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PubMed:1847912 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 0-8 Cell denotes Platelet http://purl.obolibrary.org/obo/CL:0000233
T2 231-239 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T3 690-718 Cell denotes vascular smooth muscle cells http://purl.obolibrary.org/obo/CL:0000359
T4 699-718 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T5 1890-1905 Cell denotes receptor, cells http://purl.obolibrary.org/obo/CL:0000197

GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
60 686-689 Species denotes rat 10116

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 138-145 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T3 508-515 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T5 1868-1875 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T7 1930-1937 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T9 1975-1982 Glycan_Motif denotes Heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO
T11 1992-2003 Glycan_Motif denotes chondroitin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G43702JT
T12 2272-2279 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-195 Sentence denotes Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors.
T2 196-400 Sentence denotes Elevation of intracellular Ca2+ by platelet-derived growth factor (PDGF) and other growth factors involves both release of Ca2+ from intracellular Ca2+ stores and Ca2+ entry from the extracellular medium.
T3 401-539 Sentence denotes Release from intracellular stores is believed to be mediated by inositol 1,4,5-trisphosphate (IP3) and the heparin-sensitive IP3 receptor.
T4 540-621 Sentence denotes We studied the mechanism by which entry of extracellular Ca2+ is induced by PDGF.
T5 622-756 Sentence denotes Intracellular free Ca2+ (Ca2+i) was measured in single cultured rat vascular smooth muscle cells using fura 2 microspectrofluorometry.
T6 757-993 Sentence denotes In nominally Ca2(+)-free medium, PDGF (recombinant BB, 10 ng/ml) raised intracellular Ca2+ transiently (less than 5 min); addition of 2 mM Ca2+ to the bathing medium after 5 min caused a second, prolonged increase in intracellular Ca2+.
T7 994-1124 Sentence denotes Repeated changes in extracellular Ca2+ from 0 to 2 mM over 90 min caused rapid, parallel changes in Ca2+i of approximately 200 nM.
T8 1125-1255 Sentence denotes This change in Ca2+i in response to changes in extracellular Ca2+ was virtually undetectable in control or thrombin-treated cells.
T9 1256-1391 Sentence denotes The intracellular response to changes in medium Ca2+ after PDGF was completely blocked by 10 mM CoCl2, but not by 10(-7) M nicardipine.
T10 1392-1594 Sentence denotes Microinjection of monoclonal antibodies to phosphatidylinositol 4,5-bisphosphate (PIP2) (kt 10, 2 mg/ml) totally abolished both mobilization of intracellular Ca2+ stores and entry of extracellular Ca2+.
T11 1595-1808 Sentence denotes Consistent with this finding, maintenance of Ca2+ entry required ongoing receptor occupancy, since displacement of PDGF from its receptor with suramin (1 mM) eradicated extracellular Ca2+ entry in less than 5 min.
T12 1809-1974 Sentence denotes To determine whether extracellular Ca2+ entry involves the heparin-sensitive IP3 receptor, cells were microinjected with heparin (4 mg/ml) prior to addition of PDGF.
T13 1975-2109 Sentence denotes Heparin, but not chondroitin sulfate, prevented mobilization of intracellular Ca2+ stores but did not affect extracellular Ca2+ entry.
T14 2110-2191 Sentence denotes We PDGF requires ongoing receptor occupancy and involves PIP2 or PIP2 metabolism.
T15 2192-2303 Sentence denotes However, the signal which mediates PDGF-induced Ca2+ entry does not require the heparin-sensitive IP3 receptor.
T1 0-195 Sentence denotes Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors.
T2 196-400 Sentence denotes Elevation of intracellular Ca2+ by platelet-derived growth factor (PDGF) and other growth factors involves both release of Ca2+ from intracellular Ca2+ stores and Ca2+ entry from the extracellular medium.
T3 401-539 Sentence denotes Release from intracellular stores is believed to be mediated by inositol 1,4,5-trisphosphate (IP3) and the heparin-sensitive IP3 receptor.
T4 540-621 Sentence denotes We studied the mechanism by which entry of extracellular Ca2+ is induced by PDGF.
T5 622-756 Sentence denotes Intracellular free Ca2+ (Ca2+i) was measured in single cultured rat vascular smooth muscle cells using fura 2 microspectrofluorometry.
T6 757-993 Sentence denotes In nominally Ca2(+)-free medium, PDGF (recombinant BB, 10 ng/ml) raised intracellular Ca2+ transiently (less than 5 min); addition of 2 mM Ca2+ to the bathing medium after 5 min caused a second, prolonged increase in intracellular Ca2+.
T7 994-1124 Sentence denotes Repeated changes in extracellular Ca2+ from 0 to 2 mM over 90 min caused rapid, parallel changes in Ca2+i of approximately 200 nM.
T8 1125-1255 Sentence denotes This change in Ca2+i in response to changes in extracellular Ca2+ was virtually undetectable in control or thrombin-treated cells.
T9 1256-1391 Sentence denotes The intracellular response to changes in medium Ca2+ after PDGF was completely blocked by 10 mM CoCl2, but not by 10(-7) M nicardipine.
T10 1392-1594 Sentence denotes Microinjection of monoclonal antibodies to phosphatidylinositol 4,5-bisphosphate (PIP2) (kt 10, 2 mg/ml) totally abolished both mobilization of intracellular Ca2+ stores and entry of extracellular Ca2+.
T11 1595-1808 Sentence denotes Consistent with this finding, maintenance of Ca2+ entry required ongoing receptor occupancy, since displacement of PDGF from its receptor with suramin (1 mM) eradicated extracellular Ca2+ entry in less than 5 min.
T12 1809-1974 Sentence denotes To determine whether extracellular Ca2+ entry involves the heparin-sensitive IP3 receptor, cells were microinjected with heparin (4 mg/ml) prior to addition of PDGF.
T13 1975-2109 Sentence denotes Heparin, but not chondroitin sulfate, prevented mobilization of intracellular Ca2+ stores but did not affect extracellular Ca2+ entry.
T14 2110-2191 Sentence denotes We PDGF requires ongoing receptor occupancy and involves PIP2 or PIP2 metabolism.
T15 2192-2303 Sentence denotes However, the signal which mediates PDGF-induced Ca2+ entry does not require the heparin-sensitive IP3 receptor.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 138-145 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 138-145 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T3 508-515 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T4 508-515 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T5 1868-1875 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T6 1868-1875 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T7 1930-1937 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T8 1930-1937 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin
T9 1975-1982 https://glytoucan.org/Structures/Glycans/G00021MO denotes Heparin
T10 1975-1982 https://glytoucan.org/Structures/Glycans/G54161DR denotes Heparin
T11 1992-2003 https://glytoucan.org/Structures/Glycans/G43702JT denotes chondroitin
T12 2272-2279 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T13 2272-2279 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1992-2003 http://www.glycoepitope.jp/epitopes/EP0081 denotes chondroitin

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 699-712 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T2 706-712 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1992-2003 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1992-2003 Glycan denotes chondroitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G43702JT

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 686-689 OrganismTaxon denotes rat 10114|10116

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 0-8 Cell denotes Platelet http://purl.obolibrary.org/obo/CL:0000233
T2 231-239 Cell denotes platelet http://purl.obolibrary.org/obo/CL:0000233
T3 690-718 Cell denotes vascular smooth muscle cells http://purl.obolibrary.org/obo/CL:0000359
T4 699-718 Cell denotes smooth muscle cells http://purl.obolibrary.org/obo/CL:0000192
T5 1890-1905 Cell denotes receptor, cells http://purl.obolibrary.org/obo/CL:0000197

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-8 Body_part denotes Platelet http://purl.obolibrary.org/obo/CL_0000233
T2 209-222 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 231-239 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T4 329-342 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 379-392 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T6 414-427 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 583-596 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T8 622-635 Body_part denotes Intracellular http://purl.obolibrary.org/obo/GO_0005622
T9 690-718 Body_part denotes vascular smooth muscle cells http://purl.obolibrary.org/obo/CL_0000359
T10 829-842 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T11 974-987 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T12 1014-1027 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T13 1172-1185 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T14 1260-1273 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T15 1536-1549 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T16 1575-1588 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T17 1764-1777 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T18 1830-1843 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T19 1890-1905 Body_part denotes receptor, cells http://purl.obolibrary.org/obo/CL_0000197
T20 2039-2052 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T21 2084-2097 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-195 Sentence denotes Platelet-derived growth factor-mediated Ca2+ entry is blocked by antibodies to phosphatidylinositol 4,5-bisphosphate but does not involve heparin-sensitive inositol 1,4,5-trisphosphate receptors.
T2 196-400 Sentence denotes Elevation of intracellular Ca2+ by platelet-derived growth factor (PDGF) and other growth factors involves both release of Ca2+ from intracellular Ca2+ stores and Ca2+ entry from the extracellular medium.
T3 401-539 Sentence denotes Release from intracellular stores is believed to be mediated by inositol 1,4,5-trisphosphate (IP3) and the heparin-sensitive IP3 receptor.
T4 540-621 Sentence denotes We studied the mechanism by which entry of extracellular Ca2+ is induced by PDGF.
T5 622-756 Sentence denotes Intracellular free Ca2+ (Ca2+i) was measured in single cultured rat vascular smooth muscle cells using fura 2 microspectrofluorometry.
T6 757-993 Sentence denotes In nominally Ca2(+)-free medium, PDGF (recombinant BB, 10 ng/ml) raised intracellular Ca2+ transiently (less than 5 min); addition of 2 mM Ca2+ to the bathing medium after 5 min caused a second, prolonged increase in intracellular Ca2+.
T7 994-1124 Sentence denotes Repeated changes in extracellular Ca2+ from 0 to 2 mM over 90 min caused rapid, parallel changes in Ca2+i of approximately 200 nM.
T8 1125-1255 Sentence denotes This change in Ca2+i in response to changes in extracellular Ca2+ was virtually undetectable in control or thrombin-treated cells.
T9 1256-1391 Sentence denotes The intracellular response to changes in medium Ca2+ after PDGF was completely blocked by 10 mM CoCl2, but not by 10(-7) M nicardipine.
T10 1392-1594 Sentence denotes Microinjection of monoclonal antibodies to phosphatidylinositol 4,5-bisphosphate (PIP2) (kt 10, 2 mg/ml) totally abolished both mobilization of intracellular Ca2+ stores and entry of extracellular Ca2+.
T11 1595-1808 Sentence denotes Consistent with this finding, maintenance of Ca2+ entry required ongoing receptor occupancy, since displacement of PDGF from its receptor with suramin (1 mM) eradicated extracellular Ca2+ entry in less than 5 min.
T12 1809-1974 Sentence denotes To determine whether extracellular Ca2+ entry involves the heparin-sensitive IP3 receptor, cells were microinjected with heparin (4 mg/ml) prior to addition of PDGF.
T13 1975-2109 Sentence denotes Heparin, but not chondroitin sulfate, prevented mobilization of intracellular Ca2+ stores but did not affect extracellular Ca2+ entry.
T14 2110-2191 Sentence denotes We PDGF requires ongoing receptor occupancy and involves PIP2 or PIP2 metabolism.
T15 2192-2303 Sentence denotes However, the signal which mediates PDGF-induced Ca2+ entry does not require the heparin-sensitive IP3 receptor.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1992-2003 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 0-8 Body_part denotes Platelet FMA:62851
T2 231-239 Body_part denotes platelet FMA:62851
T3 690-718 Body_part denotes vascular smooth muscle cells FMA:284560

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 699-712 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 686-689 OrganismTaxon denotes rat 10114|10116

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1992-2003 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes chondroitin http://www.glycoepitope.jp/epitopes/EP0081

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 699-712 Body_part denotes smooth muscle http://purl.obolibrary.org/obo/MAT_0000303

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 0-8 Body_part denotes Platelet http://purl.obolibrary.org/obo/CL_0000233
T2 209-222 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T3 231-239 Body_part denotes platelet http://purl.obolibrary.org/obo/CL_0000233
T4 329-342 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 379-392 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T6 414-427 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T7 583-596 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T8 622-635 Body_part denotes Intracellular http://purl.obolibrary.org/obo/GO_0005622
T9 690-718 Body_part denotes vascular smooth muscle cells http://purl.obolibrary.org/obo/CL_0000359
T10 829-842 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T11 974-987 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T12 1014-1027 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T13 1172-1185 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T14 1260-1273 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T15 1536-1549 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T16 1575-1588 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T17 1764-1777 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T18 1830-1843 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T19 1890-1905 Body_part denotes receptor, cells http://purl.obolibrary.org/obo/CL_0000197
T20 2039-2052 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T21 2084-2097 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576