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PubMed:18206535 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 134-303 DRI_Background denotes In hereditary nonpolyposis colorectal cancer (HNPCC), patients' mismatch repair (MMR) gene mutations cause MMR deficiency, leading to microsatellite instability (MSI-H).
T2 304-494 DRI_Background denotes MSI-H is also found in a substantial fraction of sporadic gastric carcinomas (SGC), mainly due to MLH1 promoter hypermethylation, although somatic mutations in MMR genes have been described.
T3 495-556 DRI_Approach denotes We aimed to investigate which MMR defects are present in SGC.
T4 557-768 DRI_Background denotes Twenty-nine MSI-H SGC investigated previously for MLH1 promoter hypermethylation were screened for somatic mutations in MLH1, MSH2, MSH6, MLH3, and MBD4 by denaturing gradient gel electrophoresis and sequencing.
T5 769-890 DRI_Background denotes Five truncating mutations (three in MSH6, one in MLH3, and one in MBD4) and one missense mutation (MLH1) were identified.
T6 891-980 DRI_Background denotes Of these, three truncating mutations were in MSI-H cases that lack MLH1 hypermethylation.
T7 981-1126 DRI_Outcome denotes As all truncating mutations were found in the coding poly-A tracts, it seems likely that they result from the MSI phenotype rather than cause it.
T8 1127-1292 DRI_Background denotes In summary, somatic mutations in MMR genes are rare in SGC and do not explain the development of these tumors reflecting, rather than causing, the mutator phenotype.
T9 1293-1385 DRI_Background denotes Other MMR genes are probably involved in MSI-H gastric cancer without MLH1 hypermethylation.

c_corpus

Id Subject Object Predicate Lexical cue
T1 21-36 GO:0006298 denotes mismatch repair
T2 63-73 D002277 denotes carcinomas
T3 63-73 D002277 denotes carcinomas
T7 137-178 D003123 denotes hereditary nonpolyposis colorectal cancer
T8 137-178 D003123 denotes hereditary nonpolyposis colorectal cancer
T11 198-213 GO:0006298 denotes mismatch repair
T14 215-218 P22897 denotes MMR
T15 215-218 PR:000002972 denotes MMR
T16 215-218 Q61830 denotes MMR
T13 215-218 CVCL_E779 denotes MMR
T12 215-218 GO:0006298 denotes MMR
T17 220-224 SO:0000704 denotes gene
T20 241-244 P22897 denotes MMR
T21 241-244 PR:000002972 denotes MMR
T22 241-244 Q61830 denotes MMR
T19 241-244 CVCL_E779 denotes MMR
T18 241-244 GO:0006298 denotes MMR
T23 241-255 C536928 denotes MMR deficiency
T24 241-255 C536928 denotes MMR deficiency
T25 245-255 SO:1000029 denotes deficiency
T26 268-282 SO:0000289 denotes microsatellite
T27 268-294 D053842 denotes microsatellite instability
T28 268-294 D053842 denotes microsatellite instability
T29 296-299 PR:000006870 denotes MSI
T30 296-299 PR:P70245 denotes MSI
T31 304-307 PR:000006870 denotes MSI
T32 304-307 PR:P70245 denotes MSI
T33 370-380 D002277 denotes carcinomas
T34 370-380 D002277 denotes carcinomas
T35 382-385 PR:Q9M345 denotes SGC
T36 402-406 PR:Q9ZRV4 denotes MLH1
T37 402-406 PR:P38920 denotes MLH1
T38 402-406 PR:Q54KD8 denotes MLH1
T40 402-406 PR:Q9JK91 denotes MLH1
T41 402-406 PR:P97679 denotes MLH1
T42 402-406 PR:Q9P7W6 denotes MLH1
T43 402-406 PR:000010442 denotes MLH1
T44 402-406 PR:P40692 denotes MLH1
T39 402-406 CVCL_G669 denotes MLH1
T45 407-415 SO:0000167 denotes promoter
T48 464-467 P22897 denotes MMR
T49 464-467 PR:000002972 denotes MMR
T50 464-467 Q61830 denotes MMR
T47 464-467 CVCL_E779 denotes MMR
T46 464-467 GO:0006298 denotes MMR
T53 525-528 P22897 denotes MMR
T54 525-528 PR:000002972 denotes MMR
T55 525-528 Q61830 denotes MMR
T52 525-528 CVCL_E779 denotes MMR
T51 525-528 GO:0006298 denotes MMR
T56 552-555 PR:Q9M345 denotes SGC
T57 569-572 PR:000006870 denotes MSI
T58 569-572 PR:P70245 denotes MSI
T59 575-578 PR:Q9M345 denotes SGC
T60 607-611 PR:Q9ZRV4 denotes MLH1
T61 607-611 PR:P38920 denotes MLH1
T62 607-611 PR:Q54KD8 denotes MLH1
T64 607-611 PR:Q9JK91 denotes MLH1
T65 607-611 PR:P97679 denotes MLH1
T66 607-611 PR:Q9P7W6 denotes MLH1
T67 607-611 PR:000010442 denotes MLH1
T68 607-611 PR:P40692 denotes MLH1
T63 607-611 CVCL_G669 denotes MLH1
T69 612-620 SO:0000167 denotes promoter
T70 677-681 PR:Q9ZRV4 denotes MLH1
T71 677-681 PR:P38920 denotes MLH1
T72 677-681 PR:Q54KD8 denotes MLH1
T74 677-681 PR:Q9JK91 denotes MLH1
T75 677-681 PR:P97679 denotes MLH1
T76 677-681 PR:Q9P7W6 denotes MLH1
T77 677-681 PR:000010442 denotes MLH1
T78 677-681 PR:P40692 denotes MLH1
T73 677-681 CVCL_G669 denotes MLH1
T80 683-686 CHEBI:16768 denotes MSH
T84 683-686 D009074 denotes MSH
T85 683-686 D009074 denotes MSH
T86 683-687 PR:000010666 denotes MSH2
T87 683-687 PR:P25847 denotes MSH2
T88 683-687 PR:P43246 denotes MSH2
T89 683-687 P22711 denotes MSH2
T90 683-687 PR:P22711 denotes MSH2
T91 683-687 PR:P54275 denotes MSH2
T92 683-687 PR:O74773 denotes MSH2
T93 683-687 PR:P43247 denotes MSH2
T94 683-687 PR:Q553L4 denotes MSH2
T95 683-687 PR:O24617 denotes MSH2
T97 689-692 CHEBI:16768 denotes MSH
T101 689-692 D009074 denotes MSH
T102 689-692 D009074 denotes MSH
T103 689-693 PR:P52701 denotes MSH6
T104 689-693 PR:P54276 denotes MSH6
T105 689-693 PR:Q9VUM0 denotes MSH6
T106 689-693 PR:Q55GU9 denotes MSH6
T107 689-693 PR:O04716 denotes MSH6
T108 689-693 PR:Q03834 denotes MSH6
T109 689-693 PR:O74502 denotes MSH6
T110 689-693 PR:000010670 denotes MSH6
T111 695-699 PR:F4JN26 denotes MLH3
T112 695-699 PR:Q12083 denotes MLH3
T113 695-699 PR:000010443 denotes MLH3
T114 695-699 PR:Q9UHC1 denotes MLH3
T118 705-709 PR:Q9LYB9 denotes MBD4
T119 705-709 P82019 denotes MBD4
T120 705-709 PR:Q9Z2D7 denotes MBD4
T121 705-709 PR:P82019 denotes MBD4
T122 705-709 PR:000010218 denotes MBD4
T123 705-709 PR:O95243 denotes MBD4
T125 805-808 CHEBI:16768 denotes MSH
T129 805-808 D009074 denotes MSH
T130 805-808 D009074 denotes MSH
T131 805-809 PR:P52701 denotes MSH6
T132 805-809 PR:P54276 denotes MSH6
T133 805-809 PR:Q9VUM0 denotes MSH6
T134 805-809 PR:Q55GU9 denotes MSH6
T135 805-809 PR:O04716 denotes MSH6
T136 805-809 PR:Q03834 denotes MSH6
T137 805-809 PR:O74502 denotes MSH6
T138 805-809 PR:000010670 denotes MSH6
T139 818-822 PR:F4JN26 denotes MLH3
T140 818-822 PR:Q12083 denotes MLH3
T141 818-822 PR:000010443 denotes MLH3
T142 818-822 PR:Q9UHC1 denotes MLH3
T146 835-839 PR:Q9LYB9 denotes MBD4
T147 835-839 P82019 denotes MBD4
T148 835-839 PR:Q9Z2D7 denotes MBD4
T149 835-839 PR:P82019 denotes MBD4
T150 835-839 PR:000010218 denotes MBD4
T151 835-839 PR:O95243 denotes MBD4
T152 849-857 SO:0001583 denotes missense
T153 858-866 SO:0000109 denotes mutation
T154 868-872 PR:Q9ZRV4 denotes MLH1
T155 868-872 PR:P38920 denotes MLH1
T156 868-872 PR:Q54KD8 denotes MLH1
T158 868-872 PR:Q9JK91 denotes MLH1
T159 868-872 PR:P97679 denotes MLH1
T160 868-872 PR:Q9P7W6 denotes MLH1
T161 868-872 PR:000010442 denotes MLH1
T162 868-872 PR:P40692 denotes MLH1
T157 868-872 CVCL_G669 denotes MLH1
T163 936-939 PR:000006870 denotes MSI
T164 936-939 PR:P70245 denotes MSI
T165 953-957 PR:Q9V853 denotes lack
T166 958-962 PR:Q9ZRV4 denotes MLH1
T167 958-962 PR:P38920 denotes MLH1
T168 958-962 PR:Q54KD8 denotes MLH1
T170 958-962 PR:Q9JK91 denotes MLH1
T171 958-962 PR:P97679 denotes MLH1
T172 958-962 PR:Q9P7W6 denotes MLH1
T173 958-962 PR:000010442 denotes MLH1
T174 958-962 PR:P40692 denotes MLH1
T169 958-962 CVCL_G669 denotes MLH1
T175 1034-1038 CL:0000775 denotes poly
T176 1034-1038 CL:0000096 denotes poly
T177 1034-1040 CHEBI:8287 denotes poly-A
T178 1034-1040 CHEBI:8756 denotes poly-A
T179 1034-1040 D011061 denotes poly-A
T180 1034-1040 D011061 denotes poly-A
T181 1091-1094 PR:000006870 denotes MSI
T182 1091-1094 PR:P70245 denotes MSI
T185 1160-1163 P22897 denotes MMR
T186 1160-1163 PR:000002972 denotes MMR
T187 1160-1163 Q61830 denotes MMR
T184 1160-1163 CVCL_E779 denotes MMR
T183 1160-1163 GO:0006298 denotes MMR
T188 1182-1185 PR:Q9M345 denotes SGC
T189 1230-1236 D009369 denotes tumors
T190 1230-1236 D009369 denotes tumors
T193 1299-1302 P22897 denotes MMR
T194 1299-1302 PR:000002972 denotes MMR
T195 1299-1302 Q61830 denotes MMR
T192 1299-1302 CVCL_E779 denotes MMR
T191 1299-1302 GO:0006298 denotes MMR
T196 1334-1337 PR:000006870 denotes MSI
T197 1334-1337 PR:P70245 denotes MSI
T198 1340-1354 D013274 denotes gastric cancer
T199 1340-1354 D013274 denotes gastric cancer
T200 1363-1367 PR:Q9ZRV4 denotes MLH1
T201 1363-1367 PR:P38920 denotes MLH1
T202 1363-1367 PR:Q54KD8 denotes MLH1
T204 1363-1367 PR:Q9JK91 denotes MLH1
T205 1363-1367 PR:P97679 denotes MLH1
T206 1363-1367 PR:Q9P7W6 denotes MLH1
T207 1363-1367 PR:000010442 denotes MLH1
T208 1363-1367 PR:P40692 denotes MLH1
T203 1363-1367 CVCL_G669 denotes MLH1

DisGeNET

Id Subject Object Predicate Lexical cue
T0 215-218 gene:4360 denotes MMR
T1 137-178 disease:C1333990 denotes hereditary nonpolyposis colorectal cancer
T2 215-218 gene:4360 denotes MMR
T3 180-185 disease:C1333990 denotes HNPCC
T4 215-218 gene:4360 denotes MMR
T5 241-255 disease:C0265325 denotes MMR deficiency
T6 1299-1302 gene:4360 denotes MMR
T7 1340-1354 disease:C0024623 denotes gastric cancer
T8 1299-1302 gene:4360 denotes MMR
T9 1340-1354 disease:C0699791 denotes gastric cancer
T10 1363-1367 gene:4292 denotes MLH1
T11 1340-1354 disease:C0024623 denotes gastric cancer
T12 1363-1367 gene:4292 denotes MLH1
T13 1340-1354 disease:C0699791 denotes gastric cancer
R1 T0 T1 associated_with MMR,hereditary nonpolyposis colorectal cancer
R2 T2 T3 associated_with MMR,HNPCC
R3 T4 T5 associated_with MMR,MMR deficiency
R4 T6 T7 associated_with MMR,gastric cancer
R5 T8 T9 associated_with MMR,gastric cancer
R6 T10 T11 associated_with MLH1,gastric cancer
R7 T12 T13 associated_with MLH1,gastric cancer