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PubMed:1840295 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 294-301 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 663-670 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 294-301 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 663-670 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 294-301 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 663-670 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes Oligosaccharides at each glycosylation site make structure-dependent contributions to biological properties of human tissue plasminogen activator.
TextSentencer_T2 147-274 Sentence denotes The effect of altering oligosaccharide structures at sites 184 and 448 of tissue plasminogen activator (tPA) has been examined.
TextSentencer_T3 275-414 Sentence denotes Alteration to high-mannose forms at sites 184 and 448 was accomplished by the growth of cells in the presence of deoxymannojirimycin (dMM).
TextSentencer_T4 415-545 Sentence denotes Modification to neutral, unsialylated forms at these sites was achieved by neuraminidase treatment of control preparations of tPA.
TextSentencer_T5 546-716 Sentence denotes Oligosaccharides at site 117 were not markedly affected by either treatment because structures at this site are high-mannose and not sialylated in untreated preparations.
TextSentencer_T6 717-901 Sentence denotes The effect on enzymatic activity and on a related property, lysine affinity, was determined. dMM treatment was found to increase both the lysine affinity and catalytic activity of tPA.
TextSentencer_T7 902-999 Sentence denotes Neuraminidase treatment increased enzyme activity, but was without effect on affinity for lysine.
TextSentencer_T8 1000-1162 Sentence denotes To evaluate the effects of alterations at site 184 and site 448, the catalytic activity and lysine affinity of type I and type II tPA were monitored individually.
TextSentencer_T9 1163-1482 Sentence denotes In the dMM-treated sample, type I tPA (with sugars at sites 117, 184 and 448) was found to have 2- to 3-fold increased catalytic activity and an affinity for lysine which was greater than that of type I from untreated preparations, but less than that of control type II tPA (containing sugar only at sites 117 and 448).
TextSentencer_T10 1483-1592 Sentence denotes In neuraminidase-treated type I, catalytic activity was also enhanced but lysine affinity remained unchanged.
TextSentencer_T11 1593-1822 Sentence denotes Type II from dMM- and neuraminidase-treated preparations had catalytic activity that was increased approximately 1.5-fold compared to untreated controls, whereas affinity for lysine was unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
T1 0-146 Sentence denotes Oligosaccharides at each glycosylation site make structure-dependent contributions to biological properties of human tissue plasminogen activator.
T2 147-274 Sentence denotes The effect of altering oligosaccharide structures at sites 184 and 448 of tissue plasminogen activator (tPA) has been examined.
T3 275-414 Sentence denotes Alteration to high-mannose forms at sites 184 and 448 was accomplished by the growth of cells in the presence of deoxymannojirimycin (dMM).
T4 415-545 Sentence denotes Modification to neutral, unsialylated forms at these sites was achieved by neuraminidase treatment of control preparations of tPA.
T5 546-716 Sentence denotes Oligosaccharides at site 117 were not markedly affected by either treatment because structures at this site are high-mannose and not sialylated in untreated preparations.
T6 717-901 Sentence denotes The effect on enzymatic activity and on a related property, lysine affinity, was determined. dMM treatment was found to increase both the lysine affinity and catalytic activity of tPA.
T7 902-999 Sentence denotes Neuraminidase treatment increased enzyme activity, but was without effect on affinity for lysine.
T8 1000-1162 Sentence denotes To evaluate the effects of alterations at site 184 and site 448, the catalytic activity and lysine affinity of type I and type II tPA were monitored individually.
T9 1163-1482 Sentence denotes In the dMM-treated sample, type I tPA (with sugars at sites 117, 184 and 448) was found to have 2- to 3-fold increased catalytic activity and an affinity for lysine which was greater than that of type I from untreated preparations, but less than that of control type II tPA (containing sugar only at sites 117 and 448).
T10 1483-1592 Sentence denotes In neuraminidase-treated type I, catalytic activity was also enhanced but lysine affinity remained unchanged.
T11 1593-1822 Sentence denotes Type II from dMM- and neuraminidase-treated preparations had catalytic activity that was increased approximately 1.5-fold compared to untreated controls, whereas affinity for lysine was unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
T1 0-146 Sentence denotes Oligosaccharides at each glycosylation site make structure-dependent contributions to biological properties of human tissue plasminogen activator.
T2 147-274 Sentence denotes The effect of altering oligosaccharide structures at sites 184 and 448 of tissue plasminogen activator (tPA) has been examined.
T3 275-414 Sentence denotes Alteration to high-mannose forms at sites 184 and 448 was accomplished by the growth of cells in the presence of deoxymannojirimycin (dMM).
T4 415-545 Sentence denotes Modification to neutral, unsialylated forms at these sites was achieved by neuraminidase treatment of control preparations of tPA.
T5 546-716 Sentence denotes Oligosaccharides at site 117 were not markedly affected by either treatment because structures at this site are high-mannose and not sialylated in untreated preparations.
T6 717-901 Sentence denotes The effect on enzymatic activity and on a related property, lysine affinity, was determined. dMM treatment was found to increase both the lysine affinity and catalytic activity of tPA.
T7 902-999 Sentence denotes Neuraminidase treatment increased enzyme activity, but was without effect on affinity for lysine.
T8 1000-1162 Sentence denotes To evaluate the effects of alterations at site 184 and site 448, the catalytic activity and lysine affinity of type I and type II tPA were monitored individually.
T9 1163-1482 Sentence denotes In the dMM-treated sample, type I tPA (with sugars at sites 117, 184 and 448) was found to have 2- to 3-fold increased catalytic activity and an affinity for lysine which was greater than that of type I from untreated preparations, but less than that of control type II tPA (containing sugar only at sites 117 and 448).
T10 1483-1592 Sentence denotes In neuraminidase-treated type I, catalytic activity was also enhanced but lysine affinity remained unchanged.
T11 1593-1822 Sentence denotes Type II from dMM- and neuraminidase-treated preparations had catalytic activity that was increased approximately 1.5-fold compared to untreated controls, whereas affinity for lysine was unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 0-16 FMAID:82742 denotes Oligosaccharides
_T2 0-16 FMAID:196731 denotes Oligosaccharides
_T3 117-123 FMAID:256050 denotes tissue
_T4 170-185 FMAID:196731 denotes oligosaccharide
_T5 170-185 FMAID:82742 denotes oligosaccharide
_T6 221-227 FMAID:256050 denotes tissue
_T7 294-301 FMAID:82801 denotes mannose
_T8 294-301 FMAID:196796 denotes mannose
_T9 363-368 FMAID:68646 denotes cells
_T10 363-368 FMAID:169002 denotes cells
_T11 546-562 FMAID:82742 denotes Oligosaccharides
_T12 546-562 FMAID:196731 denotes Oligosaccharides
_T13 663-670 FMAID:196796 denotes mannose
_T14 663-670 FMAID:82801 denotes mannose
_T15 777-783 FMAID:196747 denotes lysine
_T16 777-783 FMAID:82758 denotes lysine
_T17 855-861 FMAID:82758 denotes lysine
_T18 855-861 FMAID:196747 denotes lysine
_T19 992-998 FMAID:196747 denotes lysine
_T20 992-998 FMAID:82758 denotes lysine
_T21 1092-1098 FMAID:196747 denotes lysine
_T22 1092-1098 FMAID:82758 denotes lysine
_T23 1207-1213 FMAID:196724 denotes sugars
_T24 1321-1327 FMAID:82758 denotes lysine
_T25 1321-1327 FMAID:196747 denotes lysine
_T26 1449-1454 FMAID:196724 denotes sugar
_T27 1557-1563 FMAID:82758 denotes lysine
_T28 1557-1563 FMAID:196747 denotes lysine
_T29 1768-1774 FMAID:196747 denotes lysine
_T30 1768-1774 FMAID:82758 denotes lysine

uniprot-human

Id Subject Object Predicate Lexical cue
T1 124-135 http://www.uniprot.org/uniprot/P00747 denotes plasminogen
T2 228-239 http://www.uniprot.org/uniprot/P00747 denotes plasminogen
T3 251-254 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA
T4 541-544 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA
T5 897-900 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA
T6 1130-1133 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA
T7 1197-1200 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA
T8 1433-1436 http://www.uniprot.org/uniprot/Q9BU99 denotes tPA

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 124-135 http://www.uniprot.org/uniprot/P20918 denotes plasminogen
T2 228-239 http://www.uniprot.org/uniprot/P20918 denotes plasminogen
T3 251-254 http://www.uniprot.org/uniprot/P11214 denotes tPA
T4 541-544 http://www.uniprot.org/uniprot/P11214 denotes tPA
T5 897-900 http://www.uniprot.org/uniprot/P11214 denotes tPA
T6 1130-1133 http://www.uniprot.org/uniprot/P11214 denotes tPA
T7 1197-1200 http://www.uniprot.org/uniprot/P11214 denotes tPA
T8 1433-1436 http://www.uniprot.org/uniprot/P11214 denotes tPA
T9 1809-1811 http://www.uniprot.org/uniprot/Q8VHK8 denotes AT

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 117-123 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T2 221-227 http://purl.bioontology.org/ontology/STY/T024 denotes tissue
T3 363-368 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 759-766 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related

GO-BP

Id Subject Object Predicate Lexical cue
T1 25-38 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T2 124-145 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T3 228-249 http://purl.obolibrary.org/obo/GO_0031639 denotes plasminogen activator
T4 251-254 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T5 541-544 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T6 897-900 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T7 1130-1133 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T8 1197-1200 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T9 1433-1436 http://purl.obolibrary.org/obo/GO_0031299 denotes tPA
T10 353-359 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T11 353-368 http://purl.obolibrary.org/obo/GO_0016049 denotes growth of cells
T12 679-689 http://purl.obolibrary.org/obo/GO_0097503 denotes sialylated
T13 875-893 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T14 1069-1087 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T15 1282-1300 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T16 1516-1534 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T17 1654-1672 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T18 936-951 http://purl.obolibrary.org/obo/GO_0003824 denotes enzyme activity
T19 1079-1098 http://purl.obolibrary.org/obo/GO_0019835 denotes activity and lysine

GO-CC

Id Subject Object Predicate Lexical cue
T1 363-368 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 117-123 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T2 221-227 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 111-116 http://edamontology.org/topic_2815 denotes human
T2 1182-1188 http://edamontology.org/topic_3277 denotes sample

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 49-58 http://edamontology.org/data_0883 denotes structure
T2 186-196 http://edamontology.org/data_0883 denotes structures
T3 630-640 http://edamontology.org/data_0883 denotes structures
T4 1790-1798 http://edamontology.org/data_2849 denotes ABSTRACT

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 289-301 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose
T2 658-670 http://rdf.glycoinfo.org/glycan/G00028MO denotes high-mannose

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1207-1213 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugars
GlycanIUPAC_T2 1449-1454 "http://rdf.glycoinfo.org/glycan/G59665TO" denotes sugar
GlycanIUPAC_T3 1207-1213 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugars
GlycanIUPAC_T4 1449-1454 "http://rdf.glycoinfo.org/glycan/G32915EI" denotes sugar
GlycanIUPAC_T5 1207-1213 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugars
GlycanIUPAC_T6 1449-1454 "http://rdf.glycoinfo.org/glycan/G60625TS" denotes sugar

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 117-123 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 221-227 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 111-116 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 117-123 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T2 221-227 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 1111-1117 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T3 1190-1196 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T5 1359-1365 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138
T7 1508-1514 Cell denotes type I http://purl.obolibrary.org/obo/CL:0004120|http://purl.obolibrary.org/obo/CL:0004138