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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-90 Sentence denotes Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.
TextSentencer_T2 91-284 Sentence denotes Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.
TextSentencer_T3 285-467 Sentence denotes Here, we report that analysis of Affymetrix expression data of primary neuroblastic tumors shows an extensive overexpression of Cyclin D1, which correlates with histologic subgroups.
TextSentencer_T4 468-612 Sentence denotes Immunohistochemical analysis showed overexpression of Cyclin D1 in neuroblasts and low Cyclin D1 expression in all cell types in ganglioneuroma.
TextSentencer_T5 613-847 Sentence denotes This suggests an involvement of G(1)-regulating genes in neuronal differentiation processes which we further evaluated using RNA interference against Cyclin D1 and its kinase partners CDK4 and CDK6 in several neuroblastoma cell lines.
TextSentencer_T6 848-1089 Sentence denotes The Cyclin D1 and CDK4 knockdown resulted in pRb pathway inhibition as shown by an almost complete disappearance of CDK4/CDK6-specific pRb phosphorylation, reduction of E2F transcriptional activity, and a decrease of Cyclin A protein levels.
TextSentencer_T7 1090-1251 Sentence denotes Phenotype analysis showed a significant reduction in cell proliferation, a G(1)-specific cell cycle arrest, and, moreover, an extensive neuronal differentiation.
TextSentencer_T8 1252-1390 Sentence denotes Affymetrix microarray profiling of small interfering RNA-treated cells revealed a shift in expression profile toward a neuronal phenotype.
TextSentencer_T9 1391-1447 Sentence denotes Several new potential downstream players are identified.
TextSentencer_T10 1448-1587 Sentence denotes We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype.
T1 0-90 Sentence denotes Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.
T2 91-284 Sentence denotes Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.
T3 285-467 Sentence denotes Here, we report that analysis of Affymetrix expression data of primary neuroblastic tumors shows an extensive overexpression of Cyclin D1, which correlates with histologic subgroups.
T4 468-612 Sentence denotes Immunohistochemical analysis showed overexpression of Cyclin D1 in neuroblasts and low Cyclin D1 expression in all cell types in ganglioneuroma.
T5 613-847 Sentence denotes This suggests an involvement of G(1)-regulating genes in neuronal differentiation processes which we further evaluated using RNA interference against Cyclin D1 and its kinase partners CDK4 and CDK6 in several neuroblastoma cell lines.
T6 848-1089 Sentence denotes The Cyclin D1 and CDK4 knockdown resulted in pRb pathway inhibition as shown by an almost complete disappearance of CDK4/CDK6-specific pRb phosphorylation, reduction of E2F transcriptional activity, and a decrease of Cyclin A protein levels.
T7 1090-1251 Sentence denotes Phenotype analysis showed a significant reduction in cell proliferation, a G(1)-specific cell cycle arrest, and, moreover, an extensive neuronal differentiation.
T8 1252-1390 Sentence denotes Affymetrix microarray profiling of small interfering RNA-treated cells revealed a shift in expression profile toward a neuronal phenotype.
T9 1391-1447 Sentence denotes Several new potential downstream players are identified.
T10 1448-1587 Sentence denotes We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-9 gene:595 denotes Cyclin D1
T1 76-89 disease:C0700095 denotes neuroblastoma
T2 14-18 gene:1019 denotes CDK4
T3 76-89 disease:C0700095 denotes neuroblastoma
T4 0-9 gene:595 denotes Cyclin D1
T5 76-89 disease:C0027819 denotes neuroblastoma
T6 14-18 gene:1019 denotes CDK4
T7 76-89 disease:C0027819 denotes neuroblastoma
T8 125-130 gene:595 denotes CCND1
T9 268-283 disease:C1368871 denotes pediatric tumor
T10 125-130 gene:595 denotes CCND1
T11 151-164 disease:C0027819 denotes neuroblastoma
T12 125-130 gene:595 denotes CCND1
T13 151-164 disease:C0700095 denotes neuroblastoma
T14 114-123 gene:595 denotes Cyclin D1
T15 268-283 disease:C1368871 denotes pediatric tumor
T16 133-137 gene:1019 denotes CDK4
T17 268-283 disease:C1368871 denotes pediatric tumor
T18 143-147 gene:1021 denotes CDK6
T19 151-164 disease:C0027819 denotes neuroblastoma
T20 114-123 gene:595 denotes Cyclin D1
T21 151-164 disease:C0700095 denotes neuroblastoma
T22 143-147 gene:1021 denotes CDK6
T23 268-283 disease:C1368871 denotes pediatric tumor
T24 114-123 gene:595 denotes Cyclin D1
T25 151-164 disease:C0027819 denotes neuroblastoma
T26 143-147 gene:1021 denotes CDK6
T27 151-164 disease:C0700095 denotes neuroblastoma
T28 522-531 gene:595 denotes Cyclin D1
T29 597-611 disease:C0017075 denotes ganglioneuroma
T30 555-564 gene:595 denotes Cyclin D1
T31 597-611 disease:C0017075 denotes ganglioneuroma
T32 763-772 gene:595 denotes Cyclin D1
T33 822-835 disease:C0700095 denotes neuroblastoma
T34 763-772 gene:595 denotes Cyclin D1
T35 822-835 disease:C0027819 denotes neuroblastoma
T36 806-810 gene:1021 denotes CDK6
T37 822-835 disease:C0027819 denotes neuroblastoma
T38 806-810 gene:1021 denotes CDK6
T39 822-835 disease:C0700095 denotes neuroblastoma
R1 T0 T1 associated_with Cyclin D1,neuroblastoma
R2 T2 T3 associated_with CDK4,neuroblastoma
R3 T4 T5 associated_with Cyclin D1,neuroblastoma
R4 T6 T7 associated_with CDK4,neuroblastoma
R5 T8 T9 associated_with CCND1,pediatric tumor
R6 T10 T11 associated_with CCND1,neuroblastoma
R7 T12 T13 associated_with CCND1,neuroblastoma
R8 T14 T15 associated_with Cyclin D1,pediatric tumor
R9 T16 T17 associated_with CDK4,pediatric tumor
R10 T18 T19 associated_with CDK6,neuroblastoma
R11 T20 T21 associated_with Cyclin D1,neuroblastoma
R12 T22 T23 associated_with CDK6,pediatric tumor
R13 T24 T25 associated_with Cyclin D1,neuroblastoma
R14 T26 T27 associated_with CDK6,neuroblastoma
R15 T28 T29 associated_with Cyclin D1,ganglioneuroma
R16 T30 T31 associated_with Cyclin D1,ganglioneuroma
R17 T32 T33 associated_with Cyclin D1,neuroblastoma
R18 T34 T35 associated_with Cyclin D1,neuroblastoma
R19 T36 T37 associated_with CDK6,neuroblastoma
R20 T38 T39 associated_with CDK6,neuroblastoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18413728-0#0#9#gene595 0-9 gene595 denotes Cyclin D1
18413728-0#14#18#gene1019 14-18 gene1019 denotes CDK4
18413728-0#76#89#diseaseC0027819 76-89 diseaseC0027819 denotes neuroblastoma
18413728-0#76#89#diseaseC0700095 76-89 diseaseC0700095 denotes neuroblastoma
18413728-0#76#89#diseaseC0027819 76-89 diseaseC0027819 denotes neuroblastoma
18413728-0#76#89#diseaseC0700095 76-89 diseaseC0700095 denotes neuroblastoma
18413728-3#54#63#gene595 522-531 gene595 denotes Cyclin D1
18413728-3#87#96#gene595 555-564 gene595 denotes Cyclin D1
18413728-3#129#143#diseaseC0017075 597-611 diseaseC0017075 denotes ganglioneuroma
18413728-4#193#197#gene1021 806-810 gene1021 denotes CDK6
18413728-4#209#222#diseaseC0027819 822-835 diseaseC0027819 denotes neuroblastoma
18413728-4#209#222#diseaseC0700095 822-835 diseaseC0700095 denotes neuroblastoma
0#9#gene59576#89#diseaseC0027819 18413728-0#0#9#gene595 18413728-0#76#89#diseaseC0027819 associated_with Cyclin D1,neuroblastoma
0#9#gene59576#89#diseaseC0700095 18413728-0#0#9#gene595 18413728-0#76#89#diseaseC0700095 associated_with Cyclin D1,neuroblastoma
0#9#gene59576#89#diseaseC0027819 18413728-0#0#9#gene595 18413728-0#76#89#diseaseC0027819 associated_with Cyclin D1,neuroblastoma
0#9#gene59576#89#diseaseC0700095 18413728-0#0#9#gene595 18413728-0#76#89#diseaseC0700095 associated_with Cyclin D1,neuroblastoma
14#18#gene101976#89#diseaseC0027819 18413728-0#14#18#gene1019 18413728-0#76#89#diseaseC0027819 associated_with CDK4,neuroblastoma
14#18#gene101976#89#diseaseC0700095 18413728-0#14#18#gene1019 18413728-0#76#89#diseaseC0700095 associated_with CDK4,neuroblastoma
14#18#gene101976#89#diseaseC0027819 18413728-0#14#18#gene1019 18413728-0#76#89#diseaseC0027819 associated_with CDK4,neuroblastoma
14#18#gene101976#89#diseaseC0700095 18413728-0#14#18#gene1019 18413728-0#76#89#diseaseC0700095 associated_with CDK4,neuroblastoma
54#63#gene595129#143#diseaseC0017075 18413728-3#54#63#gene595 18413728-3#129#143#diseaseC0017075 associated_with Cyclin D1,ganglioneuroma
87#96#gene595129#143#diseaseC0017075 18413728-3#87#96#gene595 18413728-3#129#143#diseaseC0017075 associated_with Cyclin D1,ganglioneuroma
193#197#gene1021209#222#diseaseC0027819 18413728-4#193#197#gene1021 18413728-4#209#222#diseaseC0027819 associated_with CDK6,neuroblastoma
193#197#gene1021209#222#diseaseC0700095 18413728-4#193#197#gene1021 18413728-4#209#222#diseaseC0700095 associated_with CDK6,neuroblastoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2754 0-9 gene:595 denotes Cyclin D1
T2755 76-89 disease:C0027819 denotes neuroblastoma
T2756 14-18 gene:1019 denotes CDK4
T2757 806-810 gene:1021 denotes CDK6
T2758 822-835 disease:C0027819 denotes neuroblastoma
R1 T2754 T2755 associated_with Cyclin D1,neuroblastoma
R2 T2754 T2755 associated_with Cyclin D1,neuroblastoma
R3 T2756 T2755 associated_with CDK4,neuroblastoma
R4 T2756 T2755 associated_with CDK4,neuroblastoma
R5 T2757 T2758 associated_with CDK6,neuroblastoma
R6 T2757 T2758 associated_with CDK6,neuroblastoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 385-394 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 1216-1225 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 385-394 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T2 1216-1225 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensive
PD-UBERON-AE-B_T3 670-678 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T4 1226-1234 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T5 1371-1379 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal