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PubMed:18274891 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 211-227 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 986-996 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 181-195 Glycan_Motif denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T2 200-207 Glycan_Motif denotes Lewis X https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 181-195 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl Lewis X
T2 200-207 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis X

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-95 Sentence denotes Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
TextSentencer_T2 96-228 Sentence denotes The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme for synthesis of sialyl Lewis X and Lewis X in epithelial cells.
TextSentencer_T3 229-323 Sentence denotes Despite its importance, how FUT VI expression is regulated has not previously been elucidated.
TextSentencer_T4 324-436 Sentence denotes In this work, we examined transcriptional regulation of the FUT VI gene in hepatocellular carcinoma HepG2 cells.
TextSentencer_T5 437-665 Sentence denotes 5'-Rapid amplification of cDNA ends analysis revealed transcription start sites of FUT VI in HepG2 cells at +65 and +278 nucleotides (nt) downstream of the position registered in the Data Base of Human Transcription Start Sites.
TextSentencer_T6 666-762 Sentence denotes We determined promoter regions for FUT VI in HepG2 cells using a luciferase reporter gene assay.
TextSentencer_T7 763-924 Sentence denotes The promoter activities of constructs located 5'-upstream of the transcription start site decreased when the -186 to -156 and -56 to -19 nt regions were deleted.
TextSentencer_T8 925-1142 Sentence denotes Site-directed mutagenesis of these regions revealed that two hepatocyte nuclear factor-4 alpha (HNF-4 alpha) and one octamer binding transcription factor-1 (Oct-1) binding sites are essential for FUT VI transcription.
TextSentencer_T9 1143-1290 Sentence denotes Furthermore, transient over-expression of HNF-4 alpha but not Oct-1 enhanced both FUT VI promoter activities and FUT VI mRNA levels in HuH-7 cells.
TextSentencer_T10 1291-1456 Sentence denotes These results suggest that two defined regions in the 5'-flanking region of the FUT VI transcription start site are critical for FUT VI transcription in HepG2 cells.
T1 0-95 Sentence denotes Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
T2 96-228 Sentence denotes The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme for synthesis of sialyl Lewis X and Lewis X in epithelial cells.
T3 229-323 Sentence denotes Despite its importance, how FUT VI expression is regulated has not previously been elucidated.
T4 324-436 Sentence denotes In this work, we examined transcriptional regulation of the FUT VI gene in hepatocellular carcinoma HepG2 cells.
T5 437-665 Sentence denotes 5'-Rapid amplification of cDNA ends analysis revealed transcription start sites of FUT VI in HepG2 cells at +65 and +278 nucleotides (nt) downstream of the position registered in the Data Base of Human Transcription Start Sites.
T6 666-762 Sentence denotes We determined promoter regions for FUT VI in HepG2 cells using a luciferase reporter gene assay.
T7 763-924 Sentence denotes The promoter activities of constructs located 5'-upstream of the transcription start site decreased when the -186 to -156 and -56 to -19 nt regions were deleted.
T8 925-1142 Sentence denotes Site-directed mutagenesis of these regions revealed that two hepatocyte nuclear factor-4 alpha (HNF-4 alpha) and one octamer binding transcription factor-1 (Oct-1) binding sites are essential for FUT VI transcription.
T9 1143-1290 Sentence denotes Furthermore, transient over-expression of HNF-4 alpha but not Oct-1 enhanced both FUT VI promoter activities and FUT VI mRNA levels in HuH-7 cells.
T10 1291-1456 Sentence denotes These results suggest that two defined regions in the 5'-flanking region of the FUT VI transcription start site are critical for FUT VI transcription in HepG2 cells.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 181-195 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl Lewis X
T2 188-195 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X
T3 200-207 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis X

DisGeNET

Id Subject Object Predicate Lexical cue
T0 34-55 gene:2528 denotes fucosyltransferase VI
T1 64-88 disease:C2239176 denotes hepatocellular carcinoma
T2 384-390 gene:2528 denotes FUT VI
T3 399-423 disease:C2239176 denotes hepatocellular carcinoma
R1 T0 T1 associated_with fucosyltransferase VI,hepatocellular carcinoma
R2 T2 T3 associated_with FUT VI,hepatocellular carcinoma

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 181-195 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 200-207 Glycan denotes Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 64-88 Phenotype denotes hepatocellular carcinoma HP:0001402
T2 399-423 Phenotype denotes hepatocellular carcinoma HP:0001402

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 64-88 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T2 399-423 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 181-195 Glycan denotes sialyl Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 200-207 Glycan denotes Lewis X https://api.glycosmos.org/wurcs2image/latest/png/binary/G00051MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 181-195 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012
T2 200-207 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis X http://www.glycoepitope.jp/epitopes/EP0011

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 64-88 Phenotype denotes hepatocellular carcinoma HP:0001402
T2 399-423 Phenotype denotes hepatocellular carcinoma HP:0001402

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 211-227 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T2 986-996 Cell denotes hepatocyte http://purl.obolibrary.org/obo/CL:0000182

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 211-227 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T2 986-996 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 64-88 Disease denotes hepatocellular carcinoma MONDO:0007256
T2 399-423 Disease denotes hepatocellular carcinoma MONDO:0007256

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 633-638 Organism denotes Human 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-95 Sentence denotes Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.
T2 96-228 Sentence denotes The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme for synthesis of sialyl Lewis X and Lewis X in epithelial cells.
T3 229-323 Sentence denotes Despite its importance, how FUT VI expression is regulated has not previously been elucidated.
T4 324-436 Sentence denotes In this work, we examined transcriptional regulation of the FUT VI gene in hepatocellular carcinoma HepG2 cells.
T5 437-762 Sentence denotes 5'-Rapid amplification of cDNA ends analysis revealed transcription start sites of FUT VI in HepG2 cells at +65 and +278 nucleotides (nt) downstream of the position registered in the Data Base of Human Transcription Start Sites. We determined promoter regions for FUT VI in HepG2 cells using a luciferase reporter gene assay.
T6 763-924 Sentence denotes The promoter activities of constructs located 5'-upstream of the transcription start site decreased when the -186 to -156 and -56 to -19 nt regions were deleted.
T7 925-1142 Sentence denotes Site-directed mutagenesis of these regions revealed that two hepatocyte nuclear factor-4 alpha (HNF-4 alpha) and one octamer binding transcription factor-1 (Oct-1) binding sites are essential for FUT VI transcription.
T8 1143-1290 Sentence denotes Furthermore, transient over-expression of HNF-4 alpha but not Oct-1 enhanced both FUT VI promoter activities and FUT VI mRNA levels in HuH-7 cells.
T9 1291-1456 Sentence denotes These results suggest that two defined regions in the 5'-flanking region of the FUT VI transcription start site are critical for FUT VI transcription in HepG2 cells.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 181-195 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl Lewis X http://www.glycoepitope.jp/epitopes/EP0012
T2 200-207 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes Lewis X http://www.glycoepitope.jp/epitopes/EP0011

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 211-227 Body_part denotes epithelial cells FMA:66768
T2 986-996 Body_part denotes hepatocyte FMA:14515

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 633-638 OrganismTaxon denotes Human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 211-227 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T2 986-996 Body_part denotes hepatocyte http://purl.obolibrary.org/obo/CL_0000182