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PubMed:1860836 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-155 Sentence denotes Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.
T2 156-332 Sentence denotes The type II cAMP-dependent protein kinase is localized to specific subcellular environments through the binding of the regulatory subunit (RII) dimer to RII-anchoring proteins.
T3 333-642 Sentence denotes Computer-aided analysis of secondary structure, performed on four RII-anchoring protein sequences (the microtubule-associated protein 2, P150, and two thyroid proteins Ht 21 and Ht 31), has identified common regions of approximately 14 residues which display high probabilities of forming amphipathic helices.
T4 643-783 Sentence denotes The potential amphipathic helix region of Ht 31 (Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile) lies between residues 494 and 507.
T5 784-918 Sentence denotes A bacterially expressed 318-amino acid fragment, Ht 31 (418-736), containing the amphipathic helix region, was able to bind RII alpha.
T6 919-1048 Sentence denotes Site-directed mutagenesis designed to disrupt the secondary structure in the putative binding helix reduced binding dramatically.
T7 1049-1208 Sentence denotes Specifically, substitution of proline for Ala-498 significantly diminished RII alpha binding, and similar mutation of Ile-502 or Ile-507 abolished interaction.
T8 1209-1341 Sentence denotes Mutation of Ala-522 to proline, which is located outside the predicted amphipathic helix region, had no effect on RII alpha binding.
T9 1342-1448 Sentence denotes These data suggest that anchoring proteins interact with RII alpha via an amphipathic helix binding motif.
T1 0-155 Sentence denotes Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.
T2 156-332 Sentence denotes The type II cAMP-dependent protein kinase is localized to specific subcellular environments through the binding of the regulatory subunit (RII) dimer to RII-anchoring proteins.
T3 333-642 Sentence denotes Computer-aided analysis of secondary structure, performed on four RII-anchoring protein sequences (the microtubule-associated protein 2, P150, and two thyroid proteins Ht 21 and Ht 31), has identified common regions of approximately 14 residues which display high probabilities of forming amphipathic helices.
T4 643-783 Sentence denotes The potential amphipathic helix region of Ht 31 (Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile) lies between residues 494 and 507.
T5 784-918 Sentence denotes A bacterially expressed 318-amino acid fragment, Ht 31 (418-736), containing the amphipathic helix region, was able to bind RII alpha.
T6 919-1048 Sentence denotes Site-directed mutagenesis designed to disrupt the secondary structure in the putative binding helix reduced binding dramatically.
T7 1049-1208 Sentence denotes Specifically, substitution of proline for Ala-498 significantly diminished RII alpha binding, and similar mutation of Ile-502 or Ile-507 abolished interaction.
T8 1209-1341 Sentence denotes Mutation of Ala-522 to proline, which is located outside the predicted amphipathic helix region, had no effect on RII alpha binding.
T9 1342-1448 Sentence denotes These data suggest that anchoring proteins interact with RII alpha via an amphipathic helix binding motif.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 484-491 http://purl.obolibrary.org/obo/MAT_0000081 denotes thyroid

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 19-76 protein denotes regulatory subunit (RII) of cAMP-dependent protein kinase
T2 86-104 protein denotes anchoring proteins
T3 160-197 protein denotes type II cAMP-dependent protein kinase
T4 313-331 protein denotes anchoring proteins
T5 403-420 protein denotes anchoring protein
T6 436-468 protein denotes microtubule-associated protein 2
T7 511-516 protein denotes Ht 31
T8 685-690 protein denotes Ht 31
T9 833-838 protein denotes Ht 31
T10 908-917 protein denotes RII alpha
T11 1124-1133 protein denotes RII alpha
T12 1323-1332 protein denotes RII alpha
T13 1399-1408 protein denotes RII alpha

AIMed

Id Subject Object Predicate Lexical cue
T1 39-42 protein denotes RII
T2 47-76 protein denotes cAMP-dependent protein kinase
T3 82-85 protein denotes RII
T4 160-197 protein denotes type II cAMP-dependent protein kinase
T5 295-298 protein denotes RII
T6 309-312 protein denotes RII
T7 399-402 protein denotes RII
T8 436-468 protein denotes microtubule-associated protein 2
T9 470-474 protein denotes P150
T10 501-506 protein denotes Ht 21
T11 511-516 protein denotes Ht 31
T12 685-690 protein denotes Ht 31
T13 833-838 protein denotes Ht 31
T14 908-917 protein denotes RII alpha
T15 1124-1133 protein denotes RII alpha
T16 1323-1332 protein denotes RII alpha
T17 1399-1408 protein denotes RII alpha

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 484-491 Body_part denotes thyroid http://purl.obolibrary.org/obo/MAT_0000081

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 135-140 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T2 436-447 Body_part denotes microtubule http://purl.obolibrary.org/obo/GO_0005874
T3 484-491 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046
T4 669-674 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T5 877-882 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T6 1013-1018 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T7 1292-1297 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T8 1428-1433 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488