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PubMed:18504438 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 120-133 DiseaseOrPhenotypicFeature denotes neuroblastoma 0005072
T2 646-659 DiseaseOrPhenotypicFeature denotes neuroblastoma 0005072
T3 728-741 DiseaseOrPhenotypicFeature denotes neuroblastoma 0005072
T4 1250-1263 DiseaseOrPhenotypicFeature denotes neuroblastoma 0005072

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-48 Sentence denotes The MYCN oncogene is a direct target of miR-34a.
TextSentencer_T2 49-195 Sentence denotes Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype.
TextSentencer_T3 196-420 Sentence denotes Database searches identified five microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microRNAs contributes to the malignant phenotype of MYCN-amplified tumors.
TextSentencer_T4 421-695 Sentence denotes By bioinformatic analysis, we identified that three out of the five microRNAs target MYCN and of these miR-34a caused the most significant suppression of cell growth through increased apoptosis and decreased DNA synthesis in neuroblastoma cell lines with MYCN amplification.
TextSentencer_T5 696-835 Sentence denotes Quantitative RT-PCR showed that neuroblastoma tumors with 1p36 loss expressed lower level of miR-34a than those with normal copies of 1p36.
TextSentencer_T6 836-905 Sentence denotes Furthermore, we demonstrated that MYCN is a direct target of miR-34a.
TextSentencer_T7 906-1145 Sentence denotes Finally, using a series of mRNA expression profiling experiments, we identified other potential direct targets of miR-34a, and pathway analysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related genes.
TextSentencer_T8 1146-1264 Sentence denotes This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma.
T1 0-48 Sentence denotes The MYCN oncogene is a direct target of miR-34a.
T2 49-195 Sentence denotes Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype.
T3 196-420 Sentence denotes Database searches identified five microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microRNAs contributes to the malignant phenotype of MYCN-amplified tumors.
T4 421-695 Sentence denotes By bioinformatic analysis, we identified that three out of the five microRNAs target MYCN and of these miR-34a caused the most significant suppression of cell growth through increased apoptosis and decreased DNA synthesis in neuroblastoma cell lines with MYCN amplification.
T5 696-835 Sentence denotes Quantitative RT-PCR showed that neuroblastoma tumors with 1p36 loss expressed lower level of miR-34a than those with normal copies of 1p36.
T6 836-905 Sentence denotes Furthermore, we demonstrated that MYCN is a direct target of miR-34a.
T7 906-1145 Sentence denotes Finally, using a series of mRNA expression profiling experiments, we identified other potential direct targets of miR-34a, and pathway analysis demonstrated that miR-34a suppresses cell-cycle genes and induces several neural-related genes.
T8 1146-1264 Sentence denotes This study demonstrates one important regulatory role of miR-34a in cell growth and MYCN suppression in neuroblastoma.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 98-102 gene:4613 denotes MYCN
T1 120-133 disease:C0027819 denotes neuroblastoma
T2 98-102 gene:4613 denotes MYCN
T3 120-133 disease:C0700095 denotes neuroblastoma
T4 676-680 gene:4613 denotes MYCN
T5 646-659 disease:C0700095 denotes neuroblastoma
T6 676-680 gene:4613 denotes MYCN
T7 646-659 disease:C0027819 denotes neuroblastoma
T8 506-510 gene:4613 denotes MYCN
T9 646-659 disease:C0700095 denotes neuroblastoma
T10 506-510 gene:4613 denotes MYCN
T11 646-659 disease:C0027819 denotes neuroblastoma
T12 1230-1234 gene:4613 denotes MYCN
T13 1250-1263 disease:C0700095 denotes neuroblastoma
T14 1230-1234 gene:4613 denotes MYCN
T15 1250-1263 disease:C0027819 denotes neuroblastoma
R1 T0 T1 associated_with MYCN,neuroblastoma
R2 T2 T3 associated_with MYCN,neuroblastoma
R3 T4 T5 associated_with MYCN,neuroblastoma
R4 T6 T7 associated_with MYCN,neuroblastoma
R5 T8 T9 associated_with MYCN,neuroblastoma
R6 T10 T11 associated_with MYCN,neuroblastoma
R7 T12 T13 associated_with MYCN,neuroblastoma
R8 T14 T15 associated_with MYCN,neuroblastoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18504438-7#57#64#gene407040 1203-1210 gene407040 denotes miR-34a
18504438-7#84#88#gene4613 1230-1234 gene4613 denotes MYCN
18504438-7#104#117#diseaseC0027819 1250-1263 diseaseC0027819 denotes neuroblastoma
18504438-7#104#117#diseaseC0700095 1250-1263 diseaseC0700095 denotes neuroblastoma
18504438-7#104#117#diseaseC0027819 1250-1263 diseaseC0027819 denotes neuroblastoma
18504438-7#104#117#diseaseC0700095 1250-1263 diseaseC0700095 denotes neuroblastoma
57#64#gene407040104#117#diseaseC0027819 18504438-7#57#64#gene407040 18504438-7#104#117#diseaseC0027819 associated_with miR-34a,neuroblastoma
57#64#gene407040104#117#diseaseC0700095 18504438-7#57#64#gene407040 18504438-7#104#117#diseaseC0700095 associated_with miR-34a,neuroblastoma
57#64#gene407040104#117#diseaseC0027819 18504438-7#57#64#gene407040 18504438-7#104#117#diseaseC0027819 associated_with miR-34a,neuroblastoma
57#64#gene407040104#117#diseaseC0700095 18504438-7#57#64#gene407040 18504438-7#104#117#diseaseC0700095 associated_with miR-34a,neuroblastoma
84#88#gene4613104#117#diseaseC0027819 18504438-7#84#88#gene4613 18504438-7#104#117#diseaseC0027819 associated_with MYCN,neuroblastoma
84#88#gene4613104#117#diseaseC0700095 18504438-7#84#88#gene4613 18504438-7#104#117#diseaseC0700095 associated_with MYCN,neuroblastoma
84#88#gene4613104#117#diseaseC0027819 18504438-7#84#88#gene4613 18504438-7#104#117#diseaseC0027819 associated_with MYCN,neuroblastoma
84#88#gene4613104#117#diseaseC0700095 18504438-7#84#88#gene4613 18504438-7#104#117#diseaseC0700095 associated_with MYCN,neuroblastoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T560 1203-1210 gene:407040 denotes miR-34a
T561 1250-1263 disease:C0027819 denotes neuroblastoma
T562 1230-1234 gene:4613 denotes MYCN
R1 T560 T561 associated_with miR-34a,neuroblastoma
R2 T560 T561 associated_with miR-34a,neuroblastoma
R3 T562 T561 associated_with MYCN,neuroblastoma
R4 T562 T561 associated_with MYCN,neuroblastoma