PubMed:18264140 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/18264140","sourcedb":"PubMed","sourceid":"18264140","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/18264140","text":"Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.\nExpression level of metastasis-associated protein 1 (MTA1) is closely related to tumor growth and metastasis in various cancers. Although increased expression level of MTA1 was observed in hepatocellular carcinoma (HCC), role of MTA1 complex containing histone deacetylase (HDAC) in hepatitis B virus (HBV)-associated hepatocarcinogenesis has not been studied. Here, we demonstrated that HBx strongly induced the expression of MTA1 and HDAC1 genes at transcription level. MTA1 and HDAC1/2 physically associated with hypoxia-inducible factor-1 alpha (HIF-1 alpha) in vivo in the presence of HBx, which was abolished by knockdown of MTA1 by short interfering RNA (siRNA). HBx induced deacetylation of the oxygen-dependent degradation domain of HIF-1 alpha, which was accompanied with dissociation of prolyl hydroxylases and von Hippel-Lindau tumor suppressor from HIF-1 alpha. These results indicate that HBx-induced deacetylation is important for proteasomal degradation of HIF-1 alpha. Further, we observed that protein levels of MTA1 and HDAC1 were increased in the liver of HBx-transgenic mice. Also, there was a higher expression of HDAC1 in HCC than in the adjacent non-tumorous cirrhotic nodules in 10 out of 12 human HBV-associated HCC specimens. Together, our data indicate a positive cross talk between HBx and the MTA1/HDAC complex in stabilizing HIF-1 alpha, which may play a critical role in angiogenesis and metastasis of HBV-associated HCC.","tracks":[{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":63,"end":68},"obj":"gene:3065"},{"id":"T1","span":{"begin":106,"end":130},"obj":"disease:C2239176"},{"id":"T2","span":{"begin":63,"end":68},"obj":"gene:3065"},{"id":"T3","span":{"begin":0,"end":11},"obj":"disease:C0019163"},{"id":"T4","span":{"begin":54,"end":58},"obj":"gene:9112"},{"id":"T5","span":{"begin":0,"end":11},"obj":"disease:C0019163"},{"id":"T6","span":{"begin":191,"end":195},"obj":"gene:9112"},{"id":"T7","span":{"begin":236,"end":246},"obj":"disease:C2939420"},{"id":"T8","span":{"begin":191,"end":195},"obj":"gene:9112"},{"id":"T9","span":{"begin":258,"end":265},"obj":"disease:C0006826"},{"id":"T10","span":{"begin":158,"end":187},"obj":"gene:284348"},{"id":"T11","span":{"begin":236,"end":246},"obj":"disease:C2939420"},{"id":"T12","span":{"begin":158,"end":187},"obj":"gene:284348"},{"id":"T13","span":{"begin":236,"end":246},"obj":"disease:C0027627"},{"id":"T14","span":{"begin":191,"end":195},"obj":"gene:9112"},{"id":"T15","span":{"begin":236,"end":246},"obj":"disease:C0027627"},{"id":"T16","span":{"begin":158,"end":187},"obj":"gene:284348"},{"id":"T17","span":{"begin":258,"end":265},"obj":"disease:C0006826"},{"id":"T18","span":{"begin":367,"end":371},"obj":"gene:9112"},{"id":"T19","span":{"begin":327,"end":351},"obj":"disease:C2239176"},{"id":"T20","span":{"begin":367,"end":371},"obj":"gene:9112"},{"id":"T21","span":{"begin":353,"end":356},"obj":"disease:C2239176"},{"id":"T22","span":{"begin":306,"end":310},"obj":"gene:9112"},{"id":"T23","span":{"begin":421,"end":432},"obj":"disease:C0019163"},{"id":"T24","span":{"begin":367,"end":371},"obj":"gene:9112"},{"id":"T25","span":{"begin":456,"end":476},"obj":"disease:C1512409"},{"id":"T26","span":{"begin":306,"end":310},"obj":"gene:9112"},{"id":"T27","span":{"begin":353,"end":356},"obj":"disease:C2239176"},{"id":"T28","span":{"begin":306,"end":310},"obj":"gene:9112"},{"id":"T29","span":{"begin":327,"end":351},"obj":"disease:C2239176"},{"id":"T30","span":{"begin":306,"end":310},"obj":"gene:9112"},{"id":"T31","span":{"begin":456,"end":476},"obj":"disease:C1512409"},{"id":"T32","span":{"begin":367,"end":371},"obj":"gene:9112"},{"id":"T33","span":{"begin":421,"end":432},"obj":"disease:C0019163"},{"id":"T34","span":{"begin":1274,"end":1279},"obj":"gene:3065"},{"id":"T35","span":{"begin":1376,"end":1379},"obj":"disease:C2239176"},{"id":"T36","span":{"begin":1274,"end":1279},"obj":"gene:3065"},{"id":"T37","span":{"begin":1283,"end":1286},"obj":"disease:C2239176"},{"id":"T38","span":{"begin":1494,"end":1505},"obj":"gene:3091"},{"id":"T39","span":{"begin":1587,"end":1590},"obj":"disease:C2239176"},{"id":"T40","span":{"begin":1494,"end":1505},"obj":"gene:3091"},{"id":"T41","span":{"begin":1558,"end":1568},"obj":"disease:C2939420"},{"id":"T42","span":{"begin":1494,"end":1505},"obj":"gene:3091"},{"id":"T43","span":{"begin":1558,"end":1568},"obj":"disease:C0027627"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"},{"id":"R6","pred":"associated_with","subj":"T10","obj":"T11"},{"id":"R7","pred":"associated_with","subj":"T12","obj":"T13"},{"id":"R8","pred":"associated_with","subj":"T14","obj":"T15"},{"id":"R9","pred":"associated_with","subj":"T16","obj":"T17"},{"id":"R10","pred":"associated_with","subj":"T18","obj":"T19"},{"id":"R11","pred":"associated_with","subj":"T20","obj":"T21"},{"id":"R12","pred":"associated_with","subj":"T22","obj":"T23"},{"id":"R13","pred":"associated_with","subj":"T24","obj":"T25"},{"id":"R14","pred":"associated_with","subj":"T26","obj":"T27"},{"id":"R15","pred":"associated_with","subj":"T28","obj":"T29"},{"id":"R16","pred":"associated_with","subj":"T30","obj":"T31"},{"id":"R17","pred":"associated_with","subj":"T32","obj":"T33"},{"id":"R18","pred":"associated_with","subj":"T34","obj":"T35"},{"id":"R19","pred":"associated_with","subj":"T36","obj":"T37"},{"id":"R20","pred":"associated_with","subj":"T38","obj":"T39"},{"id":"R21","pred":"associated_with","subj":"T40","obj":"T41"},{"id":"R22","pred":"associated_with","subj":"T42","obj":"T43"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"},{"subj":"T8","pred":"source","obj":"DisGeNET"},{"subj":"T9","pred":"source","obj":"DisGeNET"},{"subj":"T10","pred":"source","obj":"DisGeNET"},{"subj":"T11","pred":"source","obj":"DisGeNET"},{"subj":"T12","pred":"source","obj":"DisGeNET"},{"subj":"T13","pred":"source","obj":"DisGeNET"},{"subj":"T14","pred":"source","obj":"DisGeNET"},{"subj":"T15","pred":"source","obj":"DisGeNET"},{"subj":"T16","pred":"source","obj":"DisGeNET"},{"subj":"T17","pred":"source","obj":"DisGeNET"},{"subj":"T18","pred":"source","obj":"DisGeNET"},{"subj":"T19","pred":"source","obj":"DisGeNET"},{"subj":"T20","pred":"source","obj":"DisGeNET"},{"subj":"T21","pred":"source","obj":"DisGeNET"},{"subj":"T22","pred":"source","obj":"DisGeNET"},{"subj":"T23","pred":"source","obj":"DisGeNET"},{"subj":"T24","pred":"source","obj":"DisGeNET"},{"subj":"T25","pred":"source","obj":"DisGeNET"},{"subj":"T26","pred":"source","obj":"DisGeNET"},{"subj":"T27","pred":"source","obj":"DisGeNET"},{"subj":"T28","pred":"source","obj":"DisGeNET"},{"subj":"T29","pred":"source","obj":"DisGeNET"},{"subj":"T30","pred":"source","obj":"DisGeNET"},{"subj":"T31","pred":"source","obj":"DisGeNET"},{"subj":"T32","pred":"source","obj":"DisGeNET"},{"subj":"T33","pred":"source","obj":"DisGeNET"},{"subj":"T34","pred":"source","obj":"DisGeNET"},{"subj":"T35","pred":"source","obj":"DisGeNET"},{"subj":"T36","pred":"source","obj":"DisGeNET"},{"subj":"T37","pred":"source","obj":"DisGeNET"},{"subj":"T38","pred":"source","obj":"DisGeNET"},{"subj":"T39","pred":"source","obj":"DisGeNET"},{"subj":"T40","pred":"source","obj":"DisGeNET"},{"subj":"T41","pred":"source","obj":"DisGeNET"},{"subj":"T42","pred":"source","obj":"DisGeNET"},{"subj":"T43","pred":"source","obj":"DisGeNET"}]},{"project":"bionlp-st-epi-2011-training","denotations":[{"id":"T1","span":{"begin":18,"end":19},"obj":"Protein"},{"id":"T2","span":{"begin":54,"end":58},"obj":"Protein"},{"id":"T3","span":{"begin":63,"end":68},"obj":"Protein"},{"id":"T4","span":{"begin":158,"end":189},"obj":"Protein"},{"id":"T5","span":{"begin":191,"end":195},"obj":"Protein"},{"id":"T6","span":{"begin":306,"end":310},"obj":"Protein"},{"id":"T7","span":{"begin":367,"end":371},"obj":"Protein"},{"id":"T8","span":{"begin":391,"end":398},"obj":"Protein"},{"id":"T9","span":{"begin":526,"end":529},"obj":"Protein"},{"id":"T10","span":{"begin":565,"end":569},"obj":"Protein"},{"id":"T11","span":{"begin":574,"end":579},"obj":"Protein"},{"id":"T12","span":{"begin":610,"end":614},"obj":"Protein"},{"id":"T13","span":{"begin":619,"end":624},"obj":"Protein"},{"id":"T14","span":{"begin":625,"end":626},"obj":"Protein"},{"id":"T15","span":{"begin":654,"end":686},"obj":"Protein"},{"id":"T16","span":{"begin":688,"end":699},"obj":"Protein"},{"id":"T17","span":{"begin":728,"end":731},"obj":"Protein"},{"id":"T18","span":{"begin":769,"end":773},"obj":"Protein"},{"id":"T19","span":{"begin":808,"end":811},"obj":"Protein"},{"id":"T20","span":{"begin":880,"end":891},"obj":"Protein"},{"id":"T21","span":{"begin":960,"end":994},"obj":"Protein"},{"id":"T22","span":{"begin":1000,"end":1011},"obj":"Protein"},{"id":"T23","span":{"begin":1041,"end":1044},"obj":"Protein"},{"id":"T24","span":{"begin":1111,"end":1122},"obj":"Protein"},{"id":"T25","span":{"begin":1168,"end":1172},"obj":"Protein"},{"id":"T26","span":{"begin":1177,"end":1182},"obj":"Protein"},{"id":"T27","span":{"begin":1214,"end":1217},"obj":"Protein"},{"id":"T28","span":{"begin":1274,"end":1279},"obj":"Protein"},{"id":"T29","span":{"begin":1449,"end":1452},"obj":"Protein"},{"id":"T30","span":{"begin":1461,"end":1465},"obj":"Protein"},{"id":"T31","span":{"begin":1494,"end":1505},"obj":"Protein"}],"attributes":[{"subj":"T1","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T2","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T3","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T4","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T5","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T6","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T7","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T8","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T9","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T10","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T11","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T12","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T13","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T14","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T15","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T16","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T17","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T18","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T19","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T20","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T21","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T22","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T23","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T24","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T25","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T26","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T27","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T28","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T29","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T30","pred":"source","obj":"bionlp-st-epi-2011-training"},{"subj":"T31","pred":"source","obj":"bionlp-st-epi-2011-training"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"18264140-0#54#58#gene9112","span":{"begin":54,"end":58},"obj":"gene9112"},{"id":"18264140-0#63#68#gene3065","span":{"begin":63,"end":68},"obj":"gene3065"},{"id":"18264140-0#0#11#diseaseC0019163","span":{"begin":0,"end":11},"obj":"diseaseC0019163"},{"id":"18264140-0#106#130#diseaseC2239176","span":{"begin":106,"end":130},"obj":"diseaseC2239176"},{"id":"18264140-1#20#49#gene284348","span":{"begin":158,"end":187},"obj":"gene284348"},{"id":"18264140-1#98#108#diseaseC0027627","span":{"begin":236,"end":246},"obj":"diseaseC0027627"},{"id":"18264140-2#39#43#gene9112","span":{"begin":306,"end":310},"obj":"gene9112"},{"id":"18264140-2#100#104#gene9112","span":{"begin":367,"end":371},"obj":"gene9112"},{"id":"18264140-2#60#84#diseaseC2239176","span":{"begin":327,"end":351},"obj":"diseaseC2239176"},{"id":"18264140-2#86#89#diseaseC2239176","span":{"begin":353,"end":356},"obj":"diseaseC2239176"},{"id":"18264140-2#189#209#diseaseC1512409","span":{"begin":456,"end":476},"obj":"diseaseC1512409"},{"id":"18264140-2#60#84#diseaseC2239176","span":{"begin":327,"end":351},"obj":"diseaseC2239176"},{"id":"18264140-2#86#89#diseaseC2239176","span":{"begin":353,"end":356},"obj":"diseaseC2239176"},{"id":"18264140-2#189#209#diseaseC1512409","span":{"begin":456,"end":476},"obj":"diseaseC1512409"},{"id":"18264140-9#70#74#gene9112","span":{"begin":1461,"end":1465},"obj":"gene9112"},{"id":"18264140-9#103#114#gene3091","span":{"begin":1494,"end":1505},"obj":"gene3091"},{"id":"18264140-9#103#114#gene3091","span":{"begin":1494,"end":1505},"obj":"gene3091"},{"id":"18264140-9#167#177#diseaseC0027627","span":{"begin":1558,"end":1568},"obj":"diseaseC0027627"},{"id":"18264140-9#196#199#diseaseC2239176","span":{"begin":1587,"end":1590},"obj":"diseaseC2239176"}],"relations":[{"id":"54#58#gene91120#11#diseaseC0019163","pred":"associated_with","subj":"18264140-0#54#58#gene9112","obj":"18264140-0#0#11#diseaseC0019163"},{"id":"54#58#gene9112106#130#diseaseC2239176","pred":"associated_with","subj":"18264140-0#54#58#gene9112","obj":"18264140-0#106#130#diseaseC2239176"},{"id":"63#68#gene30650#11#diseaseC0019163","pred":"associated_with","subj":"18264140-0#63#68#gene3065","obj":"18264140-0#0#11#diseaseC0019163"},{"id":"63#68#gene3065106#130#diseaseC2239176","pred":"associated_with","subj":"18264140-0#63#68#gene3065","obj":"18264140-0#106#130#diseaseC2239176"},{"id":"20#49#gene28434898#108#diseaseC0027627","pred":"associated_with","subj":"18264140-1#20#49#gene284348","obj":"18264140-1#98#108#diseaseC0027627"},{"id":"39#43#gene911260#84#diseaseC2239176","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#60#84#diseaseC2239176"},{"id":"39#43#gene911286#89#diseaseC2239176","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#86#89#diseaseC2239176"},{"id":"39#43#gene9112189#209#diseaseC1512409","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#189#209#diseaseC1512409"},{"id":"39#43#gene911260#84#diseaseC2239176","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#60#84#diseaseC2239176"},{"id":"39#43#gene911286#89#diseaseC2239176","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#86#89#diseaseC2239176"},{"id":"39#43#gene9112189#209#diseaseC1512409","pred":"associated_with","subj":"18264140-2#39#43#gene9112","obj":"18264140-2#189#209#diseaseC1512409"},{"id":"100#104#gene911260#84#diseaseC2239176","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#60#84#diseaseC2239176"},{"id":"100#104#gene911286#89#diseaseC2239176","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#86#89#diseaseC2239176"},{"id":"100#104#gene9112189#209#diseaseC1512409","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#189#209#diseaseC1512409"},{"id":"100#104#gene911260#84#diseaseC2239176","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#60#84#diseaseC2239176"},{"id":"100#104#gene911286#89#diseaseC2239176","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#86#89#diseaseC2239176"},{"id":"100#104#gene9112189#209#diseaseC1512409","pred":"associated_with","subj":"18264140-2#100#104#gene9112","obj":"18264140-2#189#209#diseaseC1512409"},{"id":"70#74#gene9112167#177#diseaseC0027627","pred":"associated_with","subj":"18264140-9#70#74#gene9112","obj":"18264140-9#167#177#diseaseC0027627"},{"id":"70#74#gene9112196#199#diseaseC2239176","pred":"associated_with","subj":"18264140-9#70#74#gene9112","obj":"18264140-9#196#199#diseaseC2239176"},{"id":"103#114#gene3091167#177#diseaseC0027627","pred":"associated_with","subj":"18264140-9#103#114#gene3091","obj":"18264140-9#167#177#diseaseC0027627"},{"id":"103#114#gene3091196#199#diseaseC2239176","pred":"associated_with","subj":"18264140-9#103#114#gene3091","obj":"18264140-9#196#199#diseaseC2239176"},{"id":"103#114#gene3091167#177#diseaseC0027627","pred":"associated_with","subj":"18264140-9#103#114#gene3091","obj":"18264140-9#167#177#diseaseC0027627"},{"id":"103#114#gene3091196#199#diseaseC2239176","pred":"associated_with","subj":"18264140-9#103#114#gene3091","obj":"18264140-9#196#199#diseaseC2239176"}],"attributes":[{"subj":"18264140-0#54#58#gene9112","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-0#63#68#gene3065","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-0#0#11#diseaseC0019163","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-0#106#130#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-1#20#49#gene284348","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-1#98#108#diseaseC0027627","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#39#43#gene9112","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#100#104#gene9112","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#60#84#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#86#89#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#189#209#diseaseC1512409","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#60#84#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#86#89#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-2#189#209#diseaseC1512409","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-9#70#74#gene9112","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-9#103#114#gene3091","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-9#103#114#gene3091","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-9#167#177#diseaseC0027627","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"18264140-9#196#199#diseaseC2239176","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"DisGeNET","color":"#c693ec","default":true},{"id":"bionlp-st-epi-2011-training","color":"#93ecac"},{"id":"DisGeNET5_gene_disease","color":"#ec9393"}]}]}}