PubMed:1840294 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T2","span":{"begin":0,"end":11},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T3","span":{"begin":110,"end":121},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T4","span":{"begin":110,"end":121},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T5","span":{"begin":281,"end":292},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T6","span":{"begin":281,"end":292},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T7","span":{"begin":879,"end":890},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T8","span":{"begin":879,"end":890},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T9","span":{"begin":1051,"end":1062},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T10","span":{"begin":1051,"end":1062},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T11","span":{"begin":1069,"end":1080},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T12","span":{"begin":1069,"end":1080},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T13","span":{"begin":1233,"end":1244},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T14","span":{"begin":1233,"end":1244},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"},{"id":"T15","span":{"begin":1372,"end":1383},"obj":"https://glytoucan.org/Structures/Glycans/G50850NI"},{"id":"T16","span":{"begin":1372,"end":1383},"obj":"https://glytoucan.org/Structures/Glycans/G78436BB"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

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{"project":"GlycoBiology-FMA","denotations":[{"id":"_T1","span":{"begin":68,"end":77},"obj":"FMAID:62852"},{"id":"_T2","span":{"begin":68,"end":77},"obj":"FMAID:167148"},{"id":"_T3","span":{"begin":213,"end":223},"obj":"FMAID:167148"},{"id":"_T4","span":{"begin":213,"end":223},"obj":"FMAID:62852"},{"id":"_T5","span":{"begin":225,"end":237},"obj":"FMAID:167154"},{"id":"_T6","span":{"begin":239,"end":248},"obj":"FMAID:167164"},{"id":"_T7","span":{"begin":239,"end":248},"obj":"FMAID:62864"},{"id":"_T8","span":{"begin":249,"end":260},"obj":"FMAID:63261"},{"id":"_T9","span":{"begin":249,"end":260},"obj":"FMAID:167685"},{"id":"_T10","span":{"begin":265,"end":278},"obj":"FMAID:167173"},{"id":"_T11","span":{"begin":265,"end":278},"obj":"FMAID:167171"},{"id":"_T12","span":{"begin":265,"end":278},"obj":"FMAID:62870"},{"id":"_T13","span":{"begin":265,"end":278},"obj":"FMAID:167174"},{"id":"_T14","span":{"begin":265,"end":278},"obj":"FMAID:167176"},{"id":"_T15","span":{"begin":265,"end":278},"obj":"FMAID:62869"},{"id":"_T16","span":{"begin":267,"end":278},"obj":"FMAID:62863"},{"id":"_T17","span":{"begin":267,"end":278},"obj":"FMAID:167163"},{"id":"_T18","span":{"begin":329,"end":345},"obj":"FMAID:196731"},{"id":"_T19","span":{"begin":329,"end":345},"obj":"FMAID:82742"},{"id":"_T20","span":{"begin":353,"end":369},"obj":"FMAID:82742"},{"id":"_T21","span":{"begin":353,"end":369},"obj":"FMAID:196731"},{"id":"_T22","span":{"begin":504,"end":512},"obj":"FMAID:226028"},{"id":"_T23","span":{"begin":504,"end":512},"obj":"FMAID:226027"},{"id":"_T24","span":{"begin":663,"end":676},"obj":"FMAID:167176"},{"id":"_T25","span":{"begin":663,"end":676},"obj":"FMAID:167173"},{"id":"_T26","span":{"begin":663,"end":676},"obj":"FMAID:167174"},{"id":"_T27","span":{"begin":663,"end":676},"obj":"FMAID:167171"},{"id":"_T28","span":{"begin":663,"end":676},"obj":"FMAID:62870"},{"id":"_T29","span":{"begin":663,"end":676},"obj":"FMAID:62869"},{"id":"_T30","span":{"begin":665,"end":676},"obj":"FMAID:167163"},{"id":"_T31","span":{"begin":665,"end":676},"obj":"FMAID:62863"},{"id":"_T32","span":{"begin":691,"end":701},"obj":"FMAID:174276"},{"id":"_T33","span":{"begin":691,"end":701},"obj":"FMAID:72202"},{"id":"_T34","span":{"begin":706,"end":719},"obj":"FMAID:62869"},{"id":"_T35","span":{"begin":706,"end":719},"obj":"FMAID:167173"},{"id":"_T36","span":{"begin":706,"end":719},"obj":"FMAID:167176"},{"id":"_T37","span":{"begin":706,"end":719},"obj":"FMAID:62870"},{"id":"_T38","span":{"begin":706,"end":719},"obj":"FMAID:167171"},{"id":"_T39","span":{"begin":706,"end":719},"obj":"FMAID:167174"},{"id":"_T40","span":{"begin":708,"end":719},"obj":"FMAID:167163"},{"id":"_T41","span":{"begin":708,"end":719},"obj":"FMAID:62863"},{"id":"_T42","span":{"begin":980,"end":984},"obj":"FMAID:84120"},{"id":"_T43","span":{"begin":980,"end":984},"obj":"FMAID:198073"},{"id":"_T44","span":{"begin":1063,"end":1067},"obj":"FMAID:198663"},{"id":"_T45","span":{"begin":1180,"end":1206},"obj":"FMAID:273572"},{"id":"_T46","span":{"begin":1180,"end":1206},"obj":"FMAID:273565"},{"id":"_T47","span":{"begin":1180,"end":1206},"obj":"FMAID:273566"},{"id":"_T48","span":{"begin":1180,"end":1206},"obj":"FMAID:273564"},{"id":"_T49","span":{"begin":1201,"end":1206},"obj":"FMAID:169002"},{"id":"_T50","span":{"begin":1201,"end":1206},"obj":"FMAID:68646"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T2","span":{"begin":110,"end":121},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T3","span":{"begin":281,"end":292},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T4","span":{"begin":1069,"end":1080},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T5","span":{"begin":1233,"end":1244},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T6","span":{"begin":135,"end":139},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T7","span":{"begin":143,"end":154},"obj":"http://www.uniprot.org/uniprot/P16150"},{"id":"T8","span":{"begin":552,"end":558},"obj":"http://www.uniprot.org/uniprot/Q92988"},{"id":"T9","span":{"begin":587,"end":593},"obj":"http://www.uniprot.org/uniprot/Q92988"},{"id":"T10","span":{"begin":605,"end":611},"obj":"http://www.uniprot.org/uniprot/Q92988"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"uniprot-mouse","denotations":[{"id":"T1","span":{"begin":0,"end":11},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T2","span":{"begin":110,"end":121},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T3","span":{"begin":281,"end":292},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T4","span":{"begin":1069,"end":1080},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T5","span":{"begin":1233,"end":1244},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T6","span":{"begin":135,"end":139},"obj":"http://www.uniprot.org/uniprot/P15702"},{"id":"T7","span":{"begin":143,"end":154},"obj":"http://www.uniprot.org/uniprot/P15702"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T1","span":{"begin":552,"end":556},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T2","span":{"begin":552,"end":556},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T3","span":{"begin":587,"end":591},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T4","span":{"begin":587,"end":591},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T5","span":{"begin":605,"end":609},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/3554"},{"id":"T6","span":{"begin":605,"end":609},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/158455"},{"id":"T7","span":{"begin":1201,"end":1206},"obj":"http://purl.bioontology.org/ontology/STY/T025"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GO-BP","denotations":[{"id":"T1","span":{"begin":68,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0002521"},{"id":"T2","span":{"begin":304,"end":316},"obj":"http://purl.obolibrary.org/obo/GO_0070085"},{"id":"T3","span":{"begin":304,"end":328},"obj":"http://purl.obolibrary.org/obo/GO_0006493"},{"id":"T4","span":{"begin":653,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0050863"},{"id":"T5","span":{"begin":653,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0051132"},{"id":"T6","span":{"begin":653,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_1903905"},{"id":"T7","span":{"begin":653,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T8","span":{"begin":653,"end":676},"obj":"http://purl.obolibrary.org/obo/GO_0050798"},{"id":"T9","span":{"begin":912,"end":923},"obj":"http://purl.obolibrary.org/obo/GO_0006412"},{"id":"T10","span":{"begin":1180,"end":1198},"obj":"http://purl.obolibrary.org/obo/GO_0019882"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GO-MF","denotations":[{"id":"T1","span":{"begin":1160,"end":1165},"obj":"http://purl.obolibrary.org/obo/GO_0070026"},{"id":"T2","span":{"begin":1160,"end":1165},"obj":"http://purl.obolibrary.org/obo/GO_0003680"},{"id":"T3","span":{"begin":1160,"end":1165},"obj":"http://purl.obolibrary.org/obo/GO_0017091"},{"id":"T4","span":{"begin":1160,"end":1165},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T5","span":{"begin":1169,"end":1176},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T6","span":{"begin":1389,"end":1396},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GO-CC","denotations":[{"id":"T1","span":{"begin":445,"end":449},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2","span":{"begin":1109,"end":1113},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3","span":{"begin":1116,"end":1120},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4","span":{"begin":1201,"end":1206},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"EDAM-topics","denotations":[{"id":"T1","span":{"begin":370,"end":378},"obj":"http://edamontology.org/topic_2839"},{"id":"T2","span":{"begin":912,"end":923},"obj":"http://edamontology.org/topic_0108"},{"id":"T3","span":{"begin":980,"end":984},"obj":"http://edamontology.org/topic_2397"},{"id":"T4","span":{"begin":980,"end":984},"obj":"http://edamontology.org/topic_3512"},{"id":"T5","span":{"begin":1003,"end":1011},"obj":"http://edamontology.org/topic_1312"},{"id":"T6","span":{"begin":1003,"end":1011},"obj":"http://edamontology.org/topic_0111"},{"id":"T7","span":{"begin":1003,"end":1011},"obj":"http://edamontology.org/topic_0749"},{"id":"T8","span":{"begin":1012,"end":1020},"obj":"http://edamontology.org/topic_3168"},{"id":"T9","span":{"begin":1012,"end":1020},"obj":"http://edamontology.org/topic_0080"},{"id":"T10","span":{"begin":1121,"end":1132},"obj":"http://edamontology.org/topic_0602"},{"id":"T11","span":{"begin":1180,"end":1187},"obj":"http://edamontology.org/topic_2830"},{"id":"T12","span":{"begin":1281,"end":1292},"obj":"http://edamontology.org/topic_0602"},{"id":"T13","span":{"begin":1357,"end":1368},"obj":"http://edamontology.org/topic_0602"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"EDAM-DFO","denotations":[{"id":"T1","span":{"begin":388,"end":398},"obj":"http://edamontology.org/data_0883"},{"id":"T2","span":{"begin":1012,"end":1020},"obj":"http://edamontology.org/operation_3218"},{"id":"T3","span":{"begin":1012,"end":1020},"obj":"http://edamontology.org/data_2044"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyTouCan-IUPAC","denotations":[{"id":"GlycanIUPAC_T1","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G23425WZ\""},{"id":"GlycanIUPAC_T2","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G02874VH\""},{"id":"GlycanIUPAC_T3","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G99699DW\""},{"id":"GlycanIUPAC_T4","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G22074RM\""},{"id":"GlycanIUPAC_T5","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G48535VZ\""},{"id":"GlycanIUPAC_T6","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G39738WL\""},{"id":"GlycanIUPAC_T7","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G42313WU\""},{"id":"GlycanIUPAC_T8","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G00393CK\""},{"id":"GlycanIUPAC_T9","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G42649EX\""},{"id":"GlycanIUPAC_T10","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G46880SB\""},{"id":"GlycanIUPAC_T11","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G75599IR\""},{"id":"GlycanIUPAC_T12","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G58985MU\""},{"id":"GlycanIUPAC_T13","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G92517PO\""},{"id":"GlycanIUPAC_T14","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G88512YL\""},{"id":"GlycanIUPAC_T15","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G41473NX\""},{"id":"GlycanIUPAC_T16","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G71089RB\""},{"id":"GlycanIUPAC_T17","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G73485GZ\""},{"id":"GlycanIUPAC_T18","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G61406KC\""},{"id":"GlycanIUPAC_T19","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G34412GZ\""},{"id":"GlycanIUPAC_T20","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G67209FP\""},{"id":"GlycanIUPAC_T21","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G61442IL\""},{"id":"GlycanIUPAC_T22","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G93729MV\""},{"id":"GlycanIUPAC_T23","span":{"begin":617,"end":623},"obj":"\"http://rdf.glycoinfo.org/glycan/G92144AE\""}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":754,"end":781},"obj":"Disease"},{"id":"T2","span":{"begin":754,"end":771},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0003778"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0021094"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"HP-phenotype","denotations":[{"id":"T1","span":{"begin":739,"end":748},"obj":"Phenotype"},{"id":"T2","span":{"begin":754,"end":771},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0001909"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002721"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T1","span":{"begin":529,"end":535},"obj":"Glycan"},{"id":"T2","span":{"begin":564,"end":570},"obj":"Glycan"},{"id":"T3","span":{"begin":617,"end":623},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G76685HR"},{"id":"A4","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G76685HR"},{"id":"A5","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A6","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-HP","denotations":[{"id":"T1","span":{"begin":739,"end":748},"obj":"Phenotype"},{"id":"T2","span":{"begin":754,"end":771},"obj":"Phenotype"}],"attributes":[{"id":"A1","pred":"hp_id","subj":"T1","obj":"HP:0001909"},{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0002721"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-CL","denotations":[{"id":"T1","span":{"begin":68,"end":77},"obj":"Cell"},{"id":"T2","span":{"begin":213,"end":223},"obj":"Cell"},{"id":"T3","span":{"begin":225,"end":237},"obj":"Cell"},{"id":"T4","span":{"begin":239,"end":248},"obj":"Cell"},{"id":"T6","span":{"begin":249,"end":260},"obj":"Cell"},{"id":"T8","span":{"begin":265,"end":278},"obj":"Cell"},{"id":"T9","span":{"begin":663,"end":676},"obj":"Cell"},{"id":"T10","span":{"begin":691,"end":701},"obj":"Cell"},{"id":"T11","span":{"begin":706,"end":719},"obj":"Cell"},{"id":"T12","span":{"begin":1107,"end":1113},"obj":"Cell"},{"id":"T13","span":{"begin":1114,"end":1120},"obj":"Cell"},{"id":"T14","span":{"begin":1199,"end":1206},"obj":"Cell"},{"id":"T15","span":{"begin":1269,"end":1280},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000738"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000738"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000094"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A5","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A7","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000893"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A12","pred":"cl_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A14","pred":"cl_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A15","pred":"cl_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL:0000738"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":110,"end":280},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":281,"end":484},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":485,"end":782},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":783,"end":891},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":892,"end":1068},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1069,"end":1207},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1208,"end":1397},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"T2","span":{"begin":110,"end":280},"obj":"Sentence"},{"id":"T3","span":{"begin":281,"end":484},"obj":"Sentence"},{"id":"T4","span":{"begin":485,"end":782},"obj":"Sentence"},{"id":"T5","span":{"begin":783,"end":891},"obj":"Sentence"},{"id":"T6","span":{"begin":892,"end":1068},"obj":"Sentence"},{"id":"T7","span":{"begin":1069,"end":1207},"obj":"Sentence"},{"id":"T8","span":{"begin":1208,"end":1397},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"T2","span":{"begin":110,"end":280},"obj":"Sentence"},{"id":"T3","span":{"begin":281,"end":484},"obj":"Sentence"},{"id":"T4","span":{"begin":485,"end":782},"obj":"Sentence"},{"id":"T5","span":{"begin":783,"end":891},"obj":"Sentence"},{"id":"T6","span":{"begin":892,"end":1068},"obj":"Sentence"},{"id":"T7","span":{"begin":1069,"end":1207},"obj":"Sentence"},{"id":"T8","span":{"begin":1208,"end":1397},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T1","span":{"begin":0,"end":109},"obj":"Sentence"},{"id":"T2","span":{"begin":110,"end":280},"obj":"Sentence"},{"id":"T3","span":{"begin":281,"end":484},"obj":"Sentence"},{"id":"T4","span":{"begin":485,"end":782},"obj":"Sentence"},{"id":"T5","span":{"begin":783,"end":891},"obj":"Sentence"},{"id":"T6","span":{"begin":892,"end":1068},"obj":"Sentence"},{"id":"T7","span":{"begin":1069,"end":1207},"obj":"Sentence"},{"id":"T8","span":{"begin":1208,"end":1397},"obj":"Sentence"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-MONDO","denotations":[{"id":"T1","span":{"begin":98,"end":108},"obj":"Disease"},{"id":"T2","span":{"begin":739,"end":748},"obj":"Disease"},{"id":"T3","span":{"begin":754,"end":781},"obj":"Disease"},{"id":"T4","span":{"begin":754,"end":771},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"MONDO:0004992"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"MONDO:0004355"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"MONDO:0003778"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"MONDO:0021094"}],"namespaces":[{"prefix":"MONDO","uri":"http://purl.obolibrary.org/obo/MONDO_"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T1","span":{"begin":68,"end":77},"obj":"Body_part"},{"id":"T2","span":{"begin":213,"end":223},"obj":"Body_part"},{"id":"T3","span":{"begin":225,"end":237},"obj":"Body_part"},{"id":"T4","span":{"begin":239,"end":248},"obj":"Body_part"},{"id":"T6","span":{"begin":249,"end":260},"obj":"Body_part"},{"id":"T7","span":{"begin":265,"end":278},"obj":"Body_part"},{"id":"T8","span":{"begin":663,"end":676},"obj":"Body_part"},{"id":"T9","span":{"begin":691,"end":701},"obj":"Body_part"},{"id":"T10","span":{"begin":706,"end":719},"obj":"Body_part"},{"id":"T11","span":{"begin":1107,"end":1113},"obj":"Body_part"},{"id":"T12","span":{"begin":1114,"end":1120},"obj":"Body_part"},{"id":"T13","span":{"begin":1269,"end":1280},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000094"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A5","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL_0000893"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL_0000738"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-FMA","denotations":[{"id":"T1","span":{"begin":68,"end":77},"obj":"Body_part"},{"id":"T2","span":{"begin":213,"end":223},"obj":"Body_part"},{"id":"T3","span":{"begin":225,"end":237},"obj":"Body_part"},{"id":"T4","span":{"begin":239,"end":248},"obj":"Body_part"},{"id":"T5","span":{"begin":249,"end":260},"obj":"Body_part"},{"id":"T6","span":{"begin":265,"end":278},"obj":"Body_part"},{"id":"T7","span":{"begin":663,"end":676},"obj":"Body_part"},{"id":"T8","span":{"begin":691,"end":701},"obj":"Body_part"},{"id":"T9","span":{"begin":706,"end":719},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"FMA:62852"},{"id":"A2","pred":"db_id","subj":"T2","obj":"FMA:62852"},{"id":"A3","pred":"db_id","subj":"T3","obj":"FMA:62854"},{"id":"A4","pred":"db_id","subj":"T4","obj":"FMA:62864"},{"id":"A5","pred":"db_id","subj":"T5","obj":"FMA:63261"},{"id":"A6","pred":"db_id","subj":"T6","obj":"FMA:62870"},{"id":"A7","pred":"db_id","subj":"T7","obj":"FMA:62870"},{"id":"A8","pred":"db_id","subj":"T8","obj":"FMA:72202"},{"id":"A9","pred":"db_id","subj":"T9","obj":"FMA:62870"}],"namespaces":[{"prefix":"FMA","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T1","span":{"begin":529,"end":535},"obj":"Glycan"},{"id":"T2","span":{"begin":564,"end":570},"obj":"Glycan"},{"id":"T3","span":{"begin":617,"end":623},"obj":"Glycan"}],"attributes":[{"id":"A1","pred":"glycosmos_id","subj":"T1","obj":"https://glycosmos.org/glycans/show/G76685HR"},{"id":"A4","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR"},{"id":"A2","pred":"glycosmos_id","subj":"T2","obj":"https://glycosmos.org/glycans/show/G76685HR"},{"id":"A5","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR"},{"id":"A3","pred":"glycosmos_id","subj":"T3","obj":"https://glycosmos.org/glycans/show/G39738WL"},{"id":"A6","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":68,"end":77},"obj":"Body_part"},{"id":"T2","span":{"begin":213,"end":223},"obj":"Body_part"},{"id":"T3","span":{"begin":225,"end":237},"obj":"Body_part"},{"id":"T4","span":{"begin":239,"end":248},"obj":"Body_part"},{"id":"T6","span":{"begin":249,"end":260},"obj":"Body_part"},{"id":"T7","span":{"begin":265,"end":278},"obj":"Body_part"},{"id":"T8","span":{"begin":663,"end":676},"obj":"Body_part"},{"id":"T9","span":{"begin":691,"end":701},"obj":"Body_part"},{"id":"T10","span":{"begin":706,"end":719},"obj":"Body_part"},{"id":"T11","span":{"begin":1107,"end":1113},"obj":"Body_part"},{"id":"T12","span":{"begin":1114,"end":1120},"obj":"Body_part"},{"id":"T13","span":{"begin":1269,"end":1280},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000094"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"A5","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0001054"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL_0000893"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL_0000236"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL_0000738"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":68,"end":77},"obj":"Cell"},{"id":"T2","span":{"begin":213,"end":223},"obj":"Cell"},{"id":"T3","span":{"begin":225,"end":237},"obj":"Cell"},{"id":"T4","span":{"begin":239,"end":248},"obj":"Cell"},{"id":"T6","span":{"begin":249,"end":260},"obj":"Cell"},{"id":"T8","span":{"begin":265,"end":278},"obj":"Cell"},{"id":"T9","span":{"begin":663,"end":676},"obj":"Cell"},{"id":"T10","span":{"begin":691,"end":701},"obj":"Cell"},{"id":"T11","span":{"begin":706,"end":719},"obj":"Cell"},{"id":"T12","span":{"begin":1107,"end":1113},"obj":"Cell"},{"id":"T13","span":{"begin":1114,"end":1120},"obj":"Cell"},{"id":"T14","span":{"begin":1199,"end":1206},"obj":"Cell"},{"id":"T15","span":{"begin":1269,"end":1280},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000738"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000738"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000094"},{"id":"A4","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0000576"},{"id":"A5","pred":"cl_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL:0001054"},{"id":"A6","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A7","pred":"cl_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"id":"A8","pred":"cl_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A9","pred":"cl_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A10","pred":"cl_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CL:0000893"},{"id":"A11","pred":"cl_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A12","pred":"cl_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/CL:0000084"},{"id":"A13","pred":"cl_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A14","pred":"cl_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/CL:0000236"},{"id":"A15","pred":"cl_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CL:0000738"}],"text":"Leukosialin, a major O-glycan-containing sialoglycoprotein defining leukocyte differentiation and malignancy.\nLeukosialin, also called CD43 or sialophorin, is a major sialoglycoprotein expressed widely in various leukocytes (granulocytes, monocytes/macrophages and T-lymphocytes). Leukosialin is heavily glycosylated by O-linked oligosaccharides (70-80 oligosaccharides/molecule) and the structures of those O-glycans are characteristic to each cell lineage and differentiation stage. In particular, the branched hexasaccharide, NeuNAc alpha 2----3Gal beta 1----3(NeuNAc alpha 2----3Gal beta 1----4GlcNAc beta 1----6)GalNAc is specifically expressed in activated T-lymphocytes as well as in thymocytes and T-lymphocytes from patients with leukaemia, and immuno-deficiency syndromes. A portion of these O-glycans are attached to a domain with tandem repeats in the polypeptide of leukosialin. However, the entire translation product, including such tandem repeats, is coded by one exon and a short novel promoter sequence confers the expression of the leukosialin gene. Leukosialin is apparently involved in T-cell-B-cell interaction during immune reaction and binds to ligands on antigen-presenting B-cells. These results imply that leukosialin plays critical roles in immune cell interaction and differences in attached O-glycans most likely influence the interaction of leukosialin with ligands."}