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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-165 Sentence denotes Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
TextSentencer_T2 166-189 Sentence denotes BACKGROUND AND PURPOSE:
TextSentencer_T3 190-432 Sentence denotes The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease.
TextSentencer_T4 433-658 Sentence denotes Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes.
TextSentencer_T5 659-667 Sentence denotes METHODS:
TextSentencer_T6 668-943 Sentence denotes A case control methodology using a UK stroke cohort (872 cases, 933 controls) was adopted, with additional 5-lipoxygenase activating protein genotyping and replication of positive findings undertaken in an independent stroke population from Germany (601 cases, 736 controls).
TextSentencer_T7 944-952 Sentence denotes RESULTS:
TextSentencer_T8 953-1123 Sentence denotes Association was identified with variants in 5-lipoxygenase activating protein, leukotriene C4 synthase (leukotriene A4 hydrolase),and the leukotriene B4 receptor complex.
TextSentencer_T9 1124-1185 Sentence denotes Differing risks were identified for ischemic stroke subtypes.
TextSentencer_T10 1186-1434 Sentence denotes A variant in leukotriene C4 synthase was found to confer a 1.5-fold increase in risk of small vessel disease (RR, 1.515; 1.041 to 2.262; P=0.043) with replication in an independent cohort showing a similar risk (RR, 1.687; 1.065 to 2.675; P=0.026).
TextSentencer_T11 1435-1723 Sentence denotes A haplotype in the leukotriene B4 receptor complex was found to confer a 2.3-fold increase in risk of cardioembolic stroke (RR, 2.118; 1.194 to 3.760; P=0.01) and replication in a German cohort revealed a similar risk with a second distinct haplotype (RR, 2.060; 1.162 to 3.665; P=0.013).
TextSentencer_T12 1724-1736 Sentence denotes CONCLUSIONS:
TextSentencer_T13 1737-1879 Sentence denotes Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations.
TextSentencer_T14 1880-1955 Sentence denotes These risks show different magnitudes depending on ischemic stroke subtype.
T1 0-165 Sentence denotes Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations.
T2 166-189 Sentence denotes BACKGROUND AND PURPOSE:
T3 190-432 Sentence denotes The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease.
T4 433-658 Sentence denotes Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes.
T5 659-667 Sentence denotes METHODS:
T6 668-943 Sentence denotes A case control methodology using a UK stroke cohort (872 cases, 933 controls) was adopted, with additional 5-lipoxygenase activating protein genotyping and replication of positive findings undertaken in an independent stroke population from Germany (601 cases, 736 controls).
T7 944-952 Sentence denotes RESULTS:
T8 953-1123 Sentence denotes Association was identified with variants in 5-lipoxygenase activating protein, leukotriene C4 synthase (leukotriene A4 hydrolase),and the leukotriene B4 receptor complex.
T9 1124-1185 Sentence denotes Differing risks were identified for ischemic stroke subtypes.
T10 1186-1434 Sentence denotes A variant in leukotriene C4 synthase was found to confer a 1.5-fold increase in risk of small vessel disease (RR, 1.515; 1.041 to 2.262; P=0.043) with replication in an independent cohort showing a similar risk (RR, 1.687; 1.065 to 2.675; P=0.026).
T11 1435-1723 Sentence denotes A haplotype in the leukotriene B4 receptor complex was found to confer a 2.3-fold increase in risk of cardioembolic stroke (RR, 2.118; 1.194 to 3.760; P=0.01) and replication in a German cohort revealed a similar risk with a second distinct haplotype (RR, 2.060; 1.162 to 3.665; P=0.013).
T12 1724-1736 Sentence denotes CONCLUSIONS:
T13 1737-1879 Sentence denotes Genetic variation in leukotriene pathway members and their receptors confer an increased risk of ischemic stroke in 2 independent populations.
T14 1880-1955 Sentence denotes These risks show different magnitudes depending on ischemic stroke subtype.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 234-248 gene:240 denotes 5-lipoxygenase
T1 329-344 disease:C0948008 denotes ischemic stroke
T2 234-248 gene:240 denotes 5-lipoxygenase
T3 329-344 disease:C3272363 denotes ischemic stroke
T4 234-248 gene:240 denotes 5-lipoxygenase
T5 409-431 disease:C0007222 denotes cardiovascular disease
T6 272-296 gene:4048 denotes leukotriene A4 hydrolase
T7 409-431 disease:C0007222 denotes cardiovascular disease
T8 272-296 gene:4048 denotes leukotriene A4 hydrolase
T9 329-344 disease:C3272363 denotes ischemic stroke
T10 272-296 gene:4048 denotes leukotriene A4 hydrolase
T11 329-344 disease:C0948008 denotes ischemic stroke
T12 775-789 gene:240 denotes 5-lipoxygenase
T13 886-892 disease:C0038454 denotes stroke
R1 T0 T1 associated_with 5-lipoxygenase,ischemic stroke
R2 T2 T3 associated_with 5-lipoxygenase,ischemic stroke
R3 T4 T5 associated_with 5-lipoxygenase,cardiovascular disease
R4 T6 T7 associated_with leukotriene A4 hydrolase,cardiovascular disease
R5 T8 T9 associated_with leukotriene A4 hydrolase,ischemic stroke
R6 T10 T11 associated_with leukotriene A4 hydrolase,ischemic stroke
R7 T12 T13 associated_with 5-lipoxygenase,stroke

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18323512-1#44#58#gene240 234-248 gene240 denotes 5-lipoxygenase
18323512-1#82#106#gene4048 272-296 gene4048 denotes leukotriene A4 hydrolase
18323512-1#44#58#gene240 234-248 gene240 denotes 5-lipoxygenase
18323512-1#82#106#gene4048 272-296 gene4048 denotes leukotriene A4 hydrolase
18323512-1#139#154#diseaseC0948008 329-344 diseaseC0948008 denotes ischemic stroke
18323512-1#139#154#diseaseC3272363 329-344 diseaseC3272363 denotes ischemic stroke
18323512-1#139#154#diseaseC0948008 329-344 diseaseC0948008 denotes ischemic stroke
18323512-1#139#154#diseaseC3272363 329-344 diseaseC3272363 denotes ischemic stroke
18323512-1#219#241#diseaseC0007222 409-431 diseaseC0007222 denotes cardiovascular disease
18323512-3#107#121#gene240 775-789 gene240 denotes 5-lipoxygenase
18323512-3#38#44#diseaseC0038454 706-712 diseaseC0038454 denotes stroke
18323512-3#218#224#diseaseC0038454 886-892 diseaseC0038454 denotes stroke
44#58#gene240139#154#diseaseC0948008 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC0948008 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC3272363 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC3272363 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC0948008 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC0948008 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC3272363 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC3272363 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240219#241#diseaseC0007222 18323512-1#44#58#gene240 18323512-1#219#241#diseaseC0007222 associated_with 5-lipoxygenase,cardiovascular disease
82#106#gene4048139#154#diseaseC0948008 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC0948008 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC3272363 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC3272363 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC0948008 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC0948008 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC3272363 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC3272363 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048219#241#diseaseC0007222 18323512-1#82#106#gene4048 18323512-1#219#241#diseaseC0007222 associated_with leukotriene A4 hydrolase,cardiovascular disease
44#58#gene240139#154#diseaseC0948008 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC0948008 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC3272363 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC3272363 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC0948008 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC0948008 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240139#154#diseaseC3272363 18323512-1#44#58#gene240 18323512-1#139#154#diseaseC3272363 associated_with 5-lipoxygenase,ischemic stroke
44#58#gene240219#241#diseaseC0007222 18323512-1#44#58#gene240 18323512-1#219#241#diseaseC0007222 associated_with 5-lipoxygenase,cardiovascular disease
82#106#gene4048139#154#diseaseC0948008 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC0948008 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC3272363 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC3272363 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC0948008 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC0948008 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048139#154#diseaseC3272363 18323512-1#82#106#gene4048 18323512-1#139#154#diseaseC3272363 associated_with leukotriene A4 hydrolase,ischemic stroke
82#106#gene4048219#241#diseaseC0007222 18323512-1#82#106#gene4048 18323512-1#219#241#diseaseC0007222 associated_with leukotriene A4 hydrolase,cardiovascular disease
107#121#gene24038#44#diseaseC0038454 18323512-3#107#121#gene240 18323512-3#38#44#diseaseC0038454 associated_with 5-lipoxygenase,stroke
107#121#gene240218#224#diseaseC0038454 18323512-3#107#121#gene240 18323512-3#218#224#diseaseC0038454 associated_with 5-lipoxygenase,stroke

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1426 234-248 gene:240 denotes 5-lipoxygenase
T1427 329-344 disease:C0948008 denotes ischemic stroke
T1428 272-296 gene:4048 denotes leukotriene A4 hydrolase
R1 T1426 T1427 associated_with 5-lipoxygenase,ischemic stroke
R2 T1426 T1427 associated_with 5-lipoxygenase,ischemic stroke
R3 T1428 T1427 associated_with leukotriene A4 hydrolase,ischemic stroke
R4 T1428 T1427 associated_with leukotriene A4 hydrolase,ischemic stroke

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1280-1286 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1280-1286 http://purl.obolibrary.org/obo/UBERON_0000055 denotes vessel