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PubMed:18223211 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T3 0-24 D002285 denotes Ductal carcinoma in situ
T4 0-24 D002285 denotes Ductal carcinoma in situ
T9 63-69 UBERON:0000310 denotes breast
T10 63-76 D001943 denotes breast cancer
T11 63-76 D001943 denotes breast cancer
T12 97-102 D006801 denotes Human
T13 112-118 UBERON:0000310 denotes breast
T14 119-126 D009369 denotes cancers
T15 119-126 D009369 denotes cancers
T16 128-131 CVCL_EQ33 denotes IBC
T19 234-258 D002285 denotes ductal carcinoma in situ
T20 234-258 D002285 denotes ductal carcinoma in situ
T26 260-264 CVCL_5552 denotes DCIS
T25 260-264 D002285 denotes DCIS
T27 260-264 D002285 denotes DCIS
T28 404-414 D015415 denotes biomarkers
T29 404-414 D015415 denotes biomarkers
T30 477-481 PR:Q8FYW3 denotes pure
T31 477-481 PR:Q54QE4 denotes pure
T32 477-481 PR:P52558 denotes pure
T33 477-481 PR:P0AG18 denotes pure
T35 477-481 PR:000023640 denotes pure
T34 477-481 GO:0034023 denotes pure
T37 482-486 CVCL_5552 denotes DCIS
T36 482-486 D002285 denotes DCIS
T38 482-486 D002285 denotes DCIS
T40 571-575 CVCL_5552 denotes DCIS
T39 571-575 D002285 denotes DCIS
T41 571-575 D002285 denotes DCIS
T43 602-605 GO:0005574 denotes DNA
T45 602-605 SO:0000352 denotes DNA
T44 602-605 CHEBI:16991 denotes DNA
T46 602-605 D004247 denotes DNA
T47 638-645 D010634 denotes luminal
T48 638-645 D010634 denotes luminal
T49 638-645 CHEBI:8069 denotes luminal
T52 658-663 PR:P70424 denotes erbB2
T53 658-663 PR:P06494 denotes erbB2
T54 658-663 PR:P04626 denotes erbB2
T55 658-663 PR:000002082 denotes erbB2
T57 735-739 CVCL_5552 denotes DCIS
T56 735-739 D002285 denotes DCIS
T58 735-739 D002285 denotes DCIS
T59 852-862 D015415 denotes biomarkers
T60 852-862 D015415 denotes biomarkers
T62 962-966 CVCL_5552 denotes DCIS
T61 962-966 D002285 denotes DCIS
T63 962-966 D002285 denotes DCIS
T64 1042-1052 D015415 denotes biomarkers
T65 1042-1052 D015415 denotes biomarkers
T67 1173-1177 CVCL_5552 denotes DCIS
T66 1173-1177 D002285 denotes DCIS
T68 1173-1177 D002285 denotes DCIS
T69 1266-1275 CHEBI:59163 denotes biomarker
T71 1341-1345 CVCL_5552 denotes DCIS
T70 1341-1345 D002285 denotes DCIS
T72 1341-1345 D002285 denotes DCIS
T74 1431-1435 CVCL_5552 denotes DCIS
T73 1431-1435 D002285 denotes DCIS
T75 1431-1435 D002285 denotes DCIS
T76 1471-1474 PR:P04637 denotes p53
T77 1471-1474 PR:000003035 denotes p53
T78 1471-1474 PR:P02340 denotes p53
T79 1471-1474 PR:Q42578 denotes p53
T80 1471-1474 PR:P10361 denotes p53
T82 1566-1570 CVCL_5552 denotes DCIS
T81 1566-1570 D002285 denotes DCIS
T83 1566-1570 D002285 denotes DCIS
T85 1613-1617 CVCL_5552 denotes DCIS
T84 1613-1617 D002285 denotes DCIS
T86 1613-1617 D002285 denotes DCIS
T87 1789-1792 PR:P04637 denotes p53
T88 1789-1792 PR:000003035 denotes p53
T89 1789-1792 PR:P02340 denotes p53
T90 1789-1792 PR:Q42578 denotes p53
T91 1789-1792 PR:P10361 denotes p53
T92 1793-1801 SO:0000109 denotes mutation
T93 1842-1845 CVCL_EQ33 denotes IBC

DisGeNET

Id Subject Object Predicate Lexical cue
T0 658-663 gene:2064 denotes erbB2
T1 571-575 disease:C0007124 denotes DCIS
R1 T0 T1 associated_with erbB2,DCIS

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-87 DRI_Background denotes Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution.
T2 97-183 DRI_Background denotes Human invasive breast cancers (IBC) show enormous histologic and biological diversity.
T3 184-300 DRI_Background denotes This study comprehensively evaluated diversity in ductal carcinoma in situ (DCIS), the immediate precursors of IBCs.
T4 322-554 DRI_Background denotes The extent of diversity for conventional histologic grade and standard prognostic biomarkers assessed by immunohistochemistry was evaluated in a series of pure DCIS (n = 200) compared with a contemporaneous series of IBCs (n = 200).
T5 555-683 DRI_Approach denotes A subset of the DCIS (n = 25) was evaluated by DNA microarrays for the presence of luminal, basal, and erbB2 intrinsic subtypes.
T6 684-952 DRI_Approach denotes The extent of diversity within individual cases of DCIS (n = 120) was determined by assessing multiple regions independently for histologic (nuclear) grade and several biomarkers by immunohistochemistry, which approximate microarrays in determining intrinsic subtypes.
T7 962-1122 DRI_Background denotes DCIS showed a broad distribution of conventional histologic grades and standard biomarkers ranging from well to poorly differentiated, nearly identical to IBCs.
T8 1123-1189 DRI_Outcome denotes Microarrays showed the same intrinsic subtypes in DCIS as in IBCs.
T9 1190-1404 DRI_Outcome denotes However, higher resolution analysis showed that multiple histologic grades, biomarker phenotypes, and intrinsic subtypes often coexist within the same DCIS, and these diverse regions probably compete for dominance.
T10 1405-1488 DRI_Background denotes Diversity within cases of DCIS was highly correlated with mutated p53 (P = 0.0007).
T11 1502-1709 DRI_Background denotes These results support the hypothesis that poorly differentiated DCIS gradually evolve from well-differentiated DCIS by randomly acquiring genetic defects resulting in increasingly abnormal cellular features.
T12 1710-1897 DRI_Background denotes This diversity is amplified by defects resulting in genetic instability (e.g., p53 mutation), and the alterations are propagated to IBC in a manner independent of progression to invasion.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
18223211-4#103#108#gene2064 658-663 gene2064 denotes erbB2
18223211-4#16#20#diseaseC0007124 571-575 diseaseC0007124 denotes DCIS
18223211-9#66#69#gene7157 1471-1474 gene7157 denotes p53
18223211-9#26#30#diseaseC0007124 1431-1435 diseaseC0007124 denotes DCIS
103#108#gene206416#20#diseaseC0007124 18223211-4#103#108#gene2064 18223211-4#16#20#diseaseC0007124 associated_with erbB2,DCIS
66#69#gene715726#30#diseaseC0007124 18223211-9#66#69#gene7157 18223211-9#26#30#diseaseC0007124 associated_with p53,DCIS