PubMed:18449914 JSONTXT

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":20,"end":25},"obj":"gene:310"},{"id":"T1","span":{"begin":129,"end":143},"obj":"disease:C0699791"},{"id":"T2","span":{"begin":20,"end":25},"obj":"gene:310"},{"id":"T3","span":{"begin":129,"end":143},"obj":"disease:C0024623"},{"id":"T4","span":{"begin":169,"end":174},"obj":"gene:310"},{"id":"T5","span":{"begin":278,"end":296},"obj":"disease:C0178874"},{"id":"T6","span":{"begin":157,"end":167},"obj":"gene:310"},{"id":"T7","span":{"begin":278,"end":296},"obj":"disease:C0178874"},{"id":"T8","span":{"begin":311,"end":316},"obj":"gene:310"},{"id":"T9","span":{"begin":374,"end":389},"obj":"disease:C0001418"},{"id":"T10","span":{"begin":501,"end":506},"obj":"gene:310"},{"id":"T11","span":{"begin":530,"end":545},"obj":"disease:C0001418"},{"id":"T12","span":{"begin":1320,"end":1325},"obj":"gene:310"},{"id":"T13","span":{"begin":1353,"end":1359},"obj":"disease:C1306459"},{"id":"T14","span":{"begin":1320,"end":1325},"obj":"gene:310"},{"id":"T15","span":{"begin":1353,"end":1359},"obj":"disease:C0006826"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"18449914-0#20#25#gene310","span":{"begin":20,"end":25},"obj":"gene310"},{"id":"18449914-0#129#143#diseaseC0024623","span":{"begin":129,"end":143},"obj":"diseaseC0024623"},{"id":"18449914-0#129#143#diseaseC0699791","span":{"begin":129,"end":143},"obj":"diseaseC0699791"},{"id":"18449914-1#0#10#gene310","span":{"begin":157,"end":167},"obj":"gene310"},{"id":"18449914-1#12#17#gene310","span":{"begin":169,"end":174},"obj":"gene310"},{"id":"18449914-1#121#139#diseaseC0178874","span":{"begin":278,"end":296},"obj":"diseaseC0178874"},{"id":"18449914-10#26#31#gene310","span":{"begin":1526,"end":1531},"obj":"gene310"},{"id":"18449914-10#59#69#diseaseC0027627","span":{"begin":1559,"end":1569},"obj":"diseaseC0027627"},{"id":"18449914-3#32#37#gene310","span":{"begin":501,"end":506},"obj":"gene310"},{"id":"18449914-3#61#76#diseaseC0001418","span":{"begin":530,"end":545},"obj":"diseaseC0001418"}],"relations":[{"id":"20#25#gene310129#143#diseaseC0024623","pred":"associated_with","subj":"18449914-0#20#25#gene310","obj":"18449914-0#129#143#diseaseC0024623"},{"id":"20#25#gene310129#143#diseaseC0699791","pred":"associated_with","subj":"18449914-0#20#25#gene310","obj":"18449914-0#129#143#diseaseC0699791"},{"id":"0#10#gene310121#139#diseaseC0178874","pred":"associated_with","subj":"18449914-1#0#10#gene310","obj":"18449914-1#121#139#diseaseC0178874"},{"id":"12#17#gene310121#139#diseaseC0178874","pred":"associated_with","subj":"18449914-1#12#17#gene310","obj":"18449914-1#121#139#diseaseC0178874"},{"id":"26#31#gene31059#69#diseaseC0027627","pred":"associated_with","subj":"18449914-10#26#31#gene310","obj":"18449914-10#59#69#diseaseC0027627"},{"id":"32#37#gene31061#76#diseaseC0001418","pred":"associated_with","subj":"18449914-3#32#37#gene310","obj":"18449914-3#61#76#diseaseC0001418"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":145,"end":156},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":157,"end":297},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":298,"end":459},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":460,"end":468},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":469,"end":633},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":634,"end":642},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":643,"end":736},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":737,"end":1007},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1008,"end":1156},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1157,"end":1259},"obj":"Sentence"},{"id":"TextSentencer_T12","span":{"begin":1260,"end":1381},"obj":"Sentence"},{"id":"TextSentencer_T13","span":{"begin":1382,"end":1394},"obj":"Sentence"},{"id":"TextSentencer_T14","span":{"begin":1395,"end":1499},"obj":"Sentence"},{"id":"TextSentencer_T15","span":{"begin":1500,"end":1570},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":144},"obj":"Sentence"},{"id":"T2","span":{"begin":145,"end":156},"obj":"Sentence"},{"id":"T3","span":{"begin":157,"end":297},"obj":"Sentence"},{"id":"T4","span":{"begin":298,"end":459},"obj":"Sentence"},{"id":"T5","span":{"begin":460,"end":468},"obj":"Sentence"},{"id":"T6","span":{"begin":469,"end":633},"obj":"Sentence"},{"id":"T7","span":{"begin":634,"end":642},"obj":"Sentence"},{"id":"T8","span":{"begin":643,"end":736},"obj":"Sentence"},{"id":"T9","span":{"begin":737,"end":1007},"obj":"Sentence"},{"id":"T10","span":{"begin":1008,"end":1156},"obj":"Sentence"},{"id":"T11","span":{"begin":1157,"end":1259},"obj":"Sentence"},{"id":"T12","span":{"begin":1260,"end":1381},"obj":"Sentence"},{"id":"T13","span":{"begin":1382,"end":1394},"obj":"Sentence"},{"id":"T14","span":{"begin":1395,"end":1499},"obj":"Sentence"},{"id":"T15","span":{"begin":1500,"end":1570},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T348","span":{"begin":1526,"end":1531},"obj":"gene:310"},{"id":"T349","span":{"begin":1559,"end":1569},"obj":"disease:C0027627"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T348","obj":"T349"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1085,"end":1095},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":1085,"end":1095},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"}],"text":"The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer.\nBACKGROUND: Annexin-A7 (ANXA7) exhibits biological and genetic properties expected of a tumor suppressor gene and may play a role in cancer progression. However, the ANXA7 expression in different histological subtypes of gastric adenocarcinomas and its correlation with invasive potentials has not been elucidated.\nMETHODS: Immunohistochemical staining of ANXA7 for 84 primary gastric adenocarcinomas was performed, and data was correlated with clinicopathological parameters of patients.\nRESULTS: The ANXA7 expression was well correlated with the grade of differentiation of primary tumors. Its expression was detected in 100% (8/8), 64.9% (24/37), 66.7% (2/3), 31.9% (13/31), 0% (0/3), and 0% (0/2) of well-differentiated tubular, moderately-differentiated tubular, papillary, poorly differentiated, signet-ring cell, and mucinous adenocarcinoma, respectively. According to the Lauren's classification, the ANXA7 expression was higher in intestinal type than in diffuse type tumor (71.9% vs. 6.1%, P = 0.003). The loss of expression of ANXA7 expression was significantly related to distant metastasis (P = 0.04). However, there were no significant associations between the ANXA7 expression and survival of cancer patients (P = 0.159).\nCONCLUSIONS: A striking correlation between ANXA7 expression and cell differentiation of gastric cancer was observed. The loss of expression of ANXA7 is associated with distant metastasis."}