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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 305-308 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 305-308 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 388-391 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 388-391 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 846-849 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T6 846-849 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T7 1359-1362 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 1359-1362 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 305-308 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T3 388-391 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T5 846-849 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T7 1359-1362 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 305-308 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T2 305-308 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T3 388-391 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T4 388-391 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T5 846-849 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T6 846-849 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T7 1359-1362 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T8 1359-1362 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-121 Sentence denotes Sialyl cholesterol is translocated into cell nuclei and it promotes neurite outgrowth in a mouse neuroblastoma cell line.
TextSentencer_T2 122-347 Sentence denotes To determine the mechanisms of the neuritogenesis induced by synthetic sialyl cholesterol (SC) in a mouse neuroblastoma cell line, Neuro2a, the biochemical fate of SC and ganglioside GM1 (IV3NeuAc-GgOse4Cer) was investigated.
TextSentencer_T3 348-438 Sentence denotes The kinetics of incorporation of SC and GM1 into cells for the two compounds were similar.
TextSentencer_T4 439-612 Sentence denotes SC was not degraded nor modified for at least 24 h after the incorporation, indicating that SC itself and not its metabolites were responsible for the neuritogenic activity.
TextSentencer_T5 613-800 Sentence denotes Cell fractionation experiments showed that approximately 40% of the incorporated SC was localized in the nucleus, 25% in the plasma membrane fractions, and 11-14% in the granule fraction.
TextSentencer_T6 801-850 Sentence denotes This distribution was different from that of GM1.
TextSentencer_T7 851-988 Sentence denotes The nuclear SC was found to affect de novo RNA synthesis, indicating its biological effect may be mediated at the level of transcription.
TextSentencer_T8 989-1115 Sentence denotes SC also increased the rates of both Ca2+ influx and efflux, although the intracellular level of total Ca2+ remained unchanged.
TextSentencer_T9 1116-1299 Sentence denotes Levels of inositol 1,4,5-triphosphate (IP3) also remained unchanged and the SC dependent neuritogenesis was not inhibited by an excess amount of W-7, an inhibitor of Ca2+/CaM kinases.
TextSentencer_T10 1300-1441 Sentence denotes These results again accord with the suggestion that SC and GM1 do not utilize Ca2+, IP3 or Ca2+/CaM as a second messenger for neuritogenesis.
TextSentencer_T11 1442-1540 Sentence denotes Rather it appears very likely that the nuclear localized SC may play a key role in neuritogenesis.
T1 0-121 Sentence denotes Sialyl cholesterol is translocated into cell nuclei and it promotes neurite outgrowth in a mouse neuroblastoma cell line.
T2 122-347 Sentence denotes To determine the mechanisms of the neuritogenesis induced by synthetic sialyl cholesterol (SC) in a mouse neuroblastoma cell line, Neuro2a, the biochemical fate of SC and ganglioside GM1 (IV3NeuAc-GgOse4Cer) was investigated.
T3 348-438 Sentence denotes The kinetics of incorporation of SC and GM1 into cells for the two compounds were similar.
T4 439-612 Sentence denotes SC was not degraded nor modified for at least 24 h after the incorporation, indicating that SC itself and not its metabolites were responsible for the neuritogenic activity.
T5 613-800 Sentence denotes Cell fractionation experiments showed that approximately 40% of the incorporated SC was localized in the nucleus, 25% in the plasma membrane fractions, and 11-14% in the granule fraction.
T6 801-850 Sentence denotes This distribution was different from that of GM1.
T7 851-988 Sentence denotes The nuclear SC was found to affect de novo RNA synthesis, indicating its biological effect may be mediated at the level of transcription.
T8 989-1115 Sentence denotes SC also increased the rates of both Ca2+ influx and efflux, although the intracellular level of total Ca2+ remained unchanged.
T9 1116-1299 Sentence denotes Levels of inositol 1,4,5-triphosphate (IP3) also remained unchanged and the SC dependent neuritogenesis was not inhibited by an excess amount of W-7, an inhibitor of Ca2+/CaM kinases.
T10 1300-1441 Sentence denotes These results again accord with the suggestion that SC and GM1 do not utilize Ca2+, IP3 or Ca2+/CaM as a second messenger for neuritogenesis.
T11 1442-1540 Sentence denotes Rather it appears very likely that the nuclear localized SC may play a key role in neuritogenesis.
T1 0-121 Sentence denotes Sialyl cholesterol is translocated into cell nuclei and it promotes neurite outgrowth in a mouse neuroblastoma cell line.
T2 122-347 Sentence denotes To determine the mechanisms of the neuritogenesis induced by synthetic sialyl cholesterol (SC) in a mouse neuroblastoma cell line, Neuro2a, the biochemical fate of SC and ganglioside GM1 (IV3NeuAc-GgOse4Cer) was investigated.
T3 348-438 Sentence denotes The kinetics of incorporation of SC and GM1 into cells for the two compounds were similar.
T4 439-612 Sentence denotes SC was not degraded nor modified for at least 24 h after the incorporation, indicating that SC itself and not its metabolites were responsible for the neuritogenic activity.
T5 613-800 Sentence denotes Cell fractionation experiments showed that approximately 40% of the incorporated SC was localized in the nucleus, 25% in the plasma membrane fractions, and 11-14% in the granule fraction.
T6 801-850 Sentence denotes This distribution was different from that of GM1.
T7 851-988 Sentence denotes The nuclear SC was found to affect de novo RNA synthesis, indicating its biological effect may be mediated at the level of transcription.
T8 989-1115 Sentence denotes SC also increased the rates of both Ca2+ influx and efflux, although the intracellular level of total Ca2+ remained unchanged.
T9 1116-1299 Sentence denotes Levels of inositol 1,4,5-triphosphate (IP3) also remained unchanged and the SC dependent neuritogenesis was not inhibited by an excess amount of W-7, an inhibitor of Ca2+/CaM kinases.
T10 1300-1441 Sentence denotes These results again accord with the suggestion that SC and GM1 do not utilize Ca2+, IP3 or Ca2+/CaM as a second messenger for neuritogenesis.
T11 1442-1540 Sentence denotes Rather it appears very likely that the nuclear localized SC may play a key role in neuritogenesis.

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 305-308 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T2 388-391 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T3 846-849 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T4 1359-1362 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 40-51 FMAID:63840 denotes cell nuclei
_T2 40-51 FMAID:162303 denotes cell nuclei
_T3 68-75 FMAID:166048 denotes neurite
_T4 68-75 FMAID:61814 denotes neurite
_T5 293-304 FMAID:196811 denotes ganglioside
_T6 293-304 FMAID:82816 denotes ganglioside
_T7 392-402 FMAID:167230 denotes into cells
_T8 397-402 FMAID:169002 denotes cells
_T9 397-402 FMAID:68646 denotes cells
_T10 415-424 FMAID:165656 denotes compounds
_T11 415-424 FMAID:67745 denotes compounds
_T12 738-744 FMAID:162307 denotes plasma
_T13 738-753 FMAID:66843 denotes plasma membrane
_T14 738-753 FMAID:63841 denotes plasma membrane
_T15 738-753 FMAID:164993 denotes plasma membrane
_T16 738-753 FMAID:210691 denotes plasma membrane
_T17 738-753 FMAID:162306 denotes plasma membrane
_T18 738-753 FMAID:166047 denotes plasma membrane
_T19 1011-1016 FMAID:217859 denotes rates
_T20 1025-1028 FMAID:182506 denotes Ca2
_T21 1025-1028 FMAID:272658 denotes Ca2
_T22 1025-1028 FMAID:272430 denotes Ca2
_T23 1091-1094 FMAID:182506 denotes Ca2
_T24 1091-1094 FMAID:272430 denotes Ca2
_T25 1091-1094 FMAID:272658 denotes Ca2
_T26 1282-1285 FMAID:182506 denotes Ca2
_T27 1282-1285 FMAID:272658 denotes Ca2
_T28 1282-1285 FMAID:272430 denotes Ca2
_T29 1287-1290 FMAID:165234 denotes CaM
_T30 1378-1381 FMAID:272658 denotes Ca2
_T31 1378-1381 FMAID:272430 denotes Ca2
_T32 1378-1381 FMAID:182506 denotes Ca2
_T33 1391-1394 FMAID:182506 denotes Ca2
_T34 1391-1394 FMAID:272430 denotes Ca2
_T35 1391-1394 FMAID:272658 denotes Ca2
_T36 1396-1399 FMAID:165234 denotes CaM

uniprot-human

Id Subject Object Predicate Lexical cue
T1 213-215 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T2 286-288 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T3 381-383 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T4 439-441 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T5 531-533 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T6 694-696 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T7 863-865 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T8 989-991 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T9 1192-1194 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T10 1352-1354 http://www.uniprot.org/uniprot/Q96PL6 denotes SC
T11 1499-1501 http://www.uniprot.org/uniprot/Q96PL6 denotes SC

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 1025-1028 http://www.uniprot.org/uniprot/P00920 denotes Ca2
T2 1091-1094 http://www.uniprot.org/uniprot/P00920 denotes Ca2
T3 1282-1285 http://www.uniprot.org/uniprot/P00920 denotes Ca2
T4 1378-1381 http://www.uniprot.org/uniprot/P00920 denotes Ca2
T5 1391-1394 http://www.uniprot.org/uniprot/P00920 denotes Ca2

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 139-149 http://purl.bioontology.org/ontology/NCBITAXON/127244 denotes mechanisms
T2 397-402 http://purl.bioontology.org/ontology/STY/T025 denotes cells

GO-BP

Id Subject Object Predicate Lexical cue
T1 0-6 http://purl.obolibrary.org/obo/GO_0097503 denotes Sialyl
T2 193-199 http://purl.obolibrary.org/obo/GO_0097503 denotes sialyl
T3 68-85 http://purl.obolibrary.org/obo/GO_0031175 denotes neurite outgrowth
T4 450-458 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T5 603-617 http://purl.obolibrary.org/obo/GO_0001775 denotes activity. Cell
T6 701-710 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T7 1489-1498 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T8 701-725 http://purl.obolibrary.org/obo/GO_0051647 denotes localized in the nucleus
T9 894-907 http://purl.obolibrary.org/obo/GO_0032774 denotes RNA synthesis
T10 898-907 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T11 974-987 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

GO-CC

Id Subject Object Predicate Lexical cue
T1 40-44 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T2 111-115 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 242-246 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4 397-402 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5 613-617 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T6 68-75 http://purl.obolibrary.org/obo/GO_0043005 denotes neurite
T7 459-462 http://purl.obolibrary.org/obo/GO_0005731 denotes nor
T8 718-725 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T9 738-753 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T10 745-753 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T11 1062-1075 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 59-67 http://edamontology.org/topic_1312 denotes promotes
T2 59-67 http://edamontology.org/topic_0111 denotes promotes
T3 59-67 http://edamontology.org/topic_0749 denotes promotes
T4 553-564 http://edamontology.org/topic_0154 denotes metabolites
T5 553-564 http://edamontology.org/topic_0079 denotes metabolites
T6 718-725 http://edamontology.org/topic_0616 denotes nucleus
T7 974-987 http://edamontology.org/topic_0110 denotes transcription
T8 974-987 http://edamontology.org/topic_3512 denotes transcription
T9 974-987 http://edamontology.org/topic_0203 denotes transcription
T10 974-987 http://edamontology.org/topic_3308 denotes transcription

GlycoBiology-Epitope

Id Subject Object Predicate Lexical cue
PD-GlycoEpitope-B_T1 305-308 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T2 388-391 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T3 846-849 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
PD-GlycoEpitope-B_T4 1359-1362 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 305-308 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 388-391 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 846-849 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 1359-1362 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 97-110 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 228-241 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 97-110 Phenotype denotes neuroblastoma HP:0003006
T2 228-241 Phenotype denotes neuroblastoma HP:0003006

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 305-308 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T2 388-391 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T3 846-849 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T4 1359-1362 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 305-308 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 388-391 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 846-849 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1359-1362 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 97-110 Phenotype denotes neuroblastoma HP:0003006
T2 228-241 Phenotype denotes neuroblastoma HP:0003006

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-75 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T2 718-725 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T4 738-753 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T5 1062-1075 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 91-96 Organism denotes mouse 10088|10090
T3 222-227 Organism denotes mouse 10088|10090

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-121 Sentence denotes Sialyl cholesterol is translocated into cell nuclei and it promotes neurite outgrowth in a mouse neuroblastoma cell line.
T2 122-347 Sentence denotes To determine the mechanisms of the neuritogenesis induced by synthetic sialyl cholesterol (SC) in a mouse neuroblastoma cell line, Neuro2a, the biochemical fate of SC and ganglioside GM1 (IV3NeuAc-GgOse4Cer) was investigated.
T3 348-438 Sentence denotes The kinetics of incorporation of SC and GM1 into cells for the two compounds were similar.
T4 439-612 Sentence denotes SC was not degraded nor modified for at least 24 h after the incorporation, indicating that SC itself and not its metabolites were responsible for the neuritogenic activity.
T5 613-800 Sentence denotes Cell fractionation experiments showed that approximately 40% of the incorporated SC was localized in the nucleus, 25% in the plasma membrane fractions, and 11-14% in the granule fraction.
T6 801-850 Sentence denotes This distribution was different from that of GM1.
T7 851-988 Sentence denotes The nuclear SC was found to affect de novo RNA synthesis, indicating its biological effect may be mediated at the level of transcription.
T8 989-1115 Sentence denotes SC also increased the rates of both Ca2+ influx and efflux, although the intracellular level of total Ca2+ remained unchanged.
T9 1116-1299 Sentence denotes Levels of inositol 1,4,5-triphosphate (IP3) also remained unchanged and the SC dependent neuritogenesis was not inhibited by an excess amount of W-7, an inhibitor of Ca2+/CaM kinases.
T10 1300-1441 Sentence denotes These results again accord with the suggestion that SC and GM1 do not utilize Ca2+, IP3 or Ca2+/CaM as a second messenger for neuritogenesis.
T11 1442-1540 Sentence denotes Rather it appears very likely that the nuclear localized SC may play a key role in neuritogenesis.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 305-308 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 388-391 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T3 846-849 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T4 1359-1362 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 97-110 Disease denotes neuroblastoma MONDO:0005072
T2 228-241 Disease denotes neuroblastoma MONDO:0005072

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 68-75 Body_part denotes neurite FMA:61814
T2 738-753 Body_part denotes plasma membrane FMA:63841

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 91-96 OrganismTaxon denotes mouse 10088|10090
T3 222-227 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 68-75 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T2 718-725 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125
T4 738-753 Body_part denotes plasma membrane http://purl.obolibrary.org/obo/GO_0005886
T5 1062-1075 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622