PubMed:18553168 JSONTXT

{"project":"GlyCosmos600-CLO","denotations":[{"id":"T1","span":{"begin":96,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":198,"end":203},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T3","span":{"begin":494,"end":499},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T4","span":{"begin":503,"end":508},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T5","span":{"begin":1169,"end":1174},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T6","span":{"begin":1320,"end":1325},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T7","span":{"begin":1361,"end":1366},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T8","span":{"begin":1453,"end":1458},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T9","span":{"begin":1588,"end":1592},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T10","span":{"begin":1729,"end":1734},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T11","span":{"begin":1856,"end":1860},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T12","span":{"begin":1873,"end":1878},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T13","span":{"begin":1946,"end":1950},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":142,"end":372},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":373,"end":395},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":396,"end":614},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":615,"end":745},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":746,"end":892},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":893,"end":989},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":990,"end":998},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":999,"end":1003},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1004,"end":1101},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1102,"end":1237},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1238,"end":1374},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1375,"end":1534},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1535,"end":1777},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1778,"end":1800},"obj":"Sentence"},{"id":"TextSentencer_T16","span":{"begin":1801,"end":1910},"obj":"Sentence"},{"id":"TextSentencer_T17","span":{"begin":1911,"end":1969},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":141},"obj":"Sentence"},{"id":"T2","span":{"begin":142,"end":372},"obj":"Sentence"},{"id":"T3","span":{"begin":373,"end":395},"obj":"Sentence"},{"id":"T4","span":{"begin":396,"end":614},"obj":"Sentence"},{"id":"T5","span":{"begin":615,"end":745},"obj":"Sentence"},{"id":"T6","span":{"begin":746,"end":892},"obj":"Sentence"},{"id":"T7","span":{"begin":893,"end":989},"obj":"Sentence"},{"id":"T8","span":{"begin":990,"end":998},"obj":"Sentence"},{"id":"T9","span":{"begin":999,"end":1003},"obj":"Sentence"},{"id":"T10","span":{"begin":1004,"end":1101},"obj":"Sentence"},{"id":"T11","span":{"begin":1102,"end":1237},"obj":"Sentence"},{"id":"T12","span":{"begin":1238,"end":1374},"obj":"Sentence"},{"id":"T13","span":{"begin":1375,"end":1534},"obj":"Sentence"},{"id":"T14","span":{"begin":1535,"end":1777},"obj":"Sentence"},{"id":"T15","span":{"begin":1778,"end":1800},"obj":"Sentence"},{"id":"T16","span":{"begin":1801,"end":1910},"obj":"Sentence"},{"id":"T17","span":{"begin":1911,"end":1969},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T1","span":{"begin":40,"end":46},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T2","span":{"begin":134,"end":140},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T3","span":{"begin":204,"end":210},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T4","span":{"begin":475,"end":481},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T5","span":{"begin":608,"end":613},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T6","span":{"begin":646,"end":652},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T7","span":{"begin":713,"end":719},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T8","span":{"begin":1175,"end":1181},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T9","span":{"begin":1326,"end":1331},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T10","span":{"begin":1367,"end":1373},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T11","span":{"begin":1459,"end":1465},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T12","span":{"begin":1480,"end":1486},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T13","span":{"begin":1735,"end":1741},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"T14","span":{"begin":1879,"end":1885},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"GlyCosmos600-FMA","denotations":[{"id":"T1","span":{"begin":40,"end":46},"obj":"Body_part"},{"id":"T2","span":{"begin":96,"end":101},"obj":"Body_part"},{"id":"T3","span":{"begin":134,"end":140},"obj":"Body_part"},{"id":"T4","span":{"begin":204,"end":210},"obj":"Body_part"},{"id":"T5","span":{"begin":475,"end":481},"obj":"Body_part"},{"id":"T6","span":{"begin":608,"end":613},"obj":"Body_part"},{"id":"T7","span":{"begin":646,"end":652},"obj":"Body_part"},{"id":"T8","span":{"begin":713,"end":719},"obj":"Body_part"},{"id":"T9","span":{"begin":879,"end":889},"obj":"Body_part"},{"id":"T10","span":{"begin":910,"end":913},"obj":"Body_part"},{"id":"T11","span":{"begin":1096,"end":1100},"obj":"Body_part"},{"id":"T12","span":{"begin":1175,"end":1181},"obj":"Body_part"},{"id":"T13","span":{"begin":1198,"end":1206},"obj":"Body_part"},{"id":"T14","span":{"begin":1267,"end":1271},"obj":"Body_part"},{"id":"T15","span":{"begin":1326,"end":1331},"obj":"Body_part"},{"id":"T16","span":{"begin":1367,"end":1373},"obj":"Body_part"},{"id":"T17","span":{"begin":1459,"end":1465},"obj":"Body_part"},{"id":"T18","span":{"begin":1480,"end":1486},"obj":"Body_part"},{"id":"T19","span":{"begin":1529,"end":1533},"obj":"Body_part"},{"id":"T20","span":{"begin":1588,"end":1592},"obj":"Body_part"},{"id":"T21","span":{"begin":1622,"end":1636},"obj":"Body_part"},{"id":"T22","span":{"begin":1735,"end":1741},"obj":"Body_part"},{"id":"T23","span":{"begin":1856,"end":1860},"obj":"Body_part"},{"id":"T24","span":{"begin":1879,"end":1885},"obj":"Body_part"},{"id":"T25","span":{"begin":1946,"end":1950},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"fma_id","subj":"T1","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A7","pred":"fma_id","subj":"T7","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A8","pred":"fma_id","subj":"T8","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A9","pred":"fma_id","subj":"T9","obj":"http://purl.org/sig/ont/fma/fma67093"},{"id":"A10","pred":"fma_id","subj":"T10","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma67122"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma9607"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"GlyCosmos600-MAT","denotations":[{"id":"PD-MAT-B_T1","span":{"begin":40,"end":46},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T2","span":{"begin":134,"end":140},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T3","span":{"begin":204,"end":210},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T4","span":{"begin":475,"end":481},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T5","span":{"begin":646,"end":652},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T6","span":{"begin":713,"end":719},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T7","span":{"begin":1175,"end":1181},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T8","span":{"begin":1367,"end":1373},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T9","span":{"begin":1459,"end":1465},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T10","span":{"begin":1480,"end":1486},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T11","span":{"begin":1735,"end":1741},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T12","span":{"begin":1879,"end":1885},"obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"PD-MAT-B_T13","span":{"begin":608,"end":613},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"PD-MAT-B_T14","span":{"begin":1326,"end":1331},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"GlyCosmos600-GlycoProteins","denotations":[{"id":"PD-GlycoProteins-B_T1","span":{"begin":1267,"end":1271},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005542"},{"id":"PD-GlycoProteins-B_T2","span":{"begin":1267,"end":1271},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005543"},{"id":"PD-GlycoProteins-B_T3","span":{"begin":1267,"end":1271},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005544"},{"id":"PD-GlycoProteins-B_T4","span":{"begin":1267,"end":1271},"obj":"https://acgg.asia/db/gpdb/id/GPDB0005545"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

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expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"Anatomy-MAT","denotations":[{"id":"T1","span":{"begin":40,"end":46},"obj":"Body_part"},{"id":"T2","span":{"begin":134,"end":140},"obj":"Body_part"},{"id":"T3","span":{"begin":204,"end":210},"obj":"Body_part"},{"id":"T4","span":{"begin":475,"end":481},"obj":"Body_part"},{"id":"T5","span":{"begin":608,"end":613},"obj":"Body_part"},{"id":"T6","span":{"begin":646,"end":652},"obj":"Body_part"},{"id":"T7","span":{"begin":713,"end":719},"obj":"Body_part"},{"id":"T8","span":{"begin":1175,"end":1181},"obj":"Body_part"},{"id":"T9","span":{"begin":1326,"end":1331},"obj":"Body_part"},{"id":"T10","span":{"begin":1367,"end":1373},"obj":"Body_part"},{"id":"T11","span":{"begin":1459,"end":1465},"obj":"Body_part"},{"id":"T12","span":{"begin":1480,"end":1486},"obj":"Body_part"},{"id":"T13","span":{"begin":1735,"end":1741},"obj":"Body_part"},{"id":"T14","span":{"begin":1879,"end":1885},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"mat_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A3","pred":"mat_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A4","pred":"mat_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A5","pred":"mat_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A6","pred":"mat_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A7","pred":"mat_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A8","pred":"mat_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A9","pred":"mat_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"A10","pred":"mat_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A11","pred":"mat_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A12","pred":"mat_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A13","pred":"mat_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MAT_0000080"},{"id":"A14","pred":"mat_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MAT_0000080"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":1937,"end":1941},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"image"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":40,"end":46},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":55,"end":59},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":134,"end":140},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":198,"end":203},"obj":"OrganismTaxon"},{"id":"T6","span":{"begin":204,"end":210},"obj":"OrganismTaxon"},{"id":"T7","span":{"begin":475,"end":481},"obj":"OrganismTaxon"},{"id":"T8","span":{"begin":494,"end":499},"obj":"OrganismTaxon"},{"id":"T10","span":{"begin":503,"end":508},"obj":"OrganismTaxon"},{"id":"T12","span":{"begin":646,"end":652},"obj":"OrganismTaxon"},{"id":"T13","span":{"begin":713,"end":719},"obj":"OrganismTaxon"},{"id":"T14","span":{"begin":1169,"end":1174},"obj":"OrganismTaxon"},{"id":"T16","span":{"begin":1175,"end":1181},"obj":"OrganismTaxon"},{"id":"T17","span":{"begin":1320,"end":1325},"obj":"OrganismTaxon"},{"id":"T19","span":{"begin":1361,"end":1366},"obj":"OrganismTaxon"},{"id":"T21","span":{"begin":1367,"end":1373},"obj":"OrganismTaxon"},{"id":"T22","span":{"begin":1453,"end":1458},"obj":"OrganismTaxon"},{"id":"T24","span":{"begin":1459,"end":1465},"obj":"OrganismTaxon"},{"id":"T25","span":{"begin":1480,"end":1486},"obj":"OrganismTaxon"},{"id":"T26","span":{"begin":1729,"end":1734},"obj":"OrganismTaxon"},{"id":"T28","span":{"begin":1735,"end":1741},"obj":"OrganismTaxon"},{"id":"T29","span":{"begin":1873,"end":1878},"obj":"OrganismTaxon"},{"id":"T31","span":{"begin":1879,"end":1885},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"49990"},{"id":"A2","pred":"db_id","subj":"T2","obj":"10088"},{"id":"A3","pred":"db_id","subj":"T3","obj":"49990"},{"id":"A4","pred":"db_id","subj":"T4","obj":"10088"},{"id":"A5","pred":"db_id","subj":"T4","obj":"10090"},{"id":"A6","pred":"db_id","subj":"T6","obj":"49990"},{"id":"A7","pred":"db_id","subj":"T7","obj":"49990"},{"id":"A8","pred":"db_id","subj":"T8","obj":"10088"},{"id":"A9","pred":"db_id","subj":"T8","obj":"10090"},{"id":"A10","pred":"db_id","subj":"T10","obj":"10088"},{"id":"A11","pred":"db_id","subj":"T10","obj":"10090"},{"id":"A12","pred":"db_id","subj":"T12","obj":"49990"},{"id":"A13","pred":"db_id","subj":"T13","obj":"49990"},{"id":"A14","pred":"db_id","subj":"T14","obj":"10088"},{"id":"A15","pred":"db_id","subj":"T14","obj":"10090"},{"id":"A16","pred":"db_id","subj":"T16","obj":"49990"},{"id":"A17","pred":"db_id","subj":"T17","obj":"10088"},{"id":"A18","pred":"db_id","subj":"T17","obj":"10090"},{"id":"A19","pred":"db_id","subj":"T19","obj":"10088"},{"id":"A20","pred":"db_id","subj":"T19","obj":"10090"},{"id":"A21","pred":"db_id","subj":"T21","obj":"49990"},{"id":"A22","pred":"db_id","subj":"T22","obj":"10088"},{"id":"A23","pred":"db_id","subj":"T22","obj":"10090"},{"id":"A24","pred":"db_id","subj":"T24","obj":"49990"},{"id":"A25","pred":"db_id","subj":"T25","obj":"49990"},{"id":"A26","pred":"db_id","subj":"T26","obj":"10088"},{"id":"A27","pred":"db_id","subj":"T26","obj":"10090"},{"id":"A28","pred":"db_id","subj":"T28","obj":"49990"},{"id":"A29","pred":"db_id","subj":"T29","obj":"10088"},{"id":"A30","pred":"db_id","subj":"T29","obj":"10090"},{"id":"A31","pred":"db_id","subj":"T31","obj":"49990"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":40,"end":46},"obj":"Body_part"},{"id":"T2","span":{"begin":134,"end":140},"obj":"Body_part"},{"id":"T3","span":{"begin":204,"end":210},"obj":"Body_part"},{"id":"T4","span":{"begin":297,"end":305},"obj":"Body_part"},{"id":"T7","span":{"begin":475,"end":481},"obj":"Body_part"},{"id":"T8","span":{"begin":608,"end":613},"obj":"Body_part"},{"id":"T9","span":{"begin":646,"end":652},"obj":"Body_part"},{"id":"T10","span":{"begin":713,"end":719},"obj":"Body_part"},{"id":"T11","span":{"begin":879,"end":889},"obj":"Body_part"},{"id":"T12","span":{"begin":1175,"end":1181},"obj":"Body_part"},{"id":"T13","span":{"begin":1326,"end":1331},"obj":"Body_part"},{"id":"T14","span":{"begin":1367,"end":1373},"obj":"Body_part"},{"id":"T15","span":{"begin":1459,"end":1465},"obj":"Body_part"},{"id":"T16","span":{"begin":1480,"end":1486},"obj":"Body_part"},{"id":"T17","span":{"begin":1735,"end":1741},"obj":"Body_part"},{"id":"T18","span":{"begin":1879,"end":1885},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"A5","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000094"},{"id":"A6","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/GO_0005694"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0002370"}],"text":"Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells \"Neu-medullocyte\" in the murine thymus.\nWe have already reported that the homogenate of the A/J mouse thymus shows a high sialidase activity at the neutral pH region and that in both soluble and membrane fractions optimal pH was 6.5-7 (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). In the present study, we investigated the level of sialidase activities in the thymus of the SM/J mouse, a mouse strain that we know to have a Neu1(a) allele that reveals a low level of sialidase activity in the liver. We found that while in the A/J thymus the soluble sialidase activity at pH 6.5 was high, the SM/J thymus lacked all such activity. A QTL analysis of SMXA recombinant inbred strains showed that soluble sialidase activity correlated well with the D1Mit8/9 marker on chromosome 1. The murine whole DNA-sequence data and the results of our FISH analysis (Kotani et al., Biochem. Biophys. Res. Comm., 286:250-258, 2001) showed that this location is consistent with the position of Neu2 gene. We confirmed that it is hard to detect the Neu2 enzyme of the SM/J mouse thymus by an anti-Neu2 antibody using a Western blot analysis. We also found that while the mRNA expression of Neu2 was quite normal in the SM/J mouse liver, it was very low in the SM/J mouse thymus. We therefore conclude that the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene. We have previously shown that the sialidase positive cell which contains the Mac-1 and immunoglobulin, and which is located sparsely in the corticomedullar region or medullary region of the A/J mouse thymus (Kijimoto-Ochiai et al., Glycoconj. J., 20:375-384, 2004). We showed now in this paper that the detection of this cell in the SM/J mouse thymus at pH 7.0 was difficult. We propose, therefore, to name the cell \"Neu-medullocyte\"."}