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PMID_GLOBAL

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 880-886 CellLine denotes Jurkat CVCL_0065

sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
T2 101-313 Sentence denotes Upon antigen recognition, T-cell receptor (TCR/CD3) and other signaling molecules become enriched in a specialized contact site between the T cell and antigen-presenting cell, i.e. the immunological synapse (IS).
T3 314-462 Sentence denotes Enrichment occurs via mechanisms that include polarized secretion from recycling endosomes, but the Rabs and RabGAPs that regulate this are unknown.
T4 463-657 Sentence denotes EPI64C (TBC1D10C) is an uncharacterized candidate RabGAP we identified by mass spectrometry as abundant in human peripheral blood T cells that is preferentially expressed in hematopoietic cells.
T5 658-767 Sentence denotes EPI64C is a Rab35-GAP based both on in vitro Rab35-specific GAP activity and findings in transfection assays.
T6 768-1008 Sentence denotes EPI64C and Rab35 dominant negative (DN) constructs each impaired transferrin export from a recycling pathway in Jurkat T-cells and induced large vacuoles marked by transferrin receptor, TCR, and SNAREs implicated in TCR-polarized secretion.
T7 1009-1135 Sentence denotes Rab35 localized to the plasma membrane and to intracellular vesicles where it substantially colocalized with TfR and with TCR.
T8 1136-1175 Sentence denotes Rab35 was strongly recruited to the IS.
T9 1176-1274 Sentence denotes Conjugate formation was impaired by transfection with Rab35-DN or EPI64C and by EPI64C knock down.
T10 1275-1325 Sentence denotes TCR enrichment at the IS was impaired by Rab35-DN.
T11 1326-1477 Sentence denotes Thus, EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to IS formation, most likely by participating in TCR transport to the IS.
T1 0-100 Sentence denotes Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
T2 101-313 Sentence denotes Upon antigen recognition, T-cell receptor (TCR/CD3) and other signaling molecules become enriched in a specialized contact site between the T cell and antigen-presenting cell, i.e. the immunological synapse (IS).
T3 314-462 Sentence denotes Enrichment occurs via mechanisms that include polarized secretion from recycling endosomes, but the Rabs and RabGAPs that regulate this are unknown.
T4 463-657 Sentence denotes EPI64C (TBC1D10C) is an uncharacterized candidate RabGAP we identified by mass spectrometry as abundant in human peripheral blood T cells that is preferentially expressed in hematopoietic cells.
T5 658-767 Sentence denotes EPI64C is a Rab35-GAP based both on in vitro Rab35-specific GAP activity and findings in transfection assays.
T6 768-1008 Sentence denotes EPI64C and Rab35 dominant negative (DN) constructs each impaired transferrin export from a recycling pathway in Jurkat T-cells and induced large vacuoles marked by transferrin receptor, TCR, and SNAREs implicated in TCR-polarized secretion.
T7 1009-1135 Sentence denotes Rab35 localized to the plasma membrane and to intracellular vesicles where it substantially colocalized with TfR and with TCR.
T8 1136-1175 Sentence denotes Rab35 was strongly recruited to the IS.
T9 1176-1274 Sentence denotes Conjugate formation was impaired by transfection with Rab35-DN or EPI64C and by EPI64C knock down.
T10 1275-1325 Sentence denotes TCR enrichment at the IS was impaired by Rab35-DN.
T11 1326-1477 Sentence denotes Thus, EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to IS formation, most likely by participating in TCR transport to the IS.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 587-592 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 587-592 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 587-592 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 570-575 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-89 Body_part denotes synapse http://purl.obolibrary.org/obo/GO_0045202
T2 127-133 Body_part denotes T-cell http://purl.obolibrary.org/obo/CL_0000084
T3 241-247 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T4 300-307 Body_part denotes synapse http://purl.obolibrary.org/obo/GO_0045202
T5 587-592 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T6 637-656 Body_part denotes hematopoietic cells http://purl.obolibrary.org/obo/CL_0000988
T7 1032-1047 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T8 1055-1077 Body_part denotes intracellular vesicles http://purl.obolibrary.org/obo/GO_0097708

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 28-35 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T2 127-133 Cell denotes T-cell http://purl.obolibrary.org/obo/CL:0000084
T3 241-247 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T4 593-600 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084
T5 637-656 Cell denotes hematopoietic cells http://purl.obolibrary.org/obo/CL:0000988
T6 887-894 Cell denotes T-cells http://purl.obolibrary.org/obo/CL:0000084
T7 1381-1388 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084