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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma.
TextSentencer_T2 128-325 Sentence denotes CCN3/nephroblastoma overexpressed belongs to the CCN family of genes that encode secreted proteins associated with the extracellular matrix (ECM) and exert regulatory effects at the cellular level.
TextSentencer_T3 326-451 Sentence denotes Overexpression of CCN3 was shown in metastatic melanoma cells compared with cells of the primary tumor from the same patient.
TextSentencer_T4 452-667 Sentence denotes Analysis of short-term cultures from 50 primary and metastatic melanomas revealed a heterogeneous expression pattern of both the 46-kDa full-length cytoplasmic/secreted protein and the 32-kDa nuclear-truncated form.
TextSentencer_T5 668-769 Sentence denotes The different protein expression patterns were not associated with gene alterations or polymorphisms.
TextSentencer_T6 770-1029 Sentence denotes Like the metastatic cells expressing high levels of the 46-kDa CCN3, cells transfected to overexpress CCN3 showed increased adhesion to ECM proteins, whereas inhibition of CCN3 expression by small interfering RNA decreased adhesion to laminin and vitronectin.
TextSentencer_T7 1030-1195 Sentence denotes CCN3 overexpression induced increased expression of laminin and vitronectin integrin receptors alpha 7 beta 1 and alpha v beta 5 by increasing their mRNA production.
TextSentencer_T8 1196-1304 Sentence denotes Moreover, CCN3 secreted by melanoma cells acted as an adhesion matrix protein for melanoma cells themselves.
TextSentencer_T9 1305-1573 Sentence denotes Analysis of CCN3 protein expression with respect to melanoma progression detected the protein in all visceral metastases tested and in most nodal metastases from relapsing patients but in only a few nodal metastases from nonrelapsing patients and cutaneous metastases.
TextSentencer_T10 1574-1707 Sentence denotes Consistently, xenotransplantation in immunodeficient mice showed a higher metastatic potential of melanoma cells overexpressing CCN3.
TextSentencer_T11 1708-1921 Sentence denotes Together, these data indicate a role for CCN3 in melanoma cell interaction with the ECM by regulating integrin expression, resulting in altered cell adhesion and leading melanoma progression to aggressive disease.
T1 0-127 Sentence denotes CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma.
T2 128-325 Sentence denotes CCN3/nephroblastoma overexpressed belongs to the CCN family of genes that encode secreted proteins associated with the extracellular matrix (ECM) and exert regulatory effects at the cellular level.
T3 326-451 Sentence denotes Overexpression of CCN3 was shown in metastatic melanoma cells compared with cells of the primary tumor from the same patient.
T4 452-667 Sentence denotes Analysis of short-term cultures from 50 primary and metastatic melanomas revealed a heterogeneous expression pattern of both the 46-kDa full-length cytoplasmic/secreted protein and the 32-kDa nuclear-truncated form.
T5 668-769 Sentence denotes The different protein expression patterns were not associated with gene alterations or polymorphisms.
T6 770-1029 Sentence denotes Like the metastatic cells expressing high levels of the 46-kDa CCN3, cells transfected to overexpress CCN3 showed increased adhesion to ECM proteins, whereas inhibition of CCN3 expression by small interfering RNA decreased adhesion to laminin and vitronectin.
T7 1030-1195 Sentence denotes CCN3 overexpression induced increased expression of laminin and vitronectin integrin receptors alpha 7 beta 1 and alpha v beta 5 by increasing their mRNA production.
T8 1196-1304 Sentence denotes Moreover, CCN3 secreted by melanoma cells acted as an adhesion matrix protein for melanoma cells themselves.
T9 1305-1573 Sentence denotes Analysis of CCN3 protein expression with respect to melanoma progression detected the protein in all visceral metastases tested and in most nodal metastases from relapsing patients but in only a few nodal metastases from nonrelapsing patients and cutaneous metastases.
T10 1574-1707 Sentence denotes Consistently, xenotransplantation in immunodeficient mice showed a higher metastatic potential of melanoma cells overexpressing CCN3.
T11 1708-1921 Sentence denotes Together, these data indicate a role for CCN3 in melanoma cell interaction with the ECM by regulating integrin expression, resulting in altered cell adhesion and leading melanoma progression to aggressive disease.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1749-1753 gene:4856 denotes CCN3
T1 1757-1765 disease:C0025202 denotes melanoma
T2 1749-1753 gene:4856 denotes CCN3
T3 1878-1886 disease:C0025202 denotes melanoma
R1 T0 T1 associated_with CCN3,melanoma
R2 T2 T3 associated_with CCN3,melanoma

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18245471-0#5#33#gene4856 133-161 gene4856 denotes nephroblastoma overexpressed
18245471-0#118#126#diseaseC0025202 1179-1231 diseaseC0025202 denotes mRNA production. Moreover, CCN3 secreted by melanoma
18245471-2#18#22#gene4856 344-348 gene4856 denotes CCN3
18245471-2#36#55#diseaseC0278883 362-381 diseaseC0278883 denotes metastatic melanoma
18245471-8#12#16#gene4856 1317-1321 gene4856 denotes CCN3
18245471-8#110#120#diseaseC0027627 1415-1425 diseaseC0027627 denotes metastases
18245471-8#146#156#diseaseC0027627 1451-1461 diseaseC0027627 denotes metastases
18245471-8#205#215#diseaseC0027627 1510-1520 diseaseC0027627 denotes metastases
18245471-8#257#267#diseaseC0027627 1562-1572 diseaseC0027627 denotes metastases
18245471-9#128#132#gene4856 1702-1706 gene4856 denotes CCN3
18245471-9#37#52#diseaseC0021051 1611-1626 diseaseC0021051 denotes immunodeficient
5#33#gene4856118#126#diseaseC0025202 18245471-0#5#33#gene4856 18245471-0#118#126#diseaseC0025202 associated_with nephroblastoma overexpressed,"mRNA production. Moreover, CCN3 secreted by melanoma"
18#22#gene485636#55#diseaseC0278883 18245471-2#18#22#gene4856 18245471-2#36#55#diseaseC0278883 associated_with CCN3,metastatic melanoma
12#16#gene4856110#120#diseaseC0027627 18245471-8#12#16#gene4856 18245471-8#110#120#diseaseC0027627 associated_with CCN3,metastases
12#16#gene4856146#156#diseaseC0027627 18245471-8#12#16#gene4856 18245471-8#146#156#diseaseC0027627 associated_with CCN3,metastases
12#16#gene4856205#215#diseaseC0027627 18245471-8#12#16#gene4856 18245471-8#205#215#diseaseC0027627 associated_with CCN3,metastases
12#16#gene4856257#267#diseaseC0027627 18245471-8#12#16#gene4856 18245471-8#257#267#diseaseC0027627 associated_with CCN3,metastases
128#132#gene485637#52#diseaseC0021051 18245471-9#128#132#gene4856 18245471-9#37#52#diseaseC0021051 associated_with CCN3,immunodeficient

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T358 1317-1321 gene:4856 denotes CCN3
T359 1415-1425 disease:C0027627 denotes metastases
T360 1451-1461 disease:C0027627 denotes metastases
T361 1510-1520 disease:C0027627 denotes metastases
T362 1562-1572 disease:C0027627 denotes metastases
R1 T358 T359 associated_with CCN3,metastases
R2 T358 T360 associated_with CCN3,metastases
R3 T358 T361 associated_with CCN3,metastases
R4 T358 T362 associated_with CCN3,metastases