PubMed:1829648
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/1829648","sourcedb":"PubMed","sourceid":"1829648","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/1829648","text":"Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.\nWe have cloned a group of cDNAs representing mRNAs that are rapidly induced following adherence of human monocytes. One of the induced transcripts (MAD-3) encodes a protein of 317 amino acids with one domain containing five tandem repeats of the cdc10/ankyrin motif, which is 60% similar (46% identical) to the ankyrin repeat region of the precursor of NF-kappa B/KBF1 p50. The C-terminus has a putative protein kinase C phosphorylation site. In vitro translated MAD-3 protein was found to specifically inhibit the DNA-binding activity of the p50/p65 NF-kappa B complex but not that of the p50/p50 KBF1 factor or of other DNA-binding proteins. The MAD-3 cDNA encodes an I kappa B-like protein that is likely to be involved in regulation of transcriptional responses to NF-kappa B, including adhesion-dependent pathways of monocyte 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