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DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18382768-0#40#55#gene83667 40-55 gene83667 denotes hypoxia-induced
18382768-0#100#119#diseaseC0002895 100-119 diseaseC0002895 denotes sickle-cell disease
40#55#gene83667100#119#diseaseC0002895 18382768-0#40#55#gene83667 18382768-0#100#119#diseaseC0002895 associated_with hypoxia-induced,sickle-cell disease

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-120 Sentence denotes Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease.
T2 121-259 Sentence denotes Patients with sickle-cell disease (SCD) suffer from tissue damage and life-threatening complications caused by vasoocclusive crisis (VOC).
T3 260-442 Sentence denotes Endothelin receptors (ETRs) are mediators of one of the most potent vasoconstrictor pathways in mammals, but the relationship between vasoconstriction and VOC is not well understood.
T4 443-575 Sentence denotes We report here that pharmacological inhibition of ETRs prevented hypoxia-induced acute VOC and organ damage in a mouse model of SCD.
T5 576-746 Sentence denotes An in vivo ultrasonographic study of renal hemodynamics showed a substantial increase in endothelin-mediated vascular resistance during hypoxia/reoxygenation-induced VOC.
T6 747-885 Sentence denotes This increase was reversed by administration of the dual ETR antagonist (ETRA) bosentan, which had pleiotropic beneficial effects in vivo.
T7 886-1077 Sentence denotes It prevented renal and pulmonary microvascular congestion, systemic inflammation, dense rbc formation, and infiltration of activated neutrophils into tissues with subsequent nitrative stress.
T8 1078-1166 Sentence denotes Bosentan also prevented death of sickle-cell mice exposed to a severe hypoxic challenge.
T9 1167-1325 Sentence denotes These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients.
T1 0-120 Sentence denotes Endothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease.
T2 121-259 Sentence denotes Patients with sickle-cell disease (SCD) suffer from tissue damage and life-threatening complications caused by vasoocclusive crisis (VOC).
T3 260-442 Sentence denotes Endothelin receptors (ETRs) are mediators of one of the most potent vasoconstrictor pathways in mammals, but the relationship between vasoconstriction and VOC is not well understood.
T4 443-575 Sentence denotes We report here that pharmacological inhibition of ETRs prevented hypoxia-induced acute VOC and organ damage in a mouse model of SCD.
T5 576-746 Sentence denotes An in vivo ultrasonographic study of renal hemodynamics showed a substantial increase in endothelin-mediated vascular resistance during hypoxia/reoxygenation-induced VOC.
T6 747-885 Sentence denotes This increase was reversed by administration of the dual ETR antagonist (ETRA) bosentan, which had pleiotropic beneficial effects in vivo.
T7 886-1077 Sentence denotes It prevented renal and pulmonary microvascular congestion, systemic inflammation, dense rbc formation, and infiltration of activated neutrophils into tissues with subsequent nitrative stress.
T8 1078-1166 Sentence denotes Bosentan also prevented death of sickle-cell mice exposed to a severe hypoxic challenge.
T9 1167-1325 Sentence denotes These findings in mice suggest that ETRA could be a potential new therapy for SCD, as it may prevent acute VOC and limit organ damage in sickle-cell patients.

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 100-119 DiseaseOrPhenotypicFeature denotes sickle-cell disease 0011382
T2 135-154 DiseaseOrPhenotypicFeature denotes sickle-cell disease 0011382
T3 156-159 DiseaseOrPhenotypicFeature denotes SCD 0000359|0007374|0011382
T6 571-574 DiseaseOrPhenotypicFeature denotes SCD 0000359|0007374|0011382
T9 1245-1248 DiseaseOrPhenotypicFeature denotes SCD 0000359|0007374|0011382