PubMed:18332098
Annnotations
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 60-64 | gene:100507436 | denotes | MICA |
| T1 | 83-98 | disease:C0011854 | denotes | type 1 diabetes |
| T2 | 69-73 | gene:4277 | denotes | MICB |
| T3 | 83-98 | disease:C0011854 | denotes | type 1 diabetes |
| T4 | 287-291 | gene:100507436 | denotes | MICA |
| T5 | 343-358 | disease:C0011854 | denotes | type 1 diabetes |
| T6 | 287-291 | gene:100507436 | denotes | MICA |
| T7 | 293-301 | disease:C0700319 | denotes | MICA-STR |
| T8 | 448-452 | gene:4277 | denotes | MICB |
| T9 | 509-524 | disease:C0011854 | denotes | type 1 diabetes |
| T10 | 448-452 | gene:4277 | denotes | MICB |
| T11 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T12 | 578-580 | gene:2651 | denotes | II |
| T13 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T14 | 587-595 | gene:3123 | denotes | HLA-DRB1 |
| T15 | 509-524 | disease:C0011854 | denotes | type 1 diabetes |
| T16 | 587-595 | gene:3123 | denotes | HLA-DRB1 |
| T17 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T18 | 600-608 | gene:3120 | denotes | HLA-DQB1 |
| T19 | 509-524 | disease:C0011854 | denotes | type 1 diabetes |
| T20 | 600-608 | gene:3119 | denotes | HLA-DQB1 |
| T21 | 509-524 | disease:C0011854 | denotes | type 1 diabetes |
| T22 | 600-608 | gene:3120 | denotes | HLA-DQB1 |
| T23 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T24 | 600-608 | gene:3119 | denotes | HLA-DQB1 |
| T25 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T26 | 439-443 | gene:100507436 | denotes | MICA |
| T27 | 552-567 | disease:C0011854 | denotes | type 1 diabetes |
| T28 | 439-443 | gene:100507436 | denotes | MICA |
| T29 | 509-524 | disease:C0011854 | denotes | type 1 diabetes |
| T30 | 699-703 | gene:100507436 | denotes | MICA |
| T31 | 754-769 | disease:C0011854 | denotes | type 1 diabetes |
| T32 | 699-703 | gene:100507436 | denotes | MICA |
| T33 | 926-934 | disease:C0700319 | denotes | MICA-STR |
| T34 | 699-703 | gene:100507436 | denotes | MICA |
| T35 | 1091-1106 | disease:C0011854 | denotes | type 1 diabetes |
| T36 | 1059-1063 | gene:4277 | denotes | MICB |
| T37 | 1091-1106 | disease:C0011854 | denotes | type 1 diabetes |
| T38 | 708-712 | gene:4277 | denotes | MICB |
| T39 | 926-934 | disease:C0700319 | denotes | MICA-STR |
| T40 | 873-877 | gene:100507436 | denotes | MICA |
| T41 | 754-769 | disease:C0011854 | denotes | type 1 diabetes |
| T42 | 873-877 | gene:100507436 | denotes | MICA |
| T43 | 926-934 | disease:C0700319 | denotes | MICA-STR |
| T44 | 873-877 | gene:100507436 | denotes | MICA |
| T45 | 1091-1106 | disease:C0011854 | denotes | type 1 diabetes |
| T46 | 889-893 | gene:4277 | denotes | MICB |
| T47 | 754-769 | disease:C0011854 | denotes | type 1 diabetes |
| T48 | 889-893 | gene:4277 | denotes | MICB |
| T49 | 926-934 | disease:C0700319 | denotes | MICA-STR |
| T50 | 889-893 | gene:4277 | denotes | MICB |
| T51 | 1091-1106 | disease:C0011854 | denotes | type 1 diabetes |
| T52 | 1050-1054 | gene:100507436 | denotes | MICA |
| T53 | 1091-1106 | disease:C0011854 | denotes | type 1 diabetes |
| T54 | 708-712 | gene:4277 | denotes | MICB |
| T55 | 754-769 | disease:C0011854 | denotes | type 1 diabetes |
| T56 | 1392-1396 | gene:100507436 | denotes | MICA |
| T57 | 1335-1350 | disease:C0011854 | denotes | type 1 diabetes |
| T58 | 1382-1384 | gene:2651 | denotes | II |
| T59 | 1335-1350 | disease:C0011854 | denotes | type 1 diabetes |
| T60 | 1325-1329 | gene:4277 | denotes | MICB |
| T61 | 1335-1350 | disease:C0011854 | denotes | type 1 diabetes |
| T62 | 1316-1320 | gene:100507436 | denotes | MICA |
| T63 | 1335-1350 | disease:C0011854 | denotes | type 1 diabetes |
| T64 | 1516-1520 | gene:4277 | denotes | MICB |
| T65 | 1624-1639 | disease:C0011854 | denotes | type 1 diabetes |
| T66 | 1516-1520 | gene:4277 | denotes | MICB |
| T67 | 1554-1562 | disease:C0700319 | denotes | MICA-STR |
| T68 | 1507-1511 | gene:100507436 | denotes | MICA |
| T69 | 1624-1639 | disease:C0011854 | denotes | type 1 diabetes |
| T70 | 1507-1511 | gene:100507436 | denotes | MICA |
| T71 | 1554-1562 | disease:C0700319 | denotes | MICA-STR |
| R1 | T0 | T1 | associated_with | MICA,type 1 diabetes |
| R2 | T2 | T3 | associated_with | MICB,type 1 diabetes |
| R3 | T4 | T5 | associated_with | MICA,type 1 diabetes |
| R4 | T6 | T7 | associated_with | MICA,MICA-STR |
| R5 | T8 | T9 | associated_with | MICB,type 1 diabetes |
| R6 | T10 | T11 | associated_with | MICB,type 1 diabetes |
| R7 | T12 | T13 | associated_with | II,type 1 diabetes |
| R8 | T14 | T15 | associated_with | HLA-DRB1,type 1 diabetes |
| R9 | T16 | T17 | associated_with | HLA-DRB1,type 1 diabetes |
| R10 | T18 | T19 | associated_with | HLA-DQB1,type 1 diabetes |
| R11 | T20 | T21 | associated_with | HLA-DQB1,type 1 diabetes |
| R12 | T22 | T23 | associated_with | HLA-DQB1,type 1 diabetes |
| R13 | T24 | T25 | associated_with | HLA-DQB1,type 1 diabetes |
| R14 | T26 | T27 | associated_with | MICA,type 1 diabetes |
| R15 | T28 | T29 | associated_with | MICA,type 1 diabetes |
| R16 | T30 | T31 | associated_with | MICA,type 1 diabetes |
| R17 | T32 | T33 | associated_with | MICA,MICA-STR |
| R18 | T34 | T35 | associated_with | MICA,type 1 diabetes |
| R19 | T36 | T37 | associated_with | MICB,type 1 diabetes |
| R20 | T38 | T39 | associated_with | MICB,MICA-STR |
| R21 | T40 | T41 | associated_with | MICA,type 1 diabetes |
| R22 | T42 | T43 | associated_with | MICA,MICA-STR |
| R23 | T44 | T45 | associated_with | MICA,type 1 diabetes |
| R24 | T46 | T47 | associated_with | MICB,type 1 diabetes |
| R25 | T48 | T49 | associated_with | MICB,MICA-STR |
| R26 | T50 | T51 | associated_with | MICB,type 1 diabetes |
| R27 | T52 | T53 | associated_with | MICA,type 1 diabetes |
| R28 | T54 | T55 | associated_with | MICB,type 1 diabetes |
| R29 | T56 | T57 | associated_with | MICA,type 1 diabetes |
| R30 | T58 | T59 | associated_with | II,type 1 diabetes |
| R31 | T60 | T61 | associated_with | MICB,type 1 diabetes |
| R32 | T62 | T63 | associated_with | MICA,type 1 diabetes |
| R33 | T64 | T65 | associated_with | MICB,type 1 diabetes |
| R34 | T66 | T67 | associated_with | MICB,MICA-STR |
| R35 | T68 | T69 | associated_with | MICA,type 1 diabetes |
| R36 | T70 | T71 | associated_with | MICA,MICA-STR |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 18332098-0#60#64#gene100507436 | 1316-1320 | gene100507436 | denotes | MICA |
| 18332098-0#69#73#gene4277 | 1325-1329 | gene4277 | denotes | MICB |
| 18332098-0#83#98#diseaseC0011854 | 1624-1639 | diseaseC0011854 | denotes | type 1 diabetes |
| 18332098-3#227#235#gene3123 | 587-595 | gene3123 | denotes | HLA-DRB1 |
| 18332098-3#240#248#gene3119 | 600-608 | gene3119 | denotes | HLA-DQB1 |
| 18332098-3#149#164#diseaseC0011854 | 509-524 | diseaseC0011854 | denotes | type 1 diabetes |
| 18332098-3#192#207#diseaseC0011854 | 552-567 | diseaseC0011854 | denotes | type 1 diabetes |
| 18332098-3#149#164#diseaseC0011854 | 509-524 | diseaseC0011854 | denotes | type 1 diabetes |
| 18332098-3#192#207#diseaseC0011854 | 552-567 | diseaseC0011854 | denotes | type 1 diabetes |
| 60#64#gene10050743683#98#diseaseC0011854 | 18332098-0#60#64#gene100507436 | 18332098-0#83#98#diseaseC0011854 | associated_with | MICA,type 1 diabetes |
| 69#73#gene427783#98#diseaseC0011854 | 18332098-0#69#73#gene4277 | 18332098-0#83#98#diseaseC0011854 | associated_with | MICB,type 1 diabetes |
| 227#235#gene3123149#164#diseaseC0011854 | 18332098-3#227#235#gene3123 | 18332098-3#149#164#diseaseC0011854 | associated_with | HLA-DRB1,type 1 diabetes |
| 227#235#gene3123192#207#diseaseC0011854 | 18332098-3#227#235#gene3123 | 18332098-3#192#207#diseaseC0011854 | associated_with | HLA-DRB1,type 1 diabetes |
| 227#235#gene3123149#164#diseaseC0011854 | 18332098-3#227#235#gene3123 | 18332098-3#149#164#diseaseC0011854 | associated_with | HLA-DRB1,type 1 diabetes |
| 227#235#gene3123192#207#diseaseC0011854 | 18332098-3#227#235#gene3123 | 18332098-3#192#207#diseaseC0011854 | associated_with | HLA-DRB1,type 1 diabetes |
| 240#248#gene3119149#164#diseaseC0011854 | 18332098-3#240#248#gene3119 | 18332098-3#149#164#diseaseC0011854 | associated_with | HLA-DQB1,type 1 diabetes |
| 240#248#gene3119192#207#diseaseC0011854 | 18332098-3#240#248#gene3119 | 18332098-3#192#207#diseaseC0011854 | associated_with | HLA-DQB1,type 1 diabetes |
| 240#248#gene3119149#164#diseaseC0011854 | 18332098-3#240#248#gene3119 | 18332098-3#149#164#diseaseC0011854 | associated_with | HLA-DQB1,type 1 diabetes |
| 240#248#gene3119192#207#diseaseC0011854 | 18332098-3#240#248#gene3119 | 18332098-3#192#207#diseaseC0011854 | associated_with | HLA-DQB1,type 1 diabetes |
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-99 | Sentence | denotes | Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. |
| T2 | 100-110 | Sentence | denotes | OBJECTIVE: |
| T3 | 111-252 | Sentence | denotes | The nonclassical major histocompatibility complex (MHC) class I chain-related molecules (MICs), encoded within the MHC, function in immunity. |
| T4 | 253-359 | Sentence | denotes | The transmembrane polymorphism in MICA (MICA-STR) has been reported to be associated with type 1 diabetes. |
| T5 | 360-609 | Sentence | denotes | In this study, we directly sequenced both of the highly polymorphic MIC genes (MICA and MICB) in order to establish whether they are associated with type 1 diabetes independently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1. |
| T6 | 610-638 | Sentence | denotes | RESEARCH DESIGN AND METHODS: |
| T7 | 639-1014 | Sentence | denotes | We developed a sequencing-based typing method and genotyped MICA and MICB in 818 families (2,944 individuals) with type 1 diabetes from the U.K. and U.S. (constructing the genotype from single nucleotide polymorphisms in exons 2-4 of MICA and 2-5 of MICB) and additionally genotyped the MICA-STR in 2,023 type 1 diabetic case subjects and 1,748 control subjects from the U.K. |
| T8 | 1015-1132 | Sentence | denotes | We analyzed the association of the MICA and MICB alleles and genotypes with type 1 diabetes using regression methods. |
| T9 | 1133-1141 | Sentence | denotes | RESULTS: |
| T10 | 1142-1221 | Sentence | denotes | We identified known MICA and MICB alleles and discovered four new MICB alleles. |
| T11 | 1222-1486 | Sentence | denotes | Based on this large-scale and detailed genotype data, we found no evidence for association of MICA and MICB with type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MICB P = 0.03, after conditioning on HLA-DRB1 and HLA-DQB1). |
| T12 | 1487-1499 | Sentence | denotes | CONCLUSIONS: |
| T13 | 1500-1640 | Sentence | denotes | Common MICA and MICB genetic variations including the MICA-STR are not associated, in a primary way, with susceptibility to type 1 diabetes. |
| T1 | 0-99 | Sentence | denotes | Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. |
| T2 | 100-110 | Sentence | denotes | OBJECTIVE: |
| T3 | 111-252 | Sentence | denotes | The nonclassical major histocompatibility complex (MHC) class I chain-related molecules (MICs), encoded within the MHC, function in immunity. |
| T4 | 253-359 | Sentence | denotes | The transmembrane polymorphism in MICA (MICA-STR) has been reported to be associated with type 1 diabetes. |
| T5 | 360-609 | Sentence | denotes | In this study, we directly sequenced both of the highly polymorphic MIC genes (MICA and MICB) in order to establish whether they are associated with type 1 diabetes independently of the known type 1 diabetes MHC class II genes HLA-DRB1 and HLA-DQB1. |
| T6 | 610-638 | Sentence | denotes | RESEARCH DESIGN AND METHODS: |
| T7 | 639-1014 | Sentence | denotes | We developed a sequencing-based typing method and genotyped MICA and MICB in 818 families (2,944 individuals) with type 1 diabetes from the U.K. and U.S. (constructing the genotype from single nucleotide polymorphisms in exons 2-4 of MICA and 2-5 of MICB) and additionally genotyped the MICA-STR in 2,023 type 1 diabetic case subjects and 1,748 control subjects from the U.K. |
| T8 | 1015-1132 | Sentence | denotes | We analyzed the association of the MICA and MICB alleles and genotypes with type 1 diabetes using regression methods. |
| T9 | 1133-1141 | Sentence | denotes | RESULTS: |
| T10 | 1142-1221 | Sentence | denotes | We identified known MICA and MICB alleles and discovered four new MICB alleles. |
| T11 | 1222-1486 | Sentence | denotes | Based on this large-scale and detailed genotype data, we found no evidence for association of MICA and MICB with type 1 diabetes independently of the MHC class II genes (MICA P = 0.08, MICA-STR P = 0.76, MICB P = 0.03, after conditioning on HLA-DRB1 and HLA-DQB1). |
| T12 | 1487-1499 | Sentence | denotes | CONCLUSIONS: |
| T13 | 1500-1640 | Sentence | denotes | Common MICA and MICB genetic variations including the MICA-STR are not associated, in a primary way, with susceptibility to type 1 diabetes. |