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PubMed:18234963 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.
TextSentencer_T2 125-188 Sentence denotes p53 family proteins include p53 tumor suppressor, p63, and p73.
TextSentencer_T3 189-319 Sentence denotes Despite the high similarity in structure and function with p53, p63, and p73 function in tumor suppression is still controversial.
TextSentencer_T4 320-466 Sentence denotes Here, we show that TAp73alpha, a transcriptionally active p73 isoform, is able to synergize p53 tumor suppressor function in thyroid cancer cells.
TextSentencer_T5 467-595 Sentence denotes Indeed, depletion of p73 by small interfering RNA in thyroid cancer cells resulted in a reduced transcriptional activity of p53.
TextSentencer_T6 596-816 Sentence denotes Ectopic coexpression of both p53 and TAp73alpha in thyroid cancer cells resulted in increased transcription and tumor suppressor function compared with p53 or TAp73alpha alone, as well as in increased p53 protein levels.
TextSentencer_T7 817-953 Sentence denotes The enhancing effect of TAp73alpha on p53 activity is Mdm2 dependent because it is prevented by Mdm2 depletion by small interfering RNA.
TextSentencer_T8 954-1039 Sentence denotes At least two mechanisms may explain the interference of TAp73alpha with p53 function.
TextSentencer_T9 1040-1175 Sentence denotes First, in thyroid cancer cells, TAp73alpha inhibits the effect of p53 on Mdm2 induction by antagonizing p53 at the Mdm2 promoter level.
TextSentencer_T10 1176-1348 Sentence denotes Second, a TAp73alpha mutant (G264W), which is devoid of DNA binding capability, is still able to increase p53 protein levels by competing with p53 for Mdm2 protein binding.
TextSentencer_T11 1349-1530 Sentence denotes Taken together, these results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation.
TextSentencer_T12 1531-1653 Sentence denotes These results may be useful for designing gene therapies aimed at restoring a normal p53 function in thyroid cancer cells.
T1 0-124 Sentence denotes TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation.
T2 125-188 Sentence denotes p53 family proteins include p53 tumor suppressor, p63, and p73.
T3 189-319 Sentence denotes Despite the high similarity in structure and function with p53, p63, and p73 function in tumor suppression is still controversial.
T4 320-466 Sentence denotes Here, we show that TAp73alpha, a transcriptionally active p73 isoform, is able to synergize p53 tumor suppressor function in thyroid cancer cells.
T5 467-595 Sentence denotes Indeed, depletion of p73 by small interfering RNA in thyroid cancer cells resulted in a reduced transcriptional activity of p53.
T6 596-816 Sentence denotes Ectopic coexpression of both p53 and TAp73alpha in thyroid cancer cells resulted in increased transcription and tumor suppressor function compared with p53 or TAp73alpha alone, as well as in increased p53 protein levels.
T7 817-953 Sentence denotes The enhancing effect of TAp73alpha on p53 activity is Mdm2 dependent because it is prevented by Mdm2 depletion by small interfering RNA.
T8 954-1039 Sentence denotes At least two mechanisms may explain the interference of TAp73alpha with p53 function.
T9 1040-1175 Sentence denotes First, in thyroid cancer cells, TAp73alpha inhibits the effect of p53 on Mdm2 induction by antagonizing p53 at the Mdm2 promoter level.
T10 1176-1348 Sentence denotes Second, a TAp73alpha mutant (G264W), which is devoid of DNA binding capability, is still able to increase p53 protein levels by competing with p53 for Mdm2 protein binding.
T11 1349-1530 Sentence denotes Taken together, these results indicate that in thyroid cancer cells, TAp73alpha is able to increase p53 protein level and function by interfering with Mdm2-mediated p53 degradation.
T12 1531-1653 Sentence denotes These results may be useful for designing gene therapies aimed at restoring a normal p53 function in thyroid cancer cells.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1449-1452 gene:7157 denotes p53
T1 1396-1410 disease:C0549473 denotes thyroid cancer
T2 1449-1452 gene:7157 denotes p53
T3 1396-1410 disease:C0007115 denotes thyroid cancer
T4 1616-1619 gene:7157 denotes p53
T5 1632-1646 disease:C0549473 denotes thyroid cancer
T6 1616-1619 gene:7157 denotes p53
T7 1632-1646 disease:C0007115 denotes thyroid cancer
R1 T0 T1 associated_with p53,thyroid cancer
R2 T2 T3 associated_with p53,thyroid cancer
R3 T4 T5 associated_with p53,thyroid cancer
R4 T6 T7 associated_with p53,thyroid cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18234963-0#22#42#gene7157 22-42 gene7157 denotes p53 tumor suppressor
18234963-0#55#69#diseaseC0007115 55-69 diseaseC0007115 denotes thyroid cancer
18234963-0#55#69#diseaseC0549473 55-69 diseaseC0549473 denotes thyroid cancer
18234963-4#21#24#gene83478 488-491 gene83478 denotes p73
18234963-4#21#24#gene7161 488-491 gene7161 denotes p73
18234963-4#53#67#diseaseC0007115 520-534 diseaseC0007115 denotes thyroid cancer
18234963-4#53#67#diseaseC0549473 520-534 diseaseC0549473 denotes thyroid cancer
18234963-4#53#67#diseaseC0007115 520-534 diseaseC0007115 denotes thyroid cancer
18234963-4#53#67#diseaseC0549473 520-534 diseaseC0549473 denotes thyroid cancer
22#42#gene715755#69#diseaseC0007115 18234963-0#22#42#gene7157 18234963-0#55#69#diseaseC0007115 associated_with p53 tumor suppressor,thyroid cancer
22#42#gene715755#69#diseaseC0549473 18234963-0#22#42#gene7157 18234963-0#55#69#diseaseC0549473 associated_with p53 tumor suppressor,thyroid cancer
21#24#gene8347853#67#diseaseC0007115 18234963-4#21#24#gene83478 18234963-4#53#67#diseaseC0007115 associated_with p73,thyroid cancer
21#24#gene8347853#67#diseaseC0549473 18234963-4#21#24#gene83478 18234963-4#53#67#diseaseC0549473 associated_with p73,thyroid cancer
21#24#gene8347853#67#diseaseC0007115 18234963-4#21#24#gene83478 18234963-4#53#67#diseaseC0007115 associated_with p73,thyroid cancer
21#24#gene8347853#67#diseaseC0549473 18234963-4#21#24#gene83478 18234963-4#53#67#diseaseC0549473 associated_with p73,thyroid cancer
21#24#gene716153#67#diseaseC0007115 18234963-4#21#24#gene7161 18234963-4#53#67#diseaseC0007115 associated_with p73,thyroid cancer
21#24#gene716153#67#diseaseC0549473 18234963-4#21#24#gene7161 18234963-4#53#67#diseaseC0549473 associated_with p73,thyroid cancer
21#24#gene716153#67#diseaseC0007115 18234963-4#21#24#gene7161 18234963-4#53#67#diseaseC0007115 associated_with p73,thyroid cancer
21#24#gene716153#67#diseaseC0549473 18234963-4#21#24#gene7161 18234963-4#53#67#diseaseC0549473 associated_with p73,thyroid cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2120 22-42 gene:7157 denotes p53 tumor suppressor
T2121 55-69 disease:C0007115 denotes thyroid cancer
T2122 488-491 gene:83478 denotes p73
T2123 520-534 disease:C0007115 denotes thyroid cancer
R1 T2120 T2121 associated_with p53 tumor suppressor,thyroid cancer
R2 T2120 T2121 associated_with p53 tumor suppressor,thyroid cancer
R3 T2122 T2123 associated_with p73,thyroid cancer
R4 T2122 T2123 associated_with p73,thyroid cancer
R5 T2122 T2123 associated_with p73,thyroid cancer
R6 T2122 T2123 associated_with p73,thyroid cancer