the neural tissue.
T5 480-656 Sentence denotes A major inhibitory component of the neural matrix is the lectican family of chondroitin sulfate proteoglycans, of which brevican is the most abundant member in the adult brain.
T6 657-773 Sentence denotes Interestingly, brevican is also highly up-regulated in gliomas and promotes glioma dispersion by unknown mechanisms.
T7 774-894 Sentence denotes Here we show that brevican secreted by glioma cells enhances cell adhesion and motility only after proteolytic cleavage.
T8 895-1142 Sentence denotes At the molecular level, brevican promotes epidermal growth factor receptor activation, increases the expression of cell adhesion molecules, and promotes the secretion of fibronectin and accumulation of fibronectin microfibrils on the cell surface.
T9 1143-1311 Sentence denotes Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
T10 1312-1490 Sentence denotes Taken together, our results provide the first evidence of the cellular and molecular mechanisms that may underlie the motility-promoting role of brevican in primary brain tumors.
T11 1491-1612 Sentence denotes In addition, these results underscore the important functional implications of brevican processing in glioma progression.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 275-297 http://purl.obolibrary.org/obo/MAT_0000457 denotes central nervous system
T2 283-297 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T3 650-655 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T4 1477-1482 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1570-1578 gene:63827 denotes brevican
T1 1593-1599 disease:C0017638 denotes glioma
R1 T0 T1 associated_with brevican,glioma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18611854-0#17#25#gene63827 17-25 gene63827 denotes brevican
18611854-0#35#46#gene2335 35-46 gene2335 denotes fibronectin
18611854-0#87#93#diseaseC0017638 87-93 diseaseC0017638 denotes glioma
18611854-9#145#153#gene63827 1457-1465 gene63827 denotes brevican
18611854-9#157#177#diseaseC0750974 1469-1489 diseaseC0750974 denotes primary brain tumors
17#25#gene6382787#93#diseaseC0017638 18611854-0#17#25#gene63827 18611854-0#87#93#diseaseC0017638 associated_with brevican,glioma
35#46#gene233587#93#diseaseC0017638 18611854-0#35#46#gene2335 18611854-0#87#93#diseaseC0017638 associated_with fibronectin,glioma
145#153#gene63827157#177#diseaseC0750974 18611854-9#145#153#gene63827 18611854-9#157#177#diseaseC0750974 associated_with brevican,primary brain tumors

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 556-567 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 87-93 Phenotype denotes glioma HP:0009733
T2 733-739 Phenotype denotes glioma HP:0009733
T3 813-819 Phenotype denotes glioma HP:0009733
T4 1304-1310 Phenotype denotes glioma HP:0009733
T5 1477-1489 Phenotype denotes brain tumors HP:0030692
T6 1593-1599 Phenotype denotes glioma HP:0009733

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 87-93 Disease denotes glioma http://purl.obolibrary.org/obo/MONDO_0021042
T2 244-250 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T3 733-739 Disease denotes glioma http://purl.obolibrary.org/obo/MONDO_0021042
T4 813-819 Disease denotes glioma http://purl.obolibrary.org/obo/MONDO_0021042
T5 1304-1310 Disease denotes glioma http://purl.obolibrary.org/obo/MONDO_0021042
T6 1469-1489 Disease denotes primary brain tumors http://purl.obolibrary.org/obo/MONDO_0001657|http://purl.obolibrary.org/obo/MONDO_0021632
T8 1593-1599 Disease denotes glioma http://purl.obolibrary.org/obo/MONDO_0021042

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 556-567 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 556-567 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 87-93 Phenotype denotes glioma HP:0009733
T2 733-739 Phenotype denotes glioma HP:0009733
T3 813-819 Phenotype denotes glioma HP:0009733
T4 1304-1310 Phenotype denotes glioma HP:0009733
T5 1477-1489 Phenotype denotes brain tumors HP:0030692
T6 1593-1599 Phenotype denotes glioma HP:0009733

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 196-211 Cell denotes barrier to cell http://purl.obolibrary.org/obo/CL:0000215
T2 1262-1276 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 126-136 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T2 160-180 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T3 196-211 Body_part denotes barrier to cell http://purl.obolibrary.org/obo/CL_0000215
T4 216-223 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T5 275-297 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T6 350-363 Body_part denotes neural tissue http://purl.obolibrary.org/obo/UBERON_0003714
T7 420-440 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T8 465-478 Body_part denotes neural tissue http://purl.obolibrary.org/obo/UBERON_0003714
T9 650-655 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T10 937-953 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T11 1477-1482 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 87-93 Disease denotes glioma MONDO:0021042|MONDO:0100342
T3 733-739 Disease denotes glioma MONDO:0021042|MONDO:0100342
T5 813-819 Disease denotes glioma MONDO:0021042|MONDO:0100342
T7 1304-1310 Disease denotes glioma MONDO:0021042|MONDO:0100342
T9 1469-1489 Disease denotes primary brain tumors MONDO:0001657|MONDO:0021632
T11 1593-1599 Disease denotes glioma MONDO:0021042|MONDO:0100342

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
T2 109-233 Sentence denotes The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier to cell and neurite motility.
T3 234-377 Sentence denotes Nonneural tumors that metastasize to the central nervous system almost never infiltrate it and instead displace the neural tissue as they grow.
T4 378-479 Sentence denotes In contrast, invasive gliomas disrupt the extracellular matrix and disperse within the neural tissue.
T5 480-656 Sentence denotes A major inhibitory component of the neural matrix is the lectican family of chondroitin sulfate proteoglycans, of which brevican is the most abundant member in the adult brain.
T6 657-773 Sentence denotes Interestingly, brevican is also highly up-regulated in gliomas and promotes glioma dispersion by unknown mechanisms.
T7 774-894 Sentence denotes Here we show that brevican secreted by glioma cells enhances cell adhesion and motility only after proteolytic cleavage.
T8 895-1142 Sentence denotes At the molecular level, brevican promotes epidermal growth factor receptor activation, increases the expression of cell adhesion molecules, and promotes the secretion of fibronectin and accumulation of fibronectin microfibrils on the cell surface.
T9 1143-1311 Sentence denotes Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
T10 1312-1490 Sentence denotes Taken together, our results provide the first evidence of the cellular and molecular mechanisms that may underlie the motility-promoting role of brevican in primary brain tumors.
T11 1491-1612 Sentence denotes In addition, these results underscore the important functional implications of brevican processing in glioma progression.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 556-567 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
T2 109-233 Sentence denotes The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier to cell and neurite motility.
T3 234-377 Sentence denotes Nonneural tumors that metastasize to the central nervous system almost never infiltrate it and instead displace the neural tissue as they grow.
T4 378-479 Sentence denotes In contrast, invasive gliomas disrupt the extracellular matrix and disperse within the neural tissue.
T5 480-656 Sentence denotes A major inhibitory component of the neural matrix is the lectican family of chondroitin sulfate proteoglycans, of which brevican is the most abundant member in the adult brain.
T6 657-773 Sentence denotes Interestingly, brevican is also highly up-regulated in gliomas and promotes glioma dispersion by unknown mechanisms.
T7 774-894 Sentence denotes Here we show that brevican secreted by glioma cells enhances cell adhesion and motility only after proteolytic cleavage.
T8 895-1142 Sentence denotes At the molecular level, brevican promotes epidermal growth factor receptor activation, increases the expression of cell adhesion molecules, and promotes the secretion of fibronectin and accumulation of fibronectin microfibrils on the cell surface.
T9 1143-1311 Sentence denotes Moreover, the N-terminal cleavage product of brevican, but not the full-length protein, associates with fibronectin in cultured cells and in surgical samples of glioma.
T10 1312-1490 Sentence denotes Taken together, our results provide the first evidence of the cellular and molecular mechanisms that may underlie the motility-promoting role of brevican in primary brain tumors.
T11 1491-1612 Sentence denotes In addition, these results underscore the important functional implications of brevican processing in glioma progression.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 126-136 Body_part denotes parenchyma FMA:45732
T2 160-180 Body_part denotes extracellular matrix FMA:9672
T3 216-223 Body_part denotes neurite FMA:61814
T4 275-297 Body_part denotes central nervous system FMA:55675
T5 350-363 Body_part denotes neural tissue FMA:9642
T6 420-440 Body_part denotes extracellular matrix FMA:9672
T7 465-478 Body_part denotes neural tissue FMA:9642
T8 650-655 Body_part denotes brain FMA:50801
T9 1129-1141 Body_part denotes cell surface FMA:67653
T10 1477-1482 Body_part denotes brain FMA:50801

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 275-297 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457
T2 650-655 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1477-1482 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 275-297 Body_part denotes central nervous system http://purl.obolibrary.org/obo/MAT_0000457
T2 650-655 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098
T3 1477-1482 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 126-136 Body_part denotes parenchyma http://purl.obolibrary.org/obo/UBERON_0000353
T2 160-180 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T3 196-211 Body_part denotes barrier to cell http://purl.obolibrary.org/obo/CL_0000215
T4 216-223 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T5 275-297 Body_part denotes central nervous system http://purl.obolibrary.org/obo/UBERON_0001017
T6 350-363 Body_part denotes neural tissue http://purl.obolibrary.org/obo/UBERON_0003714
T7 420-440 Body_part denotes extracellular matrix http://purl.obolibrary.org/obo/GO_0031012
T8 465-478 Body_part denotes neural tissue http://purl.obolibrary.org/obo/UBERON_0003714
T9 650-655 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636
T11 937-953 Body_part denotes epidermal growth http://purl.obolibrary.org/obo/UBERON_0000021
T12 1477-1482 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 196-211 Cell denotes barrier to cell http://purl.obolibrary.org/obo/CL:0000215
T2 1262-1276 Cell denotes cultured cells http://purl.obolibrary.org/obo/CL:0000010