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PubMed:18470928 JSONTXT

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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-82 Sentence denotes IL23R haplotypes provide a large population attributable risk for Crohn's disease.
T2 83-94 Sentence denotes BACKGROUND:
T3 95-225 Sentence denotes The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases.
T4 226-410 Sentence denotes Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular.
T5 411-527 Sentence denotes The aim of this work was to estimate the total contribution of this gene to CD risk test using a haplotype approach.
T6 528-536 Sentence denotes METHODS:
T7 537-678 Sentence denotes In all, 763 CD subjects and 254 controls were genotyped for single nucleotide polymorphisms in the IL23R gene using Illumina and ABI methods.
T8 679-783 Sentence denotes Haplotypes were assigned using PHASEv2 and tested for association with CD by chi-square and permutation.
T9 784-792 Sentence denotes RESULTS:
T10 793-906 Sentence denotes Haplotypes with both increased and decreased risk for CD were observed in 2 of the 4 observed blocks (Block 2 H1:
T11 907-944 Sentence denotes 55.4% control, 64% CD, P = 0.019; H2:
T12 945-992 Sentence denotes 64.5% control, 54.4% CD, P = 0.006; Block 3 H1:
T13 993-1032 Sentence denotes 55.8% control, 64.4% CD, P = 0.013; H2:
T14 1033-1069 Sentence denotes 47.0% control, 36.6% CD, P = 0.001).
T15 1070-1314 Sentence denotes The population attributable risk for these haplotypes was substantially larger than that estimated for the IL23R R381Q variant (Block 2 H1 and block 3 H1 approximately 20%, compared with approximately 4% for Block 3 H6, containing the variant).
T16 1315-1327 Sentence denotes CONCLUSIONS:
T17 1328-1499 Sentence denotes These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
T18 1500-1792 Sentence denotes These observations also support the expectation that finding "hits" from genomewide association studies will be but an important chapter in the story of unraveling the genetic contribution to CD, rather than the final chapter that brings clarity to all the plot twists of a complicated story.
T1 0-82 Sentence denotes IL23R haplotypes provide a large population attributable risk for Crohn's disease.
T2 83-94 Sentence denotes BACKGROUND:
T3 95-225 Sentence denotes The IL-23 pathway plays a pivotal role in the development of chronic mucosal inflammation seen in the inflammatory bowel diseases.
T4 226-410 Sentence denotes Multiple studies have now established the contribution of the interleukin 23 receptor gene (IL23R) to Crohn's disease (CD) risk in general and of the IL23R R381Q variant in particular.
T5 411-527 Sentence denotes The aim of this work was to estimate the total contribution of this gene to CD risk test using a haplotype approach.
T6 528-536 Sentence denotes METHODS:
T7 537-678 Sentence denotes In all, 763 CD subjects and 254 controls were genotyped for single nucleotide polymorphisms in the IL23R gene using Illumina and ABI methods.
T8 679-783 Sentence denotes Haplotypes were assigned using PHASEv2 and tested for association with CD by chi-square and permutation.
T9 784-792 Sentence denotes RESULTS:
T10 793-906 Sentence denotes Haplotypes with both increased and decreased risk for CD were observed in 2 of the 4 observed blocks (Block 2 H1:
T11 907-944 Sentence denotes 55.4% control, 64% CD, P = 0.019; H2:
T12 945-992 Sentence denotes 64.5% control, 54.4% CD, P = 0.006; Block 3 H1:
T13 993-1032 Sentence denotes 55.8% control, 64.4% CD, P = 0.013; H2:
T14 1033-1069 Sentence denotes 47.0% control, 36.6% CD, P = 0.001).
T15 1070-1314 Sentence denotes The population attributable risk for these haplotypes was substantially larger than that estimated for the IL23R R381Q variant (Block 2 H1 and block 3 H1 approximately 20%, compared with approximately 4% for Block 3 H6, containing the variant).
T16 1315-1327 Sentence denotes CONCLUSIONS:
T17 1328-1499 Sentence denotes These observations suggest that IL23R makes a substantial contribution to CD susceptibility, larger than that estimated from the population frequency of the R381Q variant.
T18 1500-1792 Sentence denotes These observations also support the expectation that finding "hits" from genomewide association studies will be but an important chapter in the story of unraveling the genetic contribution to CD, rather than the final chapter that brings clarity to all the plot twists of a complicated story.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 66-81 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T2 197-224 DiseaseOrPhenotypicFeature denotes inflammatory bowel diseases 0005265
T3 328-343 DiseaseOrPhenotypicFeature denotes Crohn's disease 0005011
T4 345-347 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T6 487-489 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T8 549-551 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T10 750-752 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T12 756-759 DiseaseOrPhenotypicFeature denotes chi 0019010
T13 847-849 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T15 926-928 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T17 966-968 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T19 1014-1016 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T21 1054-1056 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T23 1402-1404 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011
T25 1692-1694 DiseaseOrPhenotypicFeature denotes CD 0016063|0005011

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-5 gene:149233 denotes IL23R
T1 66-71 disease:C0010346 denotes Crohn
T2 99-104 gene:51561 denotes IL-23
T3 197-224 disease:C0021390 denotes inflammatory bowel diseases
T4 376-381 gene:149233 denotes IL23R
T5 328-333 disease:C0010346 denotes Crohn
T6 318-323 gene:149233 denotes IL23R
T7 328-333 disease:C0010346 denotes Crohn
T8 288-311 gene:149233 denotes interleukin 23 receptor
T9 328-333 disease:C0010346 denotes Crohn
R1 T0 T1 associated_with IL23R,Crohn
R2 T2 T3 associated_with IL-23,inflammatory bowel diseases
R3 T4 T5 associated_with IL23R,Crohn
R4 T6 T7 associated_with IL23R,Crohn
R5 T8 T9 associated_with interleukin 23 receptor,Crohn

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
18470928-8#157#162#geners11209026 1485-1490 geners11209026 denotes R381Q
18470928-8#74#76#diseaseC0010346 1402-1404 diseaseC0010346 denotes CD
157#162#geners1120902674#76#diseaseC0010346 18470928-8#157#162#geners11209026 18470928-8#74#76#diseaseC0010346 associated_with R381Q,CD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18470928-0#0#5#gene149233 0-5 gene149233 denotes IL23R
18470928-0#66#81#diseaseC0010346 66-81 diseaseC0010346 denotes Crohn's disease
18470928-1#4#9#gene51561 99-104 gene51561 denotes IL-23
18470928-1#102#129#diseaseC0021390 197-224 diseaseC0021390 denotes inflammatory bowel diseases
0#5#gene14923366#81#diseaseC0010346 18470928-0#0#5#gene149233 18470928-0#66#81#diseaseC0010346 associated_with IL23R,Crohn's disease
4#9#gene51561102#129#diseaseC0021390 18470928-1#4#9#gene51561 18470928-1#102#129#diseaseC0021390 associated_with IL-23,inflammatory bowel diseases