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PubMed:18442320 JSONTXT

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DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
18442320-0#52#61#geners5743708 52-61 geners5743708 denotes Arg753Gln
18442320-0#66#75#geners121917864 66-75 geners121917864 denotes Arg677Trp
18442320-0#93#120#diseaseC0155626 93-120 diseaseC0155626 denotes acute myocardial infarction
18442320-8#82#91#geners121917864 984-993 geners121917864 denotes Arg677Trp
18442320-8#96#105#geners5743708 998-1007 geners5743708 denotes Arg753Gln
18442320-8#110#112#diseaseC0027051 1012-1014 diseaseC0027051 denotes MI
52#61#geners574370893#120#diseaseC0155626 18442320-0#52#61#geners5743708 18442320-0#93#120#diseaseC0155626 associated_with Arg753Gln,acute myocardial infarction
66#75#geners12191786493#120#diseaseC0155626 18442320-0#66#75#geners121917864 18442320-0#93#120#diseaseC0155626 associated_with Arg677Trp,acute myocardial infarction
82#91#geners121917864110#112#diseaseC0027051 18442320-8#82#91#geners121917864 18442320-8#110#112#diseaseC0027051 associated_with Arg677Trp,MI
96#105#geners5743708110#112#diseaseC0027051 18442320-8#96#105#geners5743708 18442320-8#110#112#diseaseC0027051 associated_with Arg753Gln,MI

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18442320-0#0#4#gene7097 0-4 gene7097 denotes TLR2
18442320-0#93#120#diseaseC0155626 93-120 diseaseC0155626 denotes acute myocardial infarction
18442320-9#41#45#gene7097 1057-1061 gene7097 denotes TLR2
18442320-9#64#66#diseaseC0027051 1080-1082 diseaseC0027051 denotes MI
0#4#gene709793#120#diseaseC0155626 18442320-0#0#4#gene7097 18442320-0#93#120#diseaseC0155626 associated_with TLR2,acute myocardial infarction
41#45#gene709764#66#diseaseC0027051 18442320-9#41#45#gene7097 18442320-9#64#66#diseaseC0027051 associated_with TLR2,MI

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.
T2 122-171 Sentence denotes Inflammation is a key component of immune system.
T3 172-286 Sentence denotes It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism.
T4 287-339 Sentence denotes Its function is controlled by innate immunity genes.
T5 340-448 Sentence denotes Both their polymorphisms and environmental conditions give rise to different phenotypes in human population.
T6 449-528 Sentence denotes Proinflammatory genotype may be beneficial in early life but not in old people.
T7 529-738 Sentence denotes With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI).
T8 739-901 Sentence denotes Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI.
T9 902-1015 Sentence denotes We have evaluated the possible association between two polymorphisms of TLR2 gene-Arg677Trp and Arg753Gln-and MI.
T10 1016-1083 Sentence denotes However, we found no association between TLR2 polymorphisms and MI.
T1 0-121 Sentence denotes TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction.
T2 122-171 Sentence denotes Inflammation is a key component of immune system.
T3 172-286 Sentence denotes It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism.
T4 287-339 Sentence denotes Its function is controlled by innate immunity genes.
T5 340-448 Sentence denotes Both their polymorphisms and environmental conditions give rise to different phenotypes in human population.
T6 449-528 Sentence denotes Proinflammatory genotype may be beneficial in early life but not in old people.
T7 529-738 Sentence denotes With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI).
T8 739-901 Sentence denotes Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI.
T9 902-1015 Sentence denotes We have evaluated the possible association between two polymorphisms of TLR2 gene-Arg677Trp and Arg753Gln-and MI.
T10 1016-1083 Sentence denotes However, we found no association between TLR2 polymorphisms and MI.