PubMed:18593936
Annnotations
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0004986|0022578 |
| T3 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0004986|0022578 |
| T5 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | 0004987 |
| T6 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0004986|0022578 |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 930-933 | OrganismTaxon | denotes | Sp4 | NCBItxid:10855 |
| T2 | 1038-1041 | OrganismTaxon | denotes | Sp4 | NCBItxid:10855 |
| T3 | 1292-1296 | OrganismTaxon | denotes | mice | NCBItxid:10095|NCBItxid:10088 |
| T5 | 1381-1384 | OrganismTaxon | denotes | Sp4 | NCBItxid:10855 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T8 | 1411-1637 | Sentence | denotes | These results show for the first time that one of the underlying mechanisms of action of curcumin as a cancer chemotherapeutic agent is due, in part, to decreased expression of Sp transcription factors in bladder cancer cells. |
| T1 | 0-74 | Sentence | denotes | Curcumin decreases specificity protein expression in bladder cancer cells. |
| T2 | 75-250 | Sentence | denotes | Curcumin is the active component of tumeric, and this polyphenolic compound has been extensively investigated as an anticancer drug that modulates multiple pathways and genes. |
| T3 | 251-561 | Sentence | denotes | In this study, 10 to 25 micromol/L curcumin inhibited 253JB-V and KU7 bladder cancer cell growth, and this was accompanied by induction of apoptosis and decreased expression of the proapoptotic protein survivin and the angiogenic proteins vascular endothelial growth factor (VEGF) and VEGF receptor 1 (VEGFR1). |
| T4 | 562-836 | Sentence | denotes | Because expression of survivin, VEGF, and VEGFR1 are dependent on specificity protein (Sp) transcription factors, we also investigated the effects of curcumin on Sp protein expression as an underlying mechanism for the apoptotic and antiangiogenic activity of this compound. |
| T5 | 837-959 | Sentence | denotes | The results show that curcumin induced proteasome-dependent down-regulation of Sp1, Sp3, and Sp4 in 253JB-V and KU7 cells. |
| T6 | 960-1230 | Sentence | denotes | Moreover, using RNA interference with small inhibitory RNAs for Sp1, Sp3, and Sp4, we observed that curcumin-dependent inhibition of nuclear factor kappaB (NF-kappaB)-dependent genes, such as bcl-2, survivin, and cyclin D1, was also due, in part, to loss of Sp proteins. |
| T7 | 1231-1410 | Sentence | denotes | Curcumin also decreased bladder tumor growth in athymic nude mice bearing KU7 cells as xenografts and this was accompanied by decreased Sp1, Sp3, and Sp4 protein levels in tumors. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 5277 | 0-8 | ChemicalEntity | denotes | Curcumin | MESH:D003474 |
| 5278 | 19-38 | GeneOrGeneProduct | denotes | specificity protein | NCBIGene:6667|NCBIGene:6670|NCBIGene:6671 |
| 5279 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | MESH:D001749 |
| 5280 | 75-83 | ChemicalEntity | denotes | Curcumin | MESH:D003474 |
| 5281 | 286-294 | ChemicalEntity | denotes | curcumin | MESH:D003474 |
| 5282 | 305-312 | CellLine | denotes | 253JB-V | NCBITaxon:9606 |
| 5283 | 317-320 | CellLine | denotes | KU7 | NCBITaxon:9606 |
| 5284 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | MESH:D001749 |
| 5285 | 432-452 | GeneOrGeneProduct | denotes | proapoptotic protein | NCBIGene:332 |
| 5286 | 453-461 | GeneOrGeneProduct | denotes | survivin | NCBIGene:332 |
| 5287 | 470-489 | GeneOrGeneProduct | denotes | angiogenic proteins | NCBIGene:2321|NCBIGene:7422 |
| 5288 | 490-524 | GeneOrGeneProduct | denotes | vascular endothelial growth factor | NCBIGene:7422 |
| 5289 | 526-530 | GeneOrGeneProduct | denotes | VEGF | NCBIGene:7422 |
| 5290 | 536-551 | GeneOrGeneProduct | denotes | VEGF receptor 1 | NCBIGene:2321 |
| 5291 | 553-559 | GeneOrGeneProduct | denotes | VEGFR1 | NCBIGene:2321 |
| 5292 | 584-592 | GeneOrGeneProduct | denotes | survivin | NCBIGene:332 |
| 5293 | 594-598 | GeneOrGeneProduct | denotes | VEGF | NCBIGene:7422 |
| 5294 | 604-610 | GeneOrGeneProduct | denotes | VEGFR1 | NCBIGene:2321 |
| 5295 | 628-674 | GeneOrGeneProduct | denotes | specificity protein (Sp) transcription factors | NCBIGene:6667|NCBIGene:6670|NCBIGene:6671 |
| 5296 | 712-720 | ChemicalEntity | denotes | curcumin | MESH:D003474 |
| 5297 | 724-726 | GeneOrGeneProduct | denotes | Sp | NCBIGene:6667|NCBIGene:6670|NCBIGene:6671 |
| 5298 | 859-867 | ChemicalEntity | denotes | curcumin | MESH:D003474 |
| 5299 | 876-886 | GeneOrGeneProduct | denotes | proteasome | NCBIGene:5698 |
| 5300 | 916-919 | GeneOrGeneProduct | denotes | Sp1 | NCBIGene:6667 |
| 5301 | 921-924 | GeneOrGeneProduct | denotes | Sp3 | NCBIGene:6670 |
| 5302 | 930-933 | GeneOrGeneProduct | denotes | Sp4 | NCBIGene:6671 |
| 5303 | 937-944 | CellLine | denotes | 253JB-V | NCBITaxon:9606 |
| 5304 | 949-952 | CellLine | denotes | KU7 | NCBITaxon:9606 |
| 5305 | 1024-1027 | GeneOrGeneProduct | denotes | Sp1 | NCBIGene:6667 |
| 5306 | 1029-1032 | GeneOrGeneProduct | denotes | Sp3 | NCBIGene:6670 |
| 5307 | 1038-1041 | GeneOrGeneProduct | denotes | Sp4 | NCBIGene:6671 |
| 5308 | 1060-1068 | ChemicalEntity | denotes | curcumin | MESH:D003474 |
| 5309 | 1093-1114 | GeneOrGeneProduct | denotes | nuclear factor kappaB | NCBIGene:4790 |
| 5310 | 1116-1125 | GeneOrGeneProduct | denotes | NF-kappaB | NCBIGene:4790 |
| 5311 | 1152-1157 | GeneOrGeneProduct | denotes | bcl-2 | NCBIGene:596 |
| 5312 | 1159-1167 | GeneOrGeneProduct | denotes | survivin | NCBIGene:332 |
| 5313 | 1173-1182 | GeneOrGeneProduct | denotes | cyclin D1 | NCBIGene:595 |
| 5314 | 1218-1220 | GeneOrGeneProduct | denotes | Sp | NCBIGene:6667|NCBIGene:6670|NCBIGene:6671 |
| 5315 | 1231-1239 | ChemicalEntity | denotes | Curcumin | MESH:D003474 |
| 5316 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | MESH:D001749 |
| 5317 | 1292-1296 | OrganismTaxon | denotes | mice | NCBITaxon:10090 |
| 5318 | 1305-1308 | CellLine | denotes | KU7 | NCBITaxon:9606 |
| 5319 | 1367-1370 | GeneOrGeneProduct | denotes | Sp1 | NCBIGene:20683 |
| 5320 | 1372-1375 | GeneOrGeneProduct | denotes | Sp3 | NCBIGene:20687 |
| 5321 | 1381-1384 | GeneOrGeneProduct | denotes | Sp4 | NCBIGene:20688 |
| 5322 | 1403-1409 | DiseaseOrPhenotypicFeature | denotes | tumors | MESH:D009369 |
| 5323 | 1500-1508 | ChemicalEntity | denotes | curcumin | MESH:D003474 |
| 5324 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | MESH:D009369 |
| 5325 | 1588-1612 | GeneOrGeneProduct | denotes | Sp transcription factors | NCBIGene:6667|NCBIGene:6670|NCBIGene:6671 |
| 5326 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | MESH:D001749 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 61-67 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T2 | 329-335 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T3 | 499-510 | DiseaseOrPhenotypicFeature | denotes | endothelial | 0015292 |
| T4 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
| T5 | 1624-1630 | DiseaseOrPhenotypicFeature | denotes | cancer | 0004992 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 305-310 | SequenceVariant | denotes | 253JB |
| T2 | 937-942 | SequenceVariant | denotes | 253JB |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-38 | GeneOrGeneProduct | denotes | protein |
| T2 | 68-73 | GeneOrGeneProduct | denotes | cells |
| T3 | 91-97 | GeneOrGeneProduct | denotes | active |
| T4 | 160-171 | GeneOrGeneProduct | denotes | extensively |
| T5 | 222-230 | GeneOrGeneProduct | denotes | multiple |
| T6 | 336-340 | GeneOrGeneProduct | denotes | cell |
| T7 | 341-347 | GeneOrGeneProduct | denotes | growth |
| T8 | 390-399 | GeneOrGeneProduct | denotes | apoptosis |
| T9 | 445-452 | GeneOrGeneProduct | denotes | protein |
| T10 | 453-461 | GeneOrGeneProduct | denotes | survivin |
| T11 | 481-489 | GeneOrGeneProduct | denotes | proteins |
| T12 | 490-524 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
| T13 | 526-530 | GeneOrGeneProduct | denotes | VEGF |
| T14 | 536-549 | GeneOrGeneProduct | denotes | VEGF receptor |
| T15 | 553-559 | GeneOrGeneProduct | denotes | VEGFR1 |
| T16 | 584-592 | GeneOrGeneProduct | denotes | survivin |
| T17 | 594-598 | GeneOrGeneProduct | denotes | VEGF |
| T18 | 604-610 | GeneOrGeneProduct | denotes | VEGFR1 |
| T19 | 640-647 | GeneOrGeneProduct | denotes | protein |
| T20 | 653-674 | GeneOrGeneProduct | denotes | transcription factors |
| T21 | 727-734 | GeneOrGeneProduct | denotes | protein |
| T22 | 810-818 | GeneOrGeneProduct | denotes | activity |
| T23 | 868-875 | GeneOrGeneProduct | denotes | induced |
| T24 | 876-886 | GeneOrGeneProduct | denotes | proteasome |
| T25 | 902-912 | GeneOrGeneProduct | denotes | regulation |
| T26 | 916-919 | GeneOrGeneProduct | denotes | Sp1 |
| T27 | 921-924 | GeneOrGeneProduct | denotes | Sp3 |
| T28 | 930-933 | GeneOrGeneProduct | denotes | Sp4 |
| T29 | 953-958 | GeneOrGeneProduct | denotes | cells |
| T30 | 998-1003 | GeneOrGeneProduct | denotes | small |
| T31 | 1024-1027 | GeneOrGeneProduct | denotes | Sp1 |
| T32 | 1029-1032 | GeneOrGeneProduct | denotes | Sp3 |
| T33 | 1038-1041 | GeneOrGeneProduct | denotes | Sp4 |
| T34 | 1101-1107 | GeneOrGeneProduct | denotes | factor |
| T35 | 1116-1125 | GeneOrGeneProduct | denotes | NF-kappaB |
| T36 | 1152-1157 | GeneOrGeneProduct | denotes | bcl-2 |
| T37 | 1159-1167 | GeneOrGeneProduct | denotes | survivin |
| T38 | 1173-1182 | GeneOrGeneProduct | denotes | cyclin D1 |
| T39 | 1201-1205 | GeneOrGeneProduct | denotes | part |
| T40 | 1221-1229 | GeneOrGeneProduct | denotes | proteins |
| T41 | 1263-1268 | GeneOrGeneProduct | denotes | tumor |
| T42 | 1269-1275 | GeneOrGeneProduct | denotes | growth |
| T43 | 1287-1291 | GeneOrGeneProduct | denotes | nude |
| T44 | 1292-1296 | GeneOrGeneProduct | denotes | mice |
| T45 | 1309-1314 | GeneOrGeneProduct | denotes | cells |
| T46 | 1367-1370 | GeneOrGeneProduct | denotes | Sp1 |
| T47 | 1372-1375 | GeneOrGeneProduct | denotes | Sp3 |
| T48 | 1385-1392 | GeneOrGeneProduct | denotes | protein |
| T49 | 1403-1409 | GeneOrGeneProduct | denotes | tumors |
| T50 | 1444-1448 | GeneOrGeneProduct | denotes | time |
| T51 | 1555-1559 | GeneOrGeneProduct | denotes | part |
| T52 | 1591-1612 | GeneOrGeneProduct | denotes | transcription factors |
| T53 | 1631-1636 | GeneOrGeneProduct | denotes | cells |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-38 | GeneOrGeneProduct | denotes | protein |
| T2 | 222-230 | GeneOrGeneProduct | denotes | multiple |
| T3 | 336-340 | GeneOrGeneProduct | denotes | cell |
| T4 | 341-347 | GeneOrGeneProduct | denotes | growth |
| T5 | 390-399 | GeneOrGeneProduct | denotes | apoptosis |
| T6 | 445-452 | GeneOrGeneProduct | denotes | protein |
| T7 | 453-461 | GeneOrGeneProduct | denotes | survivin |
| T8 | 490-524 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
| T9 | 526-530 | GeneOrGeneProduct | denotes | VEGF |
| T10 | 536-549 | GeneOrGeneProduct | denotes | VEGF receptor |
| T11 | 553-559 | GeneOrGeneProduct | denotes | VEGFR1 |
| T12 | 584-592 | GeneOrGeneProduct | denotes | survivin |
| T13 | 594-598 | GeneOrGeneProduct | denotes | VEGF |
| T14 | 604-610 | GeneOrGeneProduct | denotes | VEGFR1 |
| T15 | 640-647 | GeneOrGeneProduct | denotes | protein |
| T16 | 653-674 | GeneOrGeneProduct | denotes | transcription factors |
| T17 | 727-734 | GeneOrGeneProduct | denotes | protein |
| T18 | 876-886 | GeneOrGeneProduct | denotes | proteasome |
| T19 | 998-1003 | GeneOrGeneProduct | denotes | small |
| T20 | 1101-1107 | GeneOrGeneProduct | denotes | factor |
| T21 | 1116-1125 | GeneOrGeneProduct | denotes | NF-kappaB |
| T22 | 1152-1157 | GeneOrGeneProduct | denotes | bcl-2 |
| T23 | 1159-1167 | GeneOrGeneProduct | denotes | survivin |
| T24 | 1173-1182 | GeneOrGeneProduct | denotes | cyclin D1 |
| T25 | 1269-1275 | GeneOrGeneProduct | denotes | growth |
| T26 | 1287-1291 | GeneOrGeneProduct | denotes | nude |
| T27 | 1385-1392 | GeneOrGeneProduct | denotes | protein |
| T28 | 1591-1612 | GeneOrGeneProduct | denotes | transcription factors |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T2 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T3 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | D001749 |
| T4 | 1403-1409 | DiseaseOrPhenotypicFeature | denotes | tumors | D009369 |
| T5 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T6 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0022578|0004986 |
| T3 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0022578|0004986 |
| T5 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | 0004987 |
| T6 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | 0022578|0004986 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T2 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T3 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | D001749 |
| T4 | 1403-1409 | DiseaseOrPhenotypicFeature | denotes | tumors | DISEASE|D009369 |
| T6 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T7 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
LitCoin_CellLine
| Id | Subject | Object | Predicate | Lexical cue | cellosaurus_accession_id |
|---|---|---|---|---|---|
| T1 | 305-312 | CellLine | denotes | 253JB-V | CVCL_7937 |
| T2 | 317-320 | CellLine | denotes | KU7 | CVCL_4714|CVCL_T528 |
| T4 | 937-944 | CellLine | denotes | 253JB-V | CVCL_7937 |
| T5 | 949-952 | CellLine | denotes | KU7 | CVCL_4714|CVCL_T528 |
| T7 | 1305-1308 | CellLine | denotes | KU7 | CVCL_4714|CVCL_T528 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T2 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
| T3 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | D001749 |
| T4 | 1403-1409 | DiseaseOrPhenotypicFeature | denotes | tumors | D009369 |
| T5 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 |
| T6 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 0-8 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 |
| T2 | 75-83 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 |
| T3 | 286-294 | ChemicalEntity | denotes | curcumin | D003474|http://purl.obolibrary.org/obo/CHEBI_3962 |
| T5 | 712-720 | ChemicalEntity | denotes | curcumin | D003474|http://purl.obolibrary.org/obo/CHEBI_3962 |
| T7 | 859-867 | ChemicalEntity | denotes | curcumin | D003474|http://purl.obolibrary.org/obo/CHEBI_3962 |
| T9 | 876-886 | ChemicalEntity | denotes | proteasome | D046988 |
| T10 | 1060-1068 | ChemicalEntity | denotes | curcumin | D003474|http://purl.obolibrary.org/obo/CHEBI_3962 |
| T12 | 1231-1239 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 |
| T13 | 1500-1508 | ChemicalEntity | denotes | curcumin | D003474|http://purl.obolibrary.org/obo/CHEBI_3962 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 930-933 | OrganismTaxon | denotes | Sp4 |
| T2 | 1038-1041 | OrganismTaxon | denotes | Sp4 |
| T3 | 1292-1296 | OrganismTaxon | denotes | mice |
| T4 | 1381-1384 | OrganismTaxon | denotes | Sp4 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 31-52 | GeneOrGeneProduct | denotes | protein expression in |
| T2 | 453-461 | GeneOrGeneProduct | denotes | survivin |
| T3 | 490-524 | GeneOrGeneProduct | denotes | vascular endothelial growth factor |
| T4 | 526-530 | GeneOrGeneProduct | denotes | VEGF |
| T5 | 536-549 | GeneOrGeneProduct | denotes | VEGF receptor |
| T7 | 553-559 | GeneOrGeneProduct | denotes | VEGFR1 |
| T8 | 584-592 | GeneOrGeneProduct | denotes | survivin |
| T9 | 594-598 | GeneOrGeneProduct | denotes | VEGF |
| T10 | 604-610 | GeneOrGeneProduct | denotes | VEGFR1 |
| T11 | 648-674 | GeneOrGeneProduct | denotes | (Sp) transcription factors |
| T12 | 727-745 | GeneOrGeneProduct | denotes | protein expression |
| T13 | 876-886 | GeneOrGeneProduct | denotes | proteasome |
| T14 | 1093-1114 | GeneOrGeneProduct | denotes | nuclear factor kappaB |
| T15 | 1116-1125 | GeneOrGeneProduct | denotes | NF-kappaB |
| T16 | 1152-1157 | GeneOrGeneProduct | denotes | bcl-2 |
| T17 | 1159-1167 | GeneOrGeneProduct | denotes | survivin |
| T18 | 1173-1182 | GeneOrGeneProduct | denotes | cyclin D1 |
| T19 | 1381-1392 | GeneOrGeneProduct | denotes | Sp4 protein |
| T20 | 1588-1612 | GeneOrGeneProduct | denotes | Sp transcription factors |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: | cellosaurus_accession_id |
|---|---|---|---|---|---|---|---|
| T7 | 1305-1308 | CellLine | denotes | KU7 | CVCL_T528|CVCL_4714 | ||
| T5 | 949-952 | CellLine | denotes | KU7 | CVCL_T528|CVCL_4714 | ||
| T4 | 937-944 | CellLine | denotes | 253JB-V | CVCL_7937 | ||
| T2 | 317-320 | CellLine | denotes | KU7 | CVCL_T528|CVCL_4714 | ||
| T1 | 305-312 | CellLine | denotes | 253JB-V | CVCL_7937 | ||
| T13 | 1500-1508 | ChemicalEntity | denotes | curcumin | http://purl.obolibrary.org/obo/CHEBI_3962|D003474 | ||
| T12 | 1231-1239 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 | ||
| T10 | 1060-1068 | ChemicalEntity | denotes | curcumin | http://purl.obolibrary.org/obo/CHEBI_3962|D003474 | ||
| T9 | 876-886 | ChemicalEntity | denotes | proteasome | D046988 | ||
| T73698 | 859-867 | ChemicalEntity | denotes | curcumin | http://purl.obolibrary.org/obo/CHEBI_3962|D003474 | ||
| T20223 | 712-720 | ChemicalEntity | denotes | curcumin | http://purl.obolibrary.org/obo/CHEBI_3962|D003474 | ||
| T3 | 286-294 | ChemicalEntity | denotes | curcumin | http://purl.obolibrary.org/obo/CHEBI_3962|D003474 | ||
| T53129 | 75-83 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 | ||
| T58180 | 0-8 | ChemicalEntity | denotes | Curcumin | http://purl.obolibrary.org/obo/CHEBI_3962 | ||
| T20 | 1588-1612 | GeneOrGeneProduct | denotes | Sp transcription factors | |||
| T19 | 1381-1392 | GeneOrGeneProduct | denotes | Sp4 protein | |||
| T18 | 1173-1182 | GeneOrGeneProduct | denotes | cyclin D1 | |||
| T17 | 1159-1167 | GeneOrGeneProduct | denotes | survivin | |||
| T16 | 1152-1157 | GeneOrGeneProduct | denotes | bcl-2 | |||
| T15 | 1116-1125 | GeneOrGeneProduct | denotes | NF-kappaB | |||
| T14 | 1093-1114 | GeneOrGeneProduct | denotes | nuclear factor kappaB | |||
| T90268 | 876-886 | GeneOrGeneProduct | denotes | proteasome | |||
| T57130 | 727-745 | GeneOrGeneProduct | denotes | protein expression | |||
| T11 | 648-674 | GeneOrGeneProduct | denotes | (Sp) transcription factors | |||
| T62110 | 604-610 | GeneOrGeneProduct | denotes | VEGFR1 | |||
| T99500 | 594-598 | GeneOrGeneProduct | denotes | VEGF | |||
| T8 | 584-592 | GeneOrGeneProduct | denotes | survivin | |||
| T25680 | 553-559 | GeneOrGeneProduct | denotes | VEGFR1 | |||
| T16794 | 536-549 | GeneOrGeneProduct | denotes | VEGF receptor | |||
| T51465 | 526-530 | GeneOrGeneProduct | denotes | VEGF | |||
| T40850 | 490-524 | GeneOrGeneProduct | denotes | vascular endothelial growth factor | |||
| T85350 | 453-461 | GeneOrGeneProduct | denotes | survivin | |||
| T25491 | 31-52 | GeneOrGeneProduct | denotes | protein expression in | |||
| T6 | 1616-1630 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 | ||
| T92657 | 1514-1520 | DiseaseOrPhenotypicFeature | denotes | cancer | D009369 | ||
| T69113 | 1403-1409 | DiseaseOrPhenotypicFeature | denotes | tumors | D009369 | ||
| T73033 | 1255-1268 | DiseaseOrPhenotypicFeature | denotes | bladder tumor | D001749 | ||
| T12719 | 321-335 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 | ||
| T45542 | 53-67 | DiseaseOrPhenotypicFeature | denotes | bladder cancer | D001749 | ||
| T94703 | 1381-1384 | OrganismTaxon | denotes | Sp4 | |||
| T14117 | 1292-1296 | OrganismTaxon | denotes | mice | |||
| T20516 | 1038-1041 | OrganismTaxon | denotes | Sp4 | |||
| T11231 | 930-933 | OrganismTaxon | denotes | Sp4 | |||
| T34723 | 937-942 | SequenceVariant | denotes | 253JB | |||
| T87809 | 305-310 | SequenceVariant | denotes | 253JB |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1381-1384 | gene:6671 | denotes | Sp4 |
| T1 | 1255-1268 | disease:C0005695 | denotes | bladder tumor |
| R1 | T0 | T1 | associated_with | Sp4,bladder tumor |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 18593936-6#150#153#gene6671 | 1381-1384 | gene6671 | denotes | Sp4 |
| 18593936-6#24#37#diseaseC0005695 | 1255-1268 | diseaseC0005695 | denotes | bladder tumor |
| 150#153#gene667124#37#diseaseC0005695 | 18593936-6#150#153#gene6671 | 18593936-6#24#37#diseaseC0005695 | associated_with | Sp4,bladder tumor |