> top > docs > PubMed:1848636 > annotations

PubMed:1848636 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers.
T2 120-242 Sentence denotes The metabolism of the cardioselective beta-blocker metoprolol is under genetic control of the debrisoquine/sparteine type.
T3 243-556 Sentence denotes The two metabolic phenotypes, extensive (EM) and poor metabolizers (PM), show different stereoselective metabolism, resulting in apparently higher beta-1 adrenoceptor antagonistic potency of racemic metoprolol in EMs. We investigated if the latter also applies to the beta-2 adrenoceptor antagonism by metoprolol.
T4 557-649 Sentence denotes The drug effect studied was the antagonism by metoprolol of terbutaline-induced hypokalemia.
T5 650-916 Sentence denotes By using pharmacokinetic pharmacodynamic modeling the pharmacodynamics of racemic metoprolol and the active S-isomer, were quantitated in EMs and PMs in terms of IC50 values, representing metoprolol plasma concentrations resulting in half-maximum receptor occupancy.
T6 917-988 Sentence denotes Six EMs received 0.5 mg of terbutaline s.c. on two different occasions:
T7 989-1074 Sentence denotes 1) 1 hr after administration of a placebo and 2) 1 hr after 150 mg of metoprolol p.o.
T8 1075-1185 Sentence denotes Five PMs were studied according to the same protocol, except for a higher terbutaline dose (0.75 mg) on day 2.
T9 1186-1400 Sentence denotes Blood samples for the analysis of plasma potassium, terbutaline, metoprolol (racemic, R- and S-isomer), and alpha-hydroxymetoprolol concentrations were taken at regular time intervals, during 8 hr after metoprolol.
T10 1401-1504 Sentence denotes In PMs, metoprolol increased the terbutaline area under the plasma concentration vs. time curve (+67%).
T11 1505-1625 Sentence denotes Higher metoprolol/alpha-hydroxymetoprolol ratios in PMs were predictive for higher R-/S-isomer ratios of unchanged drug.
T12 1626-1819 Sentence denotes There was a difference in metoprolol potency with higher racemic metoprolol IC50 values in PMs (72 +/- 7 ng.ml-1) than EMs (42 +/- 8 ng.ml-1, P less than .001).(ABSTRACT TRUNCATED AT 250 WORDS)

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
25 0-12 ChemicalEntity denotes Debrisoquine MESH:D003647
26 52-67 GeneOrGeneProduct denotes beta-2 receptor NCBIGene:154
27 88-98 ChemicalEntity denotes metoprolol MESH:D008790
28 171-181 ChemicalEntity denotes metoprolol MESH:D008790
29 214-226 ChemicalEntity denotes debrisoquine MESH:D003647
30 227-236 ChemicalEntity denotes sparteine MESH:D013034
31 390-409 GeneOrGeneProduct denotes beta-1 adrenoceptor NCBIGene:153
32 442-452 ChemicalEntity denotes metoprolol MESH:D008790
33 511-530 GeneOrGeneProduct denotes beta-2 adrenoceptor NCBIGene:154
34 545-555 ChemicalEntity denotes metoprolol MESH:D008790
35 603-613 ChemicalEntity denotes metoprolol MESH:D008790
36 617-628 ChemicalEntity denotes terbutaline MESH:D013726
37 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia MESH:D007008
38 732-742 ChemicalEntity denotes metoprolol MESH:D008790
39 838-848 ChemicalEntity denotes metoprolol MESH:D008790
40 944-955 ChemicalEntity denotes terbutaline MESH:D013726
41 1059-1069 ChemicalEntity denotes metoprolol MESH:D008790
42 1149-1160 ChemicalEntity denotes terbutaline MESH:D013726
43 1227-1236 ChemicalEntity denotes potassium MESH:D011188
44 1238-1249 ChemicalEntity denotes terbutaline MESH:D013726
45 1251-1261 ChemicalEntity denotes metoprolol MESH:D008790
46 1294-1317 ChemicalEntity denotes alpha-hydroxymetoprolol MESH:C029504
47 1389-1399 ChemicalEntity denotes metoprolol MESH:D008790
48 1409-1419 ChemicalEntity denotes metoprolol MESH:D008790
49 1434-1445 ChemicalEntity denotes terbutaline MESH:D013726
50 1512-1522 ChemicalEntity denotes metoprolol MESH:D008790
51 1523-1546 ChemicalEntity denotes alpha-hydroxymetoprolol MESH:C029504
52 1652-1662 ChemicalEntity denotes metoprolol MESH:D008790
53 1691-1701 ChemicalEntity denotes metoprolol MESH:D008790

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 52-58 GeneOrGeneProduct denotes beta-2
T2 59-67 GeneOrGeneProduct denotes receptor
T3 158-162 GeneOrGeneProduct denotes beta
T4 163-170 GeneOrGeneProduct denotes blocker
T5 273-282 GeneOrGeneProduct denotes extensive
T6 390-409 GeneOrGeneProduct denotes beta-1 adrenoceptor
T7 410-422 GeneOrGeneProduct denotes antagonistic
T8 511-530 GeneOrGeneProduct denotes beta-2 adrenoceptor
T9 629-636 GeneOrGeneProduct denotes induced
T10 751-757 GeneOrGeneProduct denotes active
T11 803-808 GeneOrGeneProduct denotes terms
T12 817-823 GeneOrGeneProduct denotes values
T13 897-905 GeneOrGeneProduct denotes receptor
T14 938-940 GeneOrGeneProduct denotes mg
T15 1031-1036 GeneOrGeneProduct denotes and 2
T16 1053-1055 GeneOrGeneProduct denotes mg
T17 1172-1174 GeneOrGeneProduct denotes mg
T18 1294-1299 GeneOrGeneProduct denotes alpha
T19 1347-1354 GeneOrGeneProduct denotes regular
T20 1355-1359 GeneOrGeneProduct denotes time
T21 1446-1450 GeneOrGeneProduct denotes area
T22 1486-1490 GeneOrGeneProduct denotes time
T23 1491-1496 GeneOrGeneProduct denotes curve
T24 1523-1528 GeneOrGeneProduct denotes alpha
T25 1566-1576 GeneOrGeneProduct denotes predictive
T26 1707-1713 GeneOrGeneProduct denotes values
T27 1787-1795 GeneOrGeneProduct denotes ABSTRACT
T28 1796-1805 GeneOrGeneProduct denotes TRUNCATED

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 52-58 GeneOrGeneProduct denotes beta-2
T2 59-67 GeneOrGeneProduct denotes receptor
T3 158-162 GeneOrGeneProduct denotes beta
T4 163-170 GeneOrGeneProduct denotes blocker
T5 390-409 GeneOrGeneProduct denotes beta-1 adrenoceptor
T6 511-530 GeneOrGeneProduct denotes beta-2 adrenoceptor
T7 897-905 GeneOrGeneProduct denotes receptor
T8 1294-1299 GeneOrGeneProduct denotes alpha
T9 1347-1354 GeneOrGeneProduct denotes regular
T10 1446-1450 GeneOrGeneProduct denotes area
T11 1523-1528 GeneOrGeneProduct denotes alpha

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia D007008

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 52-58 GeneOrGeneProduct denotes beta-2
T2 390-409 GeneOrGeneProduct denotes beta-1 adrenoceptor
T3 511-530 GeneOrGeneProduct denotes beta-2 adrenoceptor
T4 1294-1299 GeneOrGeneProduct denotes alpha
T5 1347-1354 GeneOrGeneProduct denotes regular
T6 1523-1528 GeneOrGeneProduct denotes alpha

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 284-286 DiseaseOrPhenotypicFeature denotes EM 0006545
T2 311-313 DiseaseOrPhenotypicFeature denotes PM 0019168|0019127
T4 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia 0003019

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia D007008

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia D007008

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 0-12 ChemicalEntity denotes Debrisoquine http://purl.obolibrary.org/obo/CHEBI_34665
T2 88-98 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T4 171-181 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T6 214-226 ChemicalEntity denotes debrisoquine D003647|http://purl.obolibrary.org/obo/CHEBI_34665
T8 227-236 ChemicalEntity denotes sparteine D013034|http://purl.obolibrary.org/obo/CHEBI_28827
T10 442-452 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T12 545-555 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T14 603-613 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T16 617-628 ChemicalEntity denotes terbutaline D013726|http://purl.obolibrary.org/obo/CHEBI_9449
T18 732-742 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T20 838-848 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T22 944-955 ChemicalEntity denotes terbutaline D013726|http://purl.obolibrary.org/obo/CHEBI_9449
T24 1059-1069 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T26 1149-1160 ChemicalEntity denotes terbutaline D013726|http://purl.obolibrary.org/obo/CHEBI_9449
T28 1227-1236 ChemicalEntity denotes potassium D011188|http://purl.obolibrary.org/obo/CHEBI_26216
T30 1238-1249 ChemicalEntity denotes terbutaline D013726|http://purl.obolibrary.org/obo/CHEBI_9449
T32 1251-1261 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T34 1294-1317 ChemicalEntity denotes alpha-hydroxymetoprolol C029504
T35 1389-1399 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T37 1409-1419 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T39 1434-1445 ChemicalEntity denotes terbutaline D013726|http://purl.obolibrary.org/obo/CHEBI_9449
T41 1512-1522 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T43 1523-1546 ChemicalEntity denotes alpha-hydroxymetoprolol C029504
T44 1652-1662 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904
T46 1691-1701 ChemicalEntity denotes metoprolol D008790|http://purl.obolibrary.org/obo/CHEBI_6904

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T46 1691-1701 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T44 1652-1662 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T43 1523-1546 ChemicalEntity denotes alpha-hydroxymetoprolol C029504
T41 1512-1522 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T39 1434-1445 ChemicalEntity denotes terbutaline http://purl.obolibrary.org/obo/CHEBI_9449|D013726
T37 1409-1419 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T35 1389-1399 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T34 1294-1317 ChemicalEntity denotes alpha-hydroxymetoprolol C029504
T32 1251-1261 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T30 1238-1249 ChemicalEntity denotes terbutaline http://purl.obolibrary.org/obo/CHEBI_9449|D013726
T28 1227-1236 ChemicalEntity denotes potassium http://purl.obolibrary.org/obo/CHEBI_26216|D011188
T26 1149-1160 ChemicalEntity denotes terbutaline http://purl.obolibrary.org/obo/CHEBI_9449|D013726
T24 1059-1069 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T22 944-955 ChemicalEntity denotes terbutaline http://purl.obolibrary.org/obo/CHEBI_9449|D013726
T20 838-848 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T18 732-742 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T16 617-628 ChemicalEntity denotes terbutaline http://purl.obolibrary.org/obo/CHEBI_9449|D013726
T14 603-613 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T12 545-555 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T10 442-452 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T8 227-236 ChemicalEntity denotes sparteine http://purl.obolibrary.org/obo/CHEBI_28827|D013034
T6 214-226 ChemicalEntity denotes debrisoquine http://purl.obolibrary.org/obo/CHEBI_34665|D003647
T4 171-181 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T2 88-98 ChemicalEntity denotes metoprolol http://purl.obolibrary.org/obo/CHEBI_6904|D008790
T1 0-12 ChemicalEntity denotes Debrisoquine http://purl.obolibrary.org/obo/CHEBI_34665
T21571 1523-1528 GeneOrGeneProduct denotes alpha
T5 1347-1354 GeneOrGeneProduct denotes regular
T57407 1294-1299 GeneOrGeneProduct denotes alpha
T3 511-530 GeneOrGeneProduct denotes beta-2 adrenoceptor
T80219 390-409 GeneOrGeneProduct denotes beta-1 adrenoceptor
T384 52-58 GeneOrGeneProduct denotes beta-2
T3796 637-648 DiseaseOrPhenotypicFeature denotes hypokalemia D007008

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Debrisoquine
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 944-955 Chemical denotes terbutaline
T14 1059-1069 Chemical denotes metoprolol
T15 1149-1160 Chemical denotes terbutaline
T16 1227-1236 Chemical denotes potassium
T17 1238-1249 Chemical denotes terbutaline
T18 1251-1261 Chemical denotes metoprolol
T19 1294-1317 Chemical denotes alpha-hydroxymetoprolol
T20 1389-1399 Chemical denotes metoprolol
T21 1409-1419 Chemical denotes metoprolol
T22 1434-1445 Chemical denotes terbutaline
T23 1512-1522 Chemical denotes metoprolol
T24 1523-1546 Chemical denotes alpha-hydroxymetoprolol
T25 1652-1662 Chemical denotes metoprolol
T26 1691-1701 Chemical denotes metoprolol

bc5cdr-valid-deepseek-nr-ng-experiment

Id Subject Object Predicate Lexical cue
T1 0-22 Disease denotes Debrisoquine phenotype
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 603-613 Chemical denotes metoprolol
T8 617-628 Chemical denotes terbutaline
T9 637-648 Disease denotes hypokalemia
T10 732-742 Chemical denotes metoprolol
T11 838-848 Chemical denotes metoprolol
T12 944-955 Chemical denotes terbutaline
T13 1059-1069 Chemical denotes metoprolol
T14 1294-1317 Chemical denotes alpha-hydroxymetoprolol

bc5cdr-valid-deepseek-nr-g-experiment

Id Subject Object Predicate Lexical cue
T1 0-22 Disease denotes Debrisoquine phenotype
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 1294-1317 Chemical denotes alpha-hydroxymetoprolol

bc5cdr-valid-gpt-r-ng-experiment

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Debrisoquine
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 944-955 Chemical denotes terbutaline
T14 1059-1069 Chemical denotes metoprolol
T15 1149-1160 Chemical denotes terbutaline
T16 1227-1236 Chemical denotes potassium
T17 1238-1249 Chemical denotes terbutaline
T18 1251-1261 Chemical denotes metoprolol
T19 1294-1317 Chemical denotes alpha-hydroxymetoprolol
T20 1389-1399 Chemical denotes metoprolol
T21 1434-1445 Chemical denotes terbutaline
T22 1512-1522 Chemical denotes metoprolol
T23 1523-1546 Chemical denotes alpha-hydroxymetoprolol
T24 1652-1662 Chemical denotes metoprolol

bc5cdr-valid-gpt-r-g-experiment

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Debrisoquine
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 944-955 Chemical denotes terbutaline
T14 1059-1069 Chemical denotes metoprolol
T15 1149-1160 Chemical denotes terbutaline
T16 1227-1236 Chemical denotes potassium
T17 1238-1249 Chemical denotes terbutaline
T18 1251-1261 Chemical denotes metoprolol
T19 1294-1317 Chemical denotes alpha-hydroxymetoprolol
T20 1389-1399 Chemical denotes metoprolol
T21 1434-1445 Chemical denotes terbutaline
T22 1512-1522 Chemical denotes metoprolol
T23 1523-1546 Chemical denotes alpha-hydroxymetoprolol
T24 1652-1662 Chemical denotes metoprolol

bc5cdr-valid-gpt-r-m30

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Debrisoquine
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 944-955 Chemical denotes terbutaline
T14 1059-1069 Chemical denotes metoprolol
T15 1149-1160 Chemical denotes terbutaline
T16 1227-1236 Chemical denotes potassium
T17 1238-1249 Chemical denotes terbutaline
T18 1251-1261 Chemical denotes metoprolol
T19 1294-1317 Chemical denotes alpha-hydroxymetoprolol
T20 1389-1399 Chemical denotes metoprolol
T21 1434-1445 Chemical denotes terbutaline
T22 1512-1522 Chemical denotes metoprolol
T23 1523-1546 Chemical denotes alpha-hydroxymetoprolol
T24 1652-1662 Chemical denotes metoprolol

bc5cdr-valid-gpt-r-m20

Id Subject Object Predicate Lexical cue
T1 0-12 Chemical denotes Debrisoquine
T2 88-98 Chemical denotes metoprolol
T3 171-181 Chemical denotes metoprolol
T4 214-226 Chemical denotes debrisoquine
T5 227-236 Chemical denotes sparteine
T6 442-452 Chemical denotes metoprolol
T7 545-555 Chemical denotes metoprolol
T8 603-613 Chemical denotes metoprolol
T9 617-628 Chemical denotes terbutaline
T10 637-648 Disease denotes hypokalemia
T11 732-742 Chemical denotes metoprolol
T12 838-848 Chemical denotes metoprolol
T13 944-955 Chemical denotes terbutaline
T14 1059-1069 Chemical denotes metoprolol
T15 1149-1160 Chemical denotes terbutaline
T16 1227-1236 Chemical denotes potassium
T17 1238-1249 Chemical denotes terbutaline
T18 1251-1261 Chemical denotes metoprolol
T19 1294-1317 Chemical denotes alpha-hydroxymetoprolol
T20 1389-1399 Chemical denotes metoprolol
T21 1434-1445 Chemical denotes terbutaline
T22 1512-1522 Chemical denotes metoprolol
T23 1523-1546 Chemical denotes alpha-hydroxymetoprolol
T24 1652-1662 Chemical denotes metoprolol