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PubMed:18287095 JSONTXT

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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 363-382 DiseaseOrPhenotypicFeature denotes bacterial infection 0005113
T2 731-736 DiseaseOrPhenotypicFeature denotes Ebola 0005737
T3 738-758 DiseaseOrPhenotypicFeature denotes vesicular stomatitis 0025028
T4 764-770 DiseaseOrPhenotypicFeature denotes rabies 0019173
T5 1211-1216 DiseaseOrPhenotypicFeature denotes Ebola 0005737

sentences

Id Subject Object Predicate Lexical cue
T1 0-86 Sentence denotes ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.
T2 87-226 Sentence denotes Interferons regulate diverse immune functions through the transcriptional activation of hundreds of genes involved in anti-viral responses.
T3 227-453 Sentence denotes The interferon-inducible ubiquitin-like protein ISG15 is expressed in cells in response to a variety of stress conditions like viral or bacterial infection and is present in its free form or is conjugated to cellular proteins.
T4 454-535 Sentence denotes In addition, protein ubiquitination plays a regulatory role in the immune system.
T5 536-640 Sentence denotes Many viruses modulate the ubiquitin (Ub) pathway to alter cellular signaling and the antiviral response.
T6 641-869 Sentence denotes Ubiquitination of retroviral group-specific antigen precursors and matrix proteins of the Ebola, vesicular stomatitis, and rabies viruses by Nedd4 family HECT domain E3 ligases is an important step in facilitating viral release.
T7 870-923 Sentence denotes We found that Nedd4 is negatively regulated by ISG15.
T8 924-1063 Sentence denotes Free ISG15 specifically bound to Nedd4 and blocked its interaction with Ub-E2 molecules, thus preventing further Ub transfer from E2 to E3.
T9 1064-1258 Sentence denotes Furthermore, overexpression of ISG15 diminished the ability of Nedd4 to ubiquitinate viral matrix proteins and led to a decrease in the release of Ebola VP40 virus-like particles from the cells.
T10 1259-1429 Sentence denotes These results point to a mechanistically novel function of ISG15 in the enhancement of the innate anti-viral response through specific inhibition of Nedd4 Ub-E3 activity.
T11 1430-1589 Sentence denotes To our knowledge, this is the first example of a Ub-like protein with the ability to interfere with Ub-E2 and E3 interaction to inhibit protein ubiquitination.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 252-280 gene:9636 denotes ubiquitin-like protein ISG15
T1 331-337 disease:C3825627 denotes stress
T2 252-280 gene:9636 denotes ubiquitin-like protein ISG15
T3 363-382 disease:C0004623 denotes bacterial infection
R1 T0 T1 associated_with ubiquitin-like protein ISG15,stress
R2 T2 T3 associated_with ubiquitin-like protein ISG15,bacterial infection

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 0-5 Protein denotes ISG15
T2 15-20 Protein denotes Nedd4
T3 252-261 Protein denotes ubiquitin
T4 275-280 Protein denotes ISG15
T5 562-571 Protein denotes ubiquitin
T6 573-575 Protein denotes Ub
T7 782-787 Protein denotes Nedd4
T8 884-889 Protein denotes Nedd4
T9 917-922 Protein denotes ISG15
T10 929-934 Protein denotes ISG15
T11 957-962 Protein denotes Nedd4
T12 996-998 Protein denotes Ub
T13 1037-1039 Protein denotes Ub
T14 1095-1100 Protein denotes ISG15
T15 1127-1132 Protein denotes Nedd4
T16 1318-1323 Protein denotes ISG15
T17 1408-1413 Protein denotes Nedd4
T18 1414-1416 Protein denotes Ub
T19 1479-1481 Protein denotes Ub
T20 1530-1532 Protein denotes Ub

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18287095-2#25#53#gene9636 252-280 gene9636 denotes ubiquitin-like protein ISG15
18287095-2#136#155#diseaseC0004623 363-382 diseaseC0004623 denotes bacterial infection
18287095-8#31#36#gene9636 1095-1100 gene9636 denotes ISG15
18287095-8#63#68#gene4734 1127-1132 gene4734 denotes Nedd4
18287095-8#147#152#diseaseC0282687 1211-1216 diseaseC0282687 denotes Ebola
25#53#gene9636136#155#diseaseC0004623 18287095-2#25#53#gene9636 18287095-2#136#155#diseaseC0004623 associated_with ubiquitin-like protein ISG15,bacterial infection
31#36#gene9636147#152#diseaseC0282687 18287095-8#31#36#gene9636 18287095-8#147#152#diseaseC0282687 associated_with ISG15,Ebola
63#68#gene4734147#152#diseaseC0282687 18287095-8#63#68#gene4734 18287095-8#147#152#diseaseC0282687 associated_with Nedd4,Ebola

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 748-758 Phenotype denotes stomatitis HP:0010280

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 363-382 Disease denotes bacterial infection http://purl.obolibrary.org/obo/MONDO_0005113
T2 731-736 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737
T3 738-758 Disease denotes vesicular stomatitis http://purl.obolibrary.org/obo/MONDO_0025028
T4 764-770 Disease denotes rabies http://purl.obolibrary.org/obo/MONDO_0019173
T5 1211-1216 Disease denotes Ebola http://purl.obolibrary.org/obo/MONDO_0005737

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 764-778 OrganismTaxon denotes rabies viruses 11292

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 521-534 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405