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PubMed:18321851 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 1107-1109 DiseaseOrPhenotypicFeature denotes TS 0010979|0016455

sentences

Id Subject Object Predicate Lexical cue
T1 0-64 Sentence denotes Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.
T2 65-253 Sentence denotes Ubc7p is a ubiquitin-conjugating enzyme (E2) that functions with endoplasmic reticulum (ER)-resident ubiquitin ligases (E3s) to promote endoplasmic reticulum-associated degradation (ERAD).
T3 254-351 Sentence denotes Ubc7p only functions in ERAD if bound to the ER surface by Cue1p, a membrane-anchored ER protein.
T4 352-449 Sentence denotes The role of Cue1p was thought to involve passive concentration of Ubc7p at the surface of the ER.
T5 450-559 Sentence denotes However, our biochemical studies of Ubc7p suggested that Cue1p may, in addition, stimulate Ubc7p E2 activity.
T6 560-635 Sentence denotes We have tested this idea and found it to be true both in vitro and in vivo.
T7 636-777 Sentence denotes Ubc7p bound to the soluble domain of Cue1p showed strongly enhanced in vitro ubiquitination activity, both in the presence and absence of E3.
T8 778-904 Sentence denotes Cue1p also enhanced Ubc7p function in vivo, and this activation was separable from the established ER-anchoring role of Cue1p.
T9 905-1013 Sentence denotes Finally, we tested in vivo activation of Ubc7p by Cue1p in an assay independent of the ER membrane and ERAD.
T10 1014-1218 Sentence denotes A chimeric E2 linking Ubc7p to the Cdc34p/Ubc3p localization domain complemented the cdc34-2 TS phenotype, and co-expression of the soluble Cue1p domain enhanced complementation by this chimeric Ubc7p E2.
T11 1219-1413 Sentence denotes These studies reveal a previously unobserved stimulation of Ubc7p E2 activity by Cue1p that is critical for full ERAD and that functions independently of the well known Cue1p anchoring function.
T12 1414-1525 Sentence denotes Moreover, it suggests a previously unappreciated mode for regulation of E2s by Cue1p-like interacting partners.

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 0-5 Protein denotes Cue1p
T2 25-30 Protein denotes Ubc7p
T3 65-70 Protein denotes Ubc7p
T4 76-85 Protein denotes ubiquitin
T5 166-175 Protein denotes ubiquitin
T6 254-259 Protein denotes Ubc7p
T7 313-318 Protein denotes Cue1p
T8 364-369 Protein denotes Cue1p
T9 418-423 Protein denotes Ubc7p
T10 486-491 Protein denotes Ubc7p
T11 507-512 Protein denotes Cue1p
T12 541-546 Protein denotes Ubc7p
T13 636-641 Protein denotes Ubc7p
T14 673-678 Protein denotes Cue1p
T15 778-783 Protein denotes Cue1p
T16 798-803 Protein denotes Ubc7p
T17 898-903 Protein denotes Cue1p
T18 946-951 Protein denotes Ubc7p
T19 955-960 Protein denotes Cue1p
T20 1036-1041 Protein denotes Ubc7p
T21 1049-1055 Protein denotes Cdc34p
T22 1056-1061 Protein denotes Ubc3p
T23 1099-1104 Protein denotes cdc34
T24 1154-1159 Protein denotes Cue1p
T25 1209-1214 Protein denotes Ubc7p
T26 1279-1284 Protein denotes Ubc7p
T27 1300-1305 Protein denotes Cue1p
T28 1388-1393 Protein denotes Cue1p
T29 1493-1498 Protein denotes Cue1p

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 580-584 OrganismTaxon denotes idea 76236

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 142-151 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 213-222 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 322-330 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T6 995-1003 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158