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PMID_GLOBAL

Id Subject Object Predicate Lexical cue mondo_id
T1 642-658 DiseaseOrPhenotypicFeature denotes T cell lymphomas 0015760
T2 693-698 DiseaseOrPhenotypicFeature denotes tumor 0005070
T3 1502-1507 DiseaseOrPhenotypicFeature denotes tumor 0005070

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-126 Sentence denotes Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
T2 127-404 Sentence denotes The protein kinase encoded by the Tpl2 protooncogene plays an obligatory role in the transduction of Toll-like receptor and death receptor signals in macrophages, B cells, mouse embryo fibroblasts, and epithelial cells in culture and promotes inflammatory responses in animals.
T3 405-585 Sentence denotes To address its role in T cell activation, we crossed the T cell receptor (TCR) transgene 2C, which recognizes class I MHC presented peptides, into the Tpl2(-/-) genetic background.
T4 586-688 Sentence denotes Surprisingly, the TCR2C(tg/tg)/Tpl2(-/-) mice developed T cell lymphomas with a latency of 4-6 months.
T5 689-874 Sentence denotes The tumor cells were consistently TCR2C(+)CD8(+)CD4(-), suggesting that they were derived either from chronically stimulated mature T cells or from immature single positive (ISP) cells.
T6 875-1039 Sentence denotes Further studies showed that the population of CD8(+) ISP cells was not expanded in the thymus of TCR2C(tg/tg)/Tpl2(-/-) mice, making the latter hypothesis unlikely.
T7 1040-1176 Sentence denotes Mature peripheral T cells of Tpl2(-/-) mice were defective in ERK activation and exhibited enhanced proliferation after TCR stimulation.
T8 1177-1319 Sentence denotes The same cells were defective in the induction of CTLA4, a negative regulator of the T cell response, which is induced by TCR signals via ERK.
T9 1320-1448 Sentence denotes These findings suggest that Tpl2 functions normally in a feedback loop that switches off the T cell response to TCR stimulation.
T10 1449-1558 Sentence denotes As a result, Tpl2, a potent oncogene, functions as a tumor suppressor gene in chronically stimulated T cells.
T1 0-126 Sentence denotes Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells.
T2 127-404 Sentence denotes The protein kinase encoded by the Tpl2 protooncogene plays an obligatory role in the transduction of Toll-like receptor and death receptor signals in macrophages, B cells, mouse embryo fibroblasts, and epithelial cells in culture and promotes inflammatory responses in animals.
T3 405-585 Sentence denotes To address its role in T cell activation, we crossed the T cell receptor (TCR) transgene 2C, which recognizes class I MHC presented peptides, into the Tpl2(-/-) genetic background.
T4 586-688 Sentence denotes Surprisingly, the TCR2C(tg/tg)/Tpl2(-/-) mice developed T cell lymphomas with a latency of 4-6 months.
T5 689-874 Sentence denotes The tumor cells were consistently TCR2C(+)CD8(+)CD4(-), suggesting that they were derived either from chronically stimulated mature T cells or from immature single positive (ISP) cells.
T6 875-1039 Sentence denotes Further studies showed that the population of CD8(+) ISP cells was not expanded in the thymus of TCR2C(tg/tg)/Tpl2(-/-) mice, making the latter hypothesis unlikely.
T7 1040-1176 Sentence denotes Mature peripheral T cells of Tpl2(-/-) mice were defective in ERK activation and exhibited enhanced proliferation after TCR stimulation.
T8 1177-1319 Sentence denotes The same cells were defective in the induction of CTLA4, a negative regulator of the T cell response, which is induced by TCR signals via ERK.
T9 1320-1448 Sentence denotes These findings suggest that Tpl2 functions normally in a feedback loop that switches off the T cell response to TCR stimulation.
T10 1449-1558 Sentence denotes As a result, Tpl2, a potent oncogene, functions as a tumor suppressor gene in chronically stimulated T cells.