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PubMed:18356166 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 417-420 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T2 628-631 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T3 765-768 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T4 848-851 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO
T5 889-892 Glycan_Motif denotes cad https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00063MO

PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 898-901 DiseaseOrPhenotypicFeature denotes can 0012833

sentences

Id Subject Object Predicate Lexical cue
T1 0-71 Sentence denotes A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus.
T2 72-224 Sentence denotes Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood.
T3 225-331 Sentence denotes E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by gamma-secretase.
T4 332-445 Sentence denotes This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol.
T5 446-500 Sentence denotes Here, we study the fate and function of this fragment.
T6 501-637 Sentence denotes First, we show that coexpression of the cadherin-binding protein, p120 catenin (p120), enhances the nuclear translocation of E-cad/CTF2.
T7 638-774 Sentence denotes By knocking down p120 with short interfering RNA, we also demonstrate that p120 is necessary for the nuclear localization of E-cad/CTF2.
T8 775-864 Sentence denotes Furthermore, p120 enhances and is required for the specific binding of E-cad/CTF2 to DNA.
T9 865-968 Sentence denotes Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus.
T10 969-1040 Sentence denotes These data indicate a novel role for cleaved E-cadherin in the nucleus.
T1 0-71 Sentence denotes A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus.
T2 72-224 Sentence denotes Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood.
T3 225-331 Sentence denotes E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by gamma-secretase.
T4 332-445 Sentence denotes This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol.
T5 446-500 Sentence denotes Here, we study the fate and function of this fragment.
T6 501-637 Sentence denotes First, we show that coexpression of the cadherin-binding protein, p120 catenin (p120), enhances the nuclear translocation of E-cad/CTF2.
T7 638-774 Sentence denotes By knocking down p120 with short interfering RNA, we also demonstrate that p120 is necessary for the nuclear localization of E-cad/CTF2.
T8 775-864 Sentence denotes Furthermore, p120 enhances and is required for the specific binding of E-cad/CTF2 to DNA.
T9 865-968 Sentence denotes Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus.
T10 969-1040 Sentence denotes These data indicate a novel role for cleaved E-cadherin in the nucleus.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 417-420 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T2 628-631 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T3 765-768 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T4 848-851 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad
T5 889-892 https://glytoucan.org/Structures/Glycans/G00063MO denotes cad

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 23-34 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T2 63-70 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T4 112-125 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T5 437-444 Body_part denotes cytosol http://purl.obolibrary.org/obo/GO_0005829
T6 960-967 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T8 1032-1039 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125